CA2676609A1 - Methods and compositions for treating neuropathies - Google Patents

Methods and compositions for treating neuropathies

Info

Publication number
CA2676609A1
CA2676609A1 CA 2676609 CA2676609A CA2676609A1 CA 2676609 A1 CA2676609 A1 CA 2676609A1 CA 2676609 CA2676609 CA 2676609 CA 2676609 A CA2676609 A CA 2676609A CA 2676609 A1 CA2676609 A1 CA 2676609A1
Authority
CA
Grant status
Application
Patent type
Prior art keywords
activity
agent
ampk
method according
nad
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2676609
Other languages
English (en)
French (fr)
Inventor
Jeffrey Milbrandt
Biplab Dasgupta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Washington University in St Louis
Original Assignee
Washington University
Jeffrey Milbrandt
Biplab Dasgupta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058Neurological cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/912Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205Phosphotransferases in general
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
CA 2676609 2007-01-26 2008-01-28 Methods and compositions for treating neuropathies Abandoned CA2676609A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US88685407 true 2007-01-26 2007-01-26
US60/886,854 2007-01-26
PCT/US2008/001085 WO2008091710A3 (en) 2007-01-26 2008-01-28 Methods and compositions for treating neuropathies

Publications (1)

Publication Number Publication Date
CA2676609A1 true true CA2676609A1 (en) 2008-07-31

Family

ID=39645095

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2676609 Abandoned CA2676609A1 (en) 2007-01-26 2008-01-28 Methods and compositions for treating neuropathies

Country Status (4)

Country Link
US (3) US20100047177A1 (3Den)
EP (1) EP2124985A4 (3Den)
CA (1) CA2676609A1 (3Den)
WO (1) WO2008091710A3 (3Den)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2259782A4 (en) 2008-03-03 2013-01-23 Nad Life Pty Ltd Pharmaceutical formulations of resveratrol and methods of use thereof for treating cell disorders
EP2323649A4 (en) * 2008-07-25 2011-09-07 Univ Emory Treating various disorders with 7,8-dihydroxyflavone and derivatives thereof
WO2010077642A1 (en) 2008-12-08 2010-07-08 Northwestern University Method of modulating hsf-1
JP2010215563A (ja) * 2009-03-17 2010-09-30 Kao Corp Lkb1活性化剤
WO2011156479A9 (en) 2010-06-09 2012-05-31 Emory University Trkb agonists and methods of use
CN102305863B (zh) * 2011-07-18 2013-11-20 厦门大学 以Nur77-LKB1相互作用为靶点的抗糖尿病药物筛选方法
US9593125B2 (en) 2012-07-27 2017-03-14 Emory University Heterocyclic flavone derivatives, compositions, and methods related thereto
EP2968306A4 (en) 2013-03-15 2016-11-02 Univ Washington Administration of nicotinamide mononucleotide in the treatment of disease
CN103877076B (zh) * 2014-03-21 2016-06-29 景临林 5,6,7,8-四羟基黄酮在制备抗缺氧药物中的应用
CN106715455A (zh) 2014-06-06 2017-05-24 葛兰素史密斯克莱知识产权(第2 号)有限公司 烟酰胺核苷类似物及其药物组合物和用途

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002512789A (ja) * 1998-04-28 2002-05-08 マイトコー 変化したミトコンドリア機能に関連する疾患の細胞および動物モデル
US6001368A (en) * 1998-09-03 1999-12-14 Protein Technologies International, Inc. Method for inhibiting or reducing the risk of macular degeneration
CA2374612A1 (en) * 1999-05-28 2000-12-07 Immunex Corporation Novel murine and human kinases
US6573299B1 (en) * 1999-09-20 2003-06-03 Advanced Medical Instruments Method and compositions for treatment of the aging eye
US6821775B1 (en) * 2000-02-11 2004-11-23 Genvec, Inc. Viral vector encoding pigment epithelium-derived factor
US6964969B2 (en) * 2001-04-19 2005-11-15 Mccleary Edward Larry Composition and method for treating impaired or deteriorating neurological function
US20050080024A1 (en) * 2002-08-15 2005-04-14 Joseph Tucker Nitric oxide donating derivatives for the treatment of cardiovascular disorders
WO2004021980B1 (en) * 2002-09-09 2004-08-19 Mitochroma Res Inc Compositions and methods for treating niddm and other conditions and disorders associated with ampk regulation
GB2402938B (en) * 2003-06-17 2005-11-09 Medical Res Council Kinase assay
US20050096256A1 (en) * 2003-07-01 2005-05-05 President And Fellows Of Harvard College Compositions for manipulating the lifespan and stress response of cells and organisms
US20060025337A1 (en) * 2003-07-01 2006-02-02 President And Fellows Of Harvard College Sirtuin related therapeutics and diagnostics for neurodegenerative diseases
US20070105109A1 (en) * 2003-07-02 2007-05-10 Geesaman Bard J Sirt1 and genetic disorders
US8017634B2 (en) * 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
JP2007527418A (ja) * 2003-12-29 2007-09-27 ザ ジェネラル ホスピタル コーポレーション 肥満及びインシュリン耐性障害を治療又は防止するための組成物
US20050227327A1 (en) * 2004-02-10 2005-10-13 Brenner Charles M Nicotinamide riboside kinase compositions and methods for using the same
ES2557810T3 (es) * 2004-06-04 2016-01-28 Washington University Métodos y composiciones para tratar neuropatías
US20060035302A1 (en) * 2004-06-21 2006-02-16 Applera Corporation Kinase substrates with multiple phosphorylation sites
WO2006001278A1 (ja) * 2004-06-28 2006-01-05 Kao Corporation Ampk活性化剤
US20070014833A1 (en) * 2005-03-30 2007-01-18 Sirtris Pharmaceuticals, Inc. Treatment of eye disorders with sirtuin modulators
WO2007019416A1 (en) * 2005-08-04 2007-02-15 Sirtris Pharmaceuticals, Inc. Benzimidazole derivatives as sirtuin modulators

Also Published As

Publication number Publication date Type
US20160367497A1 (en) 2016-12-22 application
US20100047177A1 (en) 2010-02-25 application
WO2008091710A2 (en) 2008-07-31 application
EP2124985A2 (en) 2009-12-02 application
EP2124985A4 (en) 2011-06-08 application
WO2008091710A3 (en) 2008-10-09 application
US20140011890A1 (en) 2014-01-09 application

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20130128

FZDE Dead

Effective date: 20170804