CA2679027C - Use of reverse thermosensitive polymers to control biological fluid flow following a medical procedure - Google Patents
Use of reverse thermosensitive polymers to control biological fluid flow following a medical procedure Download PDFInfo
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- CA2679027C CA2679027C CA2679027A CA2679027A CA2679027C CA 2679027 C CA2679027 C CA 2679027C CA 2679027 A CA2679027 A CA 2679027A CA 2679027 A CA2679027 A CA 2679027A CA 2679027 C CA2679027 C CA 2679027C
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- polymer composition
- viscous polymer
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- viscous
- reverse thermosensitive
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/145—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/18—Materials at least partially X-ray or laser opaque
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00641—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closing fistulae, e.g. anorectal fistulae
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
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- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
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- Optics & Photonics (AREA)
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- Molecular Biology (AREA)
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- Materials For Medical Uses (AREA)
- Surgical Instruments (AREA)
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| US90281707P | 2007-02-22 | 2007-02-22 | |
| US60/902,817 | 2007-02-22 | ||
| PCT/US2008/054694 WO2008103891A2 (en) | 2007-02-22 | 2008-02-22 | Use of reverse thermosensitive polymers to control biological fluid flow following a medical procedure |
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| CA2679027A1 CA2679027A1 (en) | 2008-08-28 |
| CA2679027C true CA2679027C (en) | 2016-05-03 |
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| CA2679027A Expired - Fee Related CA2679027C (en) | 2007-02-22 | 2008-02-22 | Use of reverse thermosensitive polymers to control biological fluid flow following a medical procedure |
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| CA (1) | CA2679027C (https=) |
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| WO (1) | WO2008103891A2 (https=) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7666459B2 (en) * | 2001-09-12 | 2010-02-23 | The Procter & Gamble Company | Pet food compositions |
| US8197499B2 (en) * | 2006-06-21 | 2012-06-12 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for joining non-conjoined lumens |
| CA2656179A1 (en) | 2006-06-21 | 2007-12-27 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for joining non-conjoined lumens |
| US8608760B2 (en) * | 2006-06-21 | 2013-12-17 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for joining non-conjoined lumens |
| BRPI0718328A2 (pt) | 2006-12-15 | 2011-10-11 | Lifebond Ltd | composição, curativo hemostático e dispositivo médico para a inserção em um corpo de um ser humano ou de um mamìfero inferior |
| ES2776709T3 (es) | 2007-11-21 | 2020-07-31 | Smith & Nephew | Apósito para heridas |
| ES2555204T3 (es) | 2007-11-21 | 2015-12-29 | T.J. Smith & Nephew Limited | Dispositivo de succión y venda |
| GB0722820D0 (en) | 2007-11-21 | 2008-01-02 | Smith & Nephew | Vacuum assisted wound dressing |
| US11253399B2 (en) | 2007-12-06 | 2022-02-22 | Smith & Nephew Plc | Wound filling apparatuses and methods |
| US20130096518A1 (en) | 2007-12-06 | 2013-04-18 | Smith & Nephew Plc | Wound filling apparatuses and methods |
| GB0723875D0 (en) | 2007-12-06 | 2008-01-16 | Smith & Nephew | Wound management |
| WO2009086206A2 (en) * | 2007-12-20 | 2009-07-09 | Synvascular, Inc. | Compositions and methods for joining non-conjoined lumens |
| GB0803564D0 (en) | 2008-02-27 | 2008-04-02 | Smith & Nephew | Fluid collection |
| EP2487206A3 (en) | 2008-06-18 | 2012-11-28 | Lifebond Ltd | Cross-linkable gelatin-based compositions |
| US8563037B2 (en) * | 2009-02-06 | 2013-10-22 | Tautona Group, L.P. | Compositions and methods for joining non-conjoined lumens |
| GB0902816D0 (en) | 2009-02-19 | 2009-04-08 | Smith & Nephew | Fluid communication path |
| WO2011077388A1 (en) | 2009-12-22 | 2011-06-30 | Lifebond Ltd | Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices |
| ES2671907T3 (es) | 2010-01-13 | 2018-06-11 | Georg Bischof | Composición para la generación de una oclusión intestinal temporal |
| US9061095B2 (en) | 2010-04-27 | 2015-06-23 | Smith & Nephew Plc | Wound dressing and method of use |
| US20110301456A1 (en) * | 2010-06-07 | 2011-12-08 | Malignext Targeting Technologies, Inc. | Tissue Marking for Lesion Removal |
| GB201011173D0 (en) | 2010-07-02 | 2010-08-18 | Smith & Nephew | Provision of wound filler |
| US8961544B2 (en) | 2010-08-05 | 2015-02-24 | Lifebond Ltd. | Dry composition wound dressings and adhesives comprising gelatin and transglutaminase in a cross-linked matrix |
| JP6078472B2 (ja) | 2010-11-25 | 2017-02-08 | スミス アンド ネフュー ピーエルシーＳｍｉｔｈ ＆ Ｎｅｐｈｅｗ Ｐｕｂｌｉｃ Ｌｉｍｉｔｅｄ Ｃｏｍｐａｎｙ | 組成物ｉ−ｉｉおよび生成物ならびにそれらの使用 |
| GB201020005D0 (en) | 2010-11-25 | 2011-01-12 | Smith & Nephew | Composition 1-1 |
| US9144450B2 (en) * | 2010-12-22 | 2015-09-29 | Boston Scientific Scimed, Inc. | Fluid sealant compositions and various medical applications pertaining to the same |
| US8845599B2 (en) | 2011-07-11 | 2014-09-30 | Boston Scientific Scimed, Inc. | Medical procedures, devices and kits for the formation and removal of plug-forming compositions |
| AT511671A1 (de) | 2011-07-13 | 2013-01-15 | Bischof Georg Dr | Zusammensetzung zur erzeugung einer vorübergehenden okklusion des darms eines säugetiers |
| WO2013025436A1 (en) | 2011-08-12 | 2013-02-21 | Boston Scientific Scimed, Inc. | Anastomosis kit for radical prostatectomy procedure |
| US20150159066A1 (en) | 2011-11-25 | 2015-06-11 | Smith & Nephew Plc | Composition, apparatus, kit and method and uses thereof |
| EP2968647B1 (en) | 2013-03-15 | 2022-06-29 | Smith & Nephew plc | Wound dressing sealant and use thereof |
| US20160120706A1 (en) | 2013-03-15 | 2016-05-05 | Smith & Nephew Plc | Wound dressing sealant and use thereof |
| EP2983716A4 (en) * | 2013-04-11 | 2017-01-25 | Commonwealth Scientific and Industrial Research Organisation | Composition for controlled delivery of bioactive agents |
| DE202013012287U1 (de) | 2013-04-23 | 2016-01-18 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Gelbildendes System zum Entfernen von Nierensteinfragmenten |
| ES2577102T3 (es) | 2013-04-23 | 2016-07-13 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Sistema gelificante para eliminar fragmentos de cálculos renales |
| EP2796101B1 (de) | 2013-04-23 | 2016-04-20 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Kit zum Herstellen eines vernetzten Gels zum Umschließen von Nierensteinen und/oder Nierensteinfragmenten |
| DE202013012275U1 (de) | 2013-04-23 | 2015-12-18 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Kit zum Herstellen eines vernetzten Gels zum Umschließen von Nierensteinen und/oder Nierensteinfragmenten |
| CA3030466A1 (en) * | 2016-07-12 | 2018-01-18 | Centre National De La Recherche Scientifique | Compositions useful for mucosal healing |
| CN106267320B (zh) * | 2016-08-10 | 2019-04-19 | 烟台益诺依生物医药科技有限公司 | 一种血管吻合剂的制备方法 |
| WO2019092608A1 (en) * | 2017-11-08 | 2019-05-16 | Materias S.R.L. | In situ gelifying powder |
| JP6383133B1 (ja) * | 2018-02-21 | 2018-08-29 | 国立大学法人信州大学 | 液体塞栓剤組成物 |
| US11207060B2 (en) | 2018-03-16 | 2021-12-28 | Critical Innovations, LLC | Systems and methods relating to medical applications of synthetic polymer formulations |
| CN108498850B (zh) * | 2018-04-10 | 2021-08-31 | 广州迈普再生医学科技股份有限公司 | 一种流体止血胶及其制备方法和应用 |
| US11998654B2 (en) | 2018-07-12 | 2024-06-04 | Bard Shannon Limited | Securing implants and medical devices |
| WO2020027882A1 (en) | 2018-08-03 | 2020-02-06 | Nectero Medical, Inc. | Purified pentagalloyl glucose and devices for delivery |
| JP2022527295A (ja) * | 2019-03-26 | 2022-06-01 | ネクテロ・メディカル・インコーポレイテッド | 血管内グラフトに関連する処置のための方法及びデバイス |
| EP4061438B1 (en) * | 2019-11-20 | 2025-07-23 | The Regents of the University of California | Liquid embolic material composition |
| EP4106826A1 (en) * | 2020-02-18 | 2022-12-28 | Boston Scientific Scimed, Inc. | Hemostatic compositions and related methods |
| US12144655B2 (en) | 2021-08-23 | 2024-11-19 | Samsung Electronics Co., Ltd. | Method and device for liveness detection |
| CN114533937B (zh) * | 2022-02-14 | 2023-01-03 | 北京冠合医疗科技有限公司 | 一种可生物降解温度敏感型栓塞凝胶及其制备方法和应用 |
| US12410293B2 (en) | 2022-11-07 | 2025-09-09 | Critical Innovations Llc | Systems and methods relating to medical applications of inverse thermosensitive polymer foam formulations |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4188373A (en) * | 1976-02-26 | 1980-02-12 | Cooper Laboratories, Inc. | Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes |
| US4474751A (en) * | 1983-05-16 | 1984-10-02 | Merck & Co., Inc. | Ophthalmic drug delivery system utilizing thermosetting gels |
| US4478822A (en) * | 1983-05-16 | 1984-10-23 | Merck & Co., Inc. | Drug delivery system utilizing thermosetting gels |
| US5567859A (en) * | 1991-03-19 | 1996-10-22 | Cytrx Corporation | Polyoxypropylene/polyoxyethylene copolymers with improved biological activity |
| US4834091A (en) * | 1987-04-10 | 1989-05-30 | Ott Douglas E | Intrauterine fallopian tube ostial plug and surgical process |
| US5696298A (en) * | 1991-03-19 | 1997-12-09 | Cytrx Corporation | Polyoxypropylene/polyoxyethylene copolymers with improved biological activity |
| ES2140408T3 (es) * | 1991-03-19 | 2000-03-01 | Cytrx Corp | Copolimeros de polioxipropileno/polioxietileno con actividad biologica mejorada. |
| US5800711A (en) * | 1996-10-18 | 1998-09-01 | Mdv Technologies, Inc. | Process for the fractionation of polyoxyalkylene block copolymers |
| ZA987019B (en) * | 1997-08-06 | 1999-06-04 | Focal Inc | Hemostatic tissue sealants |
| US6179862B1 (en) * | 1998-08-14 | 2001-01-30 | Incept Llc | Methods and apparatus for in situ formation of hydrogels |
| US6514534B1 (en) * | 1998-08-14 | 2003-02-04 | Incept Llc | Methods for forming regional tissue adherent barriers and drug delivery systems |
| JP4159254B2 (ja) * | 1998-08-14 | 2008-10-01 | インセプト エルエルシー | ヒドロゲルのインサイチュ形成のための方法および装置 |
| US6152943A (en) * | 1998-08-14 | 2000-11-28 | Incept Llc | Methods and apparatus for intraluminal deposition of hydrogels |
| US7335220B2 (en) * | 2004-11-05 | 2008-02-26 | Access Closure, Inc. | Apparatus and methods for sealing a vascular puncture |
| CA2317661C (en) * | 1998-11-20 | 2008-04-15 | Medical Industries Corp. | Hemostatic material insertion device |
| US6554851B1 (en) * | 1999-05-07 | 2003-04-29 | Scimed Life Systems, Inc. | Methods of sealing an injection site |
| DE01918975T1 (de) * | 2000-03-24 | 2006-04-13 | Biosphere Medical, Inc., Rockland | Mikrokügelchen zur aktiven Embolisierung |
| JP2001329183A (ja) * | 2000-05-22 | 2001-11-27 | Yuichi Mori | ゲル化性組成物 |
| US6761824B2 (en) * | 2000-08-17 | 2004-07-13 | Reeve Lorraine E | Process for the fractionation of polymers |
| US20020052572A1 (en) * | 2000-09-25 | 2002-05-02 | Kenneth Franco | Resorbable anastomosis stents and plugs and their use in patients |
| JP2002369874A (ja) * | 2001-06-14 | 2002-12-24 | Terumo Corp | 止血材料 |
| US6592608B2 (en) * | 2001-12-07 | 2003-07-15 | Biopsy Sciences, Llc | Bioabsorbable sealant |
| AU2004224439B2 (en) * | 2003-03-24 | 2010-07-15 | Genzyme Corporation | Temporary embolization using inverse thermosensitive polymers |
| US9289195B2 (en) * | 2003-06-04 | 2016-03-22 | Access Closure, Inc. | Auto-retraction apparatus and methods for sealing a vascular puncture |
| CN100435853C (zh) * | 2003-09-25 | 2008-11-26 | 拉特格斯州立大学 | 用于栓塞治疗的内在不透射线的聚合产物 |
| US7700086B2 (en) * | 2003-11-06 | 2010-04-20 | Pluromed, Inc. | Internal clamp for surgical procedures |
| JP2006141436A (ja) * | 2004-11-16 | 2006-06-08 | Mebiol Kk | 経皮血管穿刺封止材および経皮血管穿刺封止装置 |
| DK2601972T3 (en) * | 2005-05-02 | 2015-02-16 | Genzyme Corp | Kidney stone treatment without lithotripsy |
| JP2010512230A (ja) * | 2006-12-11 | 2010-04-22 | プルーロームド インコーポレイテッド | 灌流臓器止血法 |
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Also Published As
| Publication number | Publication date |
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| JP2010518990A (ja) | 2010-06-03 |
| CN105879128A (zh) | 2016-08-24 |
| BRPI0807558A2 (pt) | 2014-07-01 |
| AU2014213539A1 (en) | 2014-09-04 |
| KR20150032348A (ko) | 2015-03-25 |
| US20150018872A1 (en) | 2015-01-15 |
| AU2008218225A1 (en) | 2008-08-28 |
| EP2125092A1 (en) | 2009-12-02 |
| CA2679027A1 (en) | 2008-08-28 |
| CN102159274A (zh) | 2011-08-17 |
| JP2016105845A (ja) | 2016-06-16 |
| EP2125092A4 (en) | 2012-03-14 |
| KR20160089544A (ko) | 2016-07-27 |
| KR20090114469A (ko) | 2009-11-03 |
| AU2008218225B2 (en) | 2014-05-15 |
| MX2009009081A (es) | 2009-10-30 |
| WO2008103891A2 (en) | 2008-08-28 |
| US20080208163A1 (en) | 2008-08-28 |
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| EEER | Examination request |
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| MKLA | Lapsed |
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