CA2682135A1 - Nucleic acid microparticles for pulmonary delivery - Google Patents
Nucleic acid microparticles for pulmonary delivery Download PDFInfo
- Publication number
- CA2682135A1 CA2682135A1 CA002682135A CA2682135A CA2682135A1 CA 2682135 A1 CA2682135 A1 CA 2682135A1 CA 002682135 A CA002682135 A CA 002682135A CA 2682135 A CA2682135 A CA 2682135A CA 2682135 A1 CA2682135 A1 CA 2682135A1
- Authority
- CA
- Canada
- Prior art keywords
- microparticles
- nucleic acid
- solution
- cation
- polymeric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
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- NRHMKIHPTBHXPF-TUJRSCDTSA-M sodium cholate Chemical group [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 NRHMKIHPTBHXPF-TUJRSCDTSA-M 0.000 description 1
- OABYVIYXWMZFFJ-ZUHYDKSRSA-M sodium glycocholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 OABYVIYXWMZFFJ-ZUHYDKSRSA-M 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
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- AWDRATDZQPNJFN-VAYUFCLWSA-N taurodeoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@@H](O)C1 AWDRATDZQPNJFN-VAYUFCLWSA-N 0.000 description 1
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- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- UWHCKJMYHZGTIT-UHFFFAOYSA-N tetraethylene glycol Chemical compound OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 description 1
- ZUHZGEOKBKGPSW-UHFFFAOYSA-N tetraglyme Chemical compound COCCOCCOCCOCCOC ZUHZGEOKBKGPSW-UHFFFAOYSA-N 0.000 description 1
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
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- RVCNQQGZJWVLIP-VPCXQMTMSA-N uridin-5-yloxyacetic acid Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(OCC(O)=O)=C1 RVCNQQGZJWVLIP-VPCXQMTMSA-N 0.000 description 1
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- WCNMEQDMUYVWMJ-JPZHCBQBSA-N wybutoxosine Chemical compound C1=NC=2C(=O)N3C(CC([C@H](NC(=O)OC)C(=O)OC)OO)=C(C)N=C3N(C)C=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O WCNMEQDMUYVWMJ-JPZHCBQBSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91232007P | 2007-04-17 | 2007-04-17 | |
| US60/912,320 | 2007-04-17 | ||
| US93812307P | 2007-05-15 | 2007-05-15 | |
| US60/938,123 | 2007-05-15 | ||
| PCT/US2008/060669 WO2008131129A2 (en) | 2007-04-17 | 2008-04-17 | Nucleic acid microparticles for pulmonary delivery |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2682135A1 true CA2682135A1 (en) | 2008-10-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002682135A Abandoned CA2682135A1 (en) | 2007-04-17 | 2008-04-17 | Nucleic acid microparticles for pulmonary delivery |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8808747B2 (enExample) |
| EP (1) | EP2146691A2 (enExample) |
| JP (1) | JP5744513B2 (enExample) |
| CN (1) | CN101686939B (enExample) |
| AU (1) | AU2008242842B2 (enExample) |
| CA (1) | CA2682135A1 (enExample) |
| MX (1) | MX2009011218A (enExample) |
| WO (1) | WO2008131129A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20220249678A1 (en) * | 2019-07-10 | 2022-08-11 | The University Of Hong Kong | PEGylated synthetic KL4 peptide, Compositions and Methods Thereof |
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| US20060014973A1 (en) * | 2004-07-19 | 2006-01-19 | Wyeth | Processes for the preparation of 16beta-alkoxy, 17alpha-hydroxy steroids and steroidal 16beta, 17alpha-diols from 16alpha, 17alpha-epoxy steroids |
| JP5646320B2 (ja) | 2007-05-11 | 2014-12-24 | アダイニクス， インコーポレイテッド | 遺伝子発現と疼痛 |
| US8323615B2 (en) * | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing multi-phasic dispersions |
| US8367427B2 (en) * | 2008-08-20 | 2013-02-05 | Baxter International Inc. | Methods of processing compositions containing microparticles |
| US8323685B2 (en) * | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing compositions containing microparticles |
| US20100047292A1 (en) * | 2008-08-20 | 2010-02-25 | Baxter International Inc. | Methods of processing microparticles and compositions produced thereby |
| AU2011326181C1 (en) * | 2010-11-10 | 2017-06-29 | Nigel L. Webb | Nuclions and ribocapsids |
| EP2642928B1 (en) * | 2010-11-24 | 2019-07-17 | Hologic Inc. | System for improved tissue handling and in line analysis of the tissue |
| RU2668136C2 (ru) | 2012-05-10 | 2018-09-26 | Эйдинкс, Инк. | Композиции для доставки активных ингредиентов |
| ES2873600T3 (es) | 2013-02-05 | 2021-11-03 | 1Globe Health Inst Llc | Nanopartículas biodegradables y clínicamente compatibles como vehículos de suministro de fármacos. |
| WO2015125147A1 (en) * | 2014-02-20 | 2015-08-27 | B. G. Negev Technologies And Applications Ltd | Anionic polyplexes for use in the delivery of nucleic acids |
| CN106661578B (zh) | 2014-08-15 | 2020-08-04 | 埃迪恩克斯股份有限公司 | 用于疼痛治疗的寡核苷酸诱饵 |
| JP7256824B2 (ja) | 2018-04-25 | 2023-04-12 | エスリス ゲーエムベーハー | 粒子状製剤用の凍結保護剤 |
| CA3109548A1 (en) * | 2018-08-14 | 2020-02-20 | Ethris Gmbh | Lipid-based formulations containing salts for the delivery of rna |
| JP2024505429A (ja) * | 2021-01-15 | 2024-02-06 | アクエスティブ セラピューティクス インコーポレイテッド | プロドラッグ組成物及び治療の方法 |
| CN117363659B (zh) * | 2023-12-05 | 2024-03-29 | 中山大学 | 一种中华乌塘鳢生殖细胞异种移植及其嵌合体精准鉴定的方法 |
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| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
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| US4530840A (en) | 1982-07-29 | 1985-07-23 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
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-
2008
- 2008-04-17 CN CN2008800206543A patent/CN101686939B/zh not_active Expired - Fee Related
- 2008-04-17 MX MX2009011218A patent/MX2009011218A/es active IP Right Grant
- 2008-04-17 JP JP2010504252A patent/JP5744513B2/ja not_active Expired - Fee Related
- 2008-04-17 AU AU2008242842A patent/AU2008242842B2/en not_active Ceased
- 2008-04-17 CA CA002682135A patent/CA2682135A1/en not_active Abandoned
- 2008-04-17 WO PCT/US2008/060669 patent/WO2008131129A2/en not_active Ceased
- 2008-04-17 EP EP08733209A patent/EP2146691A2/en not_active Ceased
- 2008-04-17 US US12/105,213 patent/US8808747B2/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220249678A1 (en) * | 2019-07-10 | 2022-08-11 | The University Of Hong Kong | PEGylated synthetic KL4 peptide, Compositions and Methods Thereof |
| US12589161B2 (en) * | 2019-07-10 | 2026-03-31 | The University Of Hong Kong | PEGylated synthetic KL4 peptide, compositions and methods thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010524964A (ja) | 2010-07-22 |
| WO2008131129A3 (en) | 2009-05-14 |
| JP5744513B2 (ja) | 2015-07-08 |
| EP2146691A2 (en) | 2010-01-27 |
| CN101686939B (zh) | 2013-03-27 |
| US8808747B2 (en) | 2014-08-19 |
| AU2008242842B2 (en) | 2014-06-05 |
| MX2009011218A (es) | 2010-02-11 |
| US20090017124A1 (en) | 2009-01-15 |
| CN101686939A (zh) | 2010-03-31 |
| WO2008131129A2 (en) | 2008-10-30 |
| AU2008242842A1 (en) | 2008-10-30 |
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