CA2697024C - Bilayers - Google Patents
Bilayers Download PDFInfo
- Publication number
- CA2697024C CA2697024C CA2697024A CA2697024A CA2697024C CA 2697024 C CA2697024 C CA 2697024C CA 2697024 A CA2697024 A CA 2697024A CA 2697024 A CA2697024 A CA 2697024A CA 2697024 C CA2697024 C CA 2697024C
- Authority
- CA
- Canada
- Prior art keywords
- bilayer
- hydrated
- lipid
- support
- hydrated support
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/5432—Liposomes or microcapsules
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
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- Investigating Or Analysing Biological Materials (AREA)
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- Physical Or Chemical Processes And Apparatus (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
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| PCT/GB2008/002805 WO2009024775A1 (en) | 2007-08-21 | 2008-08-19 | Bilayers |
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| CA2697024A1 CA2697024A1 (en) | 2009-02-26 |
| CA2697024C true CA2697024C (en) | 2016-10-18 |
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| CA2697024A Active CA2697024C (en) | 2007-08-21 | 2008-08-19 | Bilayers |
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| EP (1) | EP2183594B1 (https=) |
| JP (1) | JP5797405B2 (https=) |
| CN (1) | CN101821626B (https=) |
| CA (1) | CA2697024C (https=) |
| GB (1) | GB0716264D0 (https=) |
| WO (1) | WO2009024775A1 (https=) |
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| WO2007070660A2 (en) | 2005-12-13 | 2007-06-21 | President And Fellows Of Harvard College | Scaffolds for cell transplantation |
| US20110121840A1 (en) | 2007-02-20 | 2011-05-26 | Gurdial Singh Sanghera | Lipid Bilayer Sensor System |
| GB0724736D0 (en) | 2007-12-19 | 2008-01-30 | Oxford Nanolabs Ltd | Formation of layers of amphiphilic molecules |
| GB0913823D0 (en) * | 2009-08-07 | 2009-09-16 | Isis Innovation | Bilayers |
| US8313956B2 (en) * | 2010-03-09 | 2012-11-20 | Nokia Corporation | Apparatus and associated methods |
| CN107648668B (zh) | 2010-10-06 | 2021-06-18 | 哈佛学院董事会 | 用于基于材料的细胞疗法的可注射的成孔水凝胶 |
| KR101939420B1 (ko) | 2011-02-11 | 2019-01-16 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 돌연변이체 세공 |
| EP2697394A4 (en) | 2011-04-12 | 2015-01-14 | Electronic Biosciences Inc | CHEMICALLY MODIFIED NANOPORA DEVICES AT A SPECIFIC SITE |
| US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
| GB201119032D0 (en) | 2011-11-03 | 2011-12-14 | Isis Innovation | Multisomes: encapsulated droplet networks |
| GB201202519D0 (en) | 2012-02-13 | 2012-03-28 | Oxford Nanopore Tech Ltd | Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules |
| KR102083695B1 (ko) | 2012-04-10 | 2020-03-02 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 돌연변이체 리세닌 기공 |
| DK2838515T3 (da) | 2012-04-16 | 2020-02-24 | Harvard College | Mesoporøse siliciumdioxidsammensætninger til modulering af immunresponser |
| EP2861998B1 (en) * | 2012-06-18 | 2020-07-22 | Electronic Biosciences Inc. | Cell-free assay device and methods of use |
| GB201219196D0 (en) | 2012-10-25 | 2012-12-12 | Isis Innovation | Droplet assembly method |
| GB201219201D0 (en) | 2012-10-25 | 2012-12-12 | Isis Innovation | Hydrogel network |
| JP6375301B2 (ja) * | 2012-10-26 | 2018-08-15 | オックスフォード ナノポール テクノロジーズ リミテッド | 液滴界面 |
| GB201313121D0 (en) | 2013-07-23 | 2013-09-04 | Oxford Nanopore Tech Ltd | Array of volumes of polar medium |
| KR102449271B1 (ko) | 2012-12-07 | 2022-09-29 | 옥스포드 유니버시티 이노베이션 리미티드 | 3d 프린팅에 의한 비말 어셈블리 |
| GB201313477D0 (en) | 2013-07-29 | 2013-09-11 | Univ Leuven Kath | Nanopore biosensors for detection of proteins and nucleic acids |
| CN103435269A (zh) * | 2013-08-21 | 2013-12-11 | 哈尔滨工业大学 | 一种固体支撑仿生膜体系的制备方法 |
| CN111534504B (zh) | 2014-01-22 | 2024-06-21 | 牛津纳米孔科技公开有限公司 | 将一个或多个多核苷酸结合蛋白连接到靶多核苷酸的方法 |
| EP3137105A4 (en) | 2014-04-30 | 2017-12-27 | President and Fellows of Harvard College | Combination vaccine devices and methods of killing cancer cells |
| EP3137490B1 (en) | 2014-05-02 | 2021-01-27 | Oxford Nanopore Technologies Limited | Mutant pores |
| WO2016009180A1 (en) | 2014-07-14 | 2016-01-21 | Isis Innovation Limited | Measurement of analytes with membrane channel molecules, and bilayer arrays |
| CA2959220A1 (en) | 2014-09-01 | 2016-03-10 | Vib Vzw | Mutant csgg pores |
| EP3204511B1 (en) | 2014-10-07 | 2021-07-28 | Oxford Nanopore Technologies Limited | Mutant pores |
| GB201418512D0 (en) | 2014-10-17 | 2014-12-03 | Oxford Nanopore Tech Ltd | Electrical device with detachable components |
| US11786457B2 (en) | 2015-01-30 | 2023-10-17 | President And Fellows Of Harvard College | Peritumoral and intratumoral materials for cancer therapy |
| GB201502810D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Method |
| GB201502809D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Mutant pore |
| WO2016164705A1 (en) | 2015-04-10 | 2016-10-13 | Omar Abdel-Rahman Ali | Immune cell trapping devices and methods for making and using the same |
| WO2016166232A1 (en) | 2015-04-14 | 2016-10-20 | Katholieke Universiteit Leuven | Nanopores with internal protein adaptors |
| US10641764B2 (en) | 2015-07-02 | 2020-05-05 | The University Of Massachusetts | Membrane and droplet-interface bilayer systems and methods |
| US10481120B1 (en) | 2015-08-06 | 2019-11-19 | University Of Tennessee Research Foundation | Droplet based measurement of specific capacitance and interfacial tensions |
| AU2016369071B2 (en) | 2015-12-08 | 2022-05-19 | Katholieke Universiteit Leuven Ku Leuven Research & Development | Modified nanopores, compositions comprising the same, and uses thereof |
| US11752238B2 (en) | 2016-02-06 | 2023-09-12 | President And Fellows Of Harvard College | Recapitulating the hematopoietic niche to reconstitute immunity |
| US10371610B2 (en) | 2016-02-23 | 2019-08-06 | Noul Co., Ltd. | Contact-type patch, staining method using the same, and manufacturing method thereof |
| KR20170099739A (ko) | 2016-02-23 | 2017-09-01 | 노을 주식회사 | 접촉식 염색 보조 패치, 그 제조 방법 및 이를 이용하는 염색 방법 |
| KR102478639B1 (ko) | 2016-02-23 | 2022-12-19 | 노을 주식회사 | 표지 물질을 저장하는 패치, 이를 이용하는 조직 진단 방법 및 장치 |
| CN116200476A (zh) | 2016-03-02 | 2023-06-02 | 牛津纳米孔科技公开有限公司 | 靶分析物测定方法、突变CsgG单体及其构筑体、及聚核苷酸和寡聚孔 |
| US10155979B2 (en) | 2016-03-30 | 2018-12-18 | Roche Molecular Systems, Inc. | Non-destructive bilayer monitoring using measurement of bilayer response to electrical stimulus |
| US10465240B2 (en) | 2016-03-30 | 2019-11-05 | Roche Sequencing Solutions, Inc. | Electrical enhancement of bilayer formation |
| US10233486B2 (en) | 2016-03-30 | 2019-03-19 | Roche Sequencing Solutions, Inc. | Method for inline bilayer capacitance monitoring |
| EP4397970A3 (en) | 2016-04-06 | 2024-10-09 | Oxford Nanopore Technologies PLC | Mutant pore |
| GB201611770D0 (en) | 2016-07-06 | 2016-08-17 | Oxford Nanopore Tech | Microfluidic device |
| CN109789092A (zh) | 2016-07-13 | 2019-05-21 | 哈佛学院院长等 | 抗原呈递细胞模拟支架及其制备和使用方法 |
| IL264557B2 (en) | 2016-08-02 | 2024-01-01 | Harvard College | Biological agents for regulating immune responses |
| GB201615741D0 (en) | 2016-09-15 | 2016-11-02 | Univ College Cardiff Consultants Ltd | Artificial cells |
| FR3061440B1 (fr) * | 2017-01-05 | 2021-02-12 | Centre Nat Rech Scient | Procede de fabrication d’une membrane multicouche sur support solide a base de copolymere a blocs amphiphile |
| CN108329471A (zh) * | 2017-01-19 | 2018-07-27 | 天津大学 | 一种锂硫电池正极活性材料异戊烯醇-硫共聚物及制备方法 |
| GB201707122D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Pore |
| CN117106038B (zh) | 2017-06-30 | 2025-12-09 | 弗拉芒区生物技术研究所 | 新颖蛋白孔 |
| JP7058858B2 (ja) * | 2017-10-19 | 2022-04-25 | 地方独立行政法人神奈川県立産業技術総合研究所 | 脂質二重膜形成器具及びそれを用いた脂質二重膜形成方法 |
| DE102017126732A1 (de) * | 2017-11-14 | 2019-05-16 | Endress+Hauser Conducta Gmbh+Co. Kg | Sensormembran, Sensor, ein Messgerät umfassend den Sensor und Verwendung des Sensors |
| GB2568895B (en) | 2017-11-29 | 2021-10-27 | Oxford Nanopore Tech Ltd | Microfluidic device |
| GB2569630B (en) | 2017-12-21 | 2022-10-12 | Sharp Life Science Eu Ltd | Droplet Interfaces in Electro-wetting Devices |
| GB2574048B (en) | 2018-05-24 | 2021-06-16 | Oxford Nanopore Tech Ltd | Nanopore sensor component with electrostatic discharge protection |
| WO2020061129A1 (en) | 2018-09-19 | 2020-03-26 | President And Fellows Of Harvard College | Compositions and methods for labeling and modulation of cells in vitro and in vivo |
| JP7492200B2 (ja) | 2019-03-12 | 2024-05-29 | オックスフォード ナノポール テクノロジーズ ピーエルシー | ナノ細孔センシングデバイスと操作方法およびその成形方法 |
| CN113574388B (zh) | 2019-05-29 | 2025-12-05 | 南京大学 | 不使用电极的纳米孔单分子分析物检测 |
| WO2021061837A1 (en) | 2019-09-23 | 2021-04-01 | President And Fellows Of Harvard College | Biomaterial-based antigen free vaccine and the use thereof |
| CN112831395B (zh) * | 2019-11-25 | 2024-01-16 | 深圳华大生命科学研究院 | 用于纳米孔测序的类细胞膜 |
| GB202004944D0 (en) | 2020-04-03 | 2020-05-20 | King S College London | Method |
| EP4675256A3 (en) | 2020-07-17 | 2026-01-28 | Oxford Nanopore Technologies PLC | Nanopore sensing device |
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| JPH067737A (ja) * | 1992-06-30 | 1994-01-18 | Junjiro Aoki | 累積膜の連続製造方法 |
| WO2002072873A1 (en) * | 2001-03-14 | 2002-09-19 | Biacore Ab | Method of preparing supported lipid film membranes and use thereof |
| JP4394917B2 (ja) * | 2003-09-19 | 2010-01-06 | 独立行政法人科学技術振興機構 | 人工脂質二重膜を有する電流測定装置 |
| JP4394916B2 (ja) * | 2003-09-19 | 2010-01-06 | 独立行政法人科学技術振興機構 | 人工脂質二重膜の形成装置および人工脂質二重膜の形成方法、並びにその利用 |
| JP2005114576A (ja) * | 2003-10-08 | 2005-04-28 | Hitachi Software Eng Co Ltd | 両親媒性分子固定化ビーズ、その製造方法、及びキャピラリビーズアレイのビーズ配列方法 |
| GB0505971D0 (en) | 2005-03-23 | 2005-04-27 | Isis Innovation | Delivery of molecules to a lipid bilayer |
| US8211712B2 (en) | 2005-03-29 | 2012-07-03 | The Board Of Trustees Of The Leland Stanford Junior University | Method of fabricating lipid bilayer membranes on solid supports |
| DE602006012307D1 (de) | 2005-05-20 | 2010-04-01 | Aquaporin Aps | Membran zum filtrieren von wasser |
| JP5114702B2 (ja) | 2005-07-29 | 2013-01-09 | 国立大学法人 東京大学 | 両親媒性単分子膜の接触による二分子膜の形成方法およびその装置 |
| US20080318326A1 (en) | 2005-09-07 | 2008-12-25 | Agresearch Limited | Method of Manufacture |
| GB0614835D0 (en) * | 2006-07-26 | 2006-09-06 | Isis Innovation | Formation of bilayers of amphipathic molecules |
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| WO2009024775A8 (en) | 2009-12-03 |
| CN101821626B (zh) | 2015-04-08 |
| GB0716264D0 (en) | 2007-09-26 |
| CN101821626A (zh) | 2010-09-01 |
| EP2183594A1 (en) | 2010-05-12 |
| WO2009024775A1 (en) | 2009-02-26 |
| JP5797405B2 (ja) | 2015-10-21 |
| US8784929B2 (en) | 2014-07-22 |
| EP2183594B1 (en) | 2018-11-07 |
| US20130129910A1 (en) | 2013-05-23 |
| JP2010536551A (ja) | 2010-12-02 |
| US20110041978A1 (en) | 2011-02-24 |
| CA2697024A1 (en) | 2009-02-26 |
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