CA2696809A1 - Method of increasing protein titres - Google Patents
Method of increasing protein titres Download PDFInfo
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- CA2696809A1 CA2696809A1 CA2696809A CA2696809A CA2696809A1 CA 2696809 A1 CA2696809 A1 CA 2696809A1 CA 2696809 A CA2696809 A CA 2696809A CA 2696809 A CA2696809 A CA 2696809A CA 2696809 A1 CA2696809 A1 CA 2696809A1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
Landscapes
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- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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| EP07115227A EP2031064A1 (de) | 2007-08-29 | 2007-08-29 | Verfahren zur Steigerung von Proteintitern |
| EP07115227.6 | 2007-08-29 | ||
| PCT/EP2008/061310 WO2009027471A1 (de) | 2007-08-29 | 2008-08-28 | Verfahren zur steigerung von proteintitern |
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| CA2696809A1 true CA2696809A1 (en) | 2009-03-05 |
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| EP (2) | EP2031064A1 (enExample) |
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| KR (1) | KR20100046219A (enExample) |
| CA (1) | CA2696809A1 (enExample) |
| WO (1) | WO2009027471A1 (enExample) |
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| EP2009101B1 (en) | 2006-03-31 | 2017-10-25 | Chugai Seiyaku Kabushiki Kaisha | Antibody modification method for purifying bispecific antibody |
| DK2006381T3 (en) | 2006-03-31 | 2016-02-22 | Chugai Pharmaceutical Co Ltd | PROCEDURE FOR REGULATING ANTIBODIES BLOOD PHARMACOKINETICS |
| EP1878747A1 (en) * | 2006-07-11 | 2008-01-16 | greenovation Biotech GmbH | Glyco-engineered antibodies |
| ES2687808T3 (es) * | 2007-09-26 | 2018-10-29 | Chugai Seiyaku Kabushiki Kaisha | Región constante de anticuerpo modificado |
| DK2202245T3 (en) | 2007-09-26 | 2016-11-21 | Chugai Pharmaceutical Co Ltd | A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR |
| MX337081B (es) | 2007-12-05 | 2016-02-10 | Chugai Pharmaceutical Co Ltd | Anticuerpo anti-nr10 y su uso. |
| PT2708559T (pt) | 2008-04-11 | 2018-05-16 | Chugai Pharmaceutical Co Ltd | Molécula de ligação ao antigénio capaz de se ligar repetidamente a duas ou mais moléculas de antigénio |
| TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| WO2010107110A1 (ja) | 2009-03-19 | 2010-09-23 | 中外製薬株式会社 | 抗体定常領域改変体 |
| TWI646193B (zh) | 2009-03-19 | 2019-01-01 | 中外製藥股份有限公司 | 抗體恆定區域改變體 |
| JP5837821B2 (ja) | 2009-09-24 | 2015-12-24 | 中外製薬株式会社 | 抗体定常領域改変体 |
| EP2543730B1 (en) | 2010-03-04 | 2018-10-31 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
| EP2455403A1 (en) * | 2010-11-23 | 2012-05-23 | Pierre Fabre Medicament | Homogeneous humanized antibodies against JAM-A that inhibit proliferation |
| MX365235B (es) | 2010-11-30 | 2019-05-28 | Chugai Pharmaceutical Co Ltd | Molécula de unión a antígeno capaz de unir repetidamente a la pluralidad de moléculas de antígeno. |
| EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| EP2702164B8 (en) | 2011-04-29 | 2016-03-16 | Biocon Research Limited | A method for reducing heterogeneity of antibodies and a process of producing the antibodies thereof |
| JP2020141710A (ja) * | 2011-07-06 | 2020-09-10 | ゲンマブ エー／エス | 抗体重鎖のｃ末端の修飾による補体依存性細胞傷害の調節 |
| US10323081B2 (en) | 2011-07-06 | 2019-06-18 | Genmag A/S | Modulation of complement-dependent cytotoxicity through modifications of the C-terminus of antibody heavy chains |
| US9475858B2 (en) | 2011-07-08 | 2016-10-25 | Momenta Pharmaceuticals, Inc. | Cell culture process |
| LT2771031T (lt) | 2011-10-28 | 2018-08-27 | Prothena Biosciences Limited | Humanizuoti antikūnai, kurie atpažįsta alfa sinukleiną |
| UA115439C2 (uk) | 2012-01-27 | 2017-11-10 | Протена Біосаєнсиз Лімітед | Гуманізоване антитіло, яке розпізнає альфа-синуклеїн |
| WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
| EP2841589B1 (en) * | 2012-04-23 | 2018-09-12 | DSM IP Assets B.V. | Polypeptide expression method |
| EP4219536A3 (en) | 2012-04-30 | 2023-08-23 | Biocon Limited | Targeted/immunomodulatory fusion proteins and methods for making same |
| WO2013176754A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Inc. | Novel purification of antibodies using hydrophobic interaction chromatography |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| BR112015004467A2 (pt) | 2012-09-02 | 2017-03-21 | Abbvie Inc | método para controlar a heterogeneidade de proteínas |
| UA118441C2 (uk) | 2012-10-08 | 2019-01-25 | Протена Біосаєнсиз Лімітед | Антитіло, що розпізнає альфа-синуклеїн |
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| NZ230786A (en) * | 1988-09-28 | 1991-11-26 | Lilly Co Eli | A method of reducing the heterogeneity of secreted monoclonal antibodies |
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| CA2528591C (en) * | 2003-06-12 | 2013-01-08 | Eli Lilly And Company | Glp-1 analog fusion proteins |
| US20060024272A1 (en) * | 2004-07-29 | 2006-02-02 | Large Scale Biology Corporation | C-terminally truncated interferon |
| EA011166B1 (ru) * | 2004-12-22 | 2009-02-27 | Эли Лилли Энд Компани | Композиции слитых белков-аналогов glp-1 |
| CN102875681A (zh) * | 2005-07-08 | 2013-01-16 | 拜奥根Idec马萨诸塞公司 | 抗-αvβ6抗体及其用途 |
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2007
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- 2008-08-28 US US12/675,218 patent/US20100297697A1/en not_active Abandoned
- 2008-08-28 CA CA2696809A patent/CA2696809A1/en not_active Abandoned
- 2008-08-28 WO PCT/EP2008/061310 patent/WO2009027471A1/de not_active Ceased
- 2008-08-28 KR KR1020107004046A patent/KR20100046219A/ko not_active Withdrawn
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| EP2195431A1 (de) | 2010-06-16 |
| WO2009027471A1 (de) | 2009-03-05 |
| US20100297697A1 (en) | 2010-11-25 |
| KR20100046219A (ko) | 2010-05-06 |
| EP2031064A1 (de) | 2009-03-04 |
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