CA2682432C - Device and method for delivery of a medicament - Google Patents
Device and method for delivery of a medicament Download PDFInfo
- Publication number
- CA2682432C CA2682432C CA2682432A CA2682432A CA2682432C CA 2682432 C CA2682432 C CA 2682432C CA 2682432 A CA2682432 A CA 2682432A CA 2682432 A CA2682432 A CA 2682432A CA 2682432 C CA2682432 C CA 2682432C
- Authority
- CA
- Canada
- Prior art keywords
- nicotine
- delivery
- enhancing compound
- delivery enhancing
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 54
- 238000000034 method Methods 0.000 title abstract description 130
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims abstract description 358
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims abstract description 356
- 229960002715 nicotine Drugs 0.000 claims abstract description 356
- 230000002708 enhancing effect Effects 0.000 claims abstract description 131
- 150000001875 compounds Chemical class 0.000 claims description 148
- 239000002245 particle Substances 0.000 claims description 51
- 238000004891 communication Methods 0.000 claims description 36
- 239000012458 free base Substances 0.000 claims description 27
- 235000019504 cigarettes Nutrition 0.000 claims description 16
- 238000001179 sorption measurement Methods 0.000 claims description 16
- 239000011521 glass Substances 0.000 claims description 12
- 230000000391 smoking effect Effects 0.000 claims description 12
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 11
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 11
- -1 Polyethylene Terephthalate Polymers 0.000 claims description 10
- 241000208125 Nicotiana Species 0.000 claims description 9
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims description 9
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 8
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 8
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 7
- 229920000295 expanded polytetrafluoroethylene Polymers 0.000 claims description 7
- 229920001707 polybutylene terephthalate Polymers 0.000 claims description 7
- 239000002243 precursor Substances 0.000 claims description 6
- 229910052782 aluminium Inorganic materials 0.000 claims description 5
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 5
- 239000000796 flavoring agent Substances 0.000 claims description 5
- 235000013355 food flavoring agent Nutrition 0.000 claims description 5
- 239000012629 purifying agent Substances 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- 235000019270 ammonium chloride Nutrition 0.000 claims description 3
- 239000012080 ambient air Substances 0.000 claims description 2
- 235000019505 tobacco product Nutrition 0.000 abstract description 14
- 201000010099 disease Diseases 0.000 abstract description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 11
- 238000013461 design Methods 0.000 abstract description 9
- 238000006467 substitution reaction Methods 0.000 abstract description 9
- 230000009467 reduction Effects 0.000 abstract description 8
- 230000001225 therapeutic effect Effects 0.000 abstract description 4
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 102
- 239000002253 acid Substances 0.000 description 71
- 229940107700 pyruvic acid Drugs 0.000 description 51
- 238000002474 experimental method Methods 0.000 description 42
- 239000000126 substance Substances 0.000 description 42
- 239000002585 base Substances 0.000 description 27
- 239000000463 material Substances 0.000 description 27
- 239000000443 aerosol Substances 0.000 description 22
- 239000003570 air Substances 0.000 description 22
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 20
- 239000007788 liquid Substances 0.000 description 19
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 17
- 238000010438 heat treatment Methods 0.000 description 17
- QHKABHOOEWYVLI-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid Chemical compound CC(C)C(=O)C(O)=O QHKABHOOEWYVLI-UHFFFAOYSA-N 0.000 description 16
- 239000000523 sample Substances 0.000 description 14
- 239000003463 adsorbent Substances 0.000 description 12
- 230000001965 increasing effect Effects 0.000 description 12
- 238000013401 experimental design Methods 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 10
- 239000000843 powder Substances 0.000 description 10
- 230000002685 pulmonary effect Effects 0.000 description 10
- 230000015572 biosynthetic process Effects 0.000 description 9
- 239000012528 membrane Substances 0.000 description 9
- 229940071648 metered dose inhaler Drugs 0.000 description 9
- 239000001388 3-methyl-2-oxobutanoic acid Substances 0.000 description 8
- BKAJNAXTPSGJCU-UHFFFAOYSA-N 4-methyl-2-oxopentanoic acid Chemical compound CC(C)CC(=O)C(O)=O BKAJNAXTPSGJCU-UHFFFAOYSA-N 0.000 description 8
- 239000001142 4-methyl-2-oxopentanoic acid Substances 0.000 description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 238000011282 treatment Methods 0.000 description 8
- 239000004698 Polyethylene Substances 0.000 description 7
- 239000004809 Teflon Substances 0.000 description 7
- 229920006362 Teflon® Polymers 0.000 description 7
- 239000011888 foil Substances 0.000 description 7
- 239000007789 gas Substances 0.000 description 7
- 150000007524 organic acids Chemical class 0.000 description 7
- 229920000573 polyethylene Polymers 0.000 description 7
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical compound FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- MVJLYXCJBPXRCY-UHFFFAOYSA-N 2-methylbutyl propanoate Chemical compound CCC(C)COC(=O)CC MVJLYXCJBPXRCY-UHFFFAOYSA-N 0.000 description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 6
- 239000004743 Polypropylene Substances 0.000 description 6
- 239000002386 air freshener Substances 0.000 description 6
- 229920001155 polypropylene Polymers 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 206010057852 Nicotine dependence Diseases 0.000 description 5
- 229910021529 ammonia Inorganic materials 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 150000001735 carboxylic acids Chemical class 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 230000006872 improvement Effects 0.000 description 5
- 229910000069 nitrogen hydride Inorganic materials 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 229920006395 saturated elastomer Polymers 0.000 description 5
- 229920001824 Barex® Polymers 0.000 description 4
- 208000025569 Tobacco Use disease Diseases 0.000 description 4
- 150000007513 acids Chemical class 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 239000003610 charcoal Substances 0.000 description 4
- 239000000470 constituent Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000011049 filling Methods 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 238000011068 loading method Methods 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 238000005070 sampling Methods 0.000 description 4
- MMOPGICOOYBFJU-UHFFFAOYSA-N 3-(1-methylpyrrolidin-2-yl)pyridine;2-oxopropanoic acid Chemical compound CC(=O)C(O)=O.CN1CCCC1C1=CC=CN=C1 MMOPGICOOYBFJU-UHFFFAOYSA-N 0.000 description 3
- 208000024827 Alzheimer disease Diseases 0.000 description 3
- 206010009900 Colitis ulcerative Diseases 0.000 description 3
- DMULVCHRPCFFGV-UHFFFAOYSA-N N,N-dimethyltryptamine Chemical compound C1=CC=C2C(CCN(C)C)=CNC2=C1 DMULVCHRPCFFGV-UHFFFAOYSA-N 0.000 description 3
- 208000008589 Obesity Diseases 0.000 description 3
- 208000018737 Parkinson disease Diseases 0.000 description 3
- 201000006704 Ulcerative Colitis Diseases 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000002156 adsorbate Substances 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 238000004817 gas chromatography Methods 0.000 description 3
- 150000005828 hydrofluoroalkanes Chemical class 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 201000006417 multiple sclerosis Diseases 0.000 description 3
- 235000020824 obesity Nutrition 0.000 description 3
- 239000012466 permeate Substances 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 238000012383 pulmonary drug delivery Methods 0.000 description 3
- 230000005586 smoking cessation Effects 0.000 description 3
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 2
- PMNLUUOXGOOLSP-UHFFFAOYSA-N 2-mercaptopropanoic acid Chemical compound CC(S)C(O)=O PMNLUUOXGOOLSP-UHFFFAOYSA-N 0.000 description 2
- GPPUPQFYDYLTIY-UHFFFAOYSA-N 2-oxooctanoic acid Chemical compound CCCCCCC(=O)C(O)=O GPPUPQFYDYLTIY-UHFFFAOYSA-N 0.000 description 2
- IRJNJBIOUYJBHG-UHFFFAOYSA-N 3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound CN1CCCC1C1=CC=CN=C1.CN1CCCC1C1=CC=CN=C1 IRJNJBIOUYJBHG-UHFFFAOYSA-N 0.000 description 2
- JOOXCMJARBKPKM-UHFFFAOYSA-N 4-oxopentanoic acid Chemical compound CC(=O)CCC(O)=O JOOXCMJARBKPKM-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 description 2
- NCIKQJBVUNUXLW-UHFFFAOYSA-N N-methyltryptamine Chemical compound C1=CC=C2C(CCNC)=CNC2=C1 NCIKQJBVUNUXLW-UHFFFAOYSA-N 0.000 description 2
- FXFANIORDKRCCA-UHFFFAOYSA-N Norcotinine Chemical compound N1C(=O)CCC1C1=CC=CN=C1 FXFANIORDKRCCA-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 230000000274 adsorptive effect Effects 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- SLRCCWJSBJZJBV-UHFFFAOYSA-N alpha-isosparteine Natural products C1N2CCCCC2C2CN3CCCCC3C1C2 SLRCCWJSBJZJBV-UHFFFAOYSA-N 0.000 description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
- HJJPJSXJAXAIPN-UHFFFAOYSA-N arecoline Chemical compound COC(=O)C1=CCCN(C)C1 HJJPJSXJAXAIPN-UHFFFAOYSA-N 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- DLNKOYKMWOXYQA-IONNQARKSA-N cathine Chemical compound C[C@H](N)[C@@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-IONNQARKSA-N 0.000 description 2
- 229960003609 cathine Drugs 0.000 description 2
- HGAZMNJKRQFZKS-UHFFFAOYSA-N chloroethene;ethenyl acetate Chemical compound ClC=C.CC(=O)OC=C HGAZMNJKRQFZKS-UHFFFAOYSA-N 0.000 description 2
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 229910001873 dinitrogen Inorganic materials 0.000 description 2
- DLNKOYKMWOXYQA-UHFFFAOYSA-N dl-pseudophenylpropanolamine Natural products CC(N)C(O)C1=CC=CC=C1 DLNKOYKMWOXYQA-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 239000003000 extruded plastic Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 description 2
- HHLFWLYXYJOTON-UHFFFAOYSA-N glyoxylic acid Chemical compound OC(=O)C=O HHLFWLYXYJOTON-UHFFFAOYSA-N 0.000 description 2
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 2
- KUBCEEMXQZUPDQ-UHFFFAOYSA-N hordenine Chemical compound CN(C)CCC1=CC=C(O)C=C1 KUBCEEMXQZUPDQ-UHFFFAOYSA-N 0.000 description 2
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 description 2
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 2
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000003801 milling Methods 0.000 description 2
- DPNGWXJMIILTBS-UHFFFAOYSA-N myosmine Chemical compound C1CCN=C1C1=CC=CN=C1 DPNGWXJMIILTBS-UHFFFAOYSA-N 0.000 description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 2
- 235000005985 organic acids Nutrition 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- SLRCCWJSBJZJBV-AJNGGQMLSA-N sparteine Chemical compound C1N2CCCC[C@H]2[C@@H]2CN3CCCC[C@H]3[C@H]1C2 SLRCCWJSBJZJBV-AJNGGQMLSA-N 0.000 description 2
- 229960001945 sparteine Drugs 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- APJYDQYYACXCRM-UHFFFAOYSA-N tryptamine Chemical compound C1=CC=C2C(CCN)=CNC2=C1 APJYDQYYACXCRM-UHFFFAOYSA-N 0.000 description 2
- CEMAWMOMDPGJMB-UHFFFAOYSA-N (+-)-Oxprenolol Chemical compound CC(C)NCC(O)COC1=CC=CC=C1OCC=C CEMAWMOMDPGJMB-UHFFFAOYSA-N 0.000 description 1
- XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 description 1
- MXYUKLILVYORSK-UHFFFAOYSA-N (+/-)-allo-lobeline Natural products C1CCC(CC(=O)C=2C=CC=CC=2)N(C)C1CC(O)C1=CC=CC=C1 MXYUKLILVYORSK-UHFFFAOYSA-N 0.000 description 1
- UIKROCXWUNQSPJ-VIFPVBQESA-N (-)-cotinine Chemical compound C1CC(=O)N(C)[C@@H]1C1=CC=CN=C1 UIKROCXWUNQSPJ-VIFPVBQESA-N 0.000 description 1
- MXYUKLILVYORSK-HBMCJLEFSA-N (-)-lobeline Chemical compound C1([C@@H](O)C[C@H]2N([C@H](CCC2)CC(=O)C=2C=CC=CC=2)C)=CC=CC=C1 MXYUKLILVYORSK-HBMCJLEFSA-N 0.000 description 1
- IGLYMJRIWWIQQE-QUOODJBBSA-N (1S,2R)-2-phenylcyclopropan-1-amine (1R,2S)-2-phenylcyclopropan-1-amine Chemical compound N[C@H]1C[C@@H]1C1=CC=CC=C1.N[C@@H]1C[C@H]1C1=CC=CC=C1 IGLYMJRIWWIQQE-QUOODJBBSA-N 0.000 description 1
- ADLXTJMPCFOTOO-UHFFFAOYSA-N (E)-2-Nonenoic acid Natural products CCCCCCC=CC(O)=O ADLXTJMPCFOTOO-UHFFFAOYSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- ADLXTJMPCFOTOO-BQYQJAHWSA-N (E)-non-2-enoic acid Chemical compound CCCCCC\C=C\C(O)=O ADLXTJMPCFOTOO-BQYQJAHWSA-N 0.000 description 1
- MTXSIJUGVMTTMU-JTQLQIEISA-N (S)-anabasine Chemical compound N1CCCC[C@H]1C1=CC=CN=C1 MTXSIJUGVMTTMU-JTQLQIEISA-N 0.000 description 1
- RKUNBYITZUJHSG-FXUDXRNXSA-N (S)-atropine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@H]3CC[C@@H](C2)N3C)=CC=CC=C1 RKUNBYITZUJHSG-FXUDXRNXSA-N 0.000 description 1
- MYKUKUCHPMASKF-VIFPVBQESA-N (S)-nornicotine Chemical compound C1CCN[C@@H]1C1=CC=CN=C1 MYKUKUCHPMASKF-VIFPVBQESA-N 0.000 description 1
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 description 1
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 description 1
- XYHKNCXZYYTLRG-UHFFFAOYSA-N 1h-imidazole-2-carbaldehyde Chemical compound O=CC1=NC=CN1 XYHKNCXZYYTLRG-UHFFFAOYSA-N 0.000 description 1
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 description 1
- HVRZYSHVZOELOH-UHFFFAOYSA-N 2-Methyl-4-pentenoic acid Chemical compound OC(=O)C(C)CC=C HVRZYSHVZOELOH-UHFFFAOYSA-N 0.000 description 1
- SPCKHVPPRJWQRZ-UHFFFAOYSA-N 2-benzhydryloxy-n,n-dimethylethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 SPCKHVPPRJWQRZ-UHFFFAOYSA-N 0.000 description 1
- OKDGRDCXVWSXDC-UHFFFAOYSA-N 2-chloropyridine Chemical compound ClC1=CC=CC=N1 OKDGRDCXVWSXDC-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- IAWVHZJZHDSEOC-UHFFFAOYSA-N 3,3-dimethyl-2-oxobutanoic acid Chemical compound CC(C)(C)C(=O)C(O)=O IAWVHZJZHDSEOC-UHFFFAOYSA-N 0.000 description 1
- WAOQONBSWFLFPE-VIFPVBQESA-N 3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide Chemical compound CCN1CCC[C@H]1CNC(=O)C1=C(O)C(Cl)=CC(Cl)=C1OC WAOQONBSWFLFPE-VIFPVBQESA-N 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-M 3-Methylbutanoic acid Natural products CC(C)CC([O-])=O GWYFCOCPABKNJV-UHFFFAOYSA-M 0.000 description 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
- IWLVSVBOMBDNMZ-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid;3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound CC(C)C(=O)C(O)=O.CN1CCCC1C1=CC=CN=C1 IWLVSVBOMBDNMZ-UHFFFAOYSA-N 0.000 description 1
- MXUNKHLAEDCYJL-UHFFFAOYSA-N 5-(hydroxymethyl)-3-(3-methylphenyl)-1,3-oxazolidin-2-one Chemical compound CC1=CC=CC(N2C(OC(CO)C2)=O)=C1 MXUNKHLAEDCYJL-UHFFFAOYSA-N 0.000 description 1
- XKFPYPQQHFEXRZ-UHFFFAOYSA-N 5-methyl-N'-(phenylmethyl)-3-isoxazolecarbohydrazide Chemical compound O1C(C)=CC(C(=O)NNCC=2C=CC=CC=2)=N1 XKFPYPQQHFEXRZ-UHFFFAOYSA-N 0.000 description 1
- RYENLSMHLCNXJT-CYXFISRXSA-N 7-Hydroxymitragynine Chemical compound C1=CC(OC)=C2[C@@]3(O)CCN4C[C@@H](CC)[C@@H](\C(=C/OC)C(=O)OC)C[C@H]4C3=NC2=C1 RYENLSMHLCNXJT-CYXFISRXSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 1
- 102100033639 Acetylcholinesterase Human genes 0.000 description 1
- 108010022752 Acetylcholinesterase Proteins 0.000 description 1
- SOPPBXUYQGUQHE-UHFFFAOYSA-N Anatabine Natural products C1C=CCNC1C1=CC=CN=C1 SOPPBXUYQGUQHE-UHFFFAOYSA-N 0.000 description 1
- SOPPBXUYQGUQHE-JTQLQIEISA-N Anatabine Chemical compound C1C=CCN[C@@H]1C1=CC=CN=C1 SOPPBXUYQGUQHE-JTQLQIEISA-N 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 229930003347 Atropine Natural products 0.000 description 1
- 239000005528 B01AC05 - Ticlopidine Substances 0.000 description 1
- 229930008564 C01BA04 - Sparteine Natural products 0.000 description 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- UIKROCXWUNQSPJ-UHFFFAOYSA-N Cotinine Natural products C1CC(=O)N(C)C1C1=CC=CN=C1 UIKROCXWUNQSPJ-UHFFFAOYSA-N 0.000 description 1
- NLPRAJRHRHZCQQ-UHFFFAOYSA-N Epibatidine Natural products C1=NC(Cl)=CC=C1C1C(N2)CCC2C1 NLPRAJRHRHZCQQ-UHFFFAOYSA-N 0.000 description 1
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- NYMGNSNKLVNMIA-UHFFFAOYSA-N Iproniazid Chemical compound CC(C)NNC(=O)C1=CC=NC=C1 NYMGNSNKLVNMIA-UHFFFAOYSA-N 0.000 description 1
- 229930194542 Keto Natural products 0.000 description 1
- JAQUASYNZVUNQP-USXIJHARSA-N Levorphanol Chemical compound C1C2=CC=C(O)C=C2[C@]23CCN(C)[C@H]1[C@@H]2CCCC3 JAQUASYNZVUNQP-USXIJHARSA-N 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- LELBFTMXCIIKKX-QVRQZEMUSA-N Mitragynine Chemical compound C1=CC(OC)=C2C(CCN3C[C@H]([C@H](C[C@H]33)\C(=C/OC)C(=O)OC)CC)=C3NC2=C1 LELBFTMXCIIKKX-QVRQZEMUSA-N 0.000 description 1
- LELBFTMXCIIKKX-SUCIZOKWSA-N Mitragynine Natural products C1=CC(OC)=C2C(CCN3C[C@H]([C@H](C[C@H]33)\C(=C\OC)C(=O)OC)CC)=C3NC2=C1 LELBFTMXCIIKKX-SUCIZOKWSA-N 0.000 description 1
- RYENLSMHLCNXJT-UHFFFAOYSA-N Mitragynine hydroxyindolenine Natural products C1=CC(OC)=C2C3(O)CCN4CC(CC)C(C(=COC)C(=O)OC)CC4C3=NC2=C1 RYENLSMHLCNXJT-UHFFFAOYSA-N 0.000 description 1
- UQOFGTXDASPNLL-XHNCKOQMSA-N Muscarine Chemical compound C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O UQOFGTXDASPNLL-XHNCKOQMSA-N 0.000 description 1
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 description 1
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 description 1
- MYKUKUCHPMASKF-UHFFFAOYSA-N Nornicotine Natural products C1CCNC1C1=CC=CN=C1 MYKUKUCHPMASKF-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- RMUCZJUITONUFY-UHFFFAOYSA-N Phenelzine Chemical compound NNCCC1=CC=CC=C1 RMUCZJUITONUFY-UHFFFAOYSA-N 0.000 description 1
- BHHGXPLMPWCGHP-UHFFFAOYSA-N Phenethylamine Chemical compound NCCC1=CC=CC=C1 BHHGXPLMPWCGHP-UHFFFAOYSA-N 0.000 description 1
- PIJVFDBKTWXHHD-UHFFFAOYSA-N Physostigmine Natural products C12=CC(OC(=O)NC)=CC=C2N(C)C2C1(C)CCN2C PIJVFDBKTWXHHD-UHFFFAOYSA-N 0.000 description 1
- RVOLLAQWKVFTGE-UHFFFAOYSA-N Pyridostigmine Chemical compound CN(C)C(=O)OC1=CC=C[N+](C)=C1 RVOLLAQWKVFTGE-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 238000005411 Van der Waals force Methods 0.000 description 1
- 239000011358 absorbing material Substances 0.000 description 1
- 229940022698 acetylcholinesterase Drugs 0.000 description 1
- 238000010669 acid-base reaction Methods 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 125000002015 acyclic group Chemical group 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000012387 aerosolization Methods 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000002723 alicyclic group Chemical group 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 150000004716 alpha keto acids Chemical class 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229910000323 aluminium silicate Inorganic materials 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229930014345 anabasine Natural products 0.000 description 1
- 239000003416 antiarrhythmic agent Substances 0.000 description 1
- 239000000924 antiasthmatic agent Substances 0.000 description 1
- 229940082992 antihypertensives mao inhibitors Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 159000000032 aromatic acids Chemical class 0.000 description 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 229940072107 ascorbate Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 229960000396 atropine Drugs 0.000 description 1
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N beta-methyl-butyric acid Natural products CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 210000003123 bronchiole Anatomy 0.000 description 1
- SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical compound CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 description 1
- 229960001058 bupropion Drugs 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000019506 cigar Nutrition 0.000 description 1
- 229960001747 cinchocaine Drugs 0.000 description 1
- PUFQVTATUTYEAL-UHFFFAOYSA-N cinchocaine Chemical compound C1=CC=CC2=NC(OCCCC)=CC(C(=O)NCCN(CC)CC)=C21 PUFQVTATUTYEAL-UHFFFAOYSA-N 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 229950006073 cotinine Drugs 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- RWYFURDDADFSHT-RBBHPAOJSA-N diane Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1.C1=C(Cl)C2=CC(=O)[C@@H]3CC3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RWYFURDDADFSHT-RBBHPAOJSA-N 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- KBEZZLAAKIIPFK-NJAFHUGGSA-N dimemorfan Chemical compound C1C2=CC=C(C)C=C2[C@@]23CCN(C)[C@@H]1[C@H]2CCCC3 KBEZZLAAKIIPFK-NJAFHUGGSA-N 0.000 description 1
- 229960001056 dimemorfan Drugs 0.000 description 1
- 229960000520 diphenhydramine Drugs 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 239000013583 drug formulation Substances 0.000 description 1
- 229940112141 dry powder inhaler Drugs 0.000 description 1
- 230000003028 elevating effect Effects 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 229960002179 ephedrine Drugs 0.000 description 1
- NLPRAJRHRHZCQQ-IVZWLZJFSA-N epibatidine Chemical compound C1=NC(Cl)=CC=C1[C@@H]1[C@H](N2)CC[C@H]2C1 NLPRAJRHRHZCQQ-IVZWLZJFSA-N 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 229960003980 galantamine Drugs 0.000 description 1
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 description 1
- ZHYZQXUYZJNEHD-VQHVLOKHSA-N geranic acid Chemical compound CC(C)=CCC\C(C)=C\C(O)=O ZHYZQXUYZJNEHD-VQHVLOKHSA-N 0.000 description 1
- 229930008392 geranic acid Natural products 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 229940071490 hordenine Drugs 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229930005342 hyoscyamine Natural products 0.000 description 1
- 229960003210 hyoscyamine Drugs 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 229960002589 iproclozide Drugs 0.000 description 1
- GGECDTUJZOXAAR-UHFFFAOYSA-N iproclozide Chemical compound CC(C)NNC(=O)COC1=CC=C(Cl)C=C1 GGECDTUJZOXAAR-UHFFFAOYSA-N 0.000 description 1
- 229940070023 iproniazide Drugs 0.000 description 1
- 229960002672 isocarboxazid Drugs 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 description 1
- 150000004715 keto acids Chemical class 0.000 description 1
- 125000000468 ketone group Chemical group 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229960003406 levorphanol Drugs 0.000 description 1
- 229940040102 levulinic acid Drugs 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- TYZROVQLWOKYKF-ZDUSSCGKSA-N linezolid Chemical compound O=C1O[C@@H](CNC(=O)C)CN1C(C=C1F)=CC=C1N1CCOCC1 TYZROVQLWOKYKF-ZDUSSCGKSA-N 0.000 description 1
- 229960003907 linezolid Drugs 0.000 description 1
- 229960002339 lobeline Drugs 0.000 description 1
- 229930013610 lobeline Natural products 0.000 description 1
- IMYZQPCYWPFTAG-IQJOONFLSA-N mecamylamine Chemical compound C1C[C@@H]2C(C)(C)[C@@](NC)(C)[C@H]1C2 IMYZQPCYWPFTAG-IQJOONFLSA-N 0.000 description 1
- 229960002525 mecamylamine Drugs 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000005499 meniscus Effects 0.000 description 1
- 229960000582 mepyramine Drugs 0.000 description 1
- YECBIJXISLIIDS-UHFFFAOYSA-N mepyramine Chemical compound C1=CC(OC)=CC=C1CN(CCN(C)C)C1=CC=CC=N1 YECBIJXISLIIDS-UHFFFAOYSA-N 0.000 description 1
- DAHIQPJTGIHDGO-IAGOWNOFSA-N mesembrine Chemical compound C1=C(OC)C(OC)=CC=C1[C@]1(CCC(=O)C2)[C@@H]2N(C)CC1 DAHIQPJTGIHDGO-IAGOWNOFSA-N 0.000 description 1
- DAHIQPJTGIHDGO-UHFFFAOYSA-N mesembrine Natural products C1=C(OC)C(OC)=CC=C1C1(CCC(=O)C2)C2N(C)CC1 DAHIQPJTGIHDGO-UHFFFAOYSA-N 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- LMOINURANNBYCM-UHFFFAOYSA-N metaproterenol Chemical compound CC(C)NCC(O)C1=CC(O)=CC(O)=C1 LMOINURANNBYCM-UHFFFAOYSA-N 0.000 description 1
- SVXZBICQLNEMLC-UHFFFAOYSA-N methyl 1-methyl-3,6-dihydro-2h-pyridine-4-carboxylate Chemical compound COC(=O)C1=CCN(C)CC1 SVXZBICQLNEMLC-UHFFFAOYSA-N 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 239000002899 monoamine oxidase inhibitor Substances 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- LBHIOVVIQHSOQN-UHFFFAOYSA-N nicorandil Chemical compound [O-][N+](=O)OCCNC(=O)C1=CC=CN=C1 LBHIOVVIQHSOQN-UHFFFAOYSA-N 0.000 description 1
- 229960002497 nicorandil Drugs 0.000 description 1
- 238000002670 nicotine replacement therapy Methods 0.000 description 1
- 239000000181 nicotinic agonist Substances 0.000 description 1
- 239000003367 nicotinic antagonist Substances 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 230000009972 noncorrosive effect Effects 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229960002657 orciprenaline Drugs 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 229960004570 oxprenolol Drugs 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- HVAMZGADVCBITI-UHFFFAOYSA-N pent-4-enoic acid Chemical compound OC(=O)CCC=C HVAMZGADVCBITI-UHFFFAOYSA-N 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229960000964 phenelzine Drugs 0.000 description 1
- 229960001697 physostigmine Drugs 0.000 description 1
- PIJVFDBKTWXHHD-HIFRSBDPSA-N physostigmine Chemical compound C12=CC(OC(=O)NC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C PIJVFDBKTWXHHD-HIFRSBDPSA-N 0.000 description 1
- 229920005644 polyethylene terephthalate glycol copolymer Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 229960003712 propranolol Drugs 0.000 description 1
- KWGRBVOPPLSCSI-WCBMZHEXSA-N pseudoephedrine Chemical compound CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WCBMZHEXSA-N 0.000 description 1
- 229960003908 pseudoephedrine Drugs 0.000 description 1
- 230000001007 puffing effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 229960002290 pyridostigmine Drugs 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- SBYHFKPVCBCYGV-UHFFFAOYSA-N quinuclidine Chemical compound C1CC2CCN1CC2 SBYHFKPVCBCYGV-UHFFFAOYSA-N 0.000 description 1
- 229950001518 raclopride Drugs 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000005067 remediation Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 229960001634 ritodrine Drugs 0.000 description 1
- YJYPZLAZNIGNRP-UHFFFAOYSA-N rjr-2429 Chemical compound C1CN2CCC1CC2C1=CC=CN=C1 YJYPZLAZNIGNRP-UHFFFAOYSA-N 0.000 description 1
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 1
- 229960002646 scopolamine Drugs 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000010902 straw Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229960001685 tacrine Drugs 0.000 description 1
- YLJREFDVOIBQDA-UHFFFAOYSA-N tacrine Chemical compound C1=CC=C2C(N)=C(CCCC3)C3=NC2=C1 YLJREFDVOIBQDA-UHFFFAOYSA-N 0.000 description 1
- MKTAGSRKQIGEBH-SSDOTTSWSA-N tebanicline Chemical compound C1=NC(Cl)=CC=C1OC[C@@H]1NCC1 MKTAGSRKQIGEBH-SSDOTTSWSA-N 0.000 description 1
- 229960000195 terbutaline Drugs 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 125000003039 tetrahydroisoquinolinyl group Chemical class C1(NCCC2=CC=CC=C12)* 0.000 description 1
- PHWBOXQYWZNQIN-UHFFFAOYSA-N ticlopidine Chemical compound ClC1=CC=CC=C1CN1CC(C=CS2)=C2CC1 PHWBOXQYWZNQIN-UHFFFAOYSA-N 0.000 description 1
- 229960005001 ticlopidine Drugs 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 229960002309 toloxatone Drugs 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- ZHYZQXUYZJNEHD-UHFFFAOYSA-N trans-geranic acid Natural products CC(C)=CCCC(C)=CC(O)=O ZHYZQXUYZJNEHD-UHFFFAOYSA-N 0.000 description 1
- 229960003741 tranylcypromine Drugs 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- 239000012905 visible particle Substances 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
- A24F42/10—Devices with chemical heating means
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
- A24F40/42—Cartridges or containers for inhalable precursors
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
- A24F42/20—Devices without heating means
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
- A24F42/60—Constructional details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
- A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/06—Inhaling appliances shaped like cigars, cigarettes or pipes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/10—Devices using liquid inhalable precursors
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
- A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
- A61M11/047—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters by exothermic chemical reaction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0091—Inhalators mechanically breath-triggered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/07—General characteristics of the apparatus having air pumping means
- A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8206—Internal energy supply devices battery-operated
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Manufacture Of Tobacco Products (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2963423A CA2963423C (en) | 2007-03-30 | 2008-03-25 | Device and method for delivery of a medicament |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90930207P | 2007-03-30 | 2007-03-30 | |
| US60/909,302 | 2007-03-30 | ||
| PCT/US2008/058122 WO2008121610A1 (en) | 2007-03-30 | 2008-03-25 | Device and method for delivery of a medicament |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2963423A Division CA2963423C (en) | 2007-03-30 | 2008-03-25 | Device and method for delivery of a medicament |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2682432A1 CA2682432A1 (en) | 2008-10-09 |
| CA2682432C true CA2682432C (en) | 2017-06-06 |
Family
ID=39794782
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2682432A Expired - Fee Related CA2682432C (en) | 2007-03-30 | 2008-03-25 | Device and method for delivery of a medicament |
| CA2963423A Expired - Fee Related CA2963423C (en) | 2007-03-30 | 2008-03-25 | Device and method for delivery of a medicament |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2963423A Expired - Fee Related CA2963423C (en) | 2007-03-30 | 2008-03-25 | Device and method for delivery of a medicament |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10668058B2 (https=) |
| EP (2) | EP2134395B1 (https=) |
| JP (2) | JP2010532672A (https=) |
| CN (3) | CN102014995B (https=) |
| AU (1) | AU2008232897B2 (https=) |
| CA (2) | CA2682432C (https=) |
| WO (1) | WO2008121610A1 (https=) |
Families Citing this family (275)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10244793B2 (en) | 2005-07-19 | 2019-04-02 | Juul Labs, Inc. | Devices for vaporization of a substance |
| CN102014995B (zh) | 2007-03-30 | 2015-05-13 | 菲利普莫里斯生产公司 | 用于输送药剂的装置和方法 |
| US7845358B2 (en) * | 2007-05-03 | 2010-12-07 | TLC Consulting, Inc. | Method for controlling, reducing, and quitting smoking |
| EP2534957B1 (en) | 2007-12-14 | 2015-05-27 | AeroDesigns, Inc | Delivering aerosolizable products |
| US8991402B2 (en) | 2007-12-18 | 2015-03-31 | Pax Labs, Inc. | Aerosol devices and methods for inhaling a substance and uses thereof |
| EP2113178A1 (en) | 2008-04-30 | 2009-11-04 | Philip Morris Products S.A. | An electrically heated smoking system having a liquid storage portion |
| AT507187B1 (de) | 2008-10-23 | 2010-03-15 | Helmut Dr Buchberger | Inhalator |
| CN201379072Y (zh) | 2009-02-11 | 2010-01-13 | 韩力 | 一种改进的雾化电子烟 |
| AU2010226152B2 (en) * | 2009-03-17 | 2014-09-25 | Philip Morris Products Sa | Tobacco-based nicotine aerosol generation system |
| US8495998B2 (en) | 2009-06-17 | 2013-07-30 | British American Tobacco (Investments) Limited | Inhaler |
| US9781952B2 (en) | 2009-07-22 | 2017-10-10 | Philip Morris Products S.A. | Smokeless cigarette substitute product |
| EP2277398A1 (de) * | 2009-07-22 | 2011-01-26 | Wedegree GmbH | Rauchfreies Zigarettenersatzprodukt |
| US8287922B2 (en) * | 2009-08-17 | 2012-10-16 | Chong Corporation | Vaporized Lobelia product and method of use |
| US8962040B2 (en) | 2009-08-17 | 2015-02-24 | Alexander ChinHak Chong | Vaporized medicants and methods of use |
| WO2011022431A1 (en) * | 2009-08-17 | 2011-02-24 | Chong Corporation | Vaporized tobacco product and methods of use |
| US10918684B2 (en) | 2009-08-17 | 2021-02-16 | Cqens Technologies, Inc. | Vaporized medicants and methods of use |
| US10758582B2 (en) | 2009-08-17 | 2020-09-01 | Xten Capital Group, Inc. | Vaporized medicants and methods of use |
| US9770408B2 (en) | 2009-08-17 | 2017-09-26 | Chong Corporation | Vaporized medicants and methods of use |
| US10098918B2 (en) | 2009-08-17 | 2018-10-16 | Chong Corporation | Vaporized medicants and methods of use |
| US9254002B2 (en) | 2009-08-17 | 2016-02-09 | Chong Corporation | Tobacco solution for vaporized inhalation |
| AT508681A1 (de) * | 2009-08-19 | 2011-03-15 | Schwarz Heribert | Rauchlose zigarette |
| IN2012DN02325A (https=) * | 2009-09-16 | 2015-08-21 | Philip Morris Products Sa | |
| EP2327318A1 (en) | 2009-11-27 | 2011-06-01 | Philip Morris Products S.A. | An electrically heated smoking system with internal or external heater |
| US20130269684A1 (en) | 2012-04-16 | 2013-10-17 | Dance Pharmaceuticals, Inc. | Methods and systems for supplying aerosolization devices with liquid medicaments |
| US10525214B2 (en) | 2010-01-12 | 2020-01-07 | Dance Biopharm Inc. | Preservative-free single dose inhaler system |
| US8950394B2 (en) | 2010-01-12 | 2015-02-10 | Dance Biopharm Inc. | Preservative-free single dose inhaler systems |
| JP5371134B2 (ja) * | 2010-02-24 | 2013-12-18 | 日本たばこ産業株式会社 | 香味吸引パイプ |
| GB201003552D0 (en) * | 2010-03-03 | 2010-04-21 | Kind Consumer Ltd | A simulated cigarette |
| AT508244B1 (de) | 2010-03-10 | 2010-12-15 | Helmut Dr Buchberger | Inhalatorkomponente |
| US10159278B2 (en) * | 2010-05-15 | 2018-12-25 | Rai Strategic Holdings, Inc. | Assembly directed airflow |
| US9861772B2 (en) * | 2010-05-15 | 2018-01-09 | Rai Strategic Holdings, Inc. | Personal vaporizing inhaler cartridge |
| US11247003B2 (en) | 2010-08-23 | 2022-02-15 | Darren Rubin | Systems and methods of aerosol delivery with airflow regulation |
| LT2982255T (lt) | 2010-08-24 | 2019-08-12 | Jt International Sa | Inhaliacinis įtaisas su medžiagos naudojimo reguliavimu |
| MY164565A (en) * | 2010-08-24 | 2018-01-15 | Japan Tobacco Inc | Non-heating type flavor inhalator and method of manufacturing flavor cartridge |
| AT510837B1 (de) | 2011-07-27 | 2012-07-15 | Helmut Dr Buchberger | Inhalatorkomponente |
| CA2824970C (en) | 2011-02-11 | 2016-05-03 | Batmark Limited | Inhaler component |
| US9399110B2 (en) | 2011-03-09 | 2016-07-26 | Chong Corporation | Medicant delivery system |
| MX356624B (es) | 2011-03-09 | 2018-06-06 | Chong Corp | Sistema de entrega de medicamento. |
| US20130298921A1 (en) * | 2011-06-23 | 2013-11-14 | Rock Creek Pharmaceuticals, Inc. | Inhaler for smoking cessation |
| EP2740508B1 (en) * | 2011-08-16 | 2016-06-15 | PAX Labs, Inc. | Low temperature electronic vaporization device |
| WO2013034454A1 (en) | 2011-09-06 | 2013-03-14 | British American Tobacco (Investments) Limited | Heating smokeable material |
| PL2753202T3 (pl) | 2011-09-06 | 2016-11-30 | Podgrzewanie materiału przeznaczonego do palenia | |
| EP3892125A3 (en) | 2011-09-06 | 2022-01-05 | Nicoventures Trading Limited | Heating smokable material |
| WO2013034456A1 (en) | 2011-09-06 | 2013-03-14 | British American Tobacco (Investments) Limited | Heating smokable material |
| US20140224268A1 (en) | 2011-09-09 | 2014-08-14 | Philip Morris Products S.A. | Smoking article filter including polymeric insert |
| RU2600911C2 (ru) | 2011-09-09 | 2016-10-27 | Филип Моррис Продактс С.А. | Фильтр курительного изделия с ограничивающим элементом и полостью |
| EP2583570B1 (en) | 2011-10-21 | 2015-02-18 | Philip Morris Products S.A. | Smoking article having a mouth end cavity with indicia |
| JP5885367B2 (ja) | 2011-10-31 | 2016-03-15 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 喫煙物品のための処理デバイス及びそのためのカートリッジ |
| PL2775867T3 (pl) | 2011-11-07 | 2019-04-30 | Philip Morris Products Sa | Wyrób do palenia z segmentem zmiany koloru |
| EP2782462B1 (en) | 2011-11-07 | 2020-06-03 | Philip Morris Products S.a.s. | Smoking article with movable vapour release component |
| UA112328C2 (uk) | 2011-11-07 | 2016-08-25 | Філіп Морріс Продактс С.А. | Ментолвмісний курильний виріб |
| UA111862C2 (uk) | 2011-11-07 | 2016-06-24 | Філіп Морріс Продактс С.А. | Курильний виріб з матеріалом для доставки рідини |
| AR089183A1 (es) | 2011-11-30 | 2014-08-06 | Philip Morris Products Sa | Articulo para fumar con una boquilla ventilada que comprende primeras y segundas vias de flujo de aire |
| US8646461B2 (en) | 2011-12-14 | 2014-02-11 | Sentiens, Llc | Device and method for simulating chemosensation of smoking |
| KR101930663B1 (ko) * | 2012-04-12 | 2018-12-18 | 제이티 인터내셔널 소시에떼 아노님 | 에어로졸-발생 장치 |
| GB201207039D0 (en) | 2012-04-23 | 2012-06-06 | British American Tobacco Co | Heating smokeable material |
| GB2504076A (en) | 2012-07-16 | 2014-01-22 | Nicoventures Holdings Ltd | Electronic smoking device |
| GB2504075A (en) | 2012-07-16 | 2014-01-22 | Nicoventures Holdings Ltd | Electronic smoking device |
| US10517530B2 (en) | 2012-08-28 | 2019-12-31 | Juul Labs, Inc. | Methods and devices for delivering and monitoring of tobacco, nicotine, or other substances |
| GB201217067D0 (en) | 2012-09-25 | 2012-11-07 | British American Tobacco Co | Heating smokable material |
| US10034988B2 (en) | 2012-11-28 | 2018-07-31 | Fontem Holdings I B.V. | Methods and devices for compound delivery |
| TW201427719A (zh) * | 2012-12-18 | 2014-07-16 | Philip Morris Products Sa | 氣溶膠產生系統用之經封裝的揮發性液體源 |
| US10653180B2 (en) | 2013-06-14 | 2020-05-19 | Juul Labs, Inc. | Multiple heating elements with separate vaporizable materials in an electric vaporization device |
| SG11201507630SA (en) | 2013-03-15 | 2015-10-29 | Philip Morris Products Sa | Aerosol-generating device comprising multiple solid-liquid phase-change materials |
| US10279934B2 (en) | 2013-03-15 | 2019-05-07 | Juul Labs, Inc. | Fillable vaporizer cartridge and method of filling |
| UA116796C2 (uk) * | 2013-03-15 | 2018-05-10 | Філіп Морріс Продактс С.А. | Система, що генерує аерозоль, з диференціальним нагріванням |
| BR112015020436B1 (pt) * | 2013-03-15 | 2021-12-28 | Philip Morris Products S.A. | Sistema, dispositivo e artigo gerador de aerossol |
| CN103190708A (zh) * | 2013-04-16 | 2013-07-10 | 湖北中烟工业有限责任公司 | 化学加热式无烟卷烟 |
| CZ2015784A3 (cs) * | 2013-04-16 | 2015-12-09 | Hubei China Tobacco Industry Co., Ltd | Nízkoteplotní cigareta fyzikálně-chemického typu |
| CN103202537A (zh) * | 2013-04-16 | 2013-07-17 | 湖北中烟工业有限责任公司 | 一种化学与电子方式结合的新型无烟卷烟 |
| GB2513639A (en) | 2013-05-02 | 2014-11-05 | Nicoventures Holdings Ltd | Electronic cigarette |
| KR102490695B1 (ko) * | 2013-05-06 | 2023-01-19 | 쥴 랩스, 인크. | 에어로졸 장치를 위한 니코틴 염 제제 및 그 방법 |
| PL2999365T3 (pl) * | 2013-05-21 | 2021-04-19 | Philip Morris Products S.A. | Układ dostarczania aerozolu z grzaniem elektrycznym |
| AU2014270525B2 (en) | 2013-05-21 | 2018-06-14 | Philip Morris Products S.A. | Aerosol comprising distributing agent and a medicament source |
| US11202470B2 (en) | 2013-05-22 | 2021-12-21 | Njoy, Inc. | Compositions, devices, and methods for nicotine aerosol delivery |
| GB201311620D0 (en) | 2013-06-28 | 2013-08-14 | British American Tobacco Co | Devices Comprising a Heat Source Material and Activation Chambers for the Same |
| UA117370C2 (uk) | 2013-07-03 | 2018-07-25 | Філіп Морріс Продактс С.А. | Система, що генерує аерозоль, багаторазового застосування |
| WO2015009862A2 (en) | 2013-07-19 | 2015-01-22 | Altria Client Services Inc. | Liquid aerosol formulation of an electronic smoking article |
| WO2015009500A1 (en) * | 2013-07-19 | 2015-01-22 | Williams Jonnie R | Volatilized delivery of anatabine for treatment of substance addiction |
| US20150027468A1 (en) * | 2013-07-25 | 2015-01-29 | Altria Client Services Inc. | Electronic smoking article |
| CN105491899B (zh) * | 2013-09-19 | 2018-10-30 | 菲利普莫里斯生产公司 | 用于生成烟碱盐颗粒的气雾生成系统 |
| US10194693B2 (en) | 2013-09-20 | 2019-02-05 | Fontem Holdings 1 B.V. | Aerosol generating device |
| NZ718007A (en) | 2013-10-29 | 2017-06-30 | British American Tobacco Investments Ltd | Apparatus for heating smokable material |
| EP4552512A3 (en) | 2013-12-05 | 2025-07-02 | Juul Labs, Inc. | Nicotine liquid formulations for aerosol devices and methods thereof |
| CN105792689B (zh) | 2013-12-16 | 2019-10-01 | 菲利普莫里斯生产公司 | 包括换热器的气溶胶生成装置 |
| PL3082484T3 (pl) | 2013-12-19 | 2020-05-18 | Philip Morris Products S.A. | Układ wytwarzania aerozolu |
| MX2016007858A (es) | 2013-12-20 | 2016-09-19 | Philip Morris Products Sa | Articulo para fumar que incluye granulos saborizantes que tienen una capa exterior permeable. |
| US9549573B2 (en) | 2013-12-23 | 2017-01-24 | Pax Labs, Inc. | Vaporization device systems and methods |
| USD842536S1 (en) | 2016-07-28 | 2019-03-05 | Juul Labs, Inc. | Vaporizer cartridge |
| US20160366947A1 (en) | 2013-12-23 | 2016-12-22 | James Monsees | Vaporizer apparatus |
| US10058129B2 (en) | 2013-12-23 | 2018-08-28 | Juul Labs, Inc. | Vaporization device systems and methods |
| KR102267997B1 (ko) | 2013-12-23 | 2021-06-23 | 쥴 랩스, 인크. | 기화 디바이스 시스템 및 방법 |
| US10076139B2 (en) | 2013-12-23 | 2018-09-18 | Juul Labs, Inc. | Vaporizer apparatus |
| USD825102S1 (en) | 2016-07-28 | 2018-08-07 | Juul Labs, Inc. | Vaporizer device with cartridge |
| US10159282B2 (en) | 2013-12-23 | 2018-12-25 | Juul Labs, Inc. | Cartridge for use with a vaporizer device |
| CN105813485B (zh) | 2013-12-31 | 2020-06-12 | 菲利普莫里斯生产公司 | 具有液体递送材料的吸烟制品 |
| EP3089599B1 (en) * | 2013-12-31 | 2019-02-13 | Philip Morris Products S.a.s. | An aerosol-generating device, and a capsule for use in an aerosol-generating device |
| RU2667883C2 (ru) | 2014-01-02 | 2018-09-24 | Филип Моррис Продактс С.А. | Система, генерирующая аэрозоль, содержащая цилиндрическую полимерную капсулу |
| SG11201605633XA (en) | 2014-02-26 | 2016-08-30 | Philip Morris Products Sa | Smoking article with liquid release component having frangible shell |
| CN105960177B (zh) | 2014-02-26 | 2019-08-16 | 菲利普莫里斯生产公司 | 具有触觉液体释放组分的吸烟制品 |
| US9839238B2 (en) | 2014-02-28 | 2017-12-12 | Rai Strategic Holdings, Inc. | Control body for an electronic smoking article |
| GB2524736B (en) | 2014-03-31 | 2021-02-24 | Nicoventures Holdings Ltd | Re-charging pack for an e-cigarette |
| EP3171720B1 (en) | 2014-07-24 | 2018-10-24 | Nicoventures Holdings Limited | Re-charging pack for an e-cigarette |
| GB2524735B (en) | 2014-03-31 | 2017-10-25 | Nicoventures Holdings Ltd | Re-charging pack for an e-cigarette |
| GB201407426D0 (en) | 2014-04-28 | 2014-06-11 | Batmark Ltd | Aerosol forming component |
| UA122894C2 (uk) | 2014-04-28 | 2021-01-20 | Філіп Морріс Продактс С.А. | Інгалятор нікотинового порошку |
| RU2696570C2 (ru) | 2014-04-28 | 2019-08-06 | Филип Моррис Продактс С.А. | Ингалятор никотинового порошка |
| CA2943746C (en) * | 2014-04-28 | 2023-08-15 | Philip Morris Products S.A. | Flavoured nicotine powder inhaler |
| CA2940009C (en) | 2014-04-30 | 2023-04-04 | Philip Morris Products S.A. | A container having a heater for an aerosol-generating device, and aerosol-generating device |
| WO2015175979A1 (en) | 2014-05-16 | 2015-11-19 | Pax Labs, Inc. | Systems and methods for aerosolizing a smokeable material |
| CN115944117A (zh) * | 2014-05-21 | 2023-04-11 | 菲利普莫里斯生产公司 | 具有内部感受器的气溶胶生成制品 |
| TWI669073B (zh) | 2014-06-24 | 2019-08-21 | 瑞士商菲利浦莫里斯製品股份有限公司 | 氣溶膠產生系統、氣溶膠產生物件、氣溶膠產生裝置及控制反應化學計量的方法 |
| RU2672650C2 (ru) * | 2014-06-27 | 2018-11-16 | Филип Моррис Продактс С.А. | Система, генерирующая аэрозоль, с усовершенствованным прокалывающим элементом |
| GB201500582D0 (en) | 2015-01-14 | 2015-02-25 | British American Tobacco Co | Apparatus for heating or cooling a material contained therein |
| GB2528710B (en) * | 2014-07-24 | 2018-12-26 | Nicoventures Holdings Ltd | E-cigarette re-charging system |
| GB2528673B (en) | 2014-07-25 | 2020-07-01 | Nicoventures Holdings Ltd | Aerosol provision system |
| GB2528712B (en) | 2014-07-29 | 2019-03-27 | Nicoventures Holdings Ltd | E-cigarette and re-charging pack |
| GB2529201A (en) * | 2014-08-13 | 2016-02-17 | Batmark Ltd | Device and method |
| US11350669B2 (en) | 2014-08-22 | 2022-06-07 | Njoy, Llc | Heating control for vaporizing device |
| KR102501825B1 (ko) | 2014-09-26 | 2023-02-22 | 필립모리스 프로덕츠 에스.에이. | 신규한 전달 향상 화합물 공급원을 포함하는 에어로졸 발생 시스템 |
| US10251426B2 (en) * | 2014-10-03 | 2019-04-09 | Fertin Pharma A/S | Electronic nicotine delivery system |
| EP3009019B1 (en) * | 2014-10-17 | 2019-05-01 | Fontem Holdings 1 B.V. | Cartridge having a liquid transporting element for uses with an electronic smoking device |
| GB201418817D0 (en) | 2014-10-22 | 2014-12-03 | British American Tobacco Co | Apparatus and method for generating an inhalable medium, and a cartridge for use therewith |
| KR102627987B1 (ko) | 2014-12-05 | 2024-01-22 | 쥴 랩스, 인크. | 교정된 투여량 제어 |
| GB2533135B (en) | 2014-12-11 | 2020-11-11 | Nicoventures Holdings Ltd | Aerosol provision systems |
| US10799652B2 (en) * | 2015-01-08 | 2020-10-13 | Convexity Scientific Inc. | Nebulizer device |
| CN110547520A (zh) | 2015-02-06 | 2019-12-10 | 菲利普莫里斯生产公司 | 供气溶胶生成装置用的容器 |
| US10471052B2 (en) | 2015-02-19 | 2019-11-12 | Mymd Pharmaceuticals, Inc. | Method of treating addictions to opioids |
| CN107223024B (zh) | 2015-02-26 | 2022-09-27 | 菲利普莫里斯生产公司 | 供气溶胶生成装置用的容器 |
| GB201503411D0 (en) * | 2015-02-27 | 2015-04-15 | British American Tobacco Co | Apparatus and method for generating an inhalable medium, and a cartridge for use therewith |
| RU2692811C2 (ru) | 2015-03-27 | 2019-06-27 | Филип Моррис Продактс С.А. | Образующая аэрозоль система, содержащая биметаллическую полоску |
| WO2016156212A1 (en) * | 2015-03-27 | 2016-10-06 | Philip Morris Products S.A. | Aerosol-generating system comprising integrated piercing element |
| CA2977885A1 (en) | 2015-03-27 | 2016-10-06 | Phillip Morris Products S.A. | Aerosol-generating system comprising a rupturing portion |
| CA2978372A1 (en) * | 2015-03-27 | 2016-10-06 | Philip Morris Products S.A. | Aerosol-generating system comprising a resilient member |
| GB201505595D0 (en) | 2015-03-31 | 2015-05-13 | British American Tobacco Co | Cartridge for use with apparatus for heating smokeable material |
| GB201505593D0 (en) | 2015-03-31 | 2015-05-13 | British American Tobacco Co | Article for use with apparatus for heating smokable material |
| GB201505597D0 (en) | 2015-03-31 | 2015-05-13 | British American Tobacco Co | Article for use with apparatus for heating smokable material |
| EP3302108B1 (en) | 2015-06-05 | 2021-05-19 | Hulecos SA | Device for active humidification and flavouring, system and method of using same |
| GB201511349D0 (en) | 2015-06-29 | 2015-08-12 | Nicoventures Holdings Ltd | Electronic aerosol provision systems |
| GB201511361D0 (en) | 2015-06-29 | 2015-08-12 | Nicoventures Holdings Ltd | Electronic vapour provision system |
| US10251425B2 (en) | 2015-07-06 | 2019-04-09 | Njoy, Llc | Vaporizing device with power component |
| USD809190S1 (en) | 2015-07-13 | 2018-01-30 | Njoy, Llc | Vaporizer |
| US10039323B2 (en) | 2015-07-16 | 2018-08-07 | Njoy, Llc | Vaporizer tank with atomizer |
| WO2017011868A1 (en) * | 2015-07-20 | 2017-01-26 | Medical Developments International Limited | Inhaler device for inhalable liquids |
| CN105011380A (zh) * | 2015-08-11 | 2015-11-04 | 深圳市新宜康科技有限公司 | 叶片分隔式电子烟气道结构 |
| KR102622045B1 (ko) | 2015-08-21 | 2024-01-10 | 필립모리스 프로덕츠 에스.에이. | 에어로졸 발생 시스템용 카트리지 조립체 및 카트리지 조립체를 포함하는 에어로졸 발생 시스템 |
| US20170055575A1 (en) | 2015-08-31 | 2017-03-02 | British American Tobacco (Investments) Limited | Material for use with apparatus for heating smokable material |
| US11924930B2 (en) | 2015-08-31 | 2024-03-05 | Nicoventures Trading Limited | Article for use with apparatus for heating smokable material |
| US20170055584A1 (en) | 2015-08-31 | 2017-03-02 | British American Tobacco (Investments) Limited | Article for use with apparatus for heating smokable material |
| US20170071248A1 (en) * | 2015-09-16 | 2017-03-16 | Sansa Corporation (Barbados) Inc. | System and Method for Controlling the Harshness of Nicotine-Based Dry Powder Formulations |
| GB2542838B (en) | 2015-10-01 | 2022-01-12 | Nicoventures Trading Ltd | Aerosol provision system |
| GB201517471D0 (en) * | 2015-10-02 | 2015-11-18 | British American Tobacco Co | Apparatus for generating an inhalable medium |
| US20170119046A1 (en) | 2015-10-30 | 2017-05-04 | British American Tobacco (Investments) Limited | Apparatus for Heating Smokable Material |
| US20170119047A1 (en) | 2015-10-30 | 2017-05-04 | British American Tobacco (Investments) Limited | Article for Use with Apparatus for Heating Smokable Material |
| GB2544493B (en) * | 2015-11-17 | 2020-06-17 | Nerudia Ltd | A dispenser for dispensing a liquid for a substitute smoking device |
| WO2017108721A1 (en) * | 2015-12-21 | 2017-06-29 | Philip Morris Products S.A. | Aerosol-generating system comprising variable air inlet |
| SI3183979T1 (en) | 2015-12-22 | 2018-07-31 | Philip Morris Products S.A. | A cartridge for an aerosol-producing system and an aerosol-producing system comprising a cartridge |
| KR102932738B1 (ko) | 2015-12-22 | 2026-03-04 | 필립모리스 프로덕츠 에스.에이. | 에어로졸 발생 시스템용 카트리지 및 카트리지를 포함하는 에어로졸 발생 시스템 |
| PL3183980T3 (pl) | 2015-12-22 | 2019-02-28 | Philip Morris Products S.A. | Wkład do układu wytwarzania aerozolu i układ wytwarzania aerozolu zawierający wkład |
| US11197498B2 (en) | 2015-12-22 | 2021-12-14 | Philip Morris Products S.A. | Cartridge for an aerosol-generating system and an aerosol-generating system comprising a cartridge |
| CA3008996A1 (en) | 2015-12-24 | 2017-06-29 | Philip Morris Products S.A. | Nicotine particle capsule |
| EP3393560B1 (en) | 2015-12-24 | 2020-03-25 | Philip Morris Products S.a.s. | Nicotine powder delivery system |
| CN117695207A (zh) | 2015-12-24 | 2024-03-15 | 菲利普莫里斯生产公司 | 带香味尼古丁粉末 |
| RU2729710C2 (ru) | 2016-01-25 | 2020-08-11 | Филип Моррис Продактс С.А. | Узел картриджа, содержащий направляющий паз |
| RU2729735C2 (ru) | 2016-01-25 | 2020-08-11 | Филип Моррис Продактс С.А. | Узел картриджа со сдвижным корпусом картриджа |
| US11247004B2 (en) | 2016-01-25 | 2022-02-15 | Philip Morris Products S.A. | Cartridge assembly with helicoidal activation |
| WO2017129615A1 (en) | 2016-01-25 | 2017-08-03 | Philip Morris Products S.A. | Cartridge assembly having an actuation portion |
| WO2017139675A1 (en) | 2016-02-11 | 2017-08-17 | Pax Labs, Inc. | Securely attaching cartridges for vaporizer devices |
| MX377347B (es) | 2016-02-11 | 2025-03-07 | Juul Labs Inc | Cartucho rellenable de vaporizador y metodo de relleno |
| US10433580B2 (en) | 2016-03-03 | 2019-10-08 | Altria Client Services Llc | Methods to add menthol, botanic materials, and/or non-botanic materials to a cartridge, and/or an electronic vaping device including the cartridge |
| US10455863B2 (en) | 2016-03-03 | 2019-10-29 | Altria Client Services Llc | Cartridge for electronic vaping device |
| US10368580B2 (en) | 2016-03-08 | 2019-08-06 | Altria Client Services Llc | Combined cartridge for electronic vaping device |
| US10405582B2 (en) | 2016-03-10 | 2019-09-10 | Pax Labs, Inc. | Vaporization device with lip sensing |
| US12501928B2 (en) | 2016-03-11 | 2025-12-23 | Altria Client Services Llc | Multiple dispersion generating e-vaping device having a dual piston cylinder, configured to reduce a transmission of a pressure force from a carbon dioxide capsule to a tank configured to store a pre-aerosol formulation |
| US10368581B2 (en) | 2016-03-11 | 2019-08-06 | Altria Client Services Llc | Multiple dispersion generator e-vaping device |
| US10357060B2 (en) | 2016-03-11 | 2019-07-23 | Altria Client Services Llc | E-vaping device cartridge holder |
| US11744964B2 (en) | 2016-04-27 | 2023-09-05 | Nicoventures Trading Limited | Electronic aerosol provision system and vaporizer therefor |
| KR102535930B1 (ko) * | 2016-04-28 | 2023-05-25 | 필립모리스 프로덕츠 에스.에이. | 에어로졸 발생 시스템에서 사용하기 위한 커플링 요소를 포함하는 카트리지 |
| USD849996S1 (en) | 2016-06-16 | 2019-05-28 | Pax Labs, Inc. | Vaporizer cartridge |
| USD836541S1 (en) | 2016-06-23 | 2018-12-25 | Pax Labs, Inc. | Charging device |
| USD851830S1 (en) | 2016-06-23 | 2019-06-18 | Pax Labs, Inc. | Combined vaporizer tamp and pick tool |
| USD848057S1 (en) | 2016-06-23 | 2019-05-07 | Pax Labs, Inc. | Lid for a vaporizer |
| US10212964B2 (en) | 2016-07-07 | 2019-02-26 | Altria Client Services | Additive assembly for electronic vaping device |
| JP6976970B2 (ja) | 2016-07-07 | 2021-12-08 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | ニコチン吸入器システム |
| BR112018076760A2 (pt) * | 2016-07-21 | 2019-03-26 | Philip Morris Products Sa | inalador de pó seco |
| GB201612945D0 (en) | 2016-07-26 | 2016-09-07 | British American Tobacco Investments Ltd | Method of generating aerosol |
| DE102016114718B4 (de) * | 2016-08-09 | 2021-02-25 | Hauni Maschinenbau Gmbh | Inhalator |
| GB2556024B (en) | 2016-08-25 | 2021-12-08 | Nicoventures Trading Ltd | Electronic vapour provision device with absorbent element |
| KR102849100B1 (ko) | 2016-09-15 | 2025-08-22 | 필립모리스 프로덕츠 에스.에이. | 전자 에어로졸 발생 흡연 장치 |
| US11660403B2 (en) | 2016-09-22 | 2023-05-30 | Juul Labs, Inc. | Leak-resistant vaporizer device |
| GB201617246D0 (en) * | 2016-10-11 | 2016-11-23 | British American Tobacco (Investments) Limited | Aerosol provision system and method |
| US10130122B2 (en) | 2016-10-28 | 2018-11-20 | Funai Electric Co., Ltd. | Supply item for vapor generating device |
| GB201618481D0 (en) | 2016-11-02 | 2016-12-14 | British American Tobacco Investments Ltd | Aerosol provision article |
| WO2018102696A1 (en) | 2016-12-02 | 2018-06-07 | Vmr Products Llc | Vaporizer |
| US10130124B2 (en) * | 2016-12-06 | 2018-11-20 | Shanghai Green Vaper Technology Co., Ltd. | Low temperature heat not burn electronic cigarette |
| US10518243B2 (en) * | 2016-12-15 | 2019-12-31 | Altria Client Services Llc | Portion of an electronic vaping device formed of an oxygen sequestering agent |
| CN111713750B (zh) | 2016-12-16 | 2023-09-05 | 韩国烟草人参公社 | 气溶胶生成系统 |
| CN114868950A (zh) | 2016-12-30 | 2022-08-09 | 菲利普莫里斯生产公司 | 含有尼古丁的薄片 |
| US10383365B2 (en) * | 2017-02-07 | 2019-08-20 | Daniel Best | Craving suppression method and non-electric nicotine delivery systems and method of use thereof |
| GB201702207D0 (en) * | 2017-02-10 | 2017-03-29 | British American Tobacco Investments Ltd | Vapour provision system |
| GB201702206D0 (en) | 2017-02-10 | 2017-03-29 | British American Tobacco Investments Ltd | Vapour provision system |
| GB201703284D0 (en) | 2017-03-01 | 2017-04-12 | Nicoventures Holdings Ltd | Vapour provision device with liquid capture |
| MX2019011327A (es) * | 2017-03-29 | 2019-10-21 | Philip Morris Products Sa | Unidad de cartucho que comprende un elemento de bloqueo. |
| US12274294B2 (en) | 2017-03-30 | 2025-04-15 | Kt&G Corporation | Aerosol generating apparatus and cradle capable of receiving same |
| US11432593B2 (en) | 2017-04-11 | 2022-09-06 | Kt&G Corporation | Device for cleaning smoking member, and smoking member system |
| US11252999B2 (en) | 2017-04-11 | 2022-02-22 | Kt&G Corporation | Aerosol generating device |
| JP6942814B2 (ja) | 2017-04-11 | 2021-09-29 | ケーティー・アンド・ジー・コーポレーション | ヒータを事前予熱するエアロゾル生成システム |
| EP3984393A1 (en) | 2017-04-11 | 2022-04-20 | KT&G Corporation | Aerosol generating device and method for providing adaptive feedback through puff recognition |
| US11622582B2 (en) | 2017-04-11 | 2023-04-11 | Kt&G Corporation | Aerosol generating device and method for providing adaptive feedback through puff recognition |
| US11771138B2 (en) | 2017-04-11 | 2023-10-03 | Kt&G Corporation | Aerosol generating device and method for providing smoking restriction function in aerosol generating device |
| CN110494053B (zh) | 2017-04-11 | 2022-05-31 | 韩国烟草人参公社 | 气溶胶生成装置 |
| KR102035313B1 (ko) | 2017-05-26 | 2019-10-22 | 주식회사 케이티앤지 | 히터 조립체 및 이를 구비한 에어로졸 생성 장치 |
| EP3630243B1 (en) * | 2017-05-31 | 2021-05-05 | Philip Morris Products S.A. | Nicotine powder consumable article |
| JP7128215B2 (ja) | 2017-06-09 | 2022-08-30 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 適合可能なエアロゾル発生システム |
| WO2019031871A1 (ko) | 2017-08-09 | 2019-02-14 | 주식회사 케이티앤지 | 전자 담배 제어 방법 및 장치 |
| KR102657797B1 (ko) * | 2017-08-09 | 2024-04-17 | 필립모리스 프로덕츠 에스.에이. | 비-담배 재료의 다수의 길이방향 세장형 요소를 갖춘 로드를 갖는 에어로졸 발생 물품 |
| EP3666095A4 (en) | 2017-08-09 | 2021-11-24 | KT&G Corporation | AEROSOL GENERATING DEVICE AND CONTROL METHOD FOR AN AEROSOL GENERATING DEVICE |
| EP3997993A1 (en) | 2017-09-06 | 2022-05-18 | KT&G Corporation | Aerosol generation device |
| USD887632S1 (en) | 2017-09-14 | 2020-06-16 | Pax Labs, Inc. | Vaporizer cartridge |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| GB201721477D0 (en) | 2017-12-20 | 2018-01-31 | British American Tobacco Investments Ltd | Electronic aerosol provision system |
| GB201721447D0 (en) | 2017-12-20 | 2018-01-31 | British American Tobacco Investments Ltd | Electronic aerosol provision system |
| GB201721470D0 (en) | 2017-12-20 | 2018-01-31 | British American Tobacco Investments Ltd | Electronic aerosol provision system |
| WO2019206943A1 (en) * | 2018-04-24 | 2019-10-31 | Jt International Sa | Electronic cigarette with protective cover |
| KR102707762B1 (ko) | 2018-06-05 | 2024-09-23 | 필립모리스 프로덕츠 에스.에이. | 에어로졸 발생 시스템용 활성화 천공 부재를 구비한 카트리지 조립체 |
| EP3806671B1 (en) | 2018-06-12 | 2024-08-07 | Philip Morris Products S.A. | Aerosol generating system with heated mixing chamber |
| JP7449247B2 (ja) | 2018-06-21 | 2024-03-13 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | エアロゾル発生システム用の起動可能かつ再閉鎖可能なカートリッジ組立品 |
| BR112020024016A2 (pt) | 2018-06-21 | 2021-02-23 | Philip Morris Products S.A. | montagem de cartucho ressalável para um sistema gerador de aerossol |
| JP7381505B2 (ja) * | 2018-06-22 | 2023-11-15 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | エアロゾル発生基体の中空ロッドを備えるエアロゾル発生物品 |
| KR102713663B1 (ko) * | 2018-06-28 | 2024-10-08 | 필립모리스 프로덕츠 에스.에이. | 액체 니코틴 제제를 포함하는 니코틴 공급원을 함유하는 에어로졸 발생 시스템용 카트리지 |
| KR102734883B1 (ko) | 2018-06-28 | 2024-11-28 | 필립모리스 프로덕츠 에스.에이. | 액체 알칼로이드 제형을 포함하는 알칼로이드 공급원을 포함하는 에어로졸 발생 시스템용 카트리지 |
| JP7295149B2 (ja) | 2018-06-29 | 2023-06-20 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | エアロゾル送達が強化されたエアロゾル発生システム |
| US12011045B2 (en) | 2018-07-05 | 2024-06-18 | Philip Morris Products S.A. | Inductively heated aerosol-generating system with ambient temperature sensor |
| GB201812373D0 (en) | 2018-07-30 | 2018-09-12 | Nicoventures Trading Ltd | Generation of an inhalable medium |
| JP7417588B2 (ja) | 2018-07-31 | 2024-01-18 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | エアロゾル発生システムのための誘導加熱式カートリッジ、および誘導加熱式カートリッジを備えるエアロゾル発生システム |
| GB201814197D0 (en) | 2018-08-31 | 2018-10-17 | Nicoventures Trading Ltd | Aerosol generating material characteristic determination |
| CN108741239B (zh) * | 2018-09-17 | 2021-01-12 | 杭州清大科瑞生物科技有限公司 | 一种电子烟式烟弹可替换的干细胞吸入装置 |
| KR102467836B1 (ko) | 2018-10-30 | 2022-11-16 | 주식회사 케이티앤지 | 에어로졸 발생 물품 및 그를 포함하는 에어로졸 발생 장치 |
| GB201818711D0 (en) | 2018-11-16 | 2019-01-02 | Nicoventures Trading Ltd | Method |
| US12153059B2 (en) * | 2019-01-07 | 2024-11-26 | Luxcan Innovation S.A. | Process for producing a gaseous active ingredient or a gaseous active ingredient mixture, kit for use therein and gaseous composition |
| US11064727B2 (en) | 2019-02-06 | 2021-07-20 | Altria Client Services Llc | Sensor apparatuses and systems |
| JP7550772B2 (ja) * | 2019-02-28 | 2024-09-13 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | エアロゾル発生システムおよびエアロゾル形成基体を含むエアロゾル発生物品 |
| GB201903249D0 (en) * | 2019-03-11 | 2019-04-24 | Nicoventures Trading Ltd | Aerosol provision device |
| BR112021018067A2 (pt) * | 2019-03-11 | 2021-11-23 | Nicoventures Trading Ltd | Sistema de geração de aerossol, método para gerar um aerossol, aerossol |
| US12377112B2 (en) | 2019-04-17 | 2025-08-05 | Compass Pathfinder Limited | Methods of treating neurocognitive disorders, chronic pain and reducing inflammation |
| WO2020239635A1 (en) * | 2019-05-24 | 2020-12-03 | Nerudia Limited | Aerosol delivery device |
| US12082611B2 (en) | 2019-05-24 | 2024-09-10 | Imperial Tobacco Limited | Aerosol delivery device |
| EP3741411A1 (en) * | 2019-05-24 | 2020-11-25 | Nerudia Limited | Aerosol delivery device |
| EP3741230A1 (en) * | 2019-05-24 | 2020-11-25 | Nerudia Limited | Aerosol delivery device |
| EP3753923A1 (en) | 2019-06-19 | 2020-12-23 | GH Research Limited | Recrystallisation of 5-methoxy-n,n-dimethyltryptamine (5-meo-dmt) in methyl tert.-butyl ether (mtbe) without adding an anti-solvent |
| KR102433808B1 (ko) * | 2019-08-08 | 2022-08-18 | 주식회사 케이티앤지 | 에어로졸 생성 시스템 |
| CN119564619A (zh) * | 2019-09-12 | 2025-03-07 | 阿奇维生命科学公司 | 治疗和/或预防有需要的受试者的成瘾的包括野靛碱的组合物 |
| EP3811789A1 (en) * | 2019-10-24 | 2021-04-28 | Nerudia Limited | Smoking substitute system |
| EP4090187B1 (en) | 2020-01-14 | 2026-01-07 | Juul Labs, Inc. | Hybrid gel-fiber wick for use in a vaporizer device |
| EP3868364A1 (en) * | 2020-02-24 | 2021-08-25 | GH Research Limited | Aerosol comprising 5-methoxy-n,n-dimethyltryptamine |
| CN111407985B (zh) * | 2020-03-30 | 2021-03-12 | 四川大学华西医院 | 雾化器 |
| US12240813B2 (en) | 2020-05-19 | 2025-03-04 | Cybin Irl Limited | Deuterated tryptamine derivatives and methods of use |
| ES3040112T3 (en) * | 2020-06-15 | 2025-10-28 | Philip Morris Products Sa | Anatabine powder compositions |
| CN111607461B (zh) * | 2020-06-24 | 2021-07-09 | 深圳昱朋科技有限公司 | 含茄科植物次生代谢产物的香料及其制备方法和香料制品 |
| EP4188492A4 (en) * | 2020-07-29 | 2024-08-07 | Gregory Ellis | DELIVERY SYSTEM FOR AYAHUSCA-LIKE SUBSTANCES |
| AU2021328671A1 (en) | 2020-08-18 | 2023-02-16 | Cybin Irl Limited | Phenethylamine derivatives, compositions, and methods of use |
| EP4221682A2 (en) * | 2020-10-02 | 2023-08-09 | Cybin IRL Limited | Methods for delivery of psychedelic medications by inhalation and systems for performing the methods |
| KR102527343B1 (ko) * | 2020-10-23 | 2023-05-02 | 주식회사 케이티앤지 | 액상 조성물을 포함하는 에어로졸 생성 물품 및 이를 포함하는 에어로졸 생성 시스템 |
| JP1714442S (ja) | 2020-10-30 | 2022-05-10 | 喫煙用エアロゾル発生器 | |
| JP1714440S (ja) | 2020-10-30 | 2022-05-10 | 喫煙用エアロゾル発生器 | |
| JP1715888S (ja) | 2020-10-30 | 2022-05-25 | 喫煙用エアロゾル発生器 | |
| JP1714441S (ja) | 2020-10-30 | 2022-05-10 | 喫煙用エアロゾル発生器 | |
| JP1714443S (ja) | 2020-10-30 | 2022-05-10 | 喫煙用エアロゾル発生器 | |
| USD990765S1 (en) | 2020-10-30 | 2023-06-27 | Nicoventures Trading Limited | Aerosol generator |
| CN114947174A (zh) * | 2021-02-25 | 2022-08-30 | 深圳市合元科技有限公司 | 气溶胶形成基质以及气溶胶生成系统 |
| USD989384S1 (en) | 2021-04-30 | 2023-06-13 | Nicoventures Trading Limited | Aerosol generator |
| CN115336793B (zh) * | 2021-05-14 | 2025-09-05 | 深圳麦克韦尔科技有限公司 | 雾化器、电子雾化装置及气溶胶的产生方法 |
| WO2022236830A1 (zh) * | 2021-05-14 | 2022-11-17 | 深圳麦克韦尔科技有限公司 | 雾化器、电子雾化装置及气溶胶的产生方法 |
| CA3246274A1 (en) * | 2022-03-31 | 2023-10-05 | Cybin Irl Limited | METHODS OF ADMINISTRATING PSYCHEDELIC MEDICINES BY INHALATION AND SYSTEMS FOR IMPLEMENTING THESE METHODS |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US830626A (en) * | 1905-02-23 | 1906-09-11 | James E Van Ness | Vaporizer. |
| BE333223A (https=) * | 1925-03-03 | |||
| US3258015A (en) * | 1964-02-04 | 1966-06-28 | Battelle Memorial Institute | Smoking device |
| US3356094A (en) * | 1965-09-22 | 1967-12-05 | Battelle Memorial Institute | Smoking devices |
| JPS5922682B2 (ja) * | 1976-08-06 | 1984-05-28 | 塩野義製薬株式会社 | 殺ダニ剤 |
| EP0003064A3 (en) | 1977-12-07 | 1979-08-08 | Rabam Limited | Method for introducing analogs of vitamin a into the respiratory tract of a cigarette smoker |
| IL73912A0 (en) | 1984-01-09 | 1985-03-31 | Advanced Tobacco Prod | Nicotine preparation |
| IE80788B1 (en) | 1984-09-14 | 1999-04-24 | Reynolds Tobacco Co R | Smoking article |
| CN1024996C (zh) * | 1984-12-21 | 1994-06-15 | 美国J·R瑞诺兹烟草公司 | 吸烟制品 |
| US4800903A (en) | 1985-05-24 | 1989-01-31 | Ray Jon P | Nicotine dispenser with polymeric reservoir of nicotine |
| US4715387A (en) * | 1985-08-23 | 1987-12-29 | The Regents Of The Univ. Of California | Aerosol for use in the reduction of tobacco smoking |
| US5033483A (en) * | 1985-10-28 | 1991-07-23 | R. J. Reynolds Tobacco Company | Smoking article with tobacco jacket |
| US5316759A (en) * | 1986-03-17 | 1994-05-31 | Robert J. Schaap | Agonist-antagonist combination to reduce the use of nicotine and other drugs |
| US4765348A (en) | 1986-12-12 | 1988-08-23 | Brown & Williamson Tobacco Corporation | Non-combustible simulated cigarette device |
| IL84516A0 (en) * | 1986-12-12 | 1988-04-29 | Reynolds Tobacco Co R | Smoking articles comprising impact modifying agents |
| JPS63152968A (ja) | 1986-12-17 | 1988-06-25 | 杉浦 力夫 | 節煙用煙草およびその製造方法 |
| US4830028A (en) | 1987-02-10 | 1989-05-16 | R. J. Reynolds Tobacco Company | Salts provided from nicotine and organic acid as cigarette additives |
| JPH0217117A (ja) | 1988-07-06 | 1990-01-22 | Shin Nippon Koeki Kk | 養毛剤 |
| US4830643A (en) | 1988-07-13 | 1989-05-16 | W. L. Gore & Associates, Inc. | Expanded polytetrafluoroethylene tubular container |
| GB8819291D0 (en) * | 1988-08-12 | 1988-09-14 | British American Tobacco Co | Improvements relating to smoking articles |
| CA1313805C (en) | 1988-10-19 | 1993-02-23 | Hermann Schwartz | Article for simulation of smoking |
| US4924886A (en) * | 1988-11-21 | 1990-05-15 | Brown & Williamson Tobacco Corporation | Smoking article |
| JP2925565B2 (ja) | 1989-01-19 | 1999-07-28 | 日本たばこ産業株式会社 | 無煙たばこ |
| US4955397A (en) * | 1989-07-10 | 1990-09-11 | Brown & Williamson Tobacco Corporation | Cigarette |
| US5105834A (en) * | 1989-12-18 | 1992-04-21 | R.J. Reynolds Tobacco Company | Cigarette and cigarette filter element therefor |
| GB9018131D0 (en) | 1990-08-17 | 1990-10-03 | Rothmans International Ltd | Smoking article |
| CA2069687A1 (en) * | 1991-06-28 | 1992-12-29 | Chandra Kumar Banerjee | Tobacco smoking article with electrochemical heat source |
| US5327915A (en) * | 1992-11-13 | 1994-07-12 | Brown & Williamson Tobacco Corp. | Smoking article |
| US5441060A (en) * | 1993-02-08 | 1995-08-15 | Duke University | Dry powder delivery system |
| US6102036A (en) * | 1994-04-12 | 2000-08-15 | Smoke-Stop | Breath activated inhaler |
| KR100217828B1 (ko) | 1996-07-24 | 1999-09-01 | 박명규 | 담배 가향료용 저 니코틴 담배 추출물 및 담배 추출물을 포함하는 가향료 제조방법 |
| CN1158734A (zh) | 1996-12-27 | 1997-09-10 | 张中营 | 治疗气管炎、哮喘病的非含尼古丁的药烟及其生产方法 |
| US20020017295A1 (en) * | 2000-07-07 | 2002-02-14 | Weers Jeffry G. | Phospholipid-based powders for inhalation |
| KR100286473B1 (ko) | 1998-09-30 | 2001-04-16 | 전창호 | 흡연시 비타민과 향기가 발생되는 담배의 조성물 |
| GB9909357D0 (en) * | 1999-04-24 | 1999-06-16 | Glaxo Group Ltd | Medicament carrier |
| JP2001161819A (ja) | 1999-12-10 | 2001-06-19 | Ricoh Co Ltd | 吸入装置 |
| WO2003041521A2 (en) * | 2001-11-09 | 2003-05-22 | Vector Tobacco Inc. | Method and composition for mentholation of charcoal filtered cigarettes |
| US6772756B2 (en) * | 2002-02-09 | 2004-08-10 | Advanced Inhalation Revolutions Inc. | Method and system for vaporization of a substance |
| JP4474165B2 (ja) | 2002-02-20 | 2010-06-02 | 株式会社ネクスト２１ | 噴射用薬剤の調製方法 |
| EA005980B1 (ru) | 2002-04-12 | 2005-08-25 | Филип Моррис Продактс С.А. | Частично восстановленные добавки в виде наночастиц для снижения количества монооксида углерода и/или оксида азота в сигаретном дыме основного потока |
| WO2003094900A1 (en) * | 2002-05-13 | 2003-11-20 | Alexza Molecular Delivery Corporation | Delivery of drug amines through an inhalation route |
| US7767698B2 (en) * | 2002-06-03 | 2010-08-03 | Mcneil Ab | Formulation and use thereof |
| CA2522289C (en) | 2003-04-14 | 2008-12-09 | Japan Tobacco Inc. | Improved low flame-spreading cigarette |
| CN100381083C (zh) * | 2003-04-29 | 2008-04-16 | 韩力 | 一种非可燃性电子喷雾香烟 |
| AU2004269986A1 (en) * | 2003-09-08 | 2005-03-17 | Pfizer Consumer Healthcare Health Ab | Nicotine formulations and use thereof |
| MXPA06002967A (es) | 2003-09-30 | 2006-06-14 | Alza Corp | Aparato de suministro de agente activo de conduccion osmotica que proporciona perfil de liberacion ascendente. |
| DE10356925B4 (de) * | 2003-12-05 | 2006-05-11 | Lts Lohmann Therapie-Systeme Ag | Inhalator für basische pharmazeutische Wirkstoffe sowie Verfahren für dessen Herstellung |
| US20050150489A1 (en) * | 2004-01-12 | 2005-07-14 | Steve Dunfield | Dispensing medicaments based on rates of medicament action |
| US20050267120A1 (en) * | 2004-04-14 | 2005-12-01 | Boehringer Ingelheim International Gmbh | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds |
| WO2006004646A1 (en) * | 2004-06-28 | 2006-01-12 | Nektar Therapeutics | Aerosol formulation comprising nicotine salt |
| US8322350B2 (en) | 2004-12-30 | 2012-12-04 | Philip Morris Usa Inc. | Aerosol generator |
| IL177071A0 (en) * | 2005-08-01 | 2006-12-10 | Nitto Denko Corp | Method of preparing a nicotine transdermal preparation |
| US20070102013A1 (en) | 2005-09-30 | 2007-05-10 | Philip Morris Usa Inc. | Electrical smoking system |
| US7832397B2 (en) * | 2005-12-28 | 2010-11-16 | Philip Morris Usa Inc. | Aerosol powder delivery device |
| CN102014995B (zh) | 2007-03-30 | 2015-05-13 | 菲利普莫里斯生产公司 | 用于输送药剂的装置和方法 |
-
2008
- 2008-03-25 CN CN200880017582.7A patent/CN102014995B/zh not_active Expired - Fee Related
- 2008-03-25 EP EP08744313.1A patent/EP2134395B1/en active Active
- 2008-03-25 CA CA2682432A patent/CA2682432C/en not_active Expired - Fee Related
- 2008-03-25 JP JP2010501159A patent/JP2010532672A/ja active Pending
- 2008-03-25 CN CN201510173107.0A patent/CN104906669A/zh active Pending
- 2008-03-25 AU AU2008232897A patent/AU2008232897B2/en not_active Ceased
- 2008-03-25 CA CA2963423A patent/CA2963423C/en not_active Expired - Fee Related
- 2008-03-25 WO PCT/US2008/058122 patent/WO2008121610A1/en not_active Ceased
- 2008-03-25 EP EP13184266.8A patent/EP2708256A3/en not_active Withdrawn
- 2008-03-25 CN CN201310077083.XA patent/CN103418062B/zh not_active Expired - Fee Related
- 2008-03-25 US US12/054,883 patent/US10668058B2/en active Active
-
2013
- 2013-04-11 JP JP2013082989A patent/JP5714637B2/ja not_active Expired - Fee Related
-
2016
- 2016-01-19 US US15/000,249 patent/US20160250201A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN104906669A (zh) | 2015-09-16 |
| EP2134395A1 (en) | 2009-12-23 |
| AU2008232897A1 (en) | 2008-10-09 |
| EP2708256A2 (en) | 2014-03-19 |
| CA2963423A1 (en) | 2008-10-09 |
| US20080241255A1 (en) | 2008-10-02 |
| CA2963423C (en) | 2020-07-28 |
| AU2008232897A2 (en) | 2009-11-12 |
| WO2008121610A1 (en) | 2008-10-09 |
| CN102014995A (zh) | 2011-04-13 |
| AU2008232897B2 (en) | 2014-03-13 |
| CN102014995B (zh) | 2015-05-13 |
| JP5714637B2 (ja) | 2015-05-07 |
| CA2682432A1 (en) | 2008-10-09 |
| EP2134395A4 (en) | 2015-06-24 |
| US20160250201A1 (en) | 2016-09-01 |
| JP2010532672A (ja) | 2010-10-14 |
| EP2134395B1 (en) | 2020-03-18 |
| CN103418062A (zh) | 2013-12-04 |
| HK1156262A1 (en) | 2012-06-08 |
| EP2708256A3 (en) | 2014-04-02 |
| JP2013144157A (ja) | 2013-07-25 |
| CN103418062B (zh) | 2017-04-12 |
| US10668058B2 (en) | 2020-06-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2682432C (en) | Device and method for delivery of a medicament | |
| CA2774264C (en) | Improved device and method for delivery of a medicament | |
| US9380810B2 (en) | Tobacco-based nicotine aerosol generation system | |
| AU2018203039A1 (en) | Device and method for delivery of a medicament | |
| AU2014200827A1 (en) | Device and method for delivery of a medicament | |
| HK1191580A (en) | Device and method for delivery of a medicament | |
| HK1192491A (en) | Device and method for delivery of a medicament | |
| HK1192491B (en) | Device and method for delivery of a medicament | |
| HK1156262B (en) | Device and method for delivery of a medicament |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20130325 |
|
| MKLA | Lapsed |
Effective date: 20210325 |