CA2663913A1 - Compositions d'hygiene buccale stanneuses - Google Patents
Compositions d'hygiene buccale stanneuses Download PDFInfo
- Publication number
- CA2663913A1 CA2663913A1 CA002663913A CA2663913A CA2663913A1 CA 2663913 A1 CA2663913 A1 CA 2663913A1 CA 002663913 A CA002663913 A CA 002663913A CA 2663913 A CA2663913 A CA 2663913A CA 2663913 A1 CA2663913 A1 CA 2663913A1
- Authority
- CA
- Canada
- Prior art keywords
- stannous
- fluoride
- compositions
- poly
- oral care
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 335
- -1 stannous (Sn+2) Chemical class 0.000 claims abstract description 96
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 claims abstract description 87
- 229960002799 stannous fluoride Drugs 0.000 claims abstract description 84
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims abstract description 49
- IUTCEZPPWBHGIX-UHFFFAOYSA-N tin(2+) Chemical compound [Sn+2] IUTCEZPPWBHGIX-UHFFFAOYSA-N 0.000 claims abstract description 41
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 39
- 239000011707 mineral Substances 0.000 claims abstract description 39
- 150000001768 cations Chemical class 0.000 claims abstract description 35
- 239000004094 surface-active agent Substances 0.000 claims abstract description 34
- 229920000642 polymer Polymers 0.000 claims abstract description 31
- 238000010186 staining Methods 0.000 claims abstract description 28
- 229920001577 copolymer Polymers 0.000 claims abstract description 26
- 230000001225 therapeutic effect Effects 0.000 claims abstract description 19
- 208000007565 gingivitis Diseases 0.000 claims abstract description 16
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims abstract description 14
- 230000000845 anti-microbial effect Effects 0.000 claims abstract description 13
- 239000011575 calcium Substances 0.000 claims abstract description 13
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 13
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 12
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims abstract description 11
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 10
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims abstract description 7
- 230000003247 decreasing effect Effects 0.000 claims abstract description 7
- 230000010736 Chelating Activity Effects 0.000 claims abstract description 6
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000011701 zinc Substances 0.000 claims abstract description 6
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 6
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 5
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims abstract description 5
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229910052782 aluminium Inorganic materials 0.000 claims abstract description 5
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229910052788 barium Inorganic materials 0.000 claims abstract description 5
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000010949 copper Substances 0.000 claims abstract description 5
- 229910052802 copper Inorganic materials 0.000 claims abstract description 5
- 229910052742 iron Inorganic materials 0.000 claims abstract description 5
- 239000011777 magnesium Substances 0.000 claims abstract description 5
- 229910052749 magnesium Inorganic materials 0.000 claims abstract description 5
- 239000011572 manganese Substances 0.000 claims abstract description 5
- 229910052748 manganese Inorganic materials 0.000 claims abstract description 5
- 229910052712 strontium Inorganic materials 0.000 claims abstract description 5
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229920000388 Polyphosphate Polymers 0.000 claims description 65
- 239000001205 polyphosphate Substances 0.000 claims description 65
- 235000011176 polyphosphates Nutrition 0.000 claims description 62
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 36
- 235000010755 mineral Nutrition 0.000 claims description 35
- 238000000034 method Methods 0.000 claims description 29
- 239000000463 material Substances 0.000 claims description 26
- 239000000377 silicon dioxide Substances 0.000 claims description 18
- 150000002500 ions Chemical class 0.000 claims description 17
- 239000002253 acid Substances 0.000 claims description 14
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 12
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims description 11
- 239000000796 flavoring agent Substances 0.000 claims description 10
- 235000019634 flavors Nutrition 0.000 claims description 10
- 239000006172 buffering agent Substances 0.000 claims description 9
- 150000002688 maleic acid derivatives Chemical class 0.000 claims description 9
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 claims description 9
- 239000000178 monomer Substances 0.000 claims description 8
- 229910052708 sodium Inorganic materials 0.000 claims description 8
- 239000003086 colorant Substances 0.000 claims description 7
- XQRLCLUYWUNEEH-UHFFFAOYSA-L diphosphonate(2-) Chemical compound [O-]P(=O)OP([O-])=O XQRLCLUYWUNEEH-UHFFFAOYSA-L 0.000 claims description 7
- 239000003906 humectant Substances 0.000 claims description 7
- 239000011734 sodium Substances 0.000 claims description 7
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- FWPIDFUJEMBDLS-UHFFFAOYSA-L tin(II) chloride dihydrate Chemical compound O.O.Cl[Sn]Cl FWPIDFUJEMBDLS-UHFFFAOYSA-L 0.000 claims description 6
- 239000004408 titanium dioxide Substances 0.000 claims description 6
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 5
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 5
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 5
- 229920005646 polycarboxylate Polymers 0.000 claims description 5
- 230000008719 thickening Effects 0.000 claims description 5
- 229920001285 xanthan gum Polymers 0.000 claims description 5
- 235000010493 xanthan gum Nutrition 0.000 claims description 5
- 239000000230 xanthan gum Substances 0.000 claims description 5
- 229940082509 xanthan gum Drugs 0.000 claims description 5
- 150000003751 zinc Chemical class 0.000 claims description 5
- CKUJRAYMVVJDMG-IYEMJOQQSA-L (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate;tin(2+) Chemical compound [Sn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O CKUJRAYMVVJDMG-IYEMJOQQSA-L 0.000 claims description 4
- 229920002125 Sokalan® Polymers 0.000 claims description 4
- 235000003599 food sweetener Nutrition 0.000 claims description 4
- 229920000058 polyacrylate Polymers 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 239000011775 sodium fluoride Substances 0.000 claims description 4
- 239000003765 sweetening agent Substances 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 229920001525 carrageenan Polymers 0.000 claims description 3
- 235000010418 carrageenan Nutrition 0.000 claims description 3
- 239000000679 carrageenan Substances 0.000 claims description 3
- 229940113118 carrageenan Drugs 0.000 claims description 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 3
- YXTDAZMTQFUZHK-ZVGUSBNCSA-L (2r,3r)-2,3-dihydroxybutanedioate;tin(2+) Chemical compound [Sn+2].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O YXTDAZMTQFUZHK-ZVGUSBNCSA-L 0.000 claims description 2
- OQBLGYCUQGDOOR-UHFFFAOYSA-L 1,3,2$l^{2}-dioxastannolane-4,5-dione Chemical compound O=C1O[Sn]OC1=O OQBLGYCUQGDOOR-UHFFFAOYSA-L 0.000 claims description 2
- RMSOEGBYNWXXBG-UHFFFAOYSA-N 1-chloronaphthalen-2-ol Chemical compound C1=CC=CC2=C(Cl)C(O)=CC=C21 RMSOEGBYNWXXBG-UHFFFAOYSA-N 0.000 claims description 2
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 2
- 244000215068 Acacia senegal Species 0.000 claims description 2
- 241000416162 Astragalus gummifer Species 0.000 claims description 2
- 229920000084 Gum arabic Polymers 0.000 claims description 2
- 229920000569 Gum karaya Polymers 0.000 claims description 2
- 229920003060 Poly(vinyl benzyl chloride) Polymers 0.000 claims description 2
- 229920001615 Tragacanth Polymers 0.000 claims description 2
- 235000010489 acacia gum Nutrition 0.000 claims description 2
- 239000000205 acacia gum Substances 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 150000001767 cationic compounds Chemical class 0.000 claims description 2
- PNOXNTGLSKTMQO-UHFFFAOYSA-L diacetyloxytin Chemical compound CC(=O)O[Sn]OC(C)=O PNOXNTGLSKTMQO-UHFFFAOYSA-L 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims description 2
- 150000004676 glycans Chemical class 0.000 claims description 2
- 229910001411 inorganic cation Inorganic materials 0.000 claims description 2
- 235000010494 karaya gum Nutrition 0.000 claims description 2
- ZVVSSOQAYNYNPP-UHFFFAOYSA-N olaflur Chemical compound F.F.CCCCCCCCCCCCCCCCCCN(CCO)CCCN(CCO)CCO ZVVSSOQAYNYNPP-UHFFFAOYSA-N 0.000 claims description 2
- 229960001245 olaflur Drugs 0.000 claims description 2
- 229920001390 poly(hydroxyalkylmethacrylate) Polymers 0.000 claims description 2
- 229920000141 poly(maleic anhydride) Polymers 0.000 claims description 2
- 229920002401 polyacrylamide Polymers 0.000 claims description 2
- 229920002647 polyamide Polymers 0.000 claims description 2
- 229920000867 polyelectrolyte Polymers 0.000 claims description 2
- 229920000193 polymethacrylate Polymers 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 229920001451 polypropylene glycol Polymers 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- 229920002689 polyvinyl acetate Polymers 0.000 claims description 2
- 239000011118 polyvinyl acetate Substances 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 2
- 235000013024 sodium fluoride Nutrition 0.000 claims description 2
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 2
- RCIVOBGSMSSVTR-UHFFFAOYSA-L stannous sulfate Chemical compound [SnH2+2].[O-]S([O-])(=O)=O RCIVOBGSMSSVTR-UHFFFAOYSA-L 0.000 claims description 2
- 229940007163 stannous tartrate Drugs 0.000 claims description 2
- 229910000375 tin(II) sulfate Inorganic materials 0.000 claims description 2
- 235000015424 sodium Nutrition 0.000 claims 1
- 150000003839 salts Chemical class 0.000 abstract description 37
- 239000003795 chemical substances by application Substances 0.000 abstract description 30
- 235000019606 astringent taste Nutrition 0.000 abstract description 24
- 230000008901 benefit Effects 0.000 abstract description 23
- 230000009467 reduction Effects 0.000 abstract description 23
- 230000002829 reductive effect Effects 0.000 abstract description 21
- 208000006558 Dental Calculus Diseases 0.000 abstract description 17
- 229910019142 PO4 Inorganic materials 0.000 abstract description 14
- 230000009977 dual effect Effects 0.000 abstract description 14
- 230000015572 biosynthetic process Effects 0.000 abstract description 13
- 239000010452 phosphate Substances 0.000 abstract description 11
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract description 9
- 208000002925 dental caries Diseases 0.000 abstract description 8
- 230000006872 improvement Effects 0.000 abstract description 8
- 208000002064 Dental Plaque Diseases 0.000 abstract description 7
- 206010044029 Tooth deposit Diseases 0.000 abstract description 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract description 5
- 230000012010 growth Effects 0.000 abstract description 5
- 206010020751 Hypersensitivity Diseases 0.000 abstract description 4
- 208000026935 allergic disease Diseases 0.000 abstract description 4
- 230000009610 hypersensitivity Effects 0.000 abstract description 4
- 230000004060 metabolic process Effects 0.000 abstract description 4
- 208000028169 periodontal disease Diseases 0.000 abstract description 4
- 239000000551 dentifrice Substances 0.000 description 56
- 238000009472 formulation Methods 0.000 description 45
- 230000000694 effects Effects 0.000 description 35
- 229940091249 fluoride supplement Drugs 0.000 description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 31
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical class [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 28
- 230000027455 binding Effects 0.000 description 23
- 239000000243 solution Substances 0.000 description 20
- 235000011180 diphosphates Nutrition 0.000 description 18
- 239000004615 ingredient Substances 0.000 description 18
- 239000002738 chelating agent Substances 0.000 description 15
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 15
- 239000000047 product Substances 0.000 description 14
- 210000000214 mouth Anatomy 0.000 description 13
- 235000021317 phosphate Nutrition 0.000 description 13
- 230000036344 tooth staining Effects 0.000 description 13
- 229910052783 alkali metal Inorganic materials 0.000 description 12
- 230000002272 anti-calculus Effects 0.000 description 12
- 150000001875 compounds Chemical class 0.000 description 11
- 239000000126 substance Substances 0.000 description 11
- 235000001465 calcium Nutrition 0.000 description 10
- 150000002978 peroxides Chemical class 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
- 238000011282 treatment Methods 0.000 description 10
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 9
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- 239000003082 abrasive agent Substances 0.000 description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- 239000004599 antimicrobial Substances 0.000 description 8
- 239000000499 gel Substances 0.000 description 8
- 238000005498 polishing Methods 0.000 description 8
- 238000011105 stabilization Methods 0.000 description 8
- 239000000606 toothpaste Substances 0.000 description 8
- 229920006318 anionic polymer Polymers 0.000 description 7
- 238000000338 in vitro Methods 0.000 description 7
- 230000006641 stabilisation Effects 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical class [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 238000002835 absorbance Methods 0.000 description 6
- 230000009471 action Effects 0.000 description 6
- 125000000129 anionic group Chemical group 0.000 description 6
- 238000013459 approach Methods 0.000 description 6
- 238000003556 assay Methods 0.000 description 6
- 230000001680 brushing effect Effects 0.000 description 6
- 125000004432 carbon atom Chemical group C* 0.000 description 6
- 230000009920 chelation Effects 0.000 description 6
- 210000003298 dental enamel Anatomy 0.000 description 6
- UPBDXRPQPOWRKR-UHFFFAOYSA-N furan-2,5-dione;methoxyethene Chemical compound COC=C.O=C1OC(=O)C=C1 UPBDXRPQPOWRKR-UHFFFAOYSA-N 0.000 description 6
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 6
- ZTWTYVWXUKTLCP-UHFFFAOYSA-N vinylphosphonic acid Chemical compound OP(O)(=O)C=C ZTWTYVWXUKTLCP-UHFFFAOYSA-N 0.000 description 6
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 5
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- 239000001506 calcium phosphate Substances 0.000 description 5
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- 238000004140 cleaning Methods 0.000 description 5
- 238000010668 complexation reaction Methods 0.000 description 5
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- 229910021645 metal ion Inorganic materials 0.000 description 5
- 210000003296 saliva Anatomy 0.000 description 5
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 5
- 235000019832 sodium triphosphate Nutrition 0.000 description 5
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 5
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- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 4
- 239000002280 amphoteric surfactant Substances 0.000 description 4
- 150000001450 anions Chemical class 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 230000002882 anti-plaque Effects 0.000 description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical class OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 4
- 239000011230 binding agent Substances 0.000 description 4
- 229910000389 calcium phosphate Inorganic materials 0.000 description 4
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- 235000011187 glycerol Nutrition 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
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- 239000002736 nonionic surfactant Substances 0.000 description 4
- 239000013588 oral product Substances 0.000 description 4
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- 239000013641 positive control Substances 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
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- 229940034610 toothpaste Drugs 0.000 description 4
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- 239000011576 zinc lactate Substances 0.000 description 4
- 229940050168 zinc lactate Drugs 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000005711 Benzoic acid Chemical class 0.000 description 3
- 239000002028 Biomass Substances 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical class [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
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- BRMSVEGRHOZCAM-UHFFFAOYSA-M sodium;2-dodecanoyloxyethanesulfonate Chemical compound [Na+].CCCCCCCCCCCC(=O)OCCS([O-])(=O)=O BRMSVEGRHOZCAM-UHFFFAOYSA-M 0.000 description 1
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 235000011150 stannous chloride Nutrition 0.000 description 1
- SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000012209 synthetic fiber Substances 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 229920002803 thermoplastic polyurethane Polymers 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- VVGOCOMZRGWHPI-UHFFFAOYSA-N trans-hept-4-enal Natural products CCC=CCCC=O VVGOCOMZRGWHPI-UHFFFAOYSA-N 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
- VSJRDSLPNMGNFG-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate;trihydrate Chemical compound O.O.O.[Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O VSJRDSLPNMGNFG-UHFFFAOYSA-H 0.000 description 1
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 235000004416 zinc carbonate Nutrition 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
- 235000006076 zinc citrate Nutrition 0.000 description 1
- 229940068475 zinc citrate Drugs 0.000 description 1
- 229940085658 zinc citrate trihydrate Drugs 0.000 description 1
- 150000003752 zinc compounds Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8164—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0063—Periodont
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2006/053598 WO2008041055A1 (fr) | 2006-10-02 | 2006-10-02 | Compositions d'hygiène buccale stanneuses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2663913A1 true CA2663913A1 (fr) | 2008-04-10 |
Family
ID=38066388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002663913A Abandoned CA2663913A1 (fr) | 2006-10-02 | 2006-10-02 | Compositions d'hygiene buccale stanneuses |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP2068814A1 (fr) |
| JP (1) | JP2010505760A (fr) |
| CN (1) | CN101511327A (fr) |
| AU (1) | AU2006349144C1 (fr) |
| BR (1) | BRPI0622151B1 (fr) |
| CA (1) | CA2663913A1 (fr) |
| MX (1) | MX2009003557A (fr) |
| RU (1) | RU2469700C2 (fr) |
| WO (1) | WO2008041055A1 (fr) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10350151B2 (en) | 2014-12-26 | 2019-07-16 | Colgate-Palmolive Company | Zinc phosphate complex |
| US11213466B2 (en) | 2014-12-26 | 2022-01-04 | Colgate-Palmolive Company | Personal care compositions with zinc phosphate active |
| US11690791B2 (en) | 2014-12-26 | 2023-07-04 | Colgate-Palmolive Company | Zinc phosphate complex |
| US12005076B2 (en) | 2014-12-26 | 2024-06-11 | Colgate-Palmolive Company | Zinc phosphate complex |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0921830A8 (pt) * | 2008-11-25 | 2017-02-14 | Procter & Gamble | Composição para tratamento bucal compreendendo sílica fundida |
| JP5448531B2 (ja) * | 2009-03-31 | 2014-03-19 | サンスター株式会社 | 多価金属化合物含有口腔用組成物 |
| EP2435013B1 (fr) | 2009-05-26 | 2019-07-24 | Colgate-Palmolive Company | Composition de dentifrice |
| TWI442937B (zh) | 2009-05-26 | 2014-07-01 | Colgate Palmolive Co | 較高含量的含鋅薄膜 |
| TWI396554B (zh) * | 2009-05-26 | 2013-05-21 | Colgate Palmolive Co | 增進可溶性鋅的量之口腔保健調配物 |
| JP5764865B2 (ja) * | 2009-09-04 | 2015-08-19 | ライオン株式会社 | 練歯磨剤組成物 |
| AU2009354789B2 (en) | 2009-10-29 | 2013-06-13 | Colgate-Palmolive Company | Dentifrice comprising stannous fluoride plus zinc citrate and low levels of water |
| SG182422A1 (en) * | 2010-01-29 | 2012-08-30 | Colgate Palmolive Co | Oral care product for sensitive enamel care |
| CA2787393C (fr) | 2010-01-29 | 2015-05-05 | Colgate-Palmolive Company | Produit d'hygiene buccale pour email sensible |
| PL2374446T3 (pl) * | 2010-04-07 | 2013-08-30 | Gaba Int Holding Ag | Kompozycja do pielęgnacji jamy ustnej zawierająca jony cynawe i azotanowe |
| BR112014000423B1 (pt) | 2011-07-12 | 2018-10-09 | Unilever Nv | "composição de pasta dental, método para melhorar a higiene oral e uso de uma composição de pasta dental" |
| US9877929B2 (en) | 2011-10-13 | 2018-01-30 | Premier Dental Products Company | Topical vitamin D and ubiquinol oral supplement compositions |
| US9877930B2 (en) | 2012-10-12 | 2018-01-30 | Premier Dental Products Company | Topical ubiquinol oral supplement compositions with amorphous calcium phosphate |
| WO2015157683A1 (fr) * | 2014-04-11 | 2015-10-15 | Premier Dental Products Company | Pâte dentifrice pour la protection et la réparation de l'émail |
| BR112015015084B1 (pt) * | 2012-12-21 | 2019-04-02 | Gaba International Holding Ag | Composição para cuidado oral e usos de fluoreto de amina e polímero ácido |
| AU2012398399B2 (en) * | 2012-12-24 | 2015-11-19 | Colgate-Palmolive Company | Oral care composition |
| AU2013408261B2 (en) * | 2013-12-20 | 2016-12-15 | Colgate-Palmolive Company | Oral care compositions and methods |
| AU2013408265B2 (en) * | 2013-12-20 | 2016-12-15 | Colgate-Palmolive Company | Oral care compositions and methods |
| US9931291B2 (en) * | 2013-12-20 | 2018-04-03 | Colgate-Palmolive Company | Oral care compositions and methods |
| AU2013408266B2 (en) * | 2013-12-20 | 2016-12-15 | Colgate-Palmolive Company | Oral care compositions and methods |
| MX364737B (es) | 2014-05-07 | 2019-05-03 | Procter & Gamble | Composiciones para el cuidado bucal. |
| WO2015168877A1 (fr) | 2014-05-07 | 2015-11-12 | The Procter & Gamble Company | Compositions de soin bucco-dentaire |
| WO2015171836A1 (fr) | 2014-05-09 | 2015-11-12 | The Procter & Gamble Company | Compositions buccales contenant des composés stanneux |
| DE102014209069A1 (de) * | 2014-05-14 | 2015-11-19 | Henkel Ag & Co. Kgaa | Mund- und Zahnpflege- und -reinigungsmittel zur Verringerung der Verfärbung von Zähnen |
| BR112016026030B1 (pt) | 2014-05-15 | 2020-07-14 | The Procter & Gamble Company | Composições dentifrícias com conservantes otimizados e método de tratamento do esmalte dental |
| WO2015172354A1 (fr) | 2014-05-15 | 2015-11-19 | The Procter & Gamble Company | Compositions de dentifrice permettant d'améliorer la stabilité des ions fluorure ou l'absorption de fluorure |
| ES2686269T3 (es) | 2014-05-15 | 2018-10-17 | The Procter & Gamble Company | Composiciones para el cuidado bucal que contienen polietilenglicol para la estabilidad física |
| WO2015172345A1 (fr) | 2014-05-15 | 2015-11-19 | The Procter & Gamble Company | Compositions de soin buccal contenant du polyéthylène-glycol pour leur stabilité physique |
| WO2015172348A1 (fr) | 2014-05-15 | 2015-11-19 | The Procter & Gamble Company | Compositions de dentifrice réduisant la plaque dentaire ou présentant une meilleure capture de l'ion fluorure |
| JP5764712B1 (ja) * | 2014-12-16 | 2015-08-19 | 株式会社松風 | 歯質再生剤 |
| EP3221008B1 (fr) | 2014-12-18 | 2020-05-13 | GABA International Holding GmbH | Formulations d'eau dentaire |
| US9354219B1 (en) | 2014-12-23 | 2016-05-31 | Colgate-Palmolive Company | Detecting stannous ions |
| US9625449B2 (en) | 2014-12-23 | 2017-04-18 | Colgate-Palmolive Company | Determining the bioavailability of zinc (II) ions |
| US9435745B2 (en) | 2014-12-23 | 2016-09-06 | Colgate-Palmolive Company | Measuring the rate of release of metal ions |
| BR112018008196B1 (pt) * | 2015-11-13 | 2021-05-04 | The Procter & Gamble Company | composições dentifrícias com benefícios antitártaro e antibacterianos |
| KR20180124132A (ko) | 2016-03-29 | 2018-11-20 | 세이프화이트 인코포레이티드 | 치아 및 치아 구성요소의 미백을 위한 고분자 전해질 치과용 접착제 |
| MX2018014969A (es) | 2016-06-24 | 2019-04-25 | Colgate Palmolive Co | Una composicion para el cuidado bucal. |
| EP3481368A1 (fr) * | 2016-08-11 | 2019-05-15 | Colgate-Palmolive Company | Compositions de soins buccaux |
| WO2018118141A1 (fr) * | 2016-12-21 | 2018-06-28 | Colgate-Palmolive Company | Compositions de soins buccaux |
| JP7273805B2 (ja) * | 2017-09-29 | 2023-05-15 | スリーエム イノベイティブ プロパティズ カンパニー | 水性口腔ケアフッ化物処置組成物、及び方法 |
| BR112020010126A2 (pt) * | 2017-12-11 | 2020-10-13 | The Procter & Gamble Company | composições para tratamento bucal que compreendem fosfono-fosfato e polímeros contendo grupo aniônico |
| WO2019118414A1 (fr) * | 2017-12-11 | 2019-06-20 | The Procter & Gamble Company | Compositions de soins buccodentaires comprenant des polymères contenant un phosphonate et un groupe anionique |
| CN112135668B (zh) * | 2018-05-14 | 2024-01-02 | 宝洁公司 | 包含金属离子的口腔护理组合物 |
| US11911492B2 (en) | 2018-05-14 | 2024-02-27 | The Procter & Gamble Company | Oral care compositions comprising metal ions |
| BR112021011748A2 (pt) * | 2018-12-26 | 2021-08-31 | Colgate-Palmolive Company | Métodos de indução de siga e mucina 5b na cavidade oral |
| CN113747948B (zh) * | 2019-04-26 | 2023-12-15 | 宝洁公司 | 减少来源于阳离子抗微生物剂的牙齿变色 |
| US11696881B2 (en) | 2019-09-30 | 2023-07-11 | The Procter & Gamble Company | Oral care compositions comprising hops beta acids and fluoride ions |
| WO2021062607A1 (fr) | 2019-09-30 | 2021-04-08 | The Procter & Gamble Company | Compositions de soin buccal comprenant un bêta acide et un acide aminé hops |
| GB202117188D0 (en) * | 2021-11-29 | 2022-01-12 | GlaxoSmithKline Consumer Healthcare UK IP Ltd | Non-aqueous dentifrice composition |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE638714A (fr) * | 1958-05-29 | |||
| JPS5846483B2 (ja) * | 1979-09-20 | 1983-10-17 | ライオン株式会社 | 口腔用組成物 |
| AU648040B2 (en) * | 1989-11-15 | 1994-04-14 | Gillette Canada Inc. | Stabilized stannous fluoride compositions for oral care |
| US5017363A (en) * | 1989-11-15 | 1991-05-21 | Gillette Canada, Inc. | Stabilized stannous fluoride toothpaste |
| US5015466A (en) * | 1990-06-26 | 1991-05-14 | The Procter & Gamble Company | Anticalculus compositions using tartrate-succinates |
| CA2169460C (fr) * | 1993-09-16 | 1999-07-20 | Janet Grigor | Compositions orales renfermant des composes stanneux |
| US6187295B1 (en) * | 1996-11-21 | 2001-02-13 | The Procter & Gamble Company | Methods of reducing the astringency of stannous in dentifrice compositions |
| WO2001034108A1 (fr) * | 1999-11-12 | 2001-05-17 | The Procter & Gamble Company | Compositions buccales ameliorees contenant des sels d'etain |
| US6685920B2 (en) * | 1999-11-12 | 2004-02-03 | The Procter & Gamble Company | Method of protecting teeth against erosion |
| EP1387662B1 (fr) * | 2001-05-15 | 2006-10-04 | The Procter & Gamble Company | Compositions d'hygiene buccale |
| CN1286448C (zh) * | 2001-11-28 | 2006-11-29 | 宝洁公司 | 包括稳定的包括聚磷酸盐和离子活性成分的低含水量相的洁齿剂组合物 |
-
2006
- 2006-10-02 CA CA002663913A patent/CA2663913A1/fr not_active Abandoned
- 2006-10-02 WO PCT/IB2006/053598 patent/WO2008041055A1/fr active Application Filing
- 2006-10-02 MX MX2009003557A patent/MX2009003557A/es active IP Right Grant
- 2006-10-02 RU RU2009111321/15A patent/RU2469700C2/ru not_active IP Right Cessation
- 2006-10-02 BR BRPI0622151-3A patent/BRPI0622151B1/pt active IP Right Grant
- 2006-10-02 AU AU2006349144A patent/AU2006349144C1/en active Active
- 2006-10-02 CN CNA2006800558505A patent/CN101511327A/zh active Pending
- 2006-10-02 EP EP06809475A patent/EP2068814A1/fr not_active Withdrawn
- 2006-10-02 JP JP2009529784A patent/JP2010505760A/ja active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10350151B2 (en) | 2014-12-26 | 2019-07-16 | Colgate-Palmolive Company | Zinc phosphate complex |
| US11213466B2 (en) | 2014-12-26 | 2022-01-04 | Colgate-Palmolive Company | Personal care compositions with zinc phosphate active |
| US11344486B2 (en) | 2014-12-26 | 2022-05-31 | Colgate-Palmolive Company | Zinc phosphate complex |
| US11690791B2 (en) | 2014-12-26 | 2023-07-04 | Colgate-Palmolive Company | Zinc phosphate complex |
| US12005076B2 (en) | 2014-12-26 | 2024-06-11 | Colgate-Palmolive Company | Zinc phosphate complex |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2469700C2 (ru) | 2012-12-20 |
| AU2006349144C1 (en) | 2013-10-31 |
| CN101511327A (zh) | 2009-08-19 |
| BRPI0622151A2 (pt) | 2014-07-08 |
| AU2006349144A1 (en) | 2008-04-10 |
| MX2009003557A (es) | 2009-04-15 |
| BRPI0622151B1 (pt) | 2022-06-07 |
| WO2008041055A1 (fr) | 2008-04-10 |
| JP2010505760A (ja) | 2010-02-25 |
| RU2009111321A (ru) | 2010-11-10 |
| EP2068814A1 (fr) | 2009-06-17 |
| AU2006349144B2 (en) | 2013-06-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20130906 |