CA2701202C - Biomarkers for autism spectrum disorders - Google Patents
Biomarkers for autism spectrum disorders Download PDFInfo
- Publication number
- CA2701202C CA2701202C CA2701202A CA2701202A CA2701202C CA 2701202 C CA2701202 C CA 2701202C CA 2701202 A CA2701202 A CA 2701202A CA 2701202 A CA2701202 A CA 2701202A CA 2701202 C CA2701202 C CA 2701202C
- Authority
- CA
- Canada
- Prior art keywords
- gain
- cnvs
- loss
- spx
- asd
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96057207P | 2007-10-04 | 2007-10-04 | |
| US60/960,572 | 2007-10-04 | ||
| US829407P | 2007-12-20 | 2007-12-20 | |
| US61/008,294 | 2007-12-20 | ||
| PCT/CA2008/001767 WO2009043178A1 (en) | 2007-10-04 | 2008-10-03 | Biomarkers for autism spectrum disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2701202A1 CA2701202A1 (en) | 2009-04-09 |
| CA2701202C true CA2701202C (en) | 2018-01-02 |
Family
ID=40525814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2701202A Active CA2701202C (en) | 2007-10-04 | 2008-10-03 | Biomarkers for autism spectrum disorders |
Country Status (4)
| Country | Link |
|---|---|
| US (4) | US20100248235A1 (enExample) |
| JP (2) | JP5680964B2 (enExample) |
| CA (1) | CA2701202C (enExample) |
| WO (1) | WO2009043178A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7702468B2 (en) | 2006-05-03 | 2010-04-20 | Population Diagnostics, Inc. | Evaluating genetic disorders |
| US10522240B2 (en) | 2006-05-03 | 2019-12-31 | Population Bio, Inc. | Evaluating genetic disorders |
| WO2009043178A1 (en) | 2007-10-04 | 2009-04-09 | The Hospital For Sick Children | Biomarkers for autism spectrum disorders |
| CA2773049C (en) * | 2009-09-08 | 2019-08-20 | Laboratory Corporation Of America Holdings | Compositions and methods for diagnosing autism spectrum disorders |
| CA2797787C (en) * | 2010-04-29 | 2019-07-09 | Wisconsin Alumni Research Foundation | Metabolic biomarkers of autism |
| EP2601609B1 (en) | 2010-08-02 | 2017-05-17 | Population Bio, Inc. | Compositions and methods for discovery of causative mutations in genetic disorders |
| CA2744424A1 (en) * | 2010-09-14 | 2012-03-14 | The Hospital For Sick Children | Biomarkers for autism spectrum disorders |
| WO2012173809A2 (en) * | 2011-06-02 | 2012-12-20 | Ehli Erik | Method of identifying de novo copy number variants (cnv) using mz twins discordant for attention problems/disorders |
| EP2766483B1 (en) * | 2011-10-10 | 2022-03-23 | The Hospital For Sick Children | Methods and compositions for screening and treating developmental disorders |
| EP2773779B1 (en) | 2011-11-04 | 2020-10-14 | Population Bio, Inc. | Methods and compositions for diagnosing, prognosing, and treating neurological conditions |
| WO2013120018A1 (en) | 2012-02-09 | 2013-08-15 | Population Diagnostics, Inc. | Methods and compositions for screening and treating developmental disorders |
| EP2823055A2 (en) * | 2012-03-09 | 2015-01-14 | Integragen | A genotyping test for assessing risk of autism |
| DK2895621T3 (da) | 2012-09-14 | 2020-11-30 | Population Bio Inc | Fremgangsmåder og sammensætning til diagnosticering, prognose og behandling af neurologiske tilstande |
| EP2900835B1 (en) * | 2012-09-27 | 2025-04-30 | Population Bio, Inc. | Method for screening and treating developmental disorders |
| US10724096B2 (en) | 2014-09-05 | 2020-07-28 | Population Bio, Inc. | Methods and compositions for inhibiting and treating neurological conditions |
| WO2016109449A1 (en) * | 2014-12-29 | 2016-07-07 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of diagnosing autism spectrum disorders |
| US10240205B2 (en) | 2017-02-03 | 2019-03-26 | Population Bio, Inc. | Methods for assessing risk of developing a viral disease using a genetic test |
| US20210087631A1 (en) * | 2017-03-28 | 2021-03-25 | The Regents Of The University Of California | Methods for assessing risk of or diagnosing genetic defects by identifying de novo mutations or somatic mosaic variants in sperm or somatic tissues |
| CA3108807A1 (en) | 2018-08-08 | 2020-02-13 | Pml Screening, Llc | Methods for assessing the risk of developing progressive multifocal leukoencephalopathy caused by john cunningham virus by genetic testing |
| CN111575366A (zh) * | 2020-05-22 | 2020-08-25 | 深圳市亿立方生物技术有限公司 | 用于检测自闭症基因组拷贝数变异的引物组、探针组及试剂盒 |
| CN113528650B (zh) * | 2021-08-03 | 2022-03-08 | 长沙艾克曼生物科技有限公司 | Tmp21基因的表达可以作为自闭症早期筛查、早期识别和症状严重程度预测的客观指标 |
| EP4148147A1 (en) * | 2021-09-10 | 2023-03-15 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz | Means and method for the diagnosis and treatment of autism spectrum disorders based on the detection and modulation of a deubiquitinase |
| CN117025758B (zh) * | 2023-09-19 | 2024-04-05 | 华北理工大学 | 环状rna在制备诊断孤独症的生物标志物中的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US173495A (en) * | 1876-02-15 | Improvement in seed-sowers | ||
| JP2008504838A (ja) * | 2004-07-01 | 2008-02-21 | アンテグラジャン | Ｐｒｋｃｂ１をコードするヒト自閉症感受性遺伝子およびその使用 |
| WO2009043178A1 (en) | 2007-10-04 | 2009-04-09 | The Hospital For Sick Children | Biomarkers for autism spectrum disorders |
-
2008
- 2008-10-03 WO PCT/CA2008/001767 patent/WO2009043178A1/en not_active Ceased
- 2008-10-03 US US12/681,229 patent/US20100248235A1/en not_active Abandoned
- 2008-10-03 JP JP2010527310A patent/JP5680964B2/ja active Active
- 2008-10-03 CA CA2701202A patent/CA2701202C/en active Active
-
2014
- 2014-06-04 JP JP2014116245A patent/JP5941099B2/ja active Active
-
2015
- 2015-02-24 US US14/630,205 patent/US10526653B2/en active Active
-
2019
- 2019-11-25 US US16/694,314 patent/US11254984B2/en active Active
-
2022
- 2022-01-21 US US17/581,371 patent/US12467093B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2701202A1 (en) | 2009-04-09 |
| US10526653B2 (en) | 2020-01-07 |
| JP5680964B2 (ja) | 2015-03-04 |
| US20200157628A1 (en) | 2020-05-21 |
| US12467093B2 (en) | 2025-11-11 |
| US11254984B2 (en) | 2022-02-22 |
| US20150322518A1 (en) | 2015-11-12 |
| JP2014155507A (ja) | 2014-08-28 |
| US20220136055A1 (en) | 2022-05-05 |
| US20100248235A1 (en) | 2010-09-30 |
| JP2010539958A (ja) | 2010-12-24 |
| JP5941099B2 (ja) | 2016-06-29 |
| WO2009043178A1 (en) | 2009-04-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12467093B2 (en) | Biomarkers for autism spectrum disorders | |
| US11447826B2 (en) | Cystic fibrosis transmembrane conductance regulator gene mutations | |
| CN101679971A (zh) | 青光眼恶化风险的判定方法 | |
| US8206911B2 (en) | Identification of the gene and mutation responsible for progressive rod-cone degeneration in dog and a method for testing same | |
| Damgaard et al. | No genetic linkage or molecular evidence for involvement of the PCSK9, ARH or CYP7A1 genes in the Familial Hypercholesterolemia phenotype in a sample of Danish families without pathogenic mutations in the LDL receptor and apoB genes | |
| EP2694674A1 (en) | Association markers for beta thalassemia trait | |
| JP2014511691A5 (enExample) | ||
| CN111763728A (zh) | 一种用于阿尔茨海默病早期筛查的snp位点组合、引物组及试剂盒 | |
| KR20170051747A (ko) | 피부 주름 발생 민감도 진단용 단일염기다형성 마커 및 이의 용도 | |
| WO2011081039A1 (ja) | 加齢黄斑変性症易罹患性の判定マーカー並びに判定方法及び判定キット | |
| KR101848438B1 (ko) | 디지털 pcr을 이용한 산전진단 방법 | |
| KR102294939B1 (ko) | Lats1 유전자 변이 마커 기반의 근위축성 측삭경화증의 진단방법 | |
| JP5643933B2 (ja) | Ｚｎｆ５１２ｂ遺伝子の一塩基多型に基づく筋萎縮性側索硬化症の検査方法 | |
| US20060029930A1 (en) | Detecting genotypes associated with congenital adrenal hyperplasia | |
| Griffin et al. | Detection of hemizygosity in Hermansky–Pudlak syndrome by quantitative real‐time PCR | |
| CN116004801B (zh) | 一种导致mcph5型小头畸形的致病基因aspm复合杂合突变的应用及检测试剂和应用 | |
| EP1641937B1 (en) | Mutations in the slc40a1 gene associated to impaired iron homeostasis | |
| US8236497B2 (en) | Methods of diagnosing cardiovascular disease | |
| CN118222690A (zh) | 一种检测人tgfbi基因突变的引物探针组合物及其应用 | |
| WO2022010917A1 (en) | Methods, compositions, and systems for detecting pnpla3 allelic variants | |
| WO2009036513A1 (en) | Diagnostic and therapeutic protocols | |
| Kessler et al. | The Contribution of Molecular Techniques in Prenatal Diagnosis and Post mortem Fetus with Multiple Malformation | |
| US20130210657A1 (en) | Method of Determining Risk of Autism Spectrum Disorder | |
| Lin | Genetics of common psychiatric disorders: A Mendelian perspective based on genetic analyses of large pedigrees | |
| JP2018134060A (ja) | 側弯症の検査方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20130919 |