CA2676609A1 - Methods and compositions for treating neuropathies - Google Patents
Methods and compositions for treating neuropathies Download PDFInfo
- Publication number
- CA2676609A1 CA2676609A1 CA002676609A CA2676609A CA2676609A1 CA 2676609 A1 CA2676609 A1 CA 2676609A1 CA 002676609 A CA002676609 A CA 002676609A CA 2676609 A CA2676609 A CA 2676609A CA 2676609 A1 CA2676609 A1 CA 2676609A1
- Authority
- CA
- Canada
- Prior art keywords
- activity
- ampk
- agent
- nad
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5058—Neurological cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88685407P | 2007-01-26 | 2007-01-26 | |
US60/886,854 | 2007-01-26 | ||
PCT/US2008/001085 WO2008091710A2 (en) | 2007-01-26 | 2008-01-28 | Methods and compositions for treating neuropathies |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2676609A1 true CA2676609A1 (en) | 2008-07-31 |
Family
ID=39645095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002676609A Abandoned CA2676609A1 (en) | 2007-01-26 | 2008-01-28 | Methods and compositions for treating neuropathies |
Country Status (5)
Country | Link |
---|---|
US (3) | US20100047177A1 (3Den) |
EP (1) | EP2124985A4 (3Den) |
CA (1) | CA2676609A1 (3Den) |
MX (1) | MX2009008022A (3Den) |
WO (1) | WO2008091710A2 (3Den) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11103465B2 (en) | 2017-11-22 | 2021-08-31 | Ted's Brain Science, Inc. | Trans-resveratrol topical medication for the treatment of pain and method of manufacture thereof |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2009221634B2 (en) | 2008-03-03 | 2014-05-08 | Nad Life Pty Ltd | Pharmaceutical formulations of resveratrol and methods of use thereof for treating cell disorders |
EP2323649A4 (en) * | 2008-07-25 | 2011-09-07 | Univ Emory | TREATMENT OF VARIOUS DISORDERS WITH 7,8-DIHYDROXY FLAVONE AND ITS DERIVATIVES |
CN102369014A (zh) | 2008-12-08 | 2012-03-07 | 西北大学 | 调节hsf-i的方法 |
JP2010215563A (ja) * | 2009-03-17 | 2010-09-30 | Kao Corp | Lkb1活性化剤 |
EP2579870B1 (en) | 2010-06-09 | 2018-02-14 | Emory University | Trkb agonists and methods of use |
CN102305863B (zh) * | 2011-07-18 | 2013-11-20 | 厦门大学 | 以Nur77-LKB1相互作用为靶点的抗糖尿病药物筛选方法 |
EP2877461B1 (en) | 2012-07-27 | 2018-05-09 | Emory University | Heterocyclic flavone derivatives, compositions, and methods related thereto |
EP4233878A1 (en) | 2013-03-15 | 2023-08-30 | Washington University | Administration of nicotinamide mononucleotide in the treatment of dry eye |
CN103877076B (zh) * | 2014-03-21 | 2016-06-29 | 景临林 | 5,6,7,8-四羟基黄酮在制备抗缺氧药物中的应用 |
RU2016149767A (ru) | 2014-06-06 | 2018-07-16 | Глэксосмитклайн Интеллекчуал Проперти (Но.2) Лимитед | Аналоги никотинамидрибозида и фармацевтические композиции и их применение |
US10323058B2 (en) | 2014-07-24 | 2019-06-18 | W. R. Grace & Co.-Conn. | Crystalline form of nicotinamide riboside |
EP3268379B1 (en) | 2015-03-09 | 2023-11-01 | W.R. Grace & CO. - CONN. | Crystalline form of nicotinamide riboside |
US20170068860A1 (en) * | 2015-09-09 | 2017-03-09 | Alex Adekola | System for measuring crowd density |
WO2017201425A1 (en) * | 2016-05-20 | 2017-11-23 | The Trustees Columbia University In The City Of New York | Anabolic enhancers for ameliorating neurodegeneration |
CN112020363A (zh) | 2017-12-22 | 2020-12-01 | 益力舒健康公司 | 烟酰胺核苷氯化物的结晶形式 |
JP2022523702A (ja) | 2019-01-28 | 2022-04-26 | ミトコンドリア エモーション, インク. | トランス-4-ヒドロキシシクロヘキシルフェニルアミドマイトフュージン活性化物質及びその使用方法 |
WO2020159576A1 (en) | 2019-01-28 | 2020-08-06 | Mitochondria Emotion, Inc. | Mitofusin activators and methods of use thereof |
IT202000007726A1 (it) * | 2020-04-10 | 2021-10-10 | Solongevity Nutraceuticals S R L | Composizioni mimetiche della restrizione calorica |
CN114259486B (zh) * | 2020-09-16 | 2024-04-02 | 香港科技大学 | 木犀草素及其药物组合物的应用 |
CA3208818A1 (en) * | 2021-02-26 | 2022-09-01 | Bo Chen | A method for decreasing degeneration of retinal ganglion cells |
EP4338798A1 (en) | 2022-09-16 | 2024-03-20 | Wasilewicz, Robert Henryk | Pharmaceutical preparation containing genistein for use in the prevention or treatment of glaucoma and/or ocular hypertension |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999055845A1 (en) * | 1998-04-28 | 1999-11-04 | Mitokor | Cellular and animal models for diseases associated with altered mitochondrial function |
US6001368A (en) * | 1998-09-03 | 1999-12-14 | Protein Technologies International, Inc. | Method for inhibiting or reducing the risk of macular degeneration |
IT1302365B1 (it) * | 1998-10-09 | 2000-09-05 | Sigma Tau Healthscience Spa | Uso di carnitine e resveratrolo per produrre una composizione per laprevenzione o il trattamento terapeutico di alterazioni cerebrali |
US6514719B1 (en) * | 1999-05-28 | 2003-02-04 | Immunex Corporation | Methods for identifying compounds that alter kinase activity |
US6573299B1 (en) * | 1999-09-20 | 2003-06-03 | Advanced Medical Instruments | Method and compositions for treatment of the aging eye |
US6821775B1 (en) * | 2000-02-11 | 2004-11-23 | Genvec, Inc. | Viral vector encoding pigment epithelium-derived factor |
US6964969B2 (en) * | 2001-04-19 | 2005-11-15 | Mccleary Edward Larry | Composition and method for treating impaired or deteriorating neurological function |
US20050080024A1 (en) * | 2002-08-15 | 2005-04-14 | Joseph Tucker | Nitric oxide donating derivatives for the treatment of cardiovascular disorders |
US7320806B2 (en) * | 2002-09-09 | 2008-01-22 | Vdf Futureceuticals, Inc. | Compositions and methods for treating NIDDM and other conditions and disorders associated with AMPK regulation |
GB2402938B (en) * | 2003-06-17 | 2005-11-09 | Medical Res Council | Kinase assay |
US20060025337A1 (en) * | 2003-07-01 | 2006-02-02 | President And Fellows Of Harvard College | Sirtuin related therapeutics and diagnostics for neurodegenerative diseases |
WO2005002672A2 (en) * | 2003-07-01 | 2005-01-13 | President And Fellows Of Harvard College | Sirt1 modulators for manipulating cells/organism lifespan/stress response |
US20070105109A1 (en) * | 2003-07-02 | 2007-05-10 | Geesaman Bard J | Sirt1 and genetic disorders |
AU2004312072B2 (en) * | 2003-12-29 | 2011-06-23 | President And Fellows Of Harvard College | Compositions for treating or preventing obesity and insulin resistance disorders |
US8017634B2 (en) * | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
CA2555675A1 (en) * | 2004-02-10 | 2005-08-25 | Trustees Of Dartmouth College | Nicotinamide riboside kinase compositions and methods for using the same |
US20050227327A1 (en) * | 2004-02-10 | 2005-10-13 | Brenner Charles M | Nicotinamide riboside kinase compositions and methods for using the same |
WO2006001982A2 (en) * | 2004-06-04 | 2006-01-05 | Washington University | Methods and compositions for treating neuropathies |
US20060035302A1 (en) * | 2004-06-21 | 2006-02-16 | Applera Corporation | Kinase substrates with multiple phosphorylation sites |
WO2006001278A1 (ja) * | 2004-06-28 | 2006-01-05 | Kao Corporation | Ampk活性化剤 |
US20070014833A1 (en) * | 2005-03-30 | 2007-01-18 | Sirtris Pharmaceuticals, Inc. | Treatment of eye disorders with sirtuin modulators |
AU2006269459B2 (en) * | 2005-07-07 | 2013-02-07 | Sirtris Pharmaceuticals, Inc. | Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders |
CA2617557A1 (en) * | 2005-08-04 | 2007-02-15 | Sirtris Pharmaceuticals, Inc. | Benzimidazole derivatives as sirtuin modulators |
MY154869A (en) * | 2007-01-16 | 2015-08-14 | Ipintl Llc | Composition for treating metabolic syndrome |
-
2008
- 2008-01-28 CA CA002676609A patent/CA2676609A1/en not_active Abandoned
- 2008-01-28 WO PCT/US2008/001085 patent/WO2008091710A2/en active Application Filing
- 2008-01-28 US US12/524,718 patent/US20100047177A1/en not_active Abandoned
- 2008-01-28 EP EP08724865A patent/EP2124985A4/en not_active Withdrawn
- 2008-01-28 MX MX2009008022A patent/MX2009008022A/es not_active Application Discontinuation
-
2013
- 2013-07-26 US US13/952,183 patent/US20140011890A1/en not_active Abandoned
-
2016
- 2016-09-06 US US15/257,599 patent/US20160367497A1/en not_active Abandoned
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11103465B2 (en) | 2017-11-22 | 2021-08-31 | Ted's Brain Science, Inc. | Trans-resveratrol topical medication for the treatment of pain and method of manufacture thereof |
Also Published As
Publication number | Publication date |
---|---|
MX2009008022A (es) | 2009-12-11 |
WO2008091710A3 (en) | 2008-10-09 |
WO2008091710A2 (en) | 2008-07-31 |
EP2124985A4 (en) | 2011-06-08 |
EP2124985A2 (en) | 2009-12-02 |
US20140011890A1 (en) | 2014-01-09 |
US20100047177A1 (en) | 2010-02-25 |
US20160367497A1 (en) | 2016-12-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |
Effective date: 20130128 |
|
FZDE | Discontinued |
Effective date: 20170804 |