MX2009006113A - Proceso catalitico para hidrogenacion asimetrica. - Google Patents

Proceso catalitico para hidrogenacion asimetrica.

Info

Publication number
MX2009006113A
MX2009006113A MX2009006113A MX2009006113A MX2009006113A MX 2009006113 A MX2009006113 A MX 2009006113A MX 2009006113 A MX2009006113 A MX 2009006113A MX 2009006113 A MX2009006113 A MX 2009006113A MX 2009006113 A MX2009006113 A MX 2009006113A
Authority
MX
Mexico
Prior art keywords
aryl
halogen
alkyl
term
alkyloxy
Prior art date
Application number
MX2009006113A
Other languages
English (en)
Inventor
David Alexander Learmonth
Antonio Zanotti-Gerosa
Gabriela Alexandra Grasa
Alexander Beliaev
Original Assignee
Bial Portela & Ca Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bial Portela & Ca Sa filed Critical Bial Portela & Ca Sa
Publication of MX2009006113A publication Critical patent/MX2009006113A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Se describe un proceso para preparara el enantiómero S o R de un compuesto de la fórmula A, el proceso comprende someter un compuesto de la fórmula B a la hidrogenación asimétrica en presencia de un catalizador quiral y una fuente de hidrógeno, en donde: X es CH2, oxígeno o azufre; R1, R2 Y R3 son los mismos o diferentes y significan hidrógenos, halógenos, alquilo, alquiloxi, hiidroxilo, nitro, alquilcarbonilamino, alquilamino o dialquilamino; y R4 es alquilo o arilo, en donde, el término alquilo significa las cadenas de hidrocarburo, lineal o ramificadas, que contienen de 1 a 6 átomos de carbono, opcionalmente sustituidas con los grupos arilo, alcoxi, halógeno, alcoxicarbonilo o hidroxicarbonilo; el término arilo significa un grupo fenilo o naftilo, opcionalmente sustituido con el grupo alquiloxi, halógeno o nitro; y el término halógeno significa flúor, cloro, bromo o yodo.
MX2009006113A 2006-12-12 2007-12-12 Proceso catalitico para hidrogenacion asimetrica. MX2009006113A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86960506P 2006-12-12 2006-12-12
PCT/GB2007/004756 WO2008071951A2 (en) 2006-12-12 2007-12-12 Catalytic process for asymmetric hydrogenation

Publications (1)

Publication Number Publication Date
MX2009006113A true MX2009006113A (es) 2009-07-17

Family

ID=39247380

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009006113A MX2009006113A (es) 2006-12-12 2007-12-12 Proceso catalitico para hidrogenacion asimetrica.

Country Status (15)

Country Link
US (1) US8546571B2 (es)
EP (1) EP2102182B1 (es)
JP (1) JP5372771B2 (es)
KR (1) KR20090091326A (es)
CN (1) CN101627023A (es)
AR (1) AR064308A1 (es)
AU (1) AU2007331340A1 (es)
BR (1) BRPI0718351A2 (es)
CA (1) CA2671830C (es)
ES (1) ES2483718T3 (es)
MX (1) MX2009006113A (es)
NO (1) NO20092259L (es)
PT (1) PT103901B (es)
RU (1) RU2009126571A (es)
WO (1) WO2008071951A2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5372771B2 (ja) 2006-12-12 2013-12-18 ビアル−ポルテア アンド シー.エイ., エス.エイ. プロセス
GB0709695D0 (en) * 2007-05-21 2007-06-27 Portela & Ca Sa Process
TW200927740A (en) * 2007-11-13 2009-07-01 Bial Portela & Ca Sa Process
AR070841A1 (es) * 2008-03-13 2010-05-05 Bial Portela & Ca Sa Proceso de hidrogenacion catalitica asimetrica
EP2297042B1 (en) * 2008-03-19 2013-07-10 Bial-Portela & CA, S.A. Catalytic asymmetric hydrogenation
AR071632A1 (es) * 2008-05-06 2010-06-30 Bial Portela & Ca Sa Proceso catalitico para hidrogenacion asimetrica en la sintesis de inhibidores de la dopamina-beta-hidroxilasa"
CN111196759B (zh) * 2018-11-16 2023-03-24 上海博志研新药物技术有限公司 盐酸西那卡塞及其中间体的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202474A (en) 1989-06-22 1993-04-13 Monsanto Company Asymmetric catalytic hydrogenation of α-arylpropenoic acids
US5420151A (en) * 1989-12-22 1995-05-30 Aktiebolaget Astra Chroman derivatives
RU2145321C1 (ru) 1994-04-26 2000-02-10 Синтекс (Ю.Эс.Эй) Инк. Производные бензоциклоалкилазолотиона
US5886182A (en) * 1997-12-10 1999-03-23 The Hong Kong Polytechnic University Chiral pyridylphosphines and their application in asymmetric catalytic hydrogenation of 2-arylpropenoic acids
US7125904B2 (en) * 2002-10-11 2006-10-24 Portela & C.A., S.A. Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation
GB0316439D0 (en) * 2003-07-15 2003-08-20 Johnson Matthey Plc Catalysts
JP5372771B2 (ja) 2006-12-12 2013-12-18 ビアル−ポルテア アンド シー.エイ., エス.エイ. プロセス

Also Published As

Publication number Publication date
ES2483718T3 (es) 2014-08-07
US20100036127A1 (en) 2010-02-11
BRPI0718351A2 (pt) 2019-09-24
PT103901B (pt) 2012-03-01
EP2102182B1 (en) 2014-04-23
US8546571B2 (en) 2013-10-01
CA2671830C (en) 2019-03-19
WO2008071951A3 (en) 2008-10-02
CA2671830A1 (en) 2008-06-19
AR064308A1 (es) 2009-03-25
AU2007331340A1 (en) 2008-06-19
WO2008071951A2 (en) 2008-06-19
JP2010512379A (ja) 2010-04-22
KR20090091326A (ko) 2009-08-27
JP5372771B2 (ja) 2013-12-18
CN101627023A (zh) 2010-01-13
NO20092259L (no) 2009-06-25
EP2102182A2 (en) 2009-09-23
PT103901A (pt) 2008-06-12
RU2009126571A (ru) 2011-01-20

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