CA2684552A1 - Substituted 3-(4-hydroxyphenyl)-indolin-2-one compounds - Google Patents

Substituted 3-(4-hydroxyphenyl)-indolin-2-one compounds Download PDF

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Publication number
CA2684552A1
CA2684552A1 CA002684552A CA2684552A CA2684552A1 CA 2684552 A1 CA2684552 A1 CA 2684552A1 CA 002684552 A CA002684552 A CA 002684552A CA 2684552 A CA2684552 A CA 2684552A CA 2684552 A1 CA2684552 A1 CA 2684552A1
Authority
CA
Canada
Prior art keywords
hydroxyphenyl
indolin
compound
optionally substituted
difluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002684552A
Other languages
English (en)
French (fr)
Inventor
Mette Knak Christensen
Fredrik Bjoerkling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Onxeo DK
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2684552A1 publication Critical patent/CA2684552A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002684552A 2007-04-24 2008-04-24 Substituted 3-(4-hydroxyphenyl)-indolin-2-one compounds Abandoned CA2684552A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91362507P 2007-04-24 2007-04-24
US60/913,625 2007-04-24
PCT/EP2008/054990 WO2008129075A1 (en) 2007-04-24 2008-04-24 Substituted 3-(4-hydroxyphenyl)-indolin-2-one-compounds

Publications (1)

Publication Number Publication Date
CA2684552A1 true CA2684552A1 (en) 2008-10-30

Family

ID=39643405

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002684552A Abandoned CA2684552A1 (en) 2007-04-24 2008-04-24 Substituted 3-(4-hydroxyphenyl)-indolin-2-one compounds

Country Status (6)

Country Link
US (1) US20100227863A1 (OSRAM)
EP (1) EP2139856A1 (OSRAM)
JP (1) JP2010525024A (OSRAM)
AU (1) AU2008240599A1 (OSRAM)
CA (1) CA2684552A1 (OSRAM)
WO (1) WO2008129075A1 (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1718611A4 (en) 2004-02-13 2009-09-23 Harvard College 3-3-DI-SUBSTITUTED OXINDOLES AS INHIBITORS OF INITIATION OF TRANSLATION
WO2010109008A1 (en) 2009-03-26 2010-09-30 Topotarget A/S Prodrugs of substituted 3-(4-hydroxyphenyl)-indolin-2-ones
WO2014047437A1 (en) * 2012-09-20 2014-03-27 President And Fellows Of Harvard College 3-3-di-substituted-oxindoles as inhibitors of translation initiation
CN105017129B (zh) * 2015-07-02 2017-12-26 广东药科大学 一种吲哚生物碱及其应用
CN110526853B (zh) * 2018-05-23 2021-02-26 浙江大学 3,3-二取代-2-吲哚酮衍生物及其制备方法
MA53105A (fr) * 2018-07-03 2021-05-12 Univ Illinois Activateurs de la réponse à une protéine non dépliée
EP3912625A1 (en) * 2020-05-20 2021-11-24 Kaerus Bioscience Limited Novel maxi-k potassium channel openers for the treatment of fragile x associated disorders
AU2021366688B2 (en) * 2020-10-23 2026-03-05 The Board Of Trustees Of The University Of Illinois Anticancer compounds selective for er-positive cancers
CN113149888B (zh) * 2021-05-06 2023-03-03 中山大学 一种羟基吲哚酮类衍生物及其制备方法和应用
CN115490673B (zh) * 2022-01-11 2024-10-15 苏州浦合医药科技有限公司 3,3-二取代吲哚酮类化合物及其用途
CN120677152A (zh) * 2023-02-23 2025-09-19 上海济煜医药科技有限公司 双环类化合物及其制备方法和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1718611A4 (en) * 2004-02-13 2009-09-23 Harvard College 3-3-DI-SUBSTITUTED OXINDOLES AS INHIBITORS OF INITIATION OF TRANSLATION
CN1953747A (zh) * 2004-04-08 2007-04-25 顶标公司 二苯基－吲哚－2－酮化合物及其在治疗癌症中的用途

Also Published As

Publication number Publication date
WO2008129075A1 (en) 2008-10-30
JP2010525024A (ja) 2010-07-22
AU2008240599A1 (en) 2008-10-30
EP2139856A1 (en) 2010-01-06
US20100227863A1 (en) 2010-09-09

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Legal Events

Date Code Title Description
FZDC Discontinued application reinstated
FZDE Discontinued

Effective date: 20140424