CA2694381A1

CA2694381A1 - Aminopyrimidines useful as kinase inhibitors

Aminopyrimidines useful as kinase inhibitors Download PDF

Info

Publication number: CA2694381A1
Authority: CA; Canada
Prior art keywords: ring; compound; phenyl; independently; nitrogen
Prior art date: 2007-05-02
Legal status : Abandoned

Application number

CA2694381A

Other languages

English (en)

French (fr)

Inventor

Michael Mortimore

Julian Golec

Daniel Robinson

Current Assignee

Vertex Pharmaceuticals Inc

Original Assignee

Individual

Priority date

2007-05-02

Filing date

2008-05-02

Publication date

2008-11-13

2008-05-02 Application filed by Individual filed Critical Individual

2008-11-13 Publication of CA2694381A1 publication Critical patent/CA2694381A1/en

Status Abandoned legal-status Critical Current

Links

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238000000034 method Methods 0.000 claims abstract description 57
239000000203 mixture Substances 0.000 claims abstract description 51
150000003839 salts Chemical class 0.000 claims abstract description 29
239000003112 inhibitor Substances 0.000 claims abstract description 21
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208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 16
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102000001253 Protein Kinase Human genes 0.000 claims abstract description 5
108060006633 protein kinase Proteins 0.000 claims abstract description 5
125000003226 pyrazolyl group Chemical group 0.000 claims abstract description 4
125000000335 thiazolyl group Chemical group 0.000 claims abstract description 3
-1 -OR Chemical group 0.000 claims description 59
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 37
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