CA2671830C - Catalytic process for asymmetric hydrogenation - Google Patents

Catalytic process for asymmetric hydrogenation Download PDF

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Publication number
CA2671830C
CA2671830C CA2671830A CA2671830A CA2671830C CA 2671830 C CA2671830 C CA 2671830C CA 2671830 A CA2671830 A CA 2671830A CA 2671830 A CA2671830 A CA 2671830A CA 2671830 C CA2671830 C CA 2671830C
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CA
Canada
Prior art keywords
compound
process according
formula
enantiomer
alkyl
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Active
Application number
CA2671830A
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English (en)
French (fr)
Other versions
CA2671830A1 (en
Inventor
David Alexander Learmonth
Antonio Zanotti-Gerosa
Gabriela Alexandra Grasa
Alexander Beliaev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bial Portela and Cia SA
Original Assignee
Bial Portela and Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Bial Portela and Cia SA filed Critical Bial Portela and Cia SA
Publication of CA2671830A1 publication Critical patent/CA2671830A1/en
Application granted granted Critical
Publication of CA2671830C publication Critical patent/CA2671830C/en
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CA2671830A 2006-12-12 2007-12-12 Catalytic process for asymmetric hydrogenation Active CA2671830C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86960506P 2006-12-12 2006-12-12
US60/869,605 2006-12-12
PCT/GB2007/004756 WO2008071951A2 (en) 2006-12-12 2007-12-12 Catalytic process for asymmetric hydrogenation

Publications (2)

Publication Number Publication Date
CA2671830A1 CA2671830A1 (en) 2008-06-19
CA2671830C true CA2671830C (en) 2019-03-19

Family

ID=39247380

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2671830A Active CA2671830C (en) 2006-12-12 2007-12-12 Catalytic process for asymmetric hydrogenation

Country Status (15)

Country Link
US (1) US8546571B2 (https=)
EP (1) EP2102182B1 (https=)
JP (1) JP5372771B2 (https=)
KR (1) KR20090091326A (https=)
CN (1) CN101627023A (https=)
AR (1) AR064308A1 (https=)
AU (1) AU2007331340A1 (https=)
BR (1) BRPI0718351A2 (https=)
CA (1) CA2671830C (https=)
ES (1) ES2483718T3 (https=)
MX (1) MX2009006113A (https=)
NO (1) NO20092259L (https=)
PT (1) PT103901B (https=)
RU (1) RU2009126571A (https=)
WO (1) WO2008071951A2 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090091326A (ko) 2006-12-12 2009-08-27 바이알 - 포르텔라 앤드 씨에이 에스에이 촉매적 비대칭 수소화 방법
GB0709695D0 (en) * 2007-05-21 2007-06-27 Portela & Ca Sa Process
TW200927740A (en) * 2007-11-13 2009-07-01 Bial Portela & Ca Sa Process
AR070841A1 (es) * 2008-03-13 2010-05-05 Bial Portela & Ca Sa Proceso de hidrogenacion catalitica asimetrica
PT2297042E (pt) * 2008-03-19 2013-10-10 Bial Portela & Ca Sa Hidrogenação catalítica assimétrica
AR071632A1 (es) * 2008-05-06 2010-06-30 Bial Portela & Ca Sa Proceso catalitico para hidrogenacion asimetrica en la sintesis de inhibidores de la dopamina-beta-hidroxilasa"
CN111196759B (zh) * 2018-11-16 2023-03-24 上海博志研新药物技术有限公司 盐酸西那卡塞及其中间体的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202474A (en) 1989-06-22 1993-04-13 Monsanto Company Asymmetric catalytic hydrogenation of α-arylpropenoic acids
US5420151A (en) * 1989-12-22 1995-05-30 Aktiebolaget Astra Chroman derivatives
WO1995029165A2 (en) 1994-04-26 1995-11-02 Syntex (U.S.A.) Inc. Benzocycloalkylaz0lethione derivatives as dopamin beta-hydroxylase inhibitors
US5886182A (en) * 1997-12-10 1999-03-23 The Hong Kong Polytechnic University Chiral pyridylphosphines and their application in asymmetric catalytic hydrogenation of 2-arylpropenoic acids
US7125904B2 (en) * 2002-10-11 2006-10-24 Portela & C.A., S.A. Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation
GB0316439D0 (en) * 2003-07-15 2003-08-20 Johnson Matthey Plc Catalysts
KR20090091326A (ko) 2006-12-12 2009-08-27 바이알 - 포르텔라 앤드 씨에이 에스에이 촉매적 비대칭 수소화 방법

Also Published As

Publication number Publication date
JP5372771B2 (ja) 2013-12-18
AR064308A1 (es) 2009-03-25
WO2008071951A3 (en) 2008-10-02
PT103901A (pt) 2008-06-12
JP2010512379A (ja) 2010-04-22
AU2007331340A1 (en) 2008-06-19
MX2009006113A (es) 2009-07-17
CN101627023A (zh) 2010-01-13
RU2009126571A (ru) 2011-01-20
BRPI0718351A2 (pt) 2019-09-24
PT103901B (pt) 2012-03-01
EP2102182B1 (en) 2014-04-23
US8546571B2 (en) 2013-10-01
KR20090091326A (ko) 2009-08-27
ES2483718T3 (es) 2014-08-07
WO2008071951A2 (en) 2008-06-19
CA2671830A1 (en) 2008-06-19
NO20092259L (no) 2009-06-25
US20100036127A1 (en) 2010-02-11
EP2102182A2 (en) 2009-09-23

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Effective date: 20121212

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Effective date: 20240724