CA2696352C - Treating parasites with electric fields - Google Patents
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- CA2696352C CA2696352C CA2696352A CA2696352A CA2696352C CA 2696352 C CA2696352 C CA 2696352C CA 2696352 A CA2696352 A CA 2696352A CA 2696352 A CA2696352 A CA 2696352A CA 2696352 C CA2696352 C CA 2696352C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cell Biology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Electrotherapy Devices (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Radiation-Therapy Devices (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (3)
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| US95571907P | 2007-08-14 | 2007-08-14 | |
| US60/955,719 | 2007-08-14 | ||
| PCT/IB2008/002134 WO2009022225A1 (en) | 2007-08-14 | 2008-08-13 | Treating parasites with electric fields |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2696352A1 CA2696352A1 (en) | 2009-02-19 |
| CA2696352C true CA2696352C (en) | 2017-03-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2696352A Active CA2696352C (en) | 2007-08-14 | 2008-08-13 | Treating parasites with electric fields |
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| US (1) | US7890183B2 (enExample) |
| EP (1) | EP2183024B1 (enExample) |
| JP (1) | JP5485153B2 (enExample) |
| CN (1) | CN101820947A (enExample) |
| CA (1) | CA2696352C (enExample) |
| DK (1) | DK2183024T3 (enExample) |
| ES (1) | ES2739384T3 (enExample) |
| PT (1) | PT2183024T (enExample) |
| WO (1) | WO2009022225A1 (enExample) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8175698B2 (en) | 2000-02-17 | 2012-05-08 | Novocure Ltd. | Treating bacteria with electric fields |
| AU3399801A (en) | 2000-02-17 | 2001-08-27 | Yoram Palti | Method and apparatus for destroying dividing cells |
| US7565205B2 (en) | 2000-02-17 | 2009-07-21 | Standen Ltd. | Treating a tumor or the like with electric fields at different orientations |
| US8447395B2 (en) * | 2000-02-17 | 2013-05-21 | Novocure Ltd | Treating bacteria with electric fields |
| DE10260149A1 (de) | 2002-12-20 | 2004-07-01 | BSH Bosch und Siemens Hausgeräte GmbH | Vorrichtung zur Bestimmung des Leitwertes von Wäsche, Wäschetrockner und Verfahren zur Verhinderung von Schichtbildung auf Elektroden |
| PT2345451T (pt) * | 2004-12-07 | 2018-04-19 | Novocure Ltd | Eléctrodos para aplicar um campo eléctrico in-vivo ao longo de um extenso período de tempo |
| EP3804809B1 (en) * | 2005-10-03 | 2023-12-27 | Novocure GmbH | Optimizing characteristics of an electric field to increase the field's effect on proliferating cells |
| US8019414B2 (en) | 2006-04-05 | 2011-09-13 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with other treatment regimens |
| WO2008063338A2 (en) * | 2006-10-18 | 2008-05-29 | Buckeye Pharmaceuticals, Llc | Chemical compound delivery device and method |
| EP2167194B1 (en) * | 2007-03-06 | 2017-04-19 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with photodynamic therapy |
| WO2009022225A1 (en) | 2007-08-14 | 2009-02-19 | Novocure Ltd. | Treating parasites with electric fields |
| US8992593B2 (en) * | 2007-12-26 | 2015-03-31 | Cook Medical Technologies Llc | Apparatus and methods for deployment of a modular stent-graft system |
| US8684901B1 (en) | 2010-11-22 | 2014-04-01 | Jacob Zabara | Electromagnetic radiation treatment for cancer and pathological genetic regulations |
| US9233257B1 (en) | 2010-11-22 | 2016-01-12 | Jacob Zabara | Electromagnetic radiation treatment |
| WO2013105987A2 (en) | 2011-02-15 | 2013-07-18 | Hemosonics, Llc | Characterization of blood hemostasis and oxygen transport parameters |
| EP2522389A3 (en) * | 2011-05-13 | 2014-08-27 | Sergio Lara Pereira Monteiro | Animal and plant cell electric stimulator with randomized spatial distribution of electrodes for both current injection and for electric field shaping |
| JP2014522714A (ja) | 2011-08-08 | 2014-09-08 | ルース，リチャード，ビー． | 癌を処置する為の方法及び装置 |
| US9486625B2 (en) | 2011-08-08 | 2016-11-08 | Medamp Electronics, Llc | Method for treating benign prostate hyperplasia |
| DE102012015482A1 (de) * | 2012-08-07 | 2014-02-13 | Cinogy Gmbh | Elektrodenanordnung für ein behindertes Plasma |
| DE102012025052A1 (de) * | 2012-12-20 | 2014-06-26 | Fresenius Medical Care Deutschland Gmbh | Hämodiafiltrationsverfahren |
| US9655669B2 (en) | 2013-05-06 | 2017-05-23 | Novocure Limited | Optimizing treatment using TTFields by changing the frequency during the course of long term tumor treatment |
| US10779875B2 (en) | 2013-05-06 | 2020-09-22 | Novocure Gmbh | Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment |
| US20190117963A1 (en) * | 2014-07-25 | 2019-04-25 | Loyalty Based Innovations, LLC | Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields |
| US9726647B2 (en) | 2015-03-17 | 2017-08-08 | Hemosonics, Llc | Determining mechanical properties via ultrasound-induced resonance |
| US10188851B2 (en) | 2015-10-28 | 2019-01-29 | Novocure Limited | TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements |
| US10821283B2 (en) | 2016-04-04 | 2020-11-03 | Novocure Gmbh | Reducing motility of cancer cells using tumor treating fields (TTFields) |
| US20180001075A1 (en) | 2016-06-30 | 2018-01-04 | Novocure Limited | Arrays for Longitudinal Delivery of TTFields to a Body |
| ES2968148T3 (es) | 2016-11-24 | 2024-05-08 | Public Univ Corp Yokohama City Univ | Aparato para el tratamiento del cáncer |
| CN110178029B (zh) | 2017-01-19 | 2021-11-16 | 诺沃库勒有限责任公司 | 用于在施加TTFields的同时在显微镜下观察细胞培养物的系统 |
| EP3579920A1 (en) * | 2017-02-07 | 2019-12-18 | Santi Tofani | Apparatus for treating pathological cells |
| US11338135B2 (en) | 2017-10-23 | 2022-05-24 | Cardiac Pacemakers, Inc. | Medical devices for cancer therapy with electric field shaping elements |
| US12403306B2 (en) | 2017-10-23 | 2025-09-02 | Cardiac Pacemakers, Inc. | Electric field shaping leads for treatment of cancer |
| US10953209B2 (en) | 2018-03-28 | 2021-03-23 | Board Of Regents Of The University Of Texas System | Treating tumors using TTFields combined with a PARP inhibitor |
| JP7139448B2 (ja) | 2018-04-09 | 2022-09-20 | ノボキュア ゲーエムベーハー | ＴＴＦｉｅｌｄｓ及びオーロラキナーゼ阻害剤による腫瘍の治療 |
| EP3775956B1 (en) | 2018-04-10 | 2022-03-23 | Novocure GmbH | Low frequency (<1 mhz) ac conductivity estimates derived from two mri images having different repetition times |
| US20200009376A1 (en) | 2018-07-03 | 2020-01-09 | Edwin Chang | Using Alternating Electric Fields to Increase Cell Membrane Permeability |
| US11179322B2 (en) | 2018-07-10 | 2021-11-23 | Novocure Gmbh | Methods and compositions for treating tumors with TTFields and sorafenib |
| EP3820562A1 (en) | 2018-07-10 | 2021-05-19 | Novocure GmbH | Inhibiting viral infection using alternating electric fields |
| EP3967362A1 (en) | 2018-07-18 | 2022-03-16 | Novocure GmbH | Using power loss density and related measures to quantify the dose of tumor treating fields |
| US11400269B2 (en) | 2018-08-23 | 2022-08-02 | Novocure Gmbh | Using alternating electric fields to increase permeability of the blood brain barrier |
| US11160977B2 (en) | 2018-09-04 | 2021-11-02 | Novocure Gmbh | Delivering tumor treating fields (TTFields) to the infratentorial brain |
| US11986647B2 (en) | 2018-09-07 | 2024-05-21 | Novocure Gmbh | Treating autoinflammatory and mitochondrial diseases using an alternating electric field |
| EP3846894B8 (en) | 2018-09-07 | 2025-06-18 | Novocure GmbH | Treating autoimmune diseases using an alternating electric field to reduce the proliferation of t-cells |
| EP4137195B1 (en) | 2018-10-15 | 2024-12-11 | Novocure GmbH | Generating tumor treating fields (ttfields) with high uniformity throughout the brain |
| WO2020084596A1 (en) * | 2018-10-25 | 2020-04-30 | Zeev Bomzon | Delivering alternating electric fields (e.g., ttfields) to a subject's spinal anatomy |
| US12186575B2 (en) | 2018-11-13 | 2025-01-07 | The Methodist Hospital | Method and apparatus for oncomagnetic treatment |
| HUE065574T2 (hu) | 2018-11-19 | 2024-06-28 | Novocure Gmbh | Tömbök daganatkezelõ mezõk (TTFIELD) rendelkezésre bocsátására szelektíven címezhetõ alelemekkel |
| EP4356823A3 (en) | 2018-11-29 | 2024-06-26 | Novocure GmbH | Enhanced-flexibility transducer arrays for delivering ttfields (tumor treating fields) |
| EP3961566A1 (en) | 2019-01-08 | 2022-03-02 | Novocure GmbH | Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (ttfields) |
| US11027143B2 (en) | 2020-02-06 | 2021-06-08 | Vivek K. Sharma | System and methods for treating cancer cells with alternating polarity magnetic fields |
| US11344740B2 (en) | 2019-02-07 | 2022-05-31 | Asha Medical, Inc. | System and methods for treating cancer cells with alternating polarity magnetic fields |
| JP2022519782A (ja) | 2019-02-07 | 2022-03-24 | ヴィヴェーク・ケー・シャルマ | 交番極性磁場によってがん細胞を治療するシステム、および方法 |
| WO2020174403A1 (en) | 2019-02-26 | 2020-09-03 | Moshe Giladi | Determining a frequency for ttfields treatment based on an electrical characteristic of targeted cancer cells |
| WO2020174429A1 (en) | 2019-02-27 | 2020-09-03 | Yoram Wasserman | Delivering tumor treating fields (ttfields) using implantable transducer arrays |
| FR3093645B1 (fr) * | 2019-03-15 | 2021-04-02 | Univ Montpellier | Puce microfluidique pour attirer et détruire un élément biologique spécifique |
| EP3977991A1 (en) | 2019-03-29 | 2022-04-06 | Novocure GmbH | Methods for reducing viability of ttfields-resistant cancer cells |
| US11291837B2 (en) | 2019-04-17 | 2022-04-05 | Novocure Gmbh | Uploading data from an isolated system without compromising isolation |
| CN113727753B (zh) | 2019-04-22 | 2024-09-13 | 波士顿科学国际有限公司 | 用于癌症治疗的电刺激装置 |
| EP4480526A3 (en) | 2019-04-22 | 2025-03-12 | Boston Scientific Scimed, Inc. | Combination electrical and chemotherapeutic treatment of cancer |
| WO2020219337A1 (en) | 2019-04-22 | 2020-10-29 | Boston Scientific Scimed, Inc. | Systems for administering electrical stimulation to treat cancer |
| EP3958960B1 (en) | 2019-04-23 | 2025-06-18 | Boston Scientific Scimed, Inc. | Electrical stimulation with thermal treatment or thermal monitoring |
| US11607542B2 (en) | 2019-04-23 | 2023-03-21 | Boston Scientific Scimed, Inc. | Electrical stimulation for cancer treatment with internal and external electrodes |
| EP3958956B1 (en) | 2019-04-23 | 2024-02-28 | Boston Scientific Scimed Inc. | Electrodes for electrical stimulation to treat cancer |
| WO2021019403A1 (en) | 2019-07-31 | 2021-02-04 | Yoram Wasserman | Applying tumor treating fields (ttfields) via electrodes embedded into skull implants |
| CN114390914A (zh) | 2019-08-05 | 2022-04-22 | 诺沃库勒有限责任公司 | 通过抑制il11活性增加癌细胞对肿瘤治疗场(ttfield)的敏感性 |
| US11890467B2 (en) | 2019-08-30 | 2024-02-06 | Novocure Gmbh | Delivering tumor treating fields (TTFields) to the neck |
| CN114786763A (zh) * | 2019-12-11 | 2022-07-22 | 诺沃库勒有限责任公司 | 更改交变电场的电阻抗的合成物和方法 |
| CN114901347B (zh) | 2019-12-31 | 2025-11-04 | 诺沃库勒有限责任公司 | 防止幅度调整和信道切换期间的尖峰的高电压、高效率正弦波生成器 |
| US12121739B2 (en) * | 2019-12-31 | 2024-10-22 | Novocure Gmbh | Methods, systems, and apparatuses for managing temperatures induced by alternating fields |
| EP4212203A1 (en) | 2019-12-31 | 2023-07-19 | Novocure GmbH | Arrays for delivering tumor treating fields (ttfields) with individually accessible electrode elements and temperature sensors |
| US11883655B2 (en) | 2020-02-24 | 2024-01-30 | Boston Scientific Scimed, Inc. | Systems and methods for treatment of pancreatic cancer |
| WO2021198864A1 (en) | 2020-03-30 | 2021-10-07 | Novocure Gmbh | Intravenous / intra-spinal / intra-cavity / intraventricular delivery of ttfields (tumor treating fields) for treating cancer and metastases |
| WO2021214693A1 (en) | 2020-04-24 | 2021-10-28 | Novocure Gmbh | Using alternating electric fields to increase permeability of the blood brain barrier |
| TWI889816B (zh) | 2020-05-06 | 2025-07-11 | 瑞士商諾沃庫勒有限責任公司 | 用於產生腫瘤治療電場之導電襯墊以及生產和使用其之方法 |
| EP4168108A4 (en) | 2020-06-19 | 2024-07-17 | The Methodist Hospital dba Houston Methodist Hospital | METHOD AND APPARATUS FOR ONCOMAGNETIC TREATMENT |
| US11818943B2 (en) | 2020-06-25 | 2023-11-14 | Novocure Gmbh | Fabricating organic light emitting diodes (OLEDs) using tubulin |
| KR102490645B1 (ko) * | 2020-07-16 | 2023-01-25 | 고려대학교 산학협력단 | 흡수에너지 기반 전기장 암치료 계획 시스템 및 방법 |
| CN116367882A (zh) | 2020-09-25 | 2023-06-30 | 诺沃库勒有限责任公司 | 改变肿瘤治疗场(ttfield)系统中个体电极元件上的金属化面积以使电流最大化而不会过热 |
| DE102021102884A1 (de) * | 2021-02-08 | 2022-08-11 | Elea Vertriebs- Und Vermarktungsgesellschaft Mbh | Verfahren zum Paralysieren von Parasiten in Nahrung, insbesondere in einem Lebens- oder Futtermittel und damit hergestelltes Lebensmittel mit paralysierten Parasiten |
| CN117083103A (zh) | 2021-02-17 | 2023-11-17 | 诺沃库勒有限责任公司 | 具有具备单独可调整的有源面积的电极元件集合的用于输送肿瘤治疗场（TTFields）的阵列 |
| JP2024509964A (ja) | 2021-03-12 | 2024-03-05 | ノボキュア ゲーエムベーハー | 交流電界を用いてマクロファージの表現型をスキューイングすることによる、疾患を処置する方法 |
| US20220305277A1 (en) * | 2021-03-23 | 2022-09-29 | Novocure Gmbh | Methods and apparatuses for detecting and responding to changes in a subject |
| KR20230163379A (ko) | 2021-03-31 | 2023-11-30 | 노보큐어 게엠베하 | 종양 치료 필드(TTField) 시스템의 전극을 사용한 임피던스 단층 촬영 |
| WO2023275804A1 (en) * | 2021-06-30 | 2023-01-05 | Novocure Gmbh | Using alternating electric fields at different frequencies to increase the permeability of the blood brain barrier and also to provide other benefits |
| CN113663215B (zh) * | 2021-10-22 | 2022-01-21 | 杭州维纳安可医疗科技有限责任公司 | 电场发生装置及其控制方法、计算机可读存储介质 |
| US20230173265A1 (en) * | 2021-12-10 | 2023-06-08 | Novocure Gmbh | Garment providing a biasing force on a transducer array |
| US12377280B2 (en) | 2021-12-30 | 2025-08-05 | Novocure Gmbh | Selecting values of parameters for treatment using tumor treating fields (TTFields) |
| EP4464370A3 (en) | 2022-03-30 | 2024-12-18 | Novocure GmbH | Reducing electrosensation whilst treating a subject using alternating electric fields by pairing transducer arrays together |
| KR20240159881A (ko) | 2022-03-30 | 2024-11-07 | 노보큐어 게엠베하 | 인터리브된 냉각 기간을 사용하여 종양 치료장의 피크 강도를 증가시키는 방법 |
| CN119173302A (zh) | 2022-04-01 | 2024-12-20 | 得克萨斯大学体系董事会 | 用于应用与个性化超分割立体定向适应性放射疗法相组合的肿瘤治疗电场的方法和仪器 |
| WO2024141916A1 (en) * | 2022-12-28 | 2024-07-04 | Novocure Gmbh | Wearable garment with integrated tumor treating fields voltage generator |
| US12268863B2 (en) | 2023-02-06 | 2025-04-08 | Novocure Gmbh | Shiftable transducer array with anisotropic material layer |
| CN116020054B (zh) * | 2023-02-24 | 2023-12-08 | 北京微脊医疗科技有限公司 | 植入式电场治疗装置 |
| US12465759B2 (en) | 2023-03-14 | 2025-11-11 | Boris Kriman | Electrostatic therapeutic device |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR446660A (fr) * | 1911-09-02 | 1912-12-12 | Gottlieb Schuettel | Dispositif pour métiers continus à anneaux pour monter les curseurs sur les anneaux |
| BE794566A (fr) | 1972-01-28 | 1973-07-26 | Esb Inc | Regenerateur et stimulateur bioelectrochimique et procedes d'application in vivo d'energie electrique a des cellules et des tissus. |
| US3991770A (en) * | 1974-01-24 | 1976-11-16 | Leveen Harry H | Method for treating benign and malignant tumors utilizing radio frequency, electromagnetic radiation |
| US4016886A (en) * | 1974-11-26 | 1977-04-12 | The United States Of America As Represented By The United States Energy Research And Development Administration | Method for localizing heating in tumor tissue |
| US4121592A (en) * | 1975-08-04 | 1978-10-24 | Critical Systems, Inc. | Apparatus for heating tissue |
| JPS5547870A (en) | 1978-02-24 | 1980-04-05 | Lawrence Joseph L | Medical treatment method |
| DE2813068A1 (de) * | 1978-03-25 | 1979-10-04 | Philips Patentverwaltung | Verfahren und vorrichtung zur ermittlung von inneren koerperstrukturen |
| GB2043453A (en) | 1979-02-22 | 1980-10-08 | Electrochem Tech Corp | Improvements in or relating to an electrode |
| US4472506A (en) * | 1981-01-13 | 1984-09-18 | Liburdy Robert P | Method for determining cell membrane dielectric breakdown |
| US4467809A (en) * | 1982-09-17 | 1984-08-28 | Biolectron, Inc. | Method for non-invasive electrical stimulation of epiphyseal plate growth |
| US4622952A (en) * | 1983-01-13 | 1986-11-18 | Gordon Robert T | Cancer treatment method |
| CA1244889A (en) * | 1983-01-24 | 1988-11-15 | Kureha Chemical Ind Co Ltd | HYPERTHERMIA DEVICE |
| DE3323415C2 (de) * | 1983-06-29 | 1985-04-25 | Kernforschungsanlage Jülich GmbH, 5170 Jülich | Verwendung eines Verfahrens und einer Vorrichtung zur Bestimmung von Zellinhaltstoffe sezernierenden Zellen |
| SE455920B (sv) * | 1986-01-29 | 1988-08-22 | Hans Wiksell | Anordning for hypertermibehandling av tumorer |
| US4923814A (en) * | 1986-05-09 | 1990-05-08 | Electropore, Inc. | High speed, high power apparatus for vesicle prealignment, poration, loading and fusion in uniform electric fields and method therefor |
| CN86103803B (zh) * | 1986-06-05 | 1987-11-18 | 北京信息工程学院 | 静电场治疗装置 |
| US4822470A (en) * | 1987-10-09 | 1989-04-18 | Baylor College Of Medicine | Method of and apparatus for cell poration and cell fusion using radiofrequency electrical pulses |
| US4936303A (en) * | 1987-11-20 | 1990-06-26 | Ultrathermics | Ultrasonic heating apparatus and method |
| JPH0629196B2 (ja) * | 1987-12-01 | 1994-04-20 | 甲子郎 梅村 | 超音波による腫瘍治療用生理作用増強剤 |
| US5389069A (en) * | 1988-01-21 | 1995-02-14 | Massachusetts Institute Of Technology | Method and apparatus for in vivo electroporation of remote cells and tissue |
| FR2627987B3 (fr) | 1988-03-04 | 1990-02-02 | Indiba Sa | Appareil electronique pour la therapie medicale et cosmetique |
| US5158071A (en) * | 1988-07-01 | 1992-10-27 | Hitachi, Ltd. | Ultrasonic apparatus for therapeutical use |
| GB8904998D0 (en) * | 1989-03-04 | 1989-04-19 | Matthews Tony | Anaesthetising apparatus |
| US5099756A (en) * | 1989-06-01 | 1992-03-31 | Harry H. Leveen | Radio frequency thermotherapy |
| US5441746A (en) * | 1989-12-22 | 1995-08-15 | Molecular Bioquest, Inc. | Electromagnetic wave absorbing, surface modified magnetic particles for use in medical applications, and their method of production |
| US5236410A (en) * | 1990-08-02 | 1993-08-17 | Ferrotherm International, Inc. | Tumor treatment method |
| CA2109084C (en) * | 1991-05-03 | 2004-02-24 | John William Fisher Costerton | Biofilm reduction method |
| US5441532A (en) * | 1991-06-26 | 1995-08-15 | Massachusetts Institute Of Technology | Adaptive focusing and nulling hyperthermia annular and monopole phased array applicators |
| US5468223A (en) * | 1992-11-30 | 1995-11-21 | C.N.R.S. Paris | Electrochemotherapy |
| US5386837A (en) * | 1993-02-01 | 1995-02-07 | Mmtc, Inc. | Method for enhancing delivery of chemotherapy employing high-frequency force fields |
| FR2703253B1 (fr) * | 1993-03-30 | 1995-06-23 | Centre Nat Rech Scient | Applicateur d'impulsions electriques pour traitement de tissus biologiques. |
| IL108775A (en) * | 1994-02-25 | 2003-09-17 | Univ Ramot | Method for efficient incorporation of molecules into cells |
| US5704355A (en) * | 1994-07-01 | 1998-01-06 | Bridges; Jack E. | Non-invasive system for breast cancer detection |
| US6447499B2 (en) * | 1995-07-28 | 2002-09-10 | James R. Gray | Use of a polarized field to modify the efficacy of a bioactive agent |
| US5606971A (en) * | 1995-11-13 | 1997-03-04 | Artann Corporation, A Nj Corp. | Method and device for shear wave elasticity imaging |
| US5718246A (en) * | 1996-01-03 | 1998-02-17 | Preferential, Inc. | Preferential induction of electrically mediated cell death from applied pulses |
| US5984882A (en) * | 1996-08-19 | 1999-11-16 | Angiosonics Inc. | Methods for prevention and treatment of cancer and other proliferative diseases with ultrasonic energy |
| US5869326A (en) * | 1996-09-09 | 1999-02-09 | Genetronics, Inc. | Electroporation employing user-configured pulsing scheme |
| US6055453A (en) * | 1997-08-01 | 2000-04-25 | Genetronics, Inc. | Apparatus for addressing needle array electrodes for electroporation therapy |
| EP1003847A4 (en) * | 1997-09-04 | 2005-04-06 | Science Res Lab Inc | SEPARATION OF CELLS BY USE OF ELECTRIC FIELDS |
| US6027488A (en) * | 1998-06-03 | 2000-02-22 | Genetronics, Inc. | Flow-through electroporation system for ex vivo gene therapy |
| US5976092A (en) * | 1998-06-15 | 1999-11-02 | Chinn; Douglas O. | Combination stereotactic surgical guide and ultrasonic probe |
| US6319901B1 (en) * | 1998-10-15 | 2001-11-20 | Ichor Medical Systems, Inc. | Methods for prolonging cell membrane permeability |
| EP1158919B1 (en) * | 1999-03-09 | 2005-06-29 | Thermage, Inc. | Apparatus for treatment of tissue |
| US6678558B1 (en) * | 1999-03-25 | 2004-01-13 | Genetronics, Inc. | Method and apparatus for reducing electroporation-mediated muscle reaction and pain response |
| US6366808B1 (en) * | 2000-03-13 | 2002-04-02 | Edward A. Schroeppel | Implantable device and method for the electrical treatment of cancer |
| US6853864B2 (en) * | 2000-02-02 | 2005-02-08 | Catholic University Of America, The | Use of electromagnetic fields in cancer and other therapies |
| US7016725B2 (en) * | 2001-11-06 | 2006-03-21 | Standen Ltd. | Method and apparatus for destroying dividing cells |
| US7599746B2 (en) * | 2000-02-17 | 2009-10-06 | Standen Ltd | Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases |
| AU3399801A (en) | 2000-02-17 | 2001-08-27 | Yoram Palti | Method and apparatus for destroying dividing cells |
| US8175698B2 (en) * | 2000-02-17 | 2012-05-08 | Novocure Ltd. | Treating bacteria with electric fields |
| US7089054B2 (en) * | 2002-10-02 | 2006-08-08 | Standen Ltd. | Apparatus and method for treating a tumor or the like |
| US7565205B2 (en) * | 2000-02-17 | 2009-07-21 | Standen Ltd. | Treating a tumor or the like with electric fields at different orientations |
| US7146210B2 (en) * | 2000-02-17 | 2006-12-05 | Standen Ltd. | Apparatus and method for optimizing tumor treatment efficiency by electric fields |
| US6868289B2 (en) * | 2002-10-02 | 2005-03-15 | Standen Ltd. | Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor |
| US7136699B2 (en) * | 2002-10-02 | 2006-11-14 | Standen, Ltd. | Apparatus for destroying dividing cells |
| US6546290B1 (en) * | 2000-04-12 | 2003-04-08 | Roamitron Holding S.A. | Method and apparatus for electromedical therapy |
| US6994706B2 (en) * | 2001-08-13 | 2006-02-07 | Minnesota Medical Physics, Llc | Apparatus and method for treatment of benign prostatic hyperplasia |
| US8986944B2 (en) * | 2001-10-11 | 2015-03-24 | Aviva Biosciences Corporation | Methods and compositions for separating rare cells from fluid samples |
| DE102004028156A1 (de) * | 2004-06-09 | 2006-01-05 | Kalbe, Jochen, Dr. | Kombination von Radiowellen mit pharmakologisch aktiven Substanzen |
| PT2345451T (pt) * | 2004-12-07 | 2018-04-19 | Novocure Ltd | Eléctrodos para aplicar um campo eléctrico in-vivo ao longo de um extenso período de tempo |
| JP5559460B2 (ja) * | 2004-12-27 | 2014-07-23 | スタンデン・リミテッド | 異なる配向の電界を用いて腫瘍またはその類似物を処理する方法 |
| DK1899001T3 (en) * | 2005-06-08 | 2017-12-04 | Novocure Ltd | DEVICE FOR CANCER TREATMENT WITH ELECTRIC FIELDS MADE FOR DESIRED LOCATIONS IN A BODY |
| EP3804809B1 (en) * | 2005-10-03 | 2023-12-27 | Novocure GmbH | Optimizing characteristics of an electric field to increase the field's effect on proliferating cells |
| US8019414B2 (en) * | 2006-04-05 | 2011-09-13 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with other treatment regimens |
| EP2167194B1 (en) * | 2007-03-06 | 2017-04-19 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with photodynamic therapy |
| WO2009022225A1 (en) | 2007-08-14 | 2009-02-19 | Novocure Ltd. | Treating parasites with electric fields |
| US8715203B2 (en) * | 2007-09-17 | 2014-05-06 | Novocure Limited | Composite electrode |
-
2008
- 2008-08-13 WO PCT/IB2008/002134 patent/WO2009022225A1/en not_active Ceased
- 2008-08-13 JP JP2010520642A patent/JP5485153B2/ja active Active
- 2008-08-13 US US12/190,886 patent/US7890183B2/en not_active Expired - Lifetime
- 2008-08-13 DK DK08789083.6T patent/DK2183024T3/da active
- 2008-08-13 ES ES08789083T patent/ES2739384T3/es active Active
- 2008-08-13 EP EP08789083.6A patent/EP2183024B1/en active Active
- 2008-08-13 CN CN200880111479A patent/CN101820947A/zh active Pending
- 2008-08-13 PT PT08789083T patent/PT2183024T/pt unknown
- 2008-08-13 CA CA2696352A patent/CA2696352C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| DK2183024T3 (da) | 2019-06-24 |
| US20090043346A1 (en) | 2009-02-12 |
| JP2010536406A (ja) | 2010-12-02 |
| CA2696352A1 (en) | 2009-02-19 |
| PT2183024T (pt) | 2019-08-01 |
| EP2183024A1 (en) | 2010-05-12 |
| US7890183B2 (en) | 2011-02-15 |
| JP5485153B2 (ja) | 2014-05-07 |
| ES2739384T3 (es) | 2020-01-30 |
| WO2009022225A1 (en) | 2009-02-19 |
| EP2183024B1 (en) | 2019-05-15 |
| CN101820947A (zh) | 2010-09-01 |
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