CA2701726A1 - Sequencing nucleic acid polymers with electron microscopy - Google Patents

Sequencing nucleic acid polymers with electron microscopy Download PDF

Info

Publication number
CA2701726A1
CA2701726A1 CA2701726A CA2701726A CA2701726A1 CA 2701726 A1 CA2701726 A1 CA 2701726A1 CA 2701726 A CA2701726 A CA 2701726A CA 2701726 A CA2701726 A CA 2701726A CA 2701726 A1 CA2701726 A1 CA 2701726A1
Authority
CA
Canada
Prior art keywords
nucleic acid
strand
needle
dna
labeled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2701726A
Other languages
English (en)
French (fr)
Inventor
William Andregg
Michael Andregg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Halcyon Molecular Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2701726A1 publication Critical patent/CA2701726A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60Detection means characterised by use of a special device
    • C12Q2565/601Detection means characterised by use of a special device being a microscope, e.g. atomic force microscopy [AFM]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CA2701726A 2007-10-04 2008-10-06 Sequencing nucleic acid polymers with electron microscopy Abandoned CA2701726A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US99742707P 2007-10-04 2007-10-04
US60/997,427 2007-10-04
US13296008P 2008-06-23 2008-06-23
US61/132,960 2008-06-23
PCT/US2008/078986 WO2009046445A1 (en) 2007-10-04 2008-10-06 Sequencing nucleic acid polymers with electron microscopy

Publications (1)

Publication Number Publication Date
CA2701726A1 true CA2701726A1 (en) 2009-04-09

Family

ID=40526732

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2701726A Abandoned CA2701726A1 (en) 2007-10-04 2008-10-06 Sequencing nucleic acid polymers with electron microscopy

Country Status (12)

Country Link
US (8) US20100331195A1 (cg-RX-API-DMAC7.html)
EP (1) EP2203547A4 (cg-RX-API-DMAC7.html)
JP (1) JP2010539991A (cg-RX-API-DMAC7.html)
KR (1) KR20100089060A (cg-RX-API-DMAC7.html)
CN (1) CN101889074A (cg-RX-API-DMAC7.html)
AU (1) AU2008308457A1 (cg-RX-API-DMAC7.html)
CA (1) CA2701726A1 (cg-RX-API-DMAC7.html)
EA (1) EA201000427A1 (cg-RX-API-DMAC7.html)
IL (1) IL204866A0 (cg-RX-API-DMAC7.html)
MX (1) MX2010003724A (cg-RX-API-DMAC7.html)
WO (1) WO2009046445A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201002881B (cg-RX-API-DMAC7.html)

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8021841B1 (en) * 2007-07-11 2011-09-20 Kenneth David Schatz Methods and apparatuses for spatially separating molecules attached to a support and uses in biotechnology
US7888127B2 (en) 2008-01-15 2011-02-15 Sequenom, Inc. Methods for reducing adduct formation for mass spectrometry analysis
US8583380B2 (en) 2008-09-05 2013-11-12 Aueon, Inc. Methods for stratifying and annotating cancer drug treatment options
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
CA2785020C (en) 2009-12-22 2020-08-25 Sequenom, Inc. Processes and kits for identifying aneuploidy
WO2011090556A1 (en) 2010-01-19 2011-07-28 Verinata Health, Inc. Methods for determining fraction of fetal nucleic acid in maternal samples
CA2786564A1 (en) 2010-01-19 2011-07-28 Verinata Health, Inc. Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing
US20120100548A1 (en) 2010-10-26 2012-04-26 Verinata Health, Inc. Method for determining copy number variations
US9323888B2 (en) 2010-01-19 2016-04-26 Verinata Health, Inc. Detecting and classifying copy number variation
AU2010343276B2 (en) 2010-01-19 2015-05-28 Verinata Health, Inc. Methods for determining fraction of fetal nucleic acid in maternal samples
US8700341B2 (en) 2010-01-19 2014-04-15 Verinata Health, Inc. Partition defined detection methods
US9260745B2 (en) 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
JP2013519980A (ja) 2010-02-10 2013-05-30 モチイ,インコーポレイテッド(ディービーエー ヴォクサ) 収差補正暗視野電子顕微鏡
IN2013MN00522A (cg-RX-API-DMAC7.html) 2010-09-24 2015-05-29 Univ Leland Stanford Junior
WO2012064850A1 (en) * 2010-11-09 2012-05-18 Michael Andregg Liquid-gas interface mediated molecule manipulation
US20140121132A1 (en) * 2011-03-11 2014-05-01 Cornell University Systems and methods for high resolution biomolecular imaging and analysis
EP2691544B1 (en) 2011-03-30 2017-09-13 Verinata Health, Inc Method for verifying bioassay samples
HUE041411T2 (hu) 2011-04-12 2019-05-28 Verinata Health Inc Genomfrakciók feloldása polimorfizmus-szám alkalmazásával
CN102985561B (zh) 2011-04-14 2015-04-01 维里纳塔健康公司 用于确定并且验证常见的和罕见的染色体非整倍性的归一化染色体
US9411937B2 (en) 2011-04-15 2016-08-09 Verinata Health, Inc. Detecting and classifying copy number variation
US20140235474A1 (en) 2011-06-24 2014-08-21 Sequenom, Inc. Methods and processes for non invasive assessment of a genetic variation
US20130029348A1 (en) * 2011-07-26 2013-01-31 Opgen, Inc. Methods of elongating nucleic acids
GB2485635B (en) 2011-07-26 2012-11-28 Verinata Health Inc Method for determining the presence or absence of different aneuploidies in a sample
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
AU2012318371B2 (en) 2011-10-06 2018-03-22 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CA2850785C (en) 2011-10-06 2022-12-13 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CA2851537C (en) 2011-10-11 2020-12-29 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US8688388B2 (en) 2011-10-11 2014-04-01 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CA2850509C (en) 2011-10-14 2023-08-01 President And Fellows Of Harvard College Sequencing by structure assembly
US20140371091A1 (en) * 2011-10-25 2014-12-18 Arizona Board of Regents, a body corporate of the state of Arizona, acting for and on behalf of Programmable Arrays
JP2014176297A (ja) * 2011-11-11 2014-09-25 Nagayama Ip Holdings Llc 塩基対応標識方法、塩基配列情報取得方法及び塩基対応標識化一本鎖核酸
JP6034801B2 (ja) * 2011-11-15 2016-11-30 ナガヤマ アイピー ホールディングス エルエルシーNagayama IP Holdings, LLC 塩基配列決定装置
US10227639B2 (en) 2011-12-22 2019-03-12 President And Fellows Of Harvard College Compositions and methods for analyte detection
ES2991004T3 (es) 2011-12-22 2024-12-02 Harvard College Métodos para la detección de analitos
US8858778B2 (en) * 2012-01-19 2014-10-14 Michael James Darling Method for DNA defined etching of a graphene nanostructure
JP6431769B2 (ja) 2012-01-20 2018-11-28 セクエノム, インコーポレイテッド 実験条件を要因として含める診断プロセス
US9856513B2 (en) * 2012-01-27 2018-01-02 Cornell University Methods and arrays for controlled manipulation of DNA and chromatin fragments for genetic and epigenetic analysis
US9605313B2 (en) 2012-03-02 2017-03-28 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013184754A2 (en) 2012-06-05 2013-12-12 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using dna origami probes
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140093873A1 (en) 2012-07-13 2014-04-03 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
CA2878246C (en) 2012-07-20 2022-01-11 Verinata Health, Inc. Detecting and classifying copy number variation in a cancer genome
CA2887094C (en) 2012-10-04 2021-09-07 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CA2899859C (en) 2013-01-31 2022-08-16 Codexis, Inc. Methods, systems, and software for identifying biomolecules with interacting components
US20130189684A1 (en) 2013-03-12 2013-07-25 Sequenom, Inc. Quantification of cell-specific nucleic acid markers
EP2971184B1 (en) 2013-03-12 2019-04-17 President and Fellows of Harvard College Method of generating a three-dimensional nucleic acid containing matrix
US9305756B2 (en) 2013-03-13 2016-04-05 Agena Bioscience, Inc. Preparation enhancements and methods of use for MALDI mass spectrometry
EP3597774A1 (en) 2013-03-13 2020-01-22 Sequenom, Inc. Primers for dna methylation analysis
EP3409791B1 (en) 2013-03-15 2021-06-30 Verinata Health, Inc. Generating cell-free dna libraries directly from blood
PL2981921T3 (pl) 2013-04-03 2023-05-08 Sequenom, Inc. Metody i procesy nieinwazyjnej oceny zmienności genetycznych
WO2014182726A2 (en) 2013-05-07 2014-11-13 Sequenom, Inc. Genetic markers for macular degeneration disorder treatment
AU2014268377B2 (en) 2013-05-24 2020-10-08 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
SG11201509962QA (en) 2013-06-04 2016-01-28 Harvard College Rna-guideded transcriptional regulation
JP6521956B2 (ja) 2013-06-17 2019-05-29 ベリナタ ヘルス インコーポレイテッド 性染色体におけるコピー数変異を判定するための方法
US10622094B2 (en) 2013-06-21 2020-04-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
JP6857029B2 (ja) 2013-09-27 2021-04-14 コデクシス, インコーポレイテッド 酵素バリアントの自動スクリーニング
IL320112A (en) 2013-10-04 2025-06-01 Sequenom Inc Methods and processes for non-invasive assessment of genetic variations
WO2015054080A1 (en) 2013-10-07 2015-04-16 Sequenom, Inc. Methods and processes for non-invasive assessment of chromosome alterations
WO2015061359A1 (en) 2013-10-21 2015-04-30 Verinata Health, Inc. Method for improving the sensitivity of detection in determining copy number variations
WO2015085268A1 (en) 2013-12-05 2015-06-11 Centrillion Technology Holdings Corporation Modified surfaces
WO2015085275A2 (en) 2013-12-05 2015-06-11 Centrillion Technology Holdings Corporation Fabrication of patterned arrays
EP3077545B1 (en) 2013-12-05 2020-09-16 Centrillion Technology Holdings Corporation Methods for sequencing nucleic acids
JP6666852B2 (ja) 2014-01-16 2020-03-18 イルミナ インコーポレイテッド 前立腺がん再発の予後に関する遺伝子発現パネル
EP3736344A1 (en) 2014-03-13 2020-11-11 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US11060139B2 (en) 2014-03-28 2021-07-13 Centrillion Technology Holdings Corporation Methods for sequencing nucleic acids
IL249095B2 (en) 2014-05-30 2023-10-01 Verinata Health Inc Detection of subchromosomal aneuploidy in the fetus and variations in the number of copies
WO2016007839A1 (en) 2014-07-11 2016-01-14 President And Fellows Of Harvard College Methods for high-throughput labelling and detection of biological features in situ using microscopy
US9982295B2 (en) 2014-07-18 2018-05-29 Illumina, Inc. Non-invasive prenatal diagnosis of fetal genetic condition using cellular DNA and cell free DNA
EP3760739B1 (en) 2014-07-30 2025-09-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20160032281A1 (en) * 2014-07-31 2016-02-04 Fei Company Functionalized grids for locating and imaging biological specimens and methods of using the same
WO2016055380A1 (en) 2014-10-09 2016-04-14 Roche Diagnostics Gmbh Mutations in the epidermal growth factor receptor kinase domain
US11789906B2 (en) 2014-11-19 2023-10-17 Arc Bio, Llc Systems and methods for genomic manipulations and analysis
WO2016094853A1 (en) 2014-12-12 2016-06-16 Verinata Health, Inc. Using cell-free dna fragment size to determine copy number variations
CN104630346A (zh) * 2015-01-05 2015-05-20 东南大学 基于高分辨透射电子显微学的单分子dna测序方法
DK3332034T3 (da) 2015-08-06 2024-10-28 Arc Bio Llc Systemer og fremgangsmåder til genomisk analyse
US10774375B2 (en) 2015-09-18 2020-09-15 Agena Bioscience, Inc. Methods and compositions for the quantitation of mitochondrial nucleic acid
MX2018005611A (es) 2015-11-03 2018-11-09 Harvard College Metodo y aparato para la formacion de imagenes volumetricas de una matriz tridimensional que contiene acido nucleico.
US10095831B2 (en) 2016-02-03 2018-10-09 Verinata Health, Inc. Using cell-free DNA fragment size to determine copy number variations
US9989482B2 (en) * 2016-02-16 2018-06-05 General Electric Company Methods for radiographic and CT inspection of additively manufactured workpieces
CA3022290A1 (en) 2016-04-25 2017-11-02 President And Fellows Of Harvard College Hybridization chain reaction methods for in situ molecular detection
US11200963B2 (en) 2016-07-27 2021-12-14 Sequenom, Inc. Genetic copy number alteration classifications
EP4428536A3 (en) 2016-08-31 2024-12-04 President and Fellows of Harvard College Methods of combining the detection of biomolecules into a single assay using fluorescent in situ sequencing
EP4582805A3 (en) 2016-08-31 2025-10-08 President And Fellows Of Harvard College Methods of generating libraries of nucleic acid sequences for detection via fluorescent in situ sequencing
EP3541957B1 (en) 2016-11-21 2025-06-25 Bruker Spatial Biology, Inc. A method for sequencing nucleic acids
EP3574424A1 (en) 2017-01-24 2019-12-04 Sequenom, Inc. Methods and processes for assessment of genetic variations
JP7024490B2 (ja) * 2017-02-27 2022-02-24 住友金属鉱山株式会社 汚染堆積物の定量方法および試料分析方法
WO2018170511A1 (en) 2017-03-17 2018-09-20 Sequenom, Inc. Methods and processes for assessment of genetic mosaicism
CA3019250A1 (en) 2017-04-14 2019-10-13 President And Fellows Of Harvard College Methods for generation of cell-derived microfilament network
US11342047B2 (en) 2017-04-21 2022-05-24 Illumina, Inc. Using cell-free DNA fragment size to detect tumor-associated variant
EP3642744B1 (en) 2017-06-20 2025-02-26 Illumina, Inc. Methods for accurate computational decomposition of dna mixtures from contributors of unknown genotypes
US20210151125A1 (en) 2017-06-20 2021-05-20 Illumina, Inc. Methods and systems for decomposition and quantification of dna mixtures from multiple contributors of known or unknown genotypes
AU2018375008B2 (en) 2017-12-01 2024-06-27 Illumina, Inc. Methods and systems for determining somatic mutation clonality
JP7525402B2 (ja) 2018-05-14 2024-07-30 ナノストリング テクノロジーズ,インコーポレイティド 化学的組成物とそれを利用する方法
WO2020028194A1 (en) 2018-07-30 2020-02-06 Readcoor, Inc. Methods and systems for sample processing or analysis
WO2020076976A1 (en) 2018-10-10 2020-04-16 Readcoor, Inc. Three-dimensional spatial molecular indexing
CN111324096B (zh) * 2020-03-03 2021-04-23 郑州旭飞光电科技有限公司 一种基板玻璃加工、包装信息可追溯系统及方法
CN111537529A (zh) * 2020-04-09 2020-08-14 中国科学院微电子研究所 一种用于附着穿透式电子显微镜样品的硅网及其制备方法
US20220049303A1 (en) 2020-08-17 2022-02-17 Readcoor, Llc Methods and systems for spatial mapping of genetic variants
WO2022164968A1 (en) 2021-01-29 2022-08-04 Day Zero Diagnostics, Inc. Methods for enriching microorganisms from low abundance clinical samples for dna sequencing
US20240392363A1 (en) 2023-05-26 2024-11-28 Illumina, Inc. Methods for discriminating between fetal and maternal events in non-invasive prenatal test samples

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4689295A (en) * 1983-01-20 1987-08-25 Integrated Genetics, Inc. Test for Salmonella
US6221581B1 (en) * 1984-04-27 2001-04-24 Enzo Diagnostics, Inc. Processes for detecting polynucleotides, determining genetic mutations or defects in genetic material, separating or isolating nucleic acid of interest from samples, and useful compositions of matter and multihybrid complex compositions
US5447841A (en) 1986-01-16 1995-09-05 The Regents Of The Univ. Of California Methods for chromosome-specific staining
US6150089A (en) * 1988-09-15 2000-11-21 New York University Method and characterizing polymer molecules or the like
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5106729A (en) * 1989-07-24 1992-04-21 Arizona Board Of Regents Acting On Behalf Of Arizona State University Method for visualizing the base sequence of nucleic acid polymers
US5789161A (en) * 1990-09-20 1998-08-04 Amoco Corporation Methods for genome identification using direct label probe composition
JPH05244997A (ja) * 1992-03-04 1993-09-24 Hitachi Ltd Dnaまたはrnaの塩基配列決定法
US5871912A (en) * 1992-04-30 1999-02-16 Institut Pasteur Nucleic acid probes, sequences and methods for detecting mycobacterium tuberculosis resistant to isoniazid
US5472881A (en) * 1992-11-12 1995-12-05 University Of Utah Research Foundation Thiol labeling of DNA for attachment to gold surfaces
JPH08506664A (ja) * 1993-02-01 1996-07-16 セック,リミテッド Dna配列決定の方法および装置
GB9401200D0 (en) * 1994-01-21 1994-03-16 Medical Res Council Sequencing of nucleic acids
US20020168642A1 (en) * 1994-06-06 2002-11-14 Andrzej Drukier Sequencing duplex DNA by mass spectroscopy
WO1996009410A1 (en) * 1994-09-23 1996-03-28 Finkelstein Sydney D Topographic genotyping
US5601982A (en) * 1995-02-07 1997-02-11 Sargent; Jeannine P. Method and apparatus for determining the sequence of polynucleotides
US5843650A (en) * 1995-05-01 1998-12-01 Segev; David Nucleic acid detection and amplification by chemical linkage of oligonucleotides
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
JP4468488B2 (ja) 1996-05-29 2010-05-26 コーネル・リサーチ・ファンデーション・インコーポレイテッド 組み合せたリガーゼ検出およびポリメラーゼ連鎖反応を用いる核酸配列相違の検出
US6582921B2 (en) * 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
US6136543A (en) * 1997-01-31 2000-10-24 Hitachi, Ltd. Method for determining nucleic acids base sequence and apparatus therefor
CA2205081A1 (en) * 1997-06-04 1998-12-04 Graham Dellaire A method to map and isolate regions of chromosomes that interact or associate functionally within or between chromosomes in vivo
US5903085A (en) * 1997-06-18 1999-05-11 Phase Metrics, Inc. Piezoelectric nanopositioner
DE19900511C2 (de) * 1999-01-08 2001-03-15 Deutsches Krebsforsch Molekularbiologische Marker für die analytische Elektronenmikroskopie
WO2000075868A2 (en) 1999-06-07 2000-12-14 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for use in three-dimensional structural determination
DE19937512B4 (de) * 1999-08-09 2006-08-24 Alexander Cherkasky Verfahren und Gerät zur schnellen Genom-Sequenzierung durch Linearisierung oder Auseinanderziehen der DNA
US7211390B2 (en) * 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7244559B2 (en) * 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
JP5508654B2 (ja) * 2000-04-14 2014-06-04 コーネル・リサーチ・ファンデーション・インコーポレイテッド リガーゼ検出反応を用いた核酸配列の違いの検出のための位置特定可能なアレイの設計方法
JP2002153271A (ja) * 2000-11-17 2002-05-28 Jeol Ltd Dnaあるいはrnaの塩基配列決定方法およびdnaシーケンサー
US7419833B2 (en) * 2000-11-17 2008-09-02 Nagayama Ip Holdings Llc Method for nucleic acid sequencing
EP1354064A2 (en) * 2000-12-01 2003-10-22 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
WO2002048432A2 (en) * 2000-12-15 2002-06-20 The Arizona Board Of Regents Method for patterning metal using nanoparticle containing precursors
EP2465943A3 (en) * 2001-03-16 2012-10-03 Kalim Mir Linear polymer display
US20020182626A1 (en) * 2001-03-16 2002-12-05 Daniel Tuse Episomal non-transforming nucleic acid elements in functional genomic and antigenic applications
FR2823223B1 (fr) 2001-04-04 2004-03-12 Centre Nat Rech Scient Structure bicouche supportee de presentation d'un acide nucleique associe a une proteine
GB0112238D0 (en) * 2001-05-18 2001-07-11 Medical Biosystems Ltd Sequencing method
GB2378245A (en) 2001-08-03 2003-02-05 Mats Nilsson Nucleic acid amplification method
FR2829580B1 (fr) * 2001-09-07 2004-02-13 Bio Merieux Procede de lecture, de detection ou de quantification, hybrides ou complexes utilises dans ce procede et biopuce mettant en oeuvre ledit procede
EP1436409A2 (en) * 2001-09-07 2004-07-14 Massachusetts Institute Of Technology Lanthanide binding tags
US20040086885A1 (en) * 2002-02-22 2004-05-06 Purdue Research Foundation Magnetic nanomaterials and methods for detection of biological materials
JP4120240B2 (ja) * 2002-03-06 2008-07-16 株式会社島津製作所 生体由来異物検査法
US20060003437A1 (en) * 2002-06-26 2006-01-05 Fujitsu Limited Target detecting device and target capturer, device and method for molecular adsorption or desorption, and device and method for protein detection
US20050009055A1 (en) * 2002-07-12 2005-01-13 Affymetrix, Inc. System and method for examination of microarrays using scanning electron microscope
US20040081985A1 (en) * 2002-07-12 2004-04-29 Affymetrix, Inc. Systems and method for examination of microarrays using scanning electron microscope
EP1556506A1 (en) 2002-09-19 2005-07-27 The Chancellor, Masters And Scholars Of The University Of Oxford Molecular arrays and single molecule detection
EP1424671A1 (en) * 2002-11-29 2004-06-02 Alrec Sign & Display B.V. Illuminated sign
JP2004212355A (ja) * 2003-01-09 2004-07-29 Hitachi Ltd バイオ電子顕微鏡及び試料の観察方法
US7745116B2 (en) * 2003-04-08 2010-06-29 Pacific Biosciences Of California, Inc. Composition and method for nucleic acid sequencing
US20100035254A1 (en) * 2003-04-08 2010-02-11 Pacific Biosciences Of California, Inc. Composition and method for nucleic acid sequencing
WO2004094659A1 (en) * 2003-04-21 2004-11-04 Roche Diagnostics Gmbh Associations of polymorphisms in the frzb gene with obesity and osteoporosis
US7625346B2 (en) * 2003-05-30 2009-12-01 Boston Scientific Scimed, Inc. Transbronchial needle aspiration device
US20070072187A1 (en) * 2003-11-28 2007-03-29 Blok Herman J Novel methods and apparatus for cell based microarray assays
US20050147977A1 (en) * 2003-12-29 2005-07-07 Tae-Woong Koo Methods and compositions for nucleic acid detection and sequence analysis
US7381529B2 (en) * 2003-12-31 2008-06-03 Intel Corporation Methods and compositions for detecting nucleic acids using scanning probe microscopy and nanocodes
WO2005098895A2 (en) * 2004-04-02 2005-10-20 California Institute Of Technology Method and system for ultrafast photoelectron microscope
US7618778B2 (en) * 2004-06-02 2009-11-17 Kaufman Joseph C Producing, cataloging and classifying sequence tags
JP5224443B2 (ja) * 2004-07-14 2013-07-03 ゼットエス ジェネティクス,インコーポレーテッド 核酸ポリマーの分析システムおよび方法および関連構成要素
JP4563117B2 (ja) * 2004-09-03 2010-10-13 エスアイアイ・ナノテクノロジー株式会社 顕微鏡システム及び顕微鏡システムの走査法ならびに顕微鏡システムの画像合成法
US20090239215A1 (en) 2004-12-16 2009-09-24 Brandeis University Clonable Tag for Purification and Electron Microscopy Labeling
US7875426B2 (en) * 2005-02-04 2011-01-25 University Of South Florida DNA biochip and methods of use
JP2006262834A (ja) * 2005-03-25 2006-10-05 Canon Inc 核酸の塩基配列の決定方法及び該方法に基づく核酸の塩基配列解析装置
US20060287833A1 (en) * 2005-06-17 2006-12-21 Zohar Yakhini Method and system for sequencing nucleic acid molecules using sequencing by hybridization and comparison with decoration patterns
CN101300349A (zh) * 2005-09-09 2008-11-05 关键基因公司 植物的同源重组
CA2627410A1 (en) * 2005-10-27 2007-05-03 The Trustees Of Boston University Real time nucleic acid detection in vivo using protein complementation
TW200736401A (en) * 2005-11-09 2007-10-01 Zs Genetics Inc Nano-scale ligand arrays on substrates for particle beam instruments and related methods
ES2547554T3 (es) * 2005-11-16 2015-10-07 Ambrx, Inc. Métodos y composiciones que comprenden aminoácidos no naturales
US20070128610A1 (en) * 2005-12-02 2007-06-07 Buzby Philip R Sample preparation method and apparatus for nucleic acid sequencing
WO2007089542A2 (en) 2006-01-27 2007-08-09 Zs Genetics, Inc. Systems and methods of analyzing nucleic acid polymers by using particle beams
ES2301342B1 (es) * 2006-03-14 2009-05-01 Oryzon Genomics, S.A. "metodo de analisis de acidos nucleicos".
ATE449190T1 (de) * 2006-03-25 2009-12-15 Univ Ruprecht Karls Heidelberg Verfahren zur mikroskopischen ortsbestimmung eines ausgewählten, intrazellulären dna- abschnitts bekannter nukleotidsequenz
JP5092462B2 (ja) * 2006-06-13 2012-12-05 株式会社デンソー 力学量センサ
WO2008011430A2 (en) * 2006-07-17 2008-01-24 Fox Chase Cancer Center Compositions and methods for the treatment of diseases associated with aberrant cilia assembly and regulation
CA2658122C (en) * 2006-07-19 2014-09-02 Bionanomatrix, Inc. Nanonozzle device arrays: their preparation and use for macromolecular analysis
WO2008022035A2 (en) * 2006-08-10 2008-02-21 The Scripps Research Institute Methods for identifying cellular modulators of disaggregation activity or aggregation activity in an animal
US20080060778A1 (en) * 2006-09-08 2008-03-13 Abraham Velasco-Tellez Binder composition and method of forming foundry sand cores and molds
US20090208965A1 (en) * 2006-10-25 2009-08-20 Ikonisys, Inc. Automated method for detecting cancers and high grade hyperplasias
US20090215643A1 (en) 2007-07-26 2009-08-27 Cellay, Llc Highly Visible Chromosome-Specific Probes and Related Methods
WO2009052214A2 (en) 2007-10-15 2009-04-23 Complete Genomics, Inc. Sequence analysis using decorated nucleic acids
JP2009178159A (ja) * 2007-11-05 2009-08-13 Hitachi Plant Technologies Ltd 核酸配列の検出方法及び核酸配列検出基板

Also Published As

Publication number Publication date
KR20100089060A (ko) 2010-08-11
WO2009046445A1 (en) 2009-04-09
JP2010539991A (ja) 2010-12-24
US20100267156A1 (en) 2010-10-21
AU2008308457A1 (en) 2009-04-09
US20100267155A1 (en) 2010-10-21
EP2203547A1 (en) 2010-07-07
CN101889074A (zh) 2010-11-17
ZA201002881B (en) 2011-07-27
EP2203547A4 (en) 2011-06-01
IL204866A0 (en) 2010-11-30
US20100267157A1 (en) 2010-10-21
US20100268478A1 (en) 2010-10-21
EA201000427A1 (ru) 2010-10-29
US20100267152A1 (en) 2010-10-21
US20100267154A1 (en) 2010-10-21
MX2010003724A (es) 2010-09-14
US20100267153A1 (en) 2010-10-21
US20100331195A1 (en) 2010-12-30
US8153438B2 (en) 2012-04-10

Similar Documents

Publication Publication Date Title
US8153438B2 (en) Sequencing nucleic acid polymers with electron microscopy
EP3004385B1 (en) Nanopore-based nucleic acid analysis with mixed fret detection
EP1543152B1 (en) Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (spm) reading
EP1601791B1 (en) Random array dna analysis by hybridization
US7381529B2 (en) Methods and compositions for detecting nucleic acids using scanning probe microscopy and nanocodes
US20250320543A1 (en) Method of translocating nucleic acids through nanopores
US20250101493A1 (en) Spatial omics platforms and systems
WO2014066902A1 (en) Hybrid nanopore device with optical detection and methods of using same
WO2013119784A1 (en) Methods of sequencing nucleic acids using nanopores and active kinetic proofreading
JPH05244997A (ja) Dnaまたはrnaの塩基配列決定法
EP1546983A2 (en) Controlled aligment of nano-barcodes encoding specific information for scanning probe microscopy (spm) reading
DK2217729T3 (en) Method of concentrating nucleic acid molecules
HK1152071A (en) Sequencing nucleic acid polymers with electron microscopy
WO2010144128A2 (en) Molecular alignment and attachment of nucleic acid molecules

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20131009