CA2698989C - Plants which synthesize increased amounts of glucosaminoglycans - Google Patents

Plants which synthesize increased amounts of glucosaminoglycans Download PDF

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Publication number
CA2698989C
CA2698989C CA2698989A CA2698989A CA2698989C CA 2698989 C CA2698989 C CA 2698989C CA 2698989 A CA2698989 A CA 2698989A CA 2698989 A CA2698989 A CA 2698989A CA 2698989 C CA2698989 C CA 2698989C
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Prior art keywords
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lys
ile
ala
val
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CA2698989A
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English (en)
French (fr)
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CA2698989A1 (en
Inventor
Claus Frohberg
Bernd Essigmann
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Bayer Intellectual Property GmbH
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Bayer Intellectual Property GmbH
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Publication of CA2698989A1 publication Critical patent/CA2698989A1/en
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Publication of CA2698989C publication Critical patent/CA2698989C/en
Expired - Fee Related legal-status Critical Current
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8245Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified carbohydrate or sugar alcohol metabolism, e.g. starch biosynthesis
    • C12N15/8246Non-starch polysaccharides, e.g. cellulose, fructans, levans
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/04Preserving or maintaining viable microorganisms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/06Lysis of microorganisms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/08Reducing the nucleic acid content

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Nutrition Science (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Enzymes And Modification Thereof (AREA)
CA2698989A 2007-09-12 2008-09-11 Plants which synthesize increased amounts of glucosaminoglycans Expired - Fee Related CA2698989C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP07116174.9 2007-09-12
EP07116174A EP2036983A1 (de) 2007-09-12 2007-09-12 Pflanzen, die erhöhte Mengen an Glucosaminglycanen synthetisieren
US99357507P 2007-09-13 2007-09-13
US60/993,575 2007-09-13
PCT/EP2008/007837 WO2009033752A1 (en) 2007-09-12 2008-09-11 Plants which synthesize increased amounts of glucosaminglycans

Publications (2)

Publication Number Publication Date
CA2698989A1 CA2698989A1 (en) 2009-03-19
CA2698989C true CA2698989C (en) 2018-07-24

Family

ID=39205122

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2698989A Expired - Fee Related CA2698989C (en) 2007-09-12 2008-09-11 Plants which synthesize increased amounts of glucosaminoglycans

Country Status (9)

Country Link
US (1) US9150873B2 (enExample)
EP (2) EP2036983A1 (enExample)
JP (1) JP5529741B2 (enExample)
CN (1) CN101855354B (enExample)
AR (1) AR068623A1 (enExample)
AT (1) ATE551425T1 (enExample)
AU (1) AU2008297527B2 (enExample)
CA (1) CA2698989C (enExample)
WO (1) WO2009033752A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2947597B2 (ja) 1990-07-27 1999-09-13 日本油脂株式会社 鋳物加工品の塗装方法及びそれによって得られた意匠性鋳物塗装品
JP5081629B2 (ja) * 2005-12-15 2012-11-28 生化学工業株式会社 長鎖コンドロイチン糖鎖及びその製造方法並びにコンドロイチン合成の促進方法
CN106755022B (zh) * 2015-11-25 2020-08-04 中国科学院大连化学物理研究所 乙酰葡萄糖胺磷酸变位酶AtAGM编码基因及其酶、制备、应用与酶活性检测方法
CN113528482B (zh) * 2021-08-02 2024-02-06 山东大学 高活性肝素骨架合酶PmHS2突变体及其应用

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US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
NL8300698A (nl) 1983-02-24 1984-09-17 Univ Leiden Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; agrobacterium tumefaciens bacterien en werkwijze voor het produceren daarvan; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten.
NO161573C (no) 1983-11-25 1989-08-30 Miles Inc Fremgangsmaate til fremstilling av hyaluronsyre.
JPS60251898A (ja) * 1984-05-25 1985-12-12 Shiseido Co Ltd 醗酵法によるヒアルロン酸の製造方法
CN85100964A (zh) * 1985-04-01 1988-02-17 赵凤源 树木多代嫁接繁殖法
CN1003347B (zh) * 1985-04-27 1989-02-22 广西化工研究所 植物生长调节剂
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NO173355C (no) * 1987-03-03 1993-12-01 Chugai Pharmaceutical Co Ltd Fremgangsm}te og selektiv bestemmelse av en h!ymolekylvekts hyaluronsyre og reagenssett for utf!relse av fremgangsm}ten
ES2074999T3 (es) 1987-05-20 1995-10-01 Ciba Geigy Ag Plantas de zea mays y plantas de zea mays transgenicas regeneradas de protoplastos o celulas derivadas de protoplastos.
US4897349A (en) * 1989-04-28 1990-01-30 Medchem Products, Inc. Biosynthesis of hyaluronic acid
US7705215B1 (en) 1990-04-17 2010-04-27 Dekalb Genetics Corporation Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
DK0465875T3 (da) 1990-06-23 1999-08-09 Hoechst Schering Agrevo Gmbh Fremgangsmåde til produktion af en calluskultur af Zea mays (L.)
JPH05199877A (ja) 1991-10-03 1993-08-10 Sumitomo Chem Co Ltd バレイショおよびイネの誘導型植物防御遺伝子の制御領域、その用途およびアッセイ法
US6455304B1 (en) * 1994-07-01 2002-09-24 The Board Of Regents Of The University Of Oklahoma Hyaluronate synthase gene and uses thereof
IT1271001B (it) 1994-07-26 1997-05-26 Poli Ind Chimica Spa Procedimento di preparazione di acido ialuronico mediante fermentazione con streptococcus
DE19619918A1 (de) * 1996-05-17 1997-11-20 Planttec Biotechnologie Gmbh Nucleinsäuremoleküle codierend lösliche Stärkesynthasen aus Mais
GB9702592D0 (en) 1997-02-07 1997-03-26 Danisco Selection method
US6369298B1 (en) * 1997-04-30 2002-04-09 Pioneer Hi-Bred International, Inc. Agrobacterium mediated transformation of sorghum
US20030104601A1 (en) * 1999-04-01 2003-06-05 Deangelis Paul L. Chondroitin synthase gene and methods of making and using same
US7094581B2 (en) * 1998-10-26 2006-08-22 The Board Of Regents Of The University Of Oklahoma Hyaluronan synthases and methods of making and using same
JP2001060708A (ja) * 1999-06-18 2001-03-06 Nippon Sheet Glass Co Ltd 透明積層体およびこれを用いたガラス物品
AR044724A1 (es) 2000-03-27 2005-10-05 Syngenta Participations Ag Promotores del virus de la rizadura amarilla del cestrum
US6607745B2 (en) * 2001-05-18 2003-08-19 Harry Leneau Ingestion of hyaluronic acid for improved joint function and health
JP4702819B2 (ja) * 2001-08-01 2011-06-15 生化学工業株式会社 コンドロイチン合成酵素
JP4101548B2 (ja) * 2001-08-10 2008-06-18 生化学工業株式会社 コンドロイチン合成酵素及びそれをコードするdna
US7811806B2 (en) * 2001-12-21 2010-10-12 Novozymes, Inc. Methods for producing hyaluronan in a recombinant host cell
US20040003432A1 (en) * 2002-05-06 2004-01-01 Pharmacia Corporation Production of hexosamines and uses thereof
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ES2354696T3 (es) * 2003-07-31 2011-03-17 Toyo Boseki Kabushiki Kaisha Planta que produce ácido hialurónico.
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EP1640457A1 (de) * 2004-09-23 2006-03-29 Bayer CropScience GmbH Verfahren und Mittel zur Herstellung von Hyaluronan
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JP2009509555A (ja) * 2005-10-05 2009-03-12 バイエル・クロップサイエンス・アーゲー ヒアルロン酸の産生が増大した植物ii
CA2624496A1 (en) * 2005-10-05 2007-04-12 Bayer Cropscience Ag Plants with an increased production of hyaluronan ii
US8106256B2 (en) * 2005-10-05 2012-01-31 Bayer Cropscience Ag Methods and means for producing hyaluronan
AU2006298964B2 (en) * 2005-10-05 2013-05-02 Bayer Intellectual Property Gmbh Plants having an increased content of amino sugars

Also Published As

Publication number Publication date
JP2010538626A (ja) 2010-12-16
AU2008297527B2 (en) 2014-07-17
CA2698989A1 (en) 2009-03-19
ATE551425T1 (de) 2012-04-15
CN101855354B (zh) 2016-04-06
EP2190998B1 (en) 2012-03-28
US9150873B2 (en) 2015-10-06
JP5529741B2 (ja) 2014-06-25
CN101855354A (zh) 2010-10-06
AU2008297527A1 (en) 2009-03-19
EP2036983A1 (de) 2009-03-18
WO2009033752A1 (en) 2009-03-19
US20100196966A1 (en) 2010-08-05
AR068623A1 (es) 2009-11-25
EP2190998A1 (en) 2010-06-02

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