CN101820947A - 用电场治疗寄生物 - Google Patents
用电场治疗寄生物 Download PDFInfo
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| PCT/IB2008/002134 WO2009022225A1 (en) | 2007-08-14 | 2008-08-13 | Treating parasites with electric fields |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113908431A (zh) * | 2018-08-23 | 2022-01-11 | 诺沃库勒有限责任公司 | 使用交变电场来提高血脑屏障的通透性 |
| CN114269274A (zh) * | 2020-07-16 | 2022-04-01 | 株式会社电界 | 基于吸收能量的电场癌治疗计划系统及方法 |
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8447395B2 (en) * | 2000-02-17 | 2013-05-21 | Novocure Ltd | Treating bacteria with electric fields |
| US7805201B2 (en) | 2000-02-17 | 2010-09-28 | Standen Ltd. | Treating a tumor or the like with an electric field |
| WO2001060994A1 (en) | 2000-02-17 | 2001-08-23 | Palti Yoram Prof | Method and apparatus for destroying dividing cells |
| US8175698B2 (en) | 2000-02-17 | 2012-05-08 | Novocure Ltd. | Treating bacteria with electric fields |
| DE10260149A1 (de) * | 2002-12-20 | 2004-07-01 | BSH Bosch und Siemens Hausgeräte GmbH | Vorrichtung zur Bestimmung des Leitwertes von Wäsche, Wäschetrockner und Verfahren zur Verhinderung von Schichtbildung auf Elektroden |
| PT2345451T (pt) * | 2004-12-07 | 2018-04-19 | Novocure Ltd | Eléctrodos para aplicar um campo eléctrico in-vivo ao longo de um extenso período de tempo |
| WO2007039799A2 (en) * | 2005-10-03 | 2007-04-12 | Novocure Ltd. | Optimizing characteristics of an electric field to increase the field's effect on proliferating cells |
| US8019414B2 (en) | 2006-04-05 | 2011-09-13 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with other treatment regimens |
| US8892199B2 (en) * | 2006-10-18 | 2014-11-18 | Buckeye Pharmaceuticals | Chemical compound delivery device and method |
| EP2167194B1 (en) * | 2007-03-06 | 2017-04-19 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with photodynamic therapy |
| CA2696352C (en) | 2007-08-14 | 2017-03-21 | Novocure Limited | Treating parasites with electric fields |
| US8992593B2 (en) * | 2007-12-26 | 2015-03-31 | Cook Medical Technologies Llc | Apparatus and methods for deployment of a modular stent-graft system |
| US8684901B1 (en) | 2010-11-22 | 2014-04-01 | Jacob Zabara | Electromagnetic radiation treatment for cancer and pathological genetic regulations |
| US9233257B1 (en) | 2010-11-22 | 2016-01-12 | Jacob Zabara | Electromagnetic radiation treatment |
| WO2013105987A2 (en) | 2011-02-15 | 2013-07-18 | Hemosonics, Llc | Characterization of blood hemostasis and oxygen transport parameters |
| EP2522389A3 (en) * | 2011-05-13 | 2014-08-27 | Sergio Lara Pereira Monteiro | Animal and plant cell electric stimulator with randomized spatial distribution of electrodes for both current injection and for electric field shaping |
| JP2014522714A (ja) | 2011-08-08 | 2014-09-08 | ルース，リチャード，ビー． | 癌を処置する為の方法及び装置 |
| US9486625B2 (en) | 2011-08-08 | 2016-11-08 | Medamp Electronics, Llc | Method for treating benign prostate hyperplasia |
| DE102012015482A1 (de) * | 2012-08-07 | 2014-02-13 | Cinogy Gmbh | Elektrodenanordnung für ein behindertes Plasma |
| DE102012025052A1 (de) * | 2012-12-20 | 2014-06-26 | Fresenius Medical Care Deutschland Gmbh | Hämodiafiltrationsverfahren |
| US10779875B2 (en) | 2013-05-06 | 2020-09-22 | Novocure Gmbh | Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment |
| US9655669B2 (en) | 2013-05-06 | 2017-05-23 | Novocure Limited | Optimizing treatment using TTFields by changing the frequency during the course of long term tumor treatment |
| US20190117963A1 (en) * | 2014-07-25 | 2019-04-25 | Loyalty Based Innovations, LLC | Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields |
| US9726647B2 (en) | 2015-03-17 | 2017-08-08 | Hemosonics, Llc | Determining mechanical properties via ultrasound-induced resonance |
| US10188851B2 (en) | 2015-10-28 | 2019-01-29 | Novocure Limited | TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements |
| US10821283B2 (en) | 2016-04-04 | 2020-11-03 | Novocure Gmbh | Reducing motility of cancer cells using tumor treating fields (TTFields) |
| US10441776B2 (en) | 2016-06-30 | 2019-10-15 | Novocure Gmbh | Arrays for longitudinal delivery of TTFields to a body |
| EP4302820A3 (en) | 2016-11-24 | 2024-03-06 | Public University Corporation Yokohama City University | Cancer treatment apparatus |
| US11573221B2 (en) | 2017-01-19 | 2023-02-07 | Novocure Gmbh | System for viewing cell cultures under a microscope whilst applying TTFields |
| WO2018172863A1 (en) * | 2017-02-07 | 2018-09-27 | Santi Tofani | Apparatus for treating pathological cells |
| US12403306B2 (en) | 2017-10-23 | 2025-09-02 | Cardiac Pacemakers, Inc. | Electric field shaping leads for treatment of cancer |
| US11338135B2 (en) | 2017-10-23 | 2022-05-24 | Cardiac Pacemakers, Inc. | Medical devices for cancer therapy with electric field shaping elements |
| US10953209B2 (en) | 2018-03-28 | 2021-03-23 | Board Of Regents Of The University Of Texas System | Treating tumors using TTFields combined with a PARP inhibitor |
| EP3773726B1 (en) | 2018-04-09 | 2024-06-05 | Novocure GmbH | Treating tumors with ttfields and an aurora kinase inhibitor |
| CN112424626B (zh) | 2018-04-10 | 2025-07-08 | 诺沃库勒有限责任公司 | 优化多个电极位置并创建3d模型的方法 |
| CN116236688A (zh) | 2018-07-03 | 2023-06-09 | 埃德温·阊 | 使用交变电场提高细胞膜通透性 |
| MX2020013427A (es) | 2018-07-10 | 2021-05-27 | Novocure Gmbh | Inhibicion de infecciones virales usando campos electricos alternos. |
| US11179322B2 (en) | 2018-07-10 | 2021-11-23 | Novocure Gmbh | Methods and compositions for treating tumors with TTFields and sorafenib |
| EP3823715A1 (en) | 2018-07-18 | 2021-05-26 | Novocure GmbH | Using power loss density and related measures to quantify the dose of tumor treating fields (ttfields) |
| US11160977B2 (en) | 2018-09-04 | 2021-11-02 | Novocure Gmbh | Delivering tumor treating fields (TTFields) to the infratentorial brain |
| US11020585B2 (en) | 2018-09-07 | 2021-06-01 | Novocure Gmbh | Treating autoimmune diseases using an alternating electric field to reduce the proliferation of t-cells |
| US11986647B2 (en) | 2018-09-07 | 2024-05-21 | Novocure Gmbh | Treating autoinflammatory and mitochondrial diseases using an alternating electric field |
| HUE061361T2 (hu) | 2018-10-15 | 2023-06-28 | Novocure Gmbh | Az egész agyban nagy egyenletességû tumorkezelõ mezõk (TT-mezõk) generálása |
| EP3870271A1 (en) * | 2018-10-25 | 2021-09-01 | Zeev Bomzon | Delivering alternating electric fields (e.g., ttfields) to a subject's spinal anatomy |
| US12186575B2 (en) | 2018-11-13 | 2025-01-07 | The Methodist Hospital | Method and apparatus for oncomagnetic treatment |
| CN113015553B (zh) | 2018-11-19 | 2025-01-14 | 诺沃库勒有限责任公司 | 用于递送具有选择性可寻址子元件的肿瘤治疗场（TTField）的阵列 |
| MX2021002625A (es) | 2018-11-29 | 2021-05-12 | Novocure Gmbh | Arreglos de transductores de mayor flexibilidad para suministrar campos tt (campos de tratamiento de tumores). |
| JP7246486B2 (ja) | 2019-01-08 | 2023-03-27 | ノボキュア ゲーエムベーハー | 腫瘍治療電場（ｔｔｆｉｅｌｄｓ）を使用した治療を計画するための異なるタイプの組織への画像のセグメンテーションの品質評価 |
| US11344740B2 (en) | 2019-02-07 | 2022-05-31 | Asha Medical, Inc. | System and methods for treating cancer cells with alternating polarity magnetic fields |
| CN113692302A (zh) | 2019-02-07 | 2021-11-23 | V·K·沙玛 | 用交替极性磁场治疗癌细胞的系统及方法 |
| US11027143B2 (en) | 2020-02-06 | 2021-06-08 | Vivek K. Sharma | System and methods for treating cancer cells with alternating polarity magnetic fields |
| CA3127276A1 (en) | 2019-02-26 | 2020-09-03 | Novocure Gmbh | Determining a frequency for ttfields treatment based on an electrical characteristic of targeted cancer cells |
| US11471676B2 (en) | 2019-02-27 | 2022-10-18 | Novocure Gmbh | Delivering tumor treating fields (TTFields) using implantable transducer arrays |
| FR3093645B1 (fr) * | 2019-03-15 | 2021-04-02 | Univ Montpellier | Puce microfluidique pour attirer et détruire un élément biologique spécifique |
| US11911610B2 (en) | 2019-03-29 | 2024-02-27 | Novocure Gmbh | Methods for restoring sensitivity to TTFields in TTFields-resistant cancer cells with PTGER3 inhibitors |
| ES2940749T3 (es) | 2019-04-17 | 2023-05-11 | Novocure Gmbh | Carga de datos desde un sistema aislado sin comprometer el aislamiento |
| US12109412B2 (en) | 2019-04-22 | 2024-10-08 | Boston Scientific Scimed, Inc. | Combination electrical and chemotherapeutic treatment of cancer |
| CN113766949B (zh) | 2019-04-22 | 2025-04-08 | 波士顿科学国际有限公司 | 用于施用电刺激以治疗癌症的系统 |
| EP3958954B1 (en) | 2019-04-22 | 2024-04-24 | Boston Scientific Scimed Inc. | Electrical stimulation devices for cancer treatment |
| JP7476231B2 (ja) | 2019-04-23 | 2024-04-30 | ボストン サイエンティフィック サイムド，インコーポレイテッド | 温熱療法又は熱モニタと共に行われる電気刺激 |
| CN113747936B (zh) | 2019-04-23 | 2024-06-18 | 波士顿科学国际有限公司 | 用于电刺激来治疗癌症的电极 |
| WO2020219517A2 (en) | 2019-04-23 | 2020-10-29 | Boston Scientific Scimed, Inc. | Electrical stimulation for cancer treatment with internal and external electrodes |
| US11654279B2 (en) | 2019-07-31 | 2023-05-23 | Novocure Gmbh | Applying tumor treating fields (TTFields) via electrodes embedded into skull implants |
| WO2021024170A1 (en) | 2019-08-05 | 2021-02-11 | Voloshin Sela Tali | Increasing cancer cells' sensitivity to tumor treating fields (ttfields) by inhibiting il11 activity |
| CN114364433A (zh) | 2019-08-30 | 2022-04-15 | 诺沃库勒有限责任公司 | 向颈部输送肿瘤治疗场（TTFields） |
| IL293419A (en) * | 2019-12-11 | 2022-07-01 | Novocure Gmbh | Preparations and methods for changing electrical impedance to an alternating electric field |
| MX2022006135A (es) | 2019-12-31 | 2022-06-17 | Novocure Gmbh | Generador de ondas sinusoidales de alta eficiencia, alto voltaje, que evita los picos durante los ajustes de amplitud y la conmutacion de canales. |
| WO2021137094A1 (en) | 2019-12-31 | 2021-07-08 | Novocure Gmbh | Arrays for delivering tumor treating fields (ttfields) with individually accessible electrode elements and temperature sensors |
| US12121739B2 (en) | 2019-12-31 | 2024-10-22 | Novocure Gmbh | Methods, systems, and apparatuses for managing temperatures induced by alternating fields |
| WO2021173509A1 (en) | 2020-02-24 | 2021-09-02 | Boston Scientific Scimed, Inc. | Systems and methods for treatment of pancreatic cancer |
| US20210299440A1 (en) | 2020-03-30 | 2021-09-30 | Novocure Gmbh | Intravenous / Intra-Spinal / Intra-Cavity / Intraventricular Delivery of TTFields (Tumor Treating Fields) for Treating Cancer and Metastases |
| JP2023522817A (ja) | 2020-04-24 | 2023-06-01 | ノボキュア ゲーエムベーハー | 血液脳関門の透過性を増加させるための交流電界の使用 |
| TWI889816B (zh) | 2020-05-06 | 2025-07-11 | 瑞士商諾沃庫勒有限責任公司 | 用於產生腫瘤治療電場之導電襯墊以及生產和使用其之方法 |
| EP4168108A4 (en) | 2020-06-19 | 2024-07-17 | The Methodist Hospital dba Houston Methodist Hospital | METHOD AND APPARATUS FOR ONCOMAGNETIC TREATMENT |
| US11818943B2 (en) | 2020-06-25 | 2023-11-14 | Novocure Gmbh | Fabricating organic light emitting diodes (OLEDs) using tubulin |
| US12114991B2 (en) | 2020-09-25 | 2024-10-15 | Novocure Gmbh | Varying the metallization area on individual electrode elements in a tumor treating fields (TTFields) system to maximize current without overheating |
| DE102021102884A1 (de) * | 2021-02-08 | 2022-08-11 | Elea Vertriebs- Und Vermarktungsgesellschaft Mbh | Verfahren zum Paralysieren von Parasiten in Nahrung, insbesondere in einem Lebens- oder Futtermittel und damit hergestelltes Lebensmittel mit paralysierten Parasiten |
| WO2022175803A1 (en) | 2021-02-17 | 2022-08-25 | Novocure Gmbh | Arrays for delivering tumor treating fields (ttfields) with sets of electrode elements having individually adjustable active areas |
| EP4304704A1 (en) | 2021-03-12 | 2024-01-17 | Novocure GmbH | Methods of treating disease by skewing macrophage phenotype with alternating electric fields |
| US20220305277A1 (en) * | 2021-03-23 | 2022-09-29 | Novocure Gmbh | Methods and apparatuses for detecting and responding to changes in a subject |
| EP4596025A1 (en) | 2021-03-31 | 2025-08-06 | Novocure Gmbh | Impedance tomography using electrodes of a tumor treating fields (ttfields) system |
| US20230009366A1 (en) * | 2021-06-30 | 2023-01-12 | Novocure Gmbh | Using Alternating Electric Fields at Different Frequencies to Increase Permeability of the Blood Brain Barrier and also to Provide Other Benefits |
| CN113663215B (zh) * | 2021-10-22 | 2022-01-21 | 杭州维纳安可医疗科技有限责任公司 | 电场发生装置及其控制方法、计算机可读存储介质 |
| US20230173265A1 (en) * | 2021-12-10 | 2023-06-08 | Novocure Gmbh | Garment providing a biasing force on a transducer array |
| US12377280B2 (en) | 2021-12-30 | 2025-08-05 | Novocure Gmbh | Selecting values of parameters for treatment using tumor treating fields (TTFields) |
| IL314390A (en) | 2022-03-30 | 2024-09-01 | Novocure Gmbh | Using interleaved cooling periods to increase the peak intensity of tumor treating fields |
| CA3255016A1 (en) | 2022-03-30 | 2023-10-05 | Novocure Gmbh | REDUCING ELECTROSENSITIVITY WHILE TREATING A SUBJECT WITH ALTERNATING ELECTRIC FIELDS BY MATCHING TRANSDUCER NETWORKS TOGETHER |
| CN119173302A (zh) | 2022-04-01 | 2024-12-20 | 得克萨斯大学体系董事会 | 用于应用与个性化超分割立体定向适应性放射疗法相组合的肿瘤治疗电场的方法和仪器 |
| WO2024141916A1 (en) * | 2022-12-28 | 2024-07-04 | Novocure Gmbh | Wearable garment with integrated tumor treating fields voltage generator |
| US12268863B2 (en) | 2023-02-06 | 2025-04-08 | Novocure Gmbh | Shiftable transducer array with anisotropic material layer |
| CN116020054B (zh) * | 2023-02-24 | 2023-12-08 | 北京微脊医疗科技有限公司 | 植入式电场治疗装置 |
| US12465759B2 (en) | 2023-03-14 | 2025-11-11 | Boris Kriman | Electrostatic therapeutic device |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060167499A1 (en) * | 2000-02-17 | 2006-07-27 | Standen Ltd | Treating a tumor or the like with electric fields at different orientations |
| US20070184020A1 (en) * | 2004-06-09 | 2007-08-09 | Jochen Kalbe | Combination of radio waves with pharmacologically active substances |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR446660A (fr) | 1911-09-02 | 1912-12-12 | Gottlieb Schuettel | Dispositif pour métiers continus à anneaux pour monter les curseurs sur les anneaux |
| BE794566A (fr) | 1972-01-28 | 1973-07-26 | Esb Inc | Regenerateur et stimulateur bioelectrochimique et procedes d'application in vivo d'energie electrique a des cellules et des tissus. |
| US3991770A (en) | 1974-01-24 | 1976-11-16 | Leveen Harry H | Method for treating benign and malignant tumors utilizing radio frequency, electromagnetic radiation |
| US4016886A (en) | 1974-11-26 | 1977-04-12 | The United States Of America As Represented By The United States Energy Research And Development Administration | Method for localizing heating in tumor tissue |
| US4121592A (en) | 1975-08-04 | 1978-10-24 | Critical Systems, Inc. | Apparatus for heating tissue |
| JPS5547870A (en) | 1978-02-24 | 1980-04-05 | Lawrence Joseph L | Medical treatment method |
| DE2813068A1 (de) | 1978-03-25 | 1979-10-04 | Philips Patentverwaltung | Verfahren und vorrichtung zur ermittlung von inneren koerperstrukturen |
| GB2043453A (en) | 1979-02-22 | 1980-10-08 | Electrochem Tech Corp | Improvements in or relating to an electrode |
| US4472506A (en) | 1981-01-13 | 1984-09-18 | Liburdy Robert P | Method for determining cell membrane dielectric breakdown |
| US4467809A (en) | 1982-09-17 | 1984-08-28 | Biolectron, Inc. | Method for non-invasive electrical stimulation of epiphyseal plate growth |
| US4622952A (en) | 1983-01-13 | 1986-11-18 | Gordon Robert T | Cancer treatment method |
| CA1244889A (en) | 1983-01-24 | 1988-11-15 | Kureha Chemical Ind Co Ltd | HYPERTHERMIA DEVICE |
| DE3323415C2 (de) | 1983-06-29 | 1985-04-25 | Kernforschungsanlage Jülich GmbH, 5170 Jülich | Verwendung eines Verfahrens und einer Vorrichtung zur Bestimmung von Zellinhaltstoffe sezernierenden Zellen |
| SE455920B (sv) | 1986-01-29 | 1988-08-22 | Hans Wiksell | Anordning for hypertermibehandling av tumorer |
| US4923814A (en) | 1986-05-09 | 1990-05-08 | Electropore, Inc. | High speed, high power apparatus for vesicle prealignment, poration, loading and fusion in uniform electric fields and method therefor |
| CN86103803B (zh) | 1986-06-05 | 1987-11-18 | 北京信息工程学院 | 静电场治疗装置 |
| US4822470A (en) | 1987-10-09 | 1989-04-18 | Baylor College Of Medicine | Method of and apparatus for cell poration and cell fusion using radiofrequency electrical pulses |
| US4936303A (en) | 1987-11-20 | 1990-06-26 | Ultrathermics | Ultrasonic heating apparatus and method |
| JPH0629196B2 (ja) | 1987-12-01 | 1994-04-20 | 甲子郎 梅村 | 超音波による腫瘍治療用生理作用増強剤 |
| US5389069A (en) | 1988-01-21 | 1995-02-14 | Massachusetts Institute Of Technology | Method and apparatus for in vivo electroporation of remote cells and tissue |
| FR2627987B3 (fr) | 1988-03-04 | 1990-02-02 | Indiba Sa | Appareil electronique pour la therapie medicale et cosmetique |
| US5158071A (en) | 1988-07-01 | 1992-10-27 | Hitachi, Ltd. | Ultrasonic apparatus for therapeutical use |
| GB8904998D0 (en) | 1989-03-04 | 1989-04-19 | Matthews Tony | Anaesthetising apparatus |
| US5099756A (en) | 1989-06-01 | 1992-03-31 | Harry H. Leveen | Radio frequency thermotherapy |
| US5441746A (en) | 1989-12-22 | 1995-08-15 | Molecular Bioquest, Inc. | Electromagnetic wave absorbing, surface modified magnetic particles for use in medical applications, and their method of production |
| US5236410A (en) | 1990-08-02 | 1993-08-17 | Ferrotherm International, Inc. | Tumor treatment method |
| AU1672492A (en) | 1991-05-03 | 1992-12-21 | University Technologies International Inc. | Biofilm reduction method |
| US5441532A (en) | 1991-06-26 | 1995-08-15 | Massachusetts Institute Of Technology | Adaptive focusing and nulling hyperthermia annular and monopole phased array applicators |
| US5468223A (en) | 1992-11-30 | 1995-11-21 | C.N.R.S. Paris | Electrochemotherapy |
| US5386837A (en) | 1993-02-01 | 1995-02-07 | Mmtc, Inc. | Method for enhancing delivery of chemotherapy employing high-frequency force fields |
| FR2703253B1 (fr) | 1993-03-30 | 1995-06-23 | Centre Nat Rech Scient | Applicateur d'impulsions electriques pour traitement de tissus biologiques. |
| IL108775A (en) | 1994-02-25 | 2003-09-17 | Univ Ramot | Method for efficient incorporation of molecules into cells |
| US5704355A (en) | 1994-07-01 | 1998-01-06 | Bridges; Jack E. | Non-invasive system for breast cancer detection |
| AU6639596A (en) | 1995-07-28 | 1997-02-26 | James R. Gray | Use of a polarizing field to modify the efficacy of a bioactive agent |
| US5606971A (en) | 1995-11-13 | 1997-03-04 | Artann Corporation, A Nj Corp. | Method and device for shear wave elasticity imaging |
| US5718246A (en) | 1996-01-03 | 1998-02-17 | Preferential, Inc. | Preferential induction of electrically mediated cell death from applied pulses |
| US5984882A (en) | 1996-08-19 | 1999-11-16 | Angiosonics Inc. | Methods for prevention and treatment of cancer and other proliferative diseases with ultrasonic energy |
| US5869326A (en) | 1996-09-09 | 1999-02-09 | Genetronics, Inc. | Electroporation employing user-configured pulsing scheme |
| US6055453A (en) | 1997-08-01 | 2000-04-25 | Genetronics, Inc. | Apparatus for addressing needle array electrodes for electroporation therapy |
| EP1003847A4 (en) | 1997-09-04 | 2005-04-06 | Science Res Lab Inc | SEPARATION OF CELLS BY USE OF ELECTRIC FIELDS |
| US6027488A (en) | 1998-06-03 | 2000-02-22 | Genetronics, Inc. | Flow-through electroporation system for ex vivo gene therapy |
| US5976092A (en) | 1998-06-15 | 1999-11-02 | Chinn; Douglas O. | Combination stereotactic surgical guide and ultrasonic probe |
| US6319901B1 (en) | 1998-10-15 | 2001-11-20 | Ichor Medical Systems, Inc. | Methods for prolonging cell membrane permeability |
| EP1158919B1 (en) | 1999-03-09 | 2005-06-29 | Thermage, Inc. | Apparatus for treatment of tissue |
| US6678558B1 (en) | 1999-03-25 | 2004-01-13 | Genetronics, Inc. | Method and apparatus for reducing electroporation-mediated muscle reaction and pain response |
| US6366808B1 (en) | 2000-03-13 | 2002-04-02 | Edward A. Schroeppel | Implantable device and method for the electrical treatment of cancer |
| US6853864B2 (en) | 2000-02-02 | 2005-02-08 | Catholic University Of America, The | Use of electromagnetic fields in cancer and other therapies |
| US6868289B2 (en) | 2002-10-02 | 2005-03-15 | Standen Ltd. | Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor |
| US7805201B2 (en) | 2000-02-17 | 2010-09-28 | Standen Ltd. | Treating a tumor or the like with an electric field |
| US7136699B2 (en) | 2002-10-02 | 2006-11-14 | Standen, Ltd. | Apparatus for destroying dividing cells |
| US7146210B2 (en) | 2000-02-17 | 2006-12-05 | Standen Ltd. | Apparatus and method for optimizing tumor treatment efficiency by electric fields |
| US7599746B2 (en) | 2000-02-17 | 2009-10-06 | Standen Ltd | Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases |
| US7016725B2 (en) | 2001-11-06 | 2006-03-21 | Standen Ltd. | Method and apparatus for destroying dividing cells |
| US7089054B2 (en) | 2002-10-02 | 2006-08-08 | Standen Ltd. | Apparatus and method for treating a tumor or the like |
| WO2001060994A1 (en) | 2000-02-17 | 2001-08-23 | Palti Yoram Prof | Method and apparatus for destroying dividing cells |
| US8175698B2 (en) | 2000-02-17 | 2012-05-08 | Novocure Ltd. | Treating bacteria with electric fields |
| US6546290B1 (en) | 2000-04-12 | 2003-04-08 | Roamitron Holding S.A. | Method and apparatus for electromedical therapy |
| US6994706B2 (en) | 2001-08-13 | 2006-02-07 | Minnesota Medical Physics, Llc | Apparatus and method for treatment of benign prostatic hyperplasia |
| US8986944B2 (en) * | 2001-10-11 | 2015-03-24 | Aviva Biosciences Corporation | Methods and compositions for separating rare cells from fluid samples |
| PT2345451T (pt) | 2004-12-07 | 2018-04-19 | Novocure Ltd | Eléctrodos para aplicar um campo eléctrico in-vivo ao longo de um extenso período de tempo |
| JP5451067B2 (ja) | 2005-06-08 | 2014-03-26 | スタンデン・リミテッド | 体内の所望の位置に案内される電場による癌の治療 |
| WO2007039799A2 (en) | 2005-10-03 | 2007-04-12 | Novocure Ltd. | Optimizing characteristics of an electric field to increase the field's effect on proliferating cells |
| US8019414B2 (en) | 2006-04-05 | 2011-09-13 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with other treatment regimens |
| EP2167194B1 (en) | 2007-03-06 | 2017-04-19 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with photodynamic therapy |
| CA2696352C (en) | 2007-08-14 | 2017-03-21 | Novocure Limited | Treating parasites with electric fields |
| US8715203B2 (en) | 2007-09-17 | 2014-05-06 | Novocure Limited | Composite electrode |
-
2008
- 2008-08-13 CA CA2696352A patent/CA2696352C/en active Active
- 2008-08-13 PT PT08789083T patent/PT2183024T/pt unknown
- 2008-08-13 JP JP2010520642A patent/JP5485153B2/ja active Active
- 2008-08-13 CN CN200880111479A patent/CN101820947A/zh active Pending
- 2008-08-13 DK DK08789083.6T patent/DK2183024T3/da active
- 2008-08-13 EP EP08789083.6A patent/EP2183024B1/en active Active
- 2008-08-13 ES ES08789083T patent/ES2739384T3/es active Active
- 2008-08-13 WO PCT/IB2008/002134 patent/WO2009022225A1/en not_active Ceased
- 2008-08-13 US US12/190,886 patent/US7890183B2/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060167499A1 (en) * | 2000-02-17 | 2006-07-27 | Standen Ltd | Treating a tumor or the like with electric fields at different orientations |
| US20070184020A1 (en) * | 2004-06-09 | 2007-08-09 | Jochen Kalbe | Combination of radio waves with pharmacologically active substances |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113908431A (zh) * | 2018-08-23 | 2022-01-11 | 诺沃库勒有限责任公司 | 使用交变电场来提高血脑屏障的通透性 |
| CN114269274A (zh) * | 2020-07-16 | 2022-04-01 | 株式会社电界 | 基于吸收能量的电场癌治疗计划系统及方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20090043346A1 (en) | 2009-02-12 |
| EP2183024A1 (en) | 2010-05-12 |
| WO2009022225A1 (en) | 2009-02-19 |
| JP2010536406A (ja) | 2010-12-02 |
| ES2739384T3 (es) | 2020-01-30 |
| JP5485153B2 (ja) | 2014-05-07 |
| PT2183024T (pt) | 2019-08-01 |
| DK2183024T3 (da) | 2019-06-24 |
| CA2696352A1 (en) | 2009-02-19 |
| US7890183B2 (en) | 2011-02-15 |
| CA2696352C (en) | 2017-03-21 |
| EP2183024B1 (en) | 2019-05-15 |
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