CA2693390C - Derives de n-(arylamino)arylsulfonamide comprenant des polymorphes en tant qu'inhibiteurs de mek ainsi que compositions, procedes d'utilisation et procedes de preparation de ceux-ci - Google Patents
Derives de n-(arylamino)arylsulfonamide comprenant des polymorphes en tant qu'inhibiteurs de mek ainsi que compositions, procedes d'utilisation et procedes de preparation de ceux-ci Download PDFInfo
- Publication number
- CA2693390C CA2693390C CA2693390A CA2693390A CA2693390C CA 2693390 C CA2693390 C CA 2693390C CA 2693390 A CA2693390 A CA 2693390A CA 2693390 A CA2693390 A CA 2693390A CA 2693390 C CA2693390 C CA 2693390C
- Authority
- CA
- Canada
- Prior art keywords
- phenyl
- additional embodiments
- compound
- formula
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
- A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
- A01N41/04—Sulfonic acids; Derivatives thereof
- A01N41/06—Sulfonic acid amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/28—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2924436A CA2924436A1 (fr) | 2007-07-30 | 2008-07-28 | Combinaisons pharmaceutiques de n-3(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide comme inhibiteurs de mek et methodes d'utilisation |
CA2924418A CA2924418A1 (fr) | 2007-07-30 | 2008-07-28 | Derives de n-(arylamino)arylsulfonamide comprenant des polymorphes en tant qu'inhibiteurs de mek ainsi que compositions, procedes d'utilisation et procedes de preparation de ceux-ci |
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/830,733 US8101799B2 (en) | 2005-07-21 | 2007-07-30 | Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK |
US11/830,733 | 2007-07-30 | ||
US3446608P | 2008-03-06 | 2008-03-06 | |
US3446408P | 2008-03-06 | 2008-03-06 | |
US61/034,464 | 2008-03-06 | ||
US61/034,466 | 2008-03-06 | ||
US4488608P | 2008-04-14 | 2008-04-14 | |
US61/044,886 | 2008-04-14 | ||
PCT/US2008/071392 WO2009018233A1 (fr) | 2007-07-30 | 2008-07-28 | Dérivés de n-(arylamino)arylsulfonamide comprenant des polymorphes en tant qu'inhibiteurs de mek ainsi que compositions, procédés d'utilisation et procédés de préparation de ceux-ci |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2924418A Division CA2924418A1 (fr) | 2007-07-30 | 2008-07-28 | Derives de n-(arylamino)arylsulfonamide comprenant des polymorphes en tant qu'inhibiteurs de mek ainsi que compositions, procedes d'utilisation et procedes de preparation de ceux-ci |
CA2924436A Division CA2924436A1 (fr) | 2007-07-30 | 2008-07-28 | Combinaisons pharmaceutiques de n-3(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide comme inhibiteurs de mek et methodes d'utilisation |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2693390A1 CA2693390A1 (fr) | 2009-02-05 |
CA2693390C true CA2693390C (fr) | 2017-01-17 |
Family
ID=40304796
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2693390A Expired - Fee Related CA2693390C (fr) | 2007-07-30 | 2008-07-28 | Derives de n-(arylamino)arylsulfonamide comprenant des polymorphes en tant qu'inhibiteurs de mek ainsi que compositions, procedes d'utilisation et procedes de preparation de ceux-ci |
Country Status (23)
Country | Link |
---|---|
EP (1) | EP2184984A4 (fr) |
JP (3) | JP2010535232A (fr) |
KR (3) | KR20150091434A (fr) |
CN (2) | CN101808516B (fr) |
AP (1) | AP2817A (fr) |
AU (2) | AU2008282338B2 (fr) |
BR (1) | BRPI0815659A2 (fr) |
CA (1) | CA2693390C (fr) |
CO (1) | CO6470808A2 (fr) |
CR (1) | CR11244A (fr) |
DO (1) | DOP2010000045A (fr) |
EA (2) | EA032294B1 (fr) |
EC (1) | ECSP109910A (fr) |
HK (1) | HK1147396A1 (fr) |
HN (1) | HN2010000203A (fr) |
IL (1) | IL203296A (fr) |
MA (1) | MA31881B1 (fr) |
MX (1) | MX2010001244A (fr) |
NZ (1) | NZ582929A (fr) |
PH (1) | PH12015501914A1 (fr) |
SV (1) | SV2010003469A (fr) |
TN (1) | TN2010000049A1 (fr) |
WO (1) | WO2009018233A1 (fr) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
CN102131771A (zh) * | 2008-04-14 | 2011-07-20 | 阿迪生物科学公司 | 组合物及其制备和使用方法 |
ES2706875T3 (es) * | 2008-09-09 | 2019-04-01 | Hoffmann La Roche | Polimorfos de acilsulfonamidas |
SG190568A1 (en) | 2008-09-26 | 2013-06-28 | Oncomed Pharm Inc | Frizzled-binding agents and uses thereof |
UY32486A (es) * | 2009-03-11 | 2010-10-29 | Ardea Biosciences Inc | Tratamiento del cáncer de páncreas |
CA2972379A1 (fr) * | 2009-03-11 | 2010-09-16 | Ardea Biosciences, Inc. | Combinaisons pharmaceutiques renfermant du rdea119/bay 869766 en vue du traitement de cancers specifiques |
AU2010306830C1 (en) | 2009-10-13 | 2015-05-28 | Allomek Therapeutics Llc | Novel mek inhibitors, useful in the treatment of diseases |
CA2777304A1 (fr) * | 2009-10-21 | 2011-04-28 | Marion Hitchcock | Benzosulfonamides substitues |
TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
CN102020651B (zh) | 2010-11-02 | 2012-07-18 | 北京赛林泰医药技术有限公司 | 6-芳基氨基吡啶酮甲酰胺mek抑制剂 |
CN102649773A (zh) * | 2011-02-23 | 2012-08-29 | 苏州波锐生物医药科技有限公司 | 氨基芳香烃类化合物及其在制备抗恶性肿瘤药物中的用途 |
US20140315929A1 (en) * | 2011-04-28 | 2014-10-23 | Sloan-Kettering Institute For Cancer Research | Hsp90 combination therapy |
WO2012163799A1 (fr) * | 2011-05-27 | 2012-12-06 | Bayer Intellectual Property Gmbh | Synthèse chirale de n-{3,4-difluoro-2-[(2-fluoro-4-iodophényl)amino]-6-méthoxyphényl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamides |
WO2013086260A2 (fr) * | 2011-12-09 | 2013-06-13 | Oncomed Pharmaceuticals, Inc. | Thérapie d'association pour le traitement du cancer |
WO2013109142A1 (fr) | 2012-01-16 | 2013-07-25 | Stichting Het Nederlands Kanker Instituut | Inhibition de la voie des mapk/erk et pdk combinée dans des cas de néoplasie |
AU2013269809B2 (en) * | 2012-05-31 | 2017-12-21 | Bayer Pharma Aktiengesellschaft | Biomarkers for determining effective response of treatments of Hepatocellular carcinoma (HCC) patients |
UA114421C2 (uk) | 2012-06-04 | 2017-06-12 | Фармасайклікс Ллс | Кристалічна форма інгібітору тирозинкінази брутона |
HRP20240033T1 (hr) * | 2012-10-19 | 2024-03-29 | Array Biopharma, Inc. | Formulacija koja sadrži inhibitor mek |
CA2890238A1 (fr) | 2012-11-02 | 2014-05-08 | Merck Patent Gmbh | Methode de reduction des effets secondaires chez un patient souffrant de cancer traite par un inhibiteur de la mek |
JP2016510411A (ja) | 2013-02-04 | 2016-04-07 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Wnt経路インヒビターによる処置の方法およびモニタリング |
EP2848246A1 (fr) | 2013-09-13 | 2015-03-18 | Bayer Pharma Aktiengesellschaft | Compositions pharmaceutiques contenant du refametinib |
WO2015041534A1 (fr) | 2013-09-20 | 2015-03-26 | Stichting Het Nederlands Kanker Instituut | P90rsk en combinaison avec raf/erk/mek |
WO2015041533A1 (fr) | 2013-09-20 | 2015-03-26 | Stichting Het Nederlands Kanker Instituut | Association de rock et de la voie mapk |
US20170027940A1 (en) | 2014-04-10 | 2017-02-02 | Stichting Het Nederlands Kanker Instituut | Method for treating cancer |
WO2015178770A1 (fr) | 2014-05-19 | 2015-11-26 | Stichting Het Nederlands Kanker Instituut | Compositions pour le traitement du cancer |
CN106535931A (zh) * | 2014-08-25 | 2017-03-22 | 艾慕恩治疗公司 | 卵蛋白制剂及其制备方法 |
SG11201707122QA (en) | 2015-03-03 | 2017-09-28 | Pharmacyclics Llc | Pharmaceutical formulations of bruton's tyrosine kinase inhibtor |
MX2019015177A (es) * | 2017-06-16 | 2020-02-07 | Beta Pharma Inc | Formulaciones farmaceuticas de n-(2-(2-(dimetilamino)etoxi)-4-meto xi-5((4-(1-metil-1h-indol-3-il)pirimidin-2-il)amino)fenil)acrilam ida y las sales de ellas. |
US20220143049A1 (en) | 2019-03-21 | 2022-05-12 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
JP2023500906A (ja) | 2019-11-08 | 2023-01-11 | インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル) | キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法 |
WO2021148581A1 (fr) | 2020-01-22 | 2021-07-29 | Onxeo | Nouvelle molécule dbait et son utilisation |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5162117A (en) * | 1991-11-22 | 1992-11-10 | Schering Corporation | Controlled release flutamide composition |
JP2575590B2 (ja) * | 1992-07-31 | 1997-01-29 | 塩野義製薬株式会社 | トリアゾリルチオメチルチオセファロスポリン塩酸塩およびその水和物結晶ならびにそれらの製法 |
US5843946A (en) * | 1992-08-25 | 1998-12-01 | G.D. Searle & Co. | α-and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
US7115632B1 (en) * | 1999-05-12 | 2006-10-03 | G. D. Searle & Co. | Sulfonyl aryl or heteroaryl hydroxamic acid compounds |
CN1149204C (zh) * | 1999-01-13 | 2004-05-12 | 沃尼尔·朗伯公司 | 1-杂环取代的二芳基胺 |
GB0003224D0 (en) * | 2000-02-11 | 2000-04-05 | Glaxo Group Ltd | Chemical compounds |
US7235567B2 (en) * | 2000-06-15 | 2007-06-26 | Schering Corporation | Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist |
WO2003026574A2 (fr) * | 2001-09-24 | 2003-04-03 | Au Jessie L-S | Procedes et compositions permettant de determiner la dose de chimiosensibilisation de la suramine utilisee dans une therapie associative |
US20060089410A1 (en) * | 2002-07-17 | 2006-04-27 | Titan Pharmaceuticals, Inc. | Combination of chemotherapeutic drugs for increasing antitumor activity |
BR0313048A (pt) * | 2002-07-30 | 2005-06-14 | Zentaris Gmbh | Uso de alquilfosfocolinas em combinação com medicamentos antitumorais |
MX2007012778A (es) * | 2005-04-12 | 2008-01-11 | Elan Pharma Int Ltd | Formulaciones de derivados de quinazolina nanoparticuladas. |
CN101198582A (zh) * | 2005-04-22 | 2008-06-11 | 橘生药品工业株式会社 | 4’-{2-[(1s,2r)-2-羟基-2-(4-羟基苯基)-1-甲基乙氨基]乙氧基}-3-异丙基-3’,5’-二甲基联苯羧酸盐酸盐的结晶多形 |
CA2618218C (fr) * | 2005-07-21 | 2015-06-30 | Ardea Biosciences, Inc. | Inhibiteurs n-(arylamino)-sulfonamide de mek |
JP2007099763A (ja) * | 2005-09-08 | 2007-04-19 | Toyama Chem Co Ltd | ピペラシリンナトリウム・1水和物の新規な結晶及びその製造方法 |
TW200800150A (en) * | 2005-12-21 | 2008-01-01 | Organon Nv | Compounds with medicinal effects due to interaction with the glucocorticoid receptor |
-
2008
- 2008-07-28 KR KR1020157020493A patent/KR20150091434A/ko not_active Application Discontinuation
- 2008-07-28 KR KR1020107004742A patent/KR20100092424A/ko active Search and Examination
- 2008-07-28 CN CN2008801088296A patent/CN101808516B/zh not_active Expired - Fee Related
- 2008-07-28 MX MX2010001244A patent/MX2010001244A/es active IP Right Grant
- 2008-07-28 EA EA201400552A patent/EA032294B1/ru not_active IP Right Cessation
- 2008-07-28 NZ NZ582929A patent/NZ582929A/en not_active IP Right Cessation
- 2008-07-28 EP EP08796733.7A patent/EP2184984A4/fr not_active Ceased
- 2008-07-28 CN CN201310317815.8A patent/CN103479604B/zh not_active Expired - Fee Related
- 2008-07-28 CA CA2693390A patent/CA2693390C/fr not_active Expired - Fee Related
- 2008-07-28 EA EA201000268A patent/EA020624B1/ru not_active IP Right Cessation
- 2008-07-28 WO PCT/US2008/071392 patent/WO2009018233A1/fr active Application Filing
- 2008-07-28 AU AU2008282338A patent/AU2008282338B2/en not_active Ceased
- 2008-07-28 JP JP2010520118A patent/JP2010535232A/ja active Pending
- 2008-07-28 KR KR1020147017261A patent/KR20140098185A/ko not_active Application Discontinuation
- 2008-07-28 BR BRPI0815659-0A2A patent/BRPI0815659A2/pt not_active Application Discontinuation
- 2008-07-28 AP AP2010005134A patent/AP2817A/xx active
-
2010
- 2010-01-13 IL IL203296A patent/IL203296A/en not_active IP Right Cessation
- 2010-01-29 HN HN2010000203A patent/HN2010000203A/es unknown
- 2010-01-29 SV SV2010003469A patent/SV2010003469A/es unknown
- 2010-01-29 DO DO2010000045A patent/DOP2010000045A/es unknown
- 2010-01-29 CO CO10009526A patent/CO6470808A2/es not_active Application Discontinuation
- 2010-01-29 TN TNP2010000049A patent/TN2010000049A1/fr unknown
- 2010-01-29 CR CR11244A patent/CR11244A/es not_active Application Discontinuation
- 2010-01-29 EC EC2010009910A patent/ECSP109910A/es unknown
- 2010-02-19 MA MA32636A patent/MA31881B1/fr unknown
-
2011
- 2011-02-18 HK HK11101625.8A patent/HK1147396A1/xx not_active IP Right Cessation
-
2014
- 2014-11-14 JP JP2014231450A patent/JP6309880B2/ja not_active Expired - Fee Related
-
2015
- 2015-01-28 AU AU2015200390A patent/AU2015200390B2/en not_active Ceased
- 2015-08-28 PH PH12015501914A patent/PH12015501914A1/en unknown
-
2017
- 2017-02-03 JP JP2017018477A patent/JP2017125021A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2693390C (fr) | Derives de n-(arylamino)arylsulfonamide comprenant des polymorphes en tant qu'inhibiteurs de mek ainsi que compositions, procedes d'utilisation et procedes de preparation de ceux-ci | |
US8648116B2 (en) | Derivatives of N-(arylamino) sulfonamides including polymorphs as inhibitors of MEK as well as compositions, methods of use and methods for preparing the same | |
US8808742B2 (en) | Compositions and methods for preparing and using same | |
US8829052B2 (en) | Derivatives of N-(arylamino)sulfonamides as inhibitors of MEK | |
US8044240B2 (en) | Polymorphic form of N-(S)-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and uses thereof | |
US20160271122A1 (en) | Combinations of mek inhibitors and raf kinase inhibitors and uses thereof | |
TWI481590B (zh) | 作為mek抑制劑之n-(芳胺基)磺醯胺(包括多晶型)衍生物及組合物,使用方法及其製備方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |
Effective date: 20130704 |
|
MKLA | Lapsed |
Effective date: 20190729 |