CA2679581C - Genetic susceptibility variants associated with arterial disease - Google Patents

Genetic susceptibility variants associated with arterial disease Download PDF

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Publication number
CA2679581C
CA2679581C CA2679581A CA2679581A CA2679581C CA 2679581 C CA2679581 C CA 2679581C CA 2679581 A CA2679581 A CA 2679581A CA 2679581 A CA2679581 A CA 2679581A CA 2679581 C CA2679581 C CA 2679581C
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allele
markers
risk
marker
disease
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CA2679581A1 (en
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Anna Helgadottir
Gudmar Thorleifsson
Andrei Manolescu
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Decode Genetics ehf
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Decode Genetics ehf
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/136Screening for pharmacological compounds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/172Haplotypes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2679581A 2007-02-21 2008-02-21 Genetic susceptibility variants associated with arterial disease Active CA2679581C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
IS8613 2007-02-21
IS8613 2007-02-21
IS8640 2007-04-30
IS8640 2007-04-30
IS8701 2007-12-21
IS8701 2007-12-21
PCT/IS2008/000007 WO2008102380A1 (en) 2007-02-21 2008-02-21 Genetic susceptibility variants associated with cardiovascular disease

Publications (2)

Publication Number Publication Date
CA2679581A1 CA2679581A1 (en) 2008-08-28
CA2679581C true CA2679581C (en) 2020-12-22

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CA2679581A Active CA2679581C (en) 2007-02-21 2008-02-21 Genetic susceptibility variants associated with arterial disease

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US (2) US9617597B2 (OSRAM)
EP (2) EP2471954B1 (OSRAM)
JP (1) JP5646179B2 (OSRAM)
KR (1) KR101571523B1 (OSRAM)
CN (1) CN101668865B (OSRAM)
AU (1) AU2008218542B2 (OSRAM)
BR (1) BRPI0807927A2 (OSRAM)
CA (1) CA2679581C (OSRAM)
DK (1) DK2471954T3 (OSRAM)
EA (1) EA022610B1 (OSRAM)
HU (1) HUE030996T2 (OSRAM)
IL (1) IL200453A (OSRAM)
MX (1) MX2009008878A (OSRAM)
NZ (1) NZ579445A (OSRAM)
SG (1) SG178811A1 (OSRAM)
WO (1) WO2008102380A1 (OSRAM)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7883851B2 (en) * 2007-05-02 2011-02-08 Board Of Regents, The University Of Texas System Common allele on chromosome 9 associated with coronary heart disease
CA2712303C (en) 2008-01-18 2015-03-31 President And Fellows Of Harvard College Methods of detecting signatures of disease or conditions in bodily fluids
US20090221620A1 (en) * 2008-02-20 2009-09-03 Celera Corporation Gentic polymorphisms associated with stroke, methods of detection and uses thereof
ES2344396B1 (es) * 2009-02-24 2011-06-24 Fina Biotech Slu Marcadores geneticos del riesgo de sufrir reestenosis.
WO2010131268A1 (en) * 2009-05-11 2010-11-18 Decode Genetics Ehf Genetic variants for basal cell carcinoma, squamous cell carcinoma and cutaneous melanoma
EP2264183B1 (en) * 2009-06-09 2016-12-07 Gendiag.exe, S.L. Risk markers for cardiovascular disease
WO2010148017A1 (en) 2009-06-15 2010-12-23 Cardiodx, Inc. Determination of coronary artery disease risk.
EP2582816B1 (en) * 2010-06-15 2017-12-20 Cellagenics B.V. Novel intergenic elements for enhancing gene expression
US20130210647A1 (en) 2010-07-23 2013-08-15 President And Fellows Of Harvard College Methods of Detecting Cardiovascular Diseases or Conditions
WO2012012694A2 (en) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Methods of detecting autoimmune or immune-related diseases or conditions
BR112013001754A2 (pt) 2010-07-23 2016-05-31 Harvard College método para detectar marcas de doença ou condições em fluídos corpóreos
EP2596134B1 (en) 2010-07-23 2020-04-08 President and Fellows of Harvard College Methods of detecting diseases or conditions using phagocytic cells
US20130203624A1 (en) 2010-07-23 2013-08-08 President And Fellows Of Harvard College Methods of Detecting Prenatal or Pregnancy-Related Diseases or Conditions
EP2640857A4 (en) * 2010-11-18 2014-04-30 Decode Genetics Ehf GENETIC RISK FACTORS OF SINUS NODE SYNDROME
US20150044239A1 (en) * 2011-03-31 2015-02-12 Yale University Compositions and Methods for Diagnosing, Preventing and Treating Intracranial Aneurysms
US12077823B2 (en) 2011-08-05 2024-09-03 Genincode Plc Risk assessment for cardiovascular disease
HUE029534T2 (hu) * 2011-08-05 2017-02-28 Gendiag Exe Sl Genetikai markerek kardiovaszkuláris betegség kockázatának becslésére
WO2013032883A2 (en) * 2011-08-26 2013-03-07 Ottawa Heart Institute Research Corporation Methods of detecting and treating cardiovascular diseases
SG11201408383SA (en) 2012-06-15 2015-01-29 Harry Stylli Methods of detecting diseases or conditions using circulating diseased cells
BR112014031365A2 (pt) 2012-06-15 2017-06-27 Stylli Harry métodos de detectar doenças ou condições
MD707Z (ro) * 2013-01-18 2014-07-31 Институт Зоологии Академии Наук Молдовы Metodă de identificare a secvenţelor polimorfe 4a/4b ale genei sintetazei endoteliale a oxidului nitric
WO2014164366A1 (en) 2013-03-09 2014-10-09 Harry Stylli Methods of detecting cancer
EP4513187A3 (en) 2013-03-09 2025-05-21 Immunis.AI, Inc. Methods of detecting prostate cancer
ES2733920T3 (es) * 2013-04-26 2019-12-03 Univ Kyoto Composición que comprende un agonista del receptor 1 de esfingosina-1-fosfato para inhibir la formación y/o el aumento de tamaño de un aneurisma cerebral o para reducirlo
KR101602688B1 (ko) 2013-12-30 2016-03-11 가톨릭관동대학교산학협력단 microRNA-365 활성화제를 포함하는 혈관평활근세포 증식 또는 이동 억제용 약학적 조성물
CN104946731B (zh) * 2014-03-28 2019-12-20 中国中医科学院中药研究所 快速检测金银花的pcr试剂盒及检测方法
EP4075139B1 (en) 2014-09-11 2024-05-22 Immunis.AI, Inc. Methods of detecting prostate cancer
WO2016123163A2 (en) 2015-01-27 2016-08-04 Kardiatonos, Inc. Biomarkers of vascular disease
RU2627643C2 (ru) * 2015-08-18 2017-08-09 Государственное бюджетное учреждение "Академия наук Республики Саха(Якутия)" (ГБУ АН РС(Я) Способ прогнозирования риска субарахноидального кровоизлияния вследствие разрыва аневризмы сосудов головного мозга у лиц азиатской расы
CN106811520A (zh) * 2016-08-17 2017-06-09 上海易瑞生物科技有限公司 一种心肌梗死易感基因检测分型试剂盒及其应用
RU2693997C2 (ru) * 2017-12-04 2019-07-08 Федеральное Государственное Бюджетное Научное Учреждение "Федеральный Научно-Клинический Центр Реаниматологии И Реабилитологии" (Фнкц Рр) Способ определения степени предрасположенности к сердечно-сосудистым заболеваниям
CN108342472A (zh) * 2018-04-13 2018-07-31 东华大学 一种冠心病易感基因检测分型试剂盒
US10468141B1 (en) 2018-11-28 2019-11-05 Asia Genomics Pte. Ltd. Ancestry-specific genetic risk scores
CN113767179A (zh) * 2018-12-13 2021-12-07 国立研究开发法人国立循环器病研究中心 脑梗塞发病风险预测方法
CN109486940A (zh) * 2018-12-25 2019-03-19 北京北基医学检验实验室有限公司 一种扩增颅内动脉肿瘤相关基因的引物组及检测试剂盒
CN109628577A (zh) * 2019-01-07 2019-04-16 杭州艾迪康医学检验中心有限公司 检测冠状动脉硬化相关单核苷酸多态性位点的引物和方法
KR102158714B1 (ko) * 2019-04-03 2020-09-22 한림대학교 산학협력단 Tcf24 유전자의 단일염기다형성을 포함하는 뇌동맥류 진단용 snp 마커
KR102158720B1 (ko) * 2019-04-03 2020-09-22 한림대학교 산학협력단 Lrrc3 유전자의 단일염기다형성을 포함하는 뇌동맥류 진단용 snp 마커
US12100480B2 (en) 2019-08-27 2024-09-24 The Board Of Trustees Of The Leland Stanford Junior University Assessment of polygenic trait risk via trait components and applications thereof
RU2719914C1 (ru) * 2019-12-06 2020-04-23 федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации Способ прогнозирования исходов операций коронарного шунтирования
KR102366097B1 (ko) * 2021-05-03 2022-02-23 주식회사 바이오에이지 임상 및 유전변이 정보를 통합한 한국인 뇌혈관 질환 예측 방법 및 관련 검사추천방법
KR102344173B1 (ko) * 2021-05-03 2021-12-29 주식회사 바이오에이지 임상 및 유전변이 정보를 통합한 한국인 관상동맥 질환 예측 방법 및 관련 검사추천방법
CN113484453B (zh) * 2021-07-07 2022-08-09 天津中医药大学 一种缺血性脑卒中预警方法
CN114672548B (zh) * 2022-03-10 2024-04-19 华捷生物科技(青岛)有限公司 一种人类静脉血栓风险基因pai-1,thbd和proc基因多态性检测试剂盒及其制备方法和应用
WO2023205243A1 (en) * 2022-04-19 2023-10-26 The Regents Of The University Of Michigan Determining risk of fibromuscular dysplasia and systems and methods of use thereof
CN116144743B (zh) * 2022-12-16 2024-10-22 东华大学 基于多重长pcr结合高通量测序同时实现多个同源序列snp分型的引物、试剂盒及方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US5288611A (en) * 1983-01-10 1994-02-22 Gen-Probe Incorporated Method for detecting, identifying, and quantitating organisms and viruses
DE131052T1 (de) * 1983-01-10 1987-03-19 Gen-Probe Partners, San Diego, Calif. Verfahren zum aufspueren, identifizieren und quantifizieren von organismen und viren.
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
AU4308689A (en) 1988-09-02 1990-04-02 Protein Engineering Corporation Generation and selection of recombinant varied binding proteins
US5424186A (en) * 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5288644A (en) * 1990-04-04 1994-02-22 The Rockefeller University Instrument and method for the sequencing of genome
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
ES2139598T3 (es) 1990-07-10 2000-02-16 Medical Res Council Procedimientos para la produccion de miembros de parejas de union especifica.
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
WO1992009690A2 (en) 1990-12-03 1992-06-11 Genentech, Inc. Enrichment method for variant proteins with altered binding properties
EP1046421B8 (en) 1990-12-06 2006-01-11 Affymetrix, Inc. (a Delaware Corporation) Methods and reagents for very large scale immobilized polymer synthesis
ES2330052T3 (es) 1991-03-01 2009-12-03 Dyax Corporation Proteina quimerica que comprende micro-proteinas que tienen dos o mas puentes disulfuro y relaizaciones de las mismas.
ATE414768T1 (de) 1991-04-10 2008-12-15 Scripps Research Inst Bibliotheken heterodimerer rezeptoren mittels phagemiden
DE4122599C2 (de) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
US5384261A (en) * 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5837832A (en) * 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5858659A (en) * 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
CN1141398C (zh) * 2000-03-28 2004-03-10 陈高明 一种多基因扩增芯片及其制备方法
USH2191H1 (en) * 2000-10-24 2007-06-05 Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
USH2220H1 (en) * 2001-08-10 2008-07-01 Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
US20040267458A1 (en) * 2001-12-21 2004-12-30 Judson Richard S. Methods for obtaining and using haplotype data
CA2502359A1 (en) 2002-10-17 2004-04-29 Decode Genetics Ehf. Susceptibility gene for myocardial infarction
EP1613774A2 (en) * 2003-03-10 2006-01-11 Applera Corporation Genetic polymorphisms associated with stenosis, methods of detection and uses thereof
JP5649263B2 (ja) * 2003-11-26 2015-01-07 セレラ コーポレーション 心臓血管障害および薬物応答に関連した遺伝子多型、それらの検出方法および用途
US20050191678A1 (en) * 2004-02-12 2005-09-01 Geneob Usa Inc. Genetic predictability for acquiring a disease or condition
US20060228715A1 (en) * 2004-03-05 2006-10-12 Applera Corporation Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof
WO2005110039A2 (en) * 2004-05-07 2005-11-24 Applera Corporation Genetic polymorphisms associated with vascular diseases, methods of detection and uses thereof
US20060004526A1 (en) * 2004-07-01 2006-01-05 Ambion, Inc. System and method for processing results of a complex genetic test
US20080131887A1 (en) * 2006-11-30 2008-06-05 Stephan Dietrich A Genetic Analysis Systems and Methods
US7883851B2 (en) * 2007-05-02 2011-02-08 Board Of Regents, The University Of Texas System Common allele on chromosome 9 associated with coronary heart disease

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Publication number Publication date
JP2010518848A (ja) 2010-06-03
EA200970781A1 (ru) 2010-04-30
IL200453A (en) 2014-12-31
BRPI0807927A2 (pt) 2014-06-24
US20100068705A1 (en) 2010-03-18
EP2471954A1 (en) 2012-07-04
EP2471954B1 (en) 2016-08-24
CN101668865A (zh) 2010-03-10
WO2008102380A1 (en) 2008-08-28
SG178811A1 (en) 2012-03-29
EA022610B1 (ru) 2016-02-29
MX2009008878A (es) 2009-08-28
JP5646179B2 (ja) 2014-12-24
US9617597B2 (en) 2017-04-11
EP2115172A1 (en) 2009-11-11
KR101571523B1 (ko) 2015-11-24
NZ579445A (en) 2012-02-24
CN101668865B (zh) 2015-05-06
AU2008218542B2 (en) 2014-06-26
AU2008218542A1 (en) 2008-08-28
US20120208709A1 (en) 2012-08-16
DK2471954T3 (en) 2016-09-12
HUE030996T2 (en) 2017-06-28
KR20090117896A (ko) 2009-11-13
CA2679581A1 (en) 2008-08-28
IL200453A0 (en) 2010-04-29

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