CA2671954C - Methods for treating or preventing symptoms of hormonal variations - Google Patents
Methods for treating or preventing symptoms of hormonal variations Download PDFInfo
- Publication number
- CA2671954C CA2671954C CA2671954A CA2671954A CA2671954C CA 2671954 C CA2671954 C CA 2671954C CA 2671954 A CA2671954 A CA 2671954A CA 2671954 A CA2671954 A CA 2671954A CA 2671954 C CA2671954 C CA 2671954C
- Authority
- CA
- Canada
- Prior art keywords
- pharmaceutical composition
- risperidone
- effective amount
- per day
- symptoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 208000024891 symptom Diseases 0.000 title claims abstract description 50
- 230000003054 hormonal effect Effects 0.000 title claims abstract description 30
- 238000000034 method Methods 0.000 title abstract description 13
- 206010060800 Hot flush Diseases 0.000 claims description 75
- 208000033830 Hot Flashes Diseases 0.000 claims description 73
- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 claims description 60
- 229960001534 risperidone Drugs 0.000 claims description 58
- 239000008194 pharmaceutical composition Substances 0.000 claims description 29
- PMXMIIMHBWHSKN-UHFFFAOYSA-N 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCC(O)C4=NC=3C)=NOC2=C1 PMXMIIMHBWHSKN-UHFFFAOYSA-N 0.000 claims description 16
- 239000003814 drug Substances 0.000 claims description 13
- 230000037396 body weight Effects 0.000 claims description 10
- 230000036565 night sweats Effects 0.000 claims description 10
- 206010029410 night sweats Diseases 0.000 claims description 10
- 206010019233 Headaches Diseases 0.000 claims description 7
- 231100000869 headache Toxicity 0.000 claims description 7
- 206010033557 Palpitations Diseases 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 238000005303 weighing Methods 0.000 claims description 6
- 208000002173 dizziness Diseases 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- 238000002347 injection Methods 0.000 claims description 4
- 230000035900 sweating Effects 0.000 claims description 3
- 206010028813 Nausea Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000008693 nausea Effects 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims 3
- 239000002552 dosage form Substances 0.000 claims 2
- 208000008454 Hyperhidrosis Diseases 0.000 claims 1
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract description 46
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract description 34
- 102000005962 receptors Human genes 0.000 abstract description 24
- 108020003175 receptors Proteins 0.000 abstract description 24
- 229960003638 dopamine Drugs 0.000 abstract description 18
- 229940076279 serotonin Drugs 0.000 abstract description 16
- 102100036321 5-hydroxytryptamine receptor 2A Human genes 0.000 abstract description 14
- 101710138091 5-hydroxytryptamine receptor 2A Proteins 0.000 abstract description 9
- 229940044551 receptor antagonist Drugs 0.000 abstract description 8
- 239000002464 receptor antagonist Substances 0.000 abstract description 8
- 238000011282 treatment Methods 0.000 description 31
- 230000000694 effects Effects 0.000 description 19
- 101150049660 DRD2 gene Proteins 0.000 description 17
- 108050004812 Dopamine receptor Proteins 0.000 description 14
- 102000015554 Dopamine receptor Human genes 0.000 description 14
- 102000049773 5-HT2A Serotonin Receptor Human genes 0.000 description 11
- CEUORZQYGODEFX-UHFFFAOYSA-N Aripirazole Chemical compound ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)CCC4=CC=3)CC2)=C1Cl CEUORZQYGODEFX-UHFFFAOYSA-N 0.000 description 10
- 101150104779 HTR2A gene Proteins 0.000 description 10
- 239000005557 antagonist Substances 0.000 description 10
- 229960004372 aripiprazole Drugs 0.000 description 9
- 229960000607 ziprasidone Drugs 0.000 description 9
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 description 9
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 8
- 102000040125 5-hydroxytryptamine receptor family Human genes 0.000 description 8
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 description 8
- 230000008485 antagonism Effects 0.000 description 8
- 230000036772 blood pressure Effects 0.000 description 8
- 210000004556 brain Anatomy 0.000 description 8
- 229960004170 clozapine Drugs 0.000 description 8
- QZUDBNBUXVUHMW-UHFFFAOYSA-N clozapine Chemical compound C1CN(C)CCN1C1=NC2=CC(Cl)=CC=C2NC2=CC=CC=C12 QZUDBNBUXVUHMW-UHFFFAOYSA-N 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 230000009245 menopause Effects 0.000 description 8
- 229960002748 norepinephrine Drugs 0.000 description 8
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 8
- 229960005017 olanzapine Drugs 0.000 description 8
- KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 description 8
- 238000002560 therapeutic procedure Methods 0.000 description 8
- 230000000561 anti-psychotic effect Effects 0.000 description 7
- 229960004431 quetiapine Drugs 0.000 description 7
- URKOMYMAXPYINW-UHFFFAOYSA-N quetiapine Chemical compound C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 URKOMYMAXPYINW-UHFFFAOYSA-N 0.000 description 7
- 108010072564 5-HT2A Serotonin Receptor Proteins 0.000 description 6
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 description 6
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 description 6
- 229960002896 clonidine Drugs 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 239000000262 estrogen Substances 0.000 description 6
- 206010006187 Breast cancer Diseases 0.000 description 5
- 208000026310 Breast neoplasm Diseases 0.000 description 5
- 206010020772 Hypertension Diseases 0.000 description 5
- 229940011871 estrogen Drugs 0.000 description 5
- 229940088597 hormone Drugs 0.000 description 5
- 239000005556 hormone Substances 0.000 description 5
- 230000002829 reductive effect Effects 0.000 description 5
- 208000019901 Anxiety disease Diseases 0.000 description 4
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 4
- 102000009151 Luteinizing Hormone Human genes 0.000 description 4
- 108010073521 Luteinizing Hormone Proteins 0.000 description 4
- UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 4
- 102000004305 alpha Adrenergic Receptors Human genes 0.000 description 4
- 108090000861 alpha Adrenergic Receptors Proteins 0.000 description 4
- 238000010171 animal model Methods 0.000 description 4
- 210000001971 anterior hypothalamus Anatomy 0.000 description 4
- 230000036506 anxiety Effects 0.000 description 4
- 239000003693 atypical antipsychotic agent Substances 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 210000003016 hypothalamus Anatomy 0.000 description 4
- 229940040129 luteinizing hormone Drugs 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 238000009256 replacement therapy Methods 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- 230000007958 sleep Effects 0.000 description 4
- 230000001331 thermoregulatory effect Effects 0.000 description 4
- HDOZVRUNCMBHFH-UHFFFAOYSA-N zotepine Chemical compound CN(C)CCOC1=CC2=CC=CC=C2SC2=CC=C(Cl)C=C12 HDOZVRUNCMBHFH-UHFFFAOYSA-N 0.000 description 4
- 229960004496 zotepine Drugs 0.000 description 4
- 108060003345 Adrenergic Receptor Proteins 0.000 description 3
- 102000017910 Adrenergic receptor Human genes 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 206010040108 Serotonin syndrome Diseases 0.000 description 3
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 239000000556 agonist Substances 0.000 description 3
- 229940127088 antihypertensive drug Drugs 0.000 description 3
- 229940127236 atypical antipsychotics Drugs 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000036760 body temperature Effects 0.000 description 3
- 150000003943 catecholamines Chemical class 0.000 description 3
- 230000001713 cholinergic effect Effects 0.000 description 3
- 230000003291 dopaminomimetic effect Effects 0.000 description 3
- 206010022437 insomnia Diseases 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 239000004031 partial agonist Substances 0.000 description 3
- 201000000980 schizophrenia Diseases 0.000 description 3
- 230000000698 schizophrenic effect Effects 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 description 3
- 239000002400 serotonin 2A antagonist Substances 0.000 description 3
- 230000009885 systemic effect Effects 0.000 description 3
- 229960001603 tamoxifen Drugs 0.000 description 3
- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 description 2
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 description 2
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 2
- 229930182837 (R)-adrenaline Natural products 0.000 description 2
- 102100022738 5-hydroxytryptamine receptor 1A Human genes 0.000 description 2
- 101710138638 5-hydroxytryptamine receptor 1A Proteins 0.000 description 2
- 206010005746 Blood pressure fluctuation Diseases 0.000 description 2
- 102000000543 Histamine Receptors Human genes 0.000 description 2
- 108010002059 Histamine Receptors Proteins 0.000 description 2
- 206010020843 Hyperthermia Diseases 0.000 description 2
- AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 description 2
- 102000003946 Prolactin Human genes 0.000 description 2
- 108010057464 Prolactin Proteins 0.000 description 2
- 208000001431 Psychomotor Agitation Diseases 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- 206010039897 Sedation Diseases 0.000 description 2
- MMWCIQZXVOZEGG-HOZKJCLWSA-N [(1S,2R,3S,4S,5R,6S)-2,3,5-trihydroxy-4,6-diphosphonooxycyclohexyl] dihydrogen phosphate Chemical compound O[C@H]1[C@@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](O)[C@H]1OP(O)(O)=O MMWCIQZXVOZEGG-HOZKJCLWSA-N 0.000 description 2
- 210000001943 adrenal medulla Anatomy 0.000 description 2
- 230000001800 adrenalinergic effect Effects 0.000 description 2
- 239000000674 adrenergic antagonist Substances 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000004075 alteration Effects 0.000 description 2
- 230000001090 anti-dopaminergic effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 150000001982 diacylglycerols Chemical class 0.000 description 2
- 239000003210 dopamine receptor blocking agent Substances 0.000 description 2
- 229960005139 epinephrine Drugs 0.000 description 2
- 238000009164 estrogen replacement therapy Methods 0.000 description 2
- JKKFKPJIXZFSSB-CBZIJGRNSA-N estrone 3-sulfate Chemical compound OS(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 JKKFKPJIXZFSSB-CBZIJGRNSA-N 0.000 description 2
- 229960001340 histamine Drugs 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 230000036031 hyperthermia Effects 0.000 description 2
- 230000002267 hypothalamic effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- 230000003551 muscarinic effect Effects 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 210000002569 neuron Anatomy 0.000 description 2
- 229960002296 paroxetine Drugs 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 229940063238 premarin Drugs 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 229940097325 prolactin Drugs 0.000 description 2
- 230000000541 pulsatile effect Effects 0.000 description 2
- 230000033764 rhythmic process Effects 0.000 description 2
- 230000036280 sedation Effects 0.000 description 2
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 230000000862 serotonergic effect Effects 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 230000002889 sympathetic effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 229960004688 venlafaxine Drugs 0.000 description 2
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 description 2
- 229960001968 veralipride Drugs 0.000 description 2
- RYJXBGGBZJGVQF-UHFFFAOYSA-N veralipride Chemical compound COC1=CC(S(N)(=O)=O)=CC(C(=O)NCC2N(CCC2)CC=C)=C1OC RYJXBGGBZJGVQF-UHFFFAOYSA-N 0.000 description 2
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 description 1
- 206010001497 Agitation Diseases 0.000 description 1
- 208000020925 Bipolar disease Diseases 0.000 description 1
- 208000009132 Catalepsy Diseases 0.000 description 1
- 108010009685 Cholinergic Receptors Proteins 0.000 description 1
- 101000904177 Clupea pallasii Gonadoliberin-1 Proteins 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 102100029503 E3 ubiquitin-protein ligase TRIM32 Human genes 0.000 description 1
- 208000007530 Essential hypertension Diseases 0.000 description 1
- 206010016334 Feeling hot Diseases 0.000 description 1
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 description 1
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 description 1
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 description 1
- 102000006771 Gonadotropins Human genes 0.000 description 1
- 108010086677 Gonadotropins Proteins 0.000 description 1
- 101000634982 Homo sapiens E3 ubiquitin-protein ligase TRIM32 Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 206010026749 Mania Diseases 0.000 description 1
- 206010027304 Menopausal symptoms Diseases 0.000 description 1
- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 description 1
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 description 1
- GIYXAJPCNFJEHY-UHFFFAOYSA-N N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-1-propanamine hydrochloride (1:1) Chemical compound Cl.C=1C=CC=CC=1C(CCNC)OC1=CC=C(C(F)(F)F)C=C1 GIYXAJPCNFJEHY-UHFFFAOYSA-N 0.000 description 1
- 102000016979 Other receptors Human genes 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 201000001880 Sexual dysfunction Diseases 0.000 description 1
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- CGQCWMIAEPEHNQ-UHFFFAOYSA-N Vanillylmandelic acid Chemical compound COC1=CC(C(O)C(O)=O)=CC=C1O CGQCWMIAEPEHNQ-UHFFFAOYSA-N 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 206010047853 Waxy flexibility Diseases 0.000 description 1
- 229940056213 abilify Drugs 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 102000034337 acetylcholine receptors Human genes 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000000048 adrenergic agonist Substances 0.000 description 1
- 229940126157 adrenergic receptor agonist Drugs 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 230000008484 agonism Effects 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 230000001078 anti-cholinergic effect Effects 0.000 description 1
- 229940046836 anti-estrogen Drugs 0.000 description 1
- 230000001833 anti-estrogenic effect Effects 0.000 description 1
- 229940124604 anti-psychotic medication Drugs 0.000 description 1
- 239000000164 antipsychotic agent Substances 0.000 description 1
- 229940005529 antipsychotics Drugs 0.000 description 1
- VMWNQDUVQKEIOC-CYBMUJFWSA-N apomorphine Chemical compound C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 VMWNQDUVQKEIOC-CYBMUJFWSA-N 0.000 description 1
- 229960004046 apomorphine Drugs 0.000 description 1
- 210000003403 autonomic nervous system Anatomy 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 150000008316 benzisoxazoles Chemical class 0.000 description 1
- 210000000133 brain stem Anatomy 0.000 description 1
- 210000005242 cardiac chamber Anatomy 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 229960001653 citalopram Drugs 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000036757 core body temperature Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 230000007937 eating Effects 0.000 description 1
- 238000002592 echocardiography Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000001787 epileptiform Effects 0.000 description 1
- -1 epinephrine Chemical class 0.000 description 1
- 239000000328 estrogen antagonist Substances 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- NMCHYWGKBADVMK-UHFFFAOYSA-N fenetylline Chemical compound C1=NC=2N(C)C(=O)N(C)C(=O)C=2N1CCNC(C)CC1=CC=CC=C1 NMCHYWGKBADVMK-UHFFFAOYSA-N 0.000 description 1
- 229940028334 follicle stimulating hormone Drugs 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 description 1
- 239000002622 gonadotropin Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002489 hematologic effect Effects 0.000 description 1
- 230000000742 histaminergic effect Effects 0.000 description 1
- 229940125697 hormonal agent Drugs 0.000 description 1
- 238000002657 hormone replacement therapy Methods 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 208000031424 hyperprolactinemia Diseases 0.000 description 1
- 230000002631 hypothermal effect Effects 0.000 description 1
- 238000009802 hysterectomy Methods 0.000 description 1
- BCGWQEUPMDMJNV-UHFFFAOYSA-N imipramine Chemical compound C1CC2=CC=CC=C2N(CCCN(C)C)C2=CC=CC=C21 BCGWQEUPMDMJNV-UHFFFAOYSA-N 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 231100000225 lethality Toxicity 0.000 description 1
- 230000002197 limbic effect Effects 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000955 neuroendocrine Effects 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 230000027758 ovulation cycle Effects 0.000 description 1
- 230000001734 parasympathetic effect Effects 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000007310 pathophysiology Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 229940106887 risperdal Drugs 0.000 description 1
- 229940103136 risperidone 2 mg Drugs 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 231100000872 sexual dysfunction Toxicity 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 208000020685 sleep-wake disease Diseases 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000003687 soy isoflavones Nutrition 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 230000000946 synaptic effect Effects 0.000 description 1
- 230000028016 temperature homeostasis Effects 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000005495 thyroid hormone Substances 0.000 description 1
- 229940036555 thyroid hormone Drugs 0.000 description 1
- 229940041597 tofranil Drugs 0.000 description 1
- 238000011539 total abdominal hysterectomy Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000001457 vasomotor Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/638,282 | 2006-12-13 | ||
| US11/638,282 US7645750B2 (en) | 2006-12-13 | 2006-12-13 | Method of treating symptoms of hormonal variations |
| PCT/IB2007/004514 WO2008087491A2 (en) | 2006-12-13 | 2007-11-27 | Method for treating or preventing symptoms of hormonal variations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2671954A1 CA2671954A1 (en) | 2008-07-24 |
| CA2671954C true CA2671954C (en) | 2012-01-03 |
Family
ID=39528142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2671954A Active CA2671954C (en) | 2006-12-13 | 2007-11-27 | Methods for treating or preventing symptoms of hormonal variations |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US7645750B2 (enExample) |
| EP (1) | EP2101781B1 (enExample) |
| JP (1) | JP4643742B2 (enExample) |
| KR (1) | KR101435695B1 (enExample) |
| CN (2) | CN101588804B (enExample) |
| AT (1) | ATE506065T1 (enExample) |
| CA (1) | CA2671954C (enExample) |
| DE (1) | DE602007014102D1 (enExample) |
| MY (1) | MY162095A (enExample) |
| TW (1) | TWI330083B (enExample) |
| WO (1) | WO2008087491A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ527142A (en) | 2003-07-23 | 2006-03-31 | Douglas Pharmaceuticals Ltd | A stable suspension formulation |
| US8631151B2 (en) | 2006-05-18 | 2014-01-14 | Intel Corporation | Techniques for guaranteeing bandwidth with aggregate traffic |
| US7645750B2 (en) * | 2006-12-13 | 2010-01-12 | Yung Shin Pharmaceutical Ind. Co., Ltd. | Method of treating symptoms of hormonal variations |
| JP2010513569A (ja) * | 2006-12-19 | 2010-04-30 | ユニバーシティ オブ バージニア パテント ファウンデーション | アルコール摂取に対するトピラメートおよびオンダンセトロンの併用効果 |
| WO2009029308A1 (en) * | 2007-08-27 | 2009-03-05 | University Of Virginia Patent Foundation | Medication combinations for the treatment of alcoholism and drug addiction |
| US8420624B2 (en) * | 2007-12-04 | 2013-04-16 | Yung Shin Pharm. Ind. Co., Ltd. | Methods for treating or preventing symptoms of hormonal variations |
| ES2430940T3 (es) | 2008-02-28 | 2013-11-22 | University Of Virginia Patent Foundation | Gen del transportador de serotonina y tratamiento del alcoholismo |
| ES2574210T3 (es) * | 2010-03-02 | 2016-06-15 | Fervent Pharmaceuticals, Llc | Métodos y composiciones para tratar o prevenir los síntomas de las variaciones hormonales |
| US8461102B2 (en) | 2010-03-02 | 2013-06-11 | George E. Royster, JR. | Methods and compositions for treating and preventing symptoms of hormonal variations |
| WO2012012147A2 (en) * | 2010-06-30 | 2012-01-26 | Victoria Link Ltd | Methods and compositions for treatment of multiple sclerosis |
| HUE035574T2 (en) | 2010-07-02 | 2018-05-28 | Univ Virginia Patent Foundation | Molecular genetic approach to treatment and diagnosis of alcohol and drug dependence |
| WO2012154174A1 (en) * | 2011-05-10 | 2012-11-15 | Liu Chui Yu | Methods for treating insomnia |
| US20130096173A1 (en) | 2011-09-09 | 2013-04-18 | Bankole A. Johnson | Molecular genetic approach to treatment and diagnosis of alcohol and drug dependence |
| WO2015013285A2 (en) * | 2013-07-22 | 2015-01-29 | Ohio State Innovation Foundation | Methods for reducing the occurrence of hot flashes |
| JP6038416B1 (ja) * | 2015-04-07 | 2016-12-07 | 株式会社明治 | 火照り抑制剤 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4096254A (en) * | 1976-05-10 | 1978-06-20 | Richardson-Merrell Inc. | Method of treating the symptoms of menopause and osteoporosis |
| FR2358892A1 (fr) * | 1976-07-19 | 1978-02-17 | Ile De France | N(1'-allyl 2'-pyrrolidylmethyl)2,3-dimethoxy 5-sulfamoyl benzamide, ses derives |
| US5654011A (en) * | 1996-07-30 | 1997-08-05 | Energetics, Inc. | Dietary supplements |
| AU9621598A (en) * | 1997-10-20 | 1999-05-10 | Novo Nordisk A/S | Luteinising hormone antagonists useful for treatment of estrogen deficiencies, or as a contraceptive |
| FR2779579B1 (fr) * | 1998-06-09 | 2000-08-25 | Thomson Csf | Dispositif de commande optique pour l'emission et la reception d'un radar large bande |
| NZ517044A (en) * | 1999-07-22 | 2004-02-27 | Univ Rochester | Gamma-aminobutyric acid analogues, e.g. gabapentin and pregabalin, to treat symptoms of hormonal variation, including hot flushes, nausea, emesis and fever |
| US6613792B1 (en) * | 1999-08-02 | 2003-09-02 | Designed Nutritional Products, Inc. | Treatment of premenstrual syndrome and menopause |
| BR0013122A (pt) * | 1999-08-13 | 2002-04-30 | Vela Pharmaceuticals Inc | Ciclobenzaprina para tratamento de distúrbio de ansiedade generalizado e composições de ciclobenzaprina |
| US20040002482A1 (en) * | 2000-08-30 | 2004-01-01 | Dudley Robert E. | Androgen pharmaceutical composition and method for treating depression |
| EP1373203A1 (en) * | 2001-03-29 | 2004-01-02 | Bristol-Myers Squibb Company | Cyclopropylindole derivatives as selective serotonin reuptake inhibitors |
| WO2003037334A1 (en) * | 2001-10-31 | 2003-05-08 | Merck & Co., Inc. | Method for treating or preventing symptoms of hormonal variation including hot flashes |
| US20040101481A1 (en) * | 2002-11-26 | 2004-05-27 | Alexza Molecular Delivery Corporation | Acute treatment of headache with phenothiazine antipsychotics |
| CN1465348A (zh) | 2002-07-05 | 2004-01-07 | 复方消融合剂及其在用作制备治疗肿瘤药物上的应用 | |
| US20040127489A1 (en) * | 2002-07-29 | 2004-07-01 | David Pickar | Novel antipsychotic combination therapies and compositions useful therein |
| EP1534258A2 (en) * | 2002-08-15 | 2005-06-01 | Wyeth | AGONISM OF THE 5HT 2a RECEPTOR FOR TREATMENT OF THERMOREGULATORY DYSFUNCTION |
| US7855195B2 (en) * | 2003-12-02 | 2010-12-21 | Pharmaneuroboost N.V. | Method of treating mental disorders using D4 and 5-HT2A antagonists, inverse agonists or partial agonists |
| EP1753460A2 (en) * | 2004-05-11 | 2007-02-21 | Pfizer Products Inc. | Combination of atypical antipsychotics and 5-ht1b receptor antagonists |
| CA2569411A1 (en) * | 2004-06-04 | 2005-12-22 | Mood Management Sciences, Llc | Methods and compositions for treating mood disorder |
| TW200631584A (en) | 2004-11-15 | 2006-09-16 | Akzo Nobel Nv | A medicament related to mirtazapine for the treatment of hot flush |
| EP1827450A4 (en) * | 2004-11-17 | 2009-04-22 | Cypress Bioscience Inc | METHOD FOR REDUCING THE SIDE EFFECTS OF TREATMENT WITH MIRTAZAPINE |
| US7645750B2 (en) * | 2006-12-13 | 2010-01-12 | Yung Shin Pharmaceutical Ind. Co., Ltd. | Method of treating symptoms of hormonal variations |
-
2006
- 2006-12-13 US US11/638,282 patent/US7645750B2/en active Active
-
2007
- 2007-10-26 TW TW096140356A patent/TWI330083B/zh not_active IP Right Cessation
- 2007-11-27 EP EP07872103A patent/EP2101781B1/en not_active Not-in-force
- 2007-11-27 JP JP2009540891A patent/JP4643742B2/ja not_active Expired - Fee Related
- 2007-11-27 DE DE602007014102T patent/DE602007014102D1/de active Active
- 2007-11-27 CN CN2007800463514A patent/CN101588804B/zh not_active Expired - Fee Related
- 2007-11-27 AT AT07872103T patent/ATE506065T1/de not_active IP Right Cessation
- 2007-11-27 MY MYPI20092347A patent/MY162095A/en unknown
- 2007-11-27 CN CN201210178935.XA patent/CN102697785B/zh not_active Expired - Fee Related
- 2007-11-27 CA CA2671954A patent/CA2671954C/en active Active
- 2007-11-27 WO PCT/IB2007/004514 patent/WO2008087491A2/en not_active Ceased
- 2007-11-27 KR KR1020097012120A patent/KR101435695B1/ko not_active Expired - Fee Related
-
2009
- 2009-12-11 US US12/636,552 patent/US20100093762A1/en not_active Abandoned
-
2015
- 2015-03-03 US US14/637,200 patent/US20150246056A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20080146541A1 (en) | 2008-06-19 |
| CN102697785B (zh) | 2015-02-18 |
| WO2008087491A8 (en) | 2008-10-30 |
| US20150246056A1 (en) | 2015-09-03 |
| CA2671954A1 (en) | 2008-07-24 |
| TWI330083B (en) | 2010-09-11 |
| US7645750B2 (en) | 2010-01-12 |
| CN102697785A (zh) | 2012-10-03 |
| CN101588804B (zh) | 2012-09-05 |
| EP2101781A4 (en) | 2010-02-10 |
| JP4643742B2 (ja) | 2011-03-02 |
| TW200825082A (en) | 2008-06-16 |
| CN101588804A (zh) | 2009-11-25 |
| WO2008087491A3 (en) | 2008-12-18 |
| KR20090103876A (ko) | 2009-10-01 |
| US20100093762A1 (en) | 2010-04-15 |
| ATE506065T1 (de) | 2011-05-15 |
| WO2008087491A2 (en) | 2008-07-24 |
| EP2101781B1 (en) | 2011-04-20 |
| KR101435695B1 (ko) | 2014-09-02 |
| JP2010522137A (ja) | 2010-07-01 |
| MY162095A (en) | 2017-05-31 |
| EP2101781A2 (en) | 2009-09-23 |
| DE602007014102D1 (de) | 2011-06-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2101781B1 (en) | Method for treating or preventing symptoms of hormonal variations | |
| US8420624B2 (en) | Methods for treating or preventing symptoms of hormonal variations | |
| US20080227850A1 (en) | Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms | |
| AU2016213776B2 (en) | Methods and compositions for treating or preventing symptoms of hormonal variations | |
| US20040152710A1 (en) | Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms | |
| CA2502027A1 (en) | A method of treating vasomotor symptoms comprising a compound having norepinephrine reuptake inhibitor activity and 5-ht2a antagonistic activity | |
| US20040092519A1 (en) | New treatment for hot flashes | |
| US10806722B1 (en) | Method and compound for treatment of menopausal symptoms | |
| CA2866494C (en) | Compounds, compositions, and uses thereof for treatment of menopausal symptoms and menopausal hot flashes | |
| JP2007515395A (ja) | 血管運動症状の治療方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |