CA2663323A1 - Formulations for therapeutic administration of thyroid stimulating hormone (tsh) - Google Patents
Formulations for therapeutic administration of thyroid stimulating hormone (tsh) Download PDFInfo
- Publication number
- CA2663323A1 CA2663323A1 CA002663323A CA2663323A CA2663323A1 CA 2663323 A1 CA2663323 A1 CA 2663323A1 CA 002663323 A CA002663323 A CA 002663323A CA 2663323 A CA2663323 A CA 2663323A CA 2663323 A1 CA2663323 A1 CA 2663323A1
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- Prior art keywords
- tsh
- pharmaceutical composition
- patient
- rhtsh
- pharmaceutically
- Prior art date
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- 229940126534 drug product Drugs 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 230000003325 follicular Effects 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- 150000004688 heptahydrates Chemical class 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000002657 hormone replacement therapy Methods 0.000 description 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 229960001078 lithium Drugs 0.000 description 1
- 238000011551 log transformation method Methods 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 239000008176 lyophilized powder Substances 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000006984 memory degeneration Effects 0.000 description 1
- 208000023060 memory loss Diseases 0.000 description 1
- 230000003821 menstrual periods Effects 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 238000009206 nuclear medicine Methods 0.000 description 1
- 230000027758 ovulation cycle Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000001698 pyrogenic effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 229960002175 thyroglobulin Drugs 0.000 description 1
- 230000001971 thyroidal effect Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Anesthesiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84607706P | 2006-09-19 | 2006-09-19 | |
| US60/846,077 | 2006-09-19 | ||
| PCT/US2007/020221 WO2008036271A1 (en) | 2006-09-19 | 2007-09-18 | Formulations for therapeutic administration of thyroid stimulating hormone (tsh) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2663323A1 true CA2663323A1 (en) | 2008-03-27 |
Family
ID=39018092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002663323A Abandoned CA2663323A1 (en) | 2006-09-19 | 2007-09-18 | Formulations for therapeutic administration of thyroid stimulating hormone (tsh) |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20100048455A1 (enExample) |
| EP (1) | EP2063909B1 (enExample) |
| JP (1) | JP2010503689A (enExample) |
| AR (1) | AR062894A1 (enExample) |
| BR (1) | BRPI0717077A2 (enExample) |
| CA (1) | CA2663323A1 (enExample) |
| DK (1) | DK2063909T3 (enExample) |
| ES (1) | ES2396502T3 (enExample) |
| MX (1) | MX2009002985A (enExample) |
| PL (1) | PL2063909T3 (enExample) |
| PT (1) | PT2063909E (enExample) |
| SI (1) | SI2063909T1 (enExample) |
| WO (1) | WO2008036271A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2793948B1 (en) * | 2011-12-19 | 2022-03-23 | Genzyme Corporation | Thyroid stimulating hormone compositions |
| ES2947985T3 (es) * | 2017-12-14 | 2023-08-25 | The London Psychiatry Centre | Tratamiento de la depresión resistente mediante la aplicación de estimulación magnética transcraneal repetitiva con tratamiento con hormona tiroidea |
| CN113740523A (zh) * | 2021-09-14 | 2021-12-03 | 首都医科大学附属北京朝阳医院 | 一种基于量值溯源的tsh多系统赋值方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0228604A3 (en) * | 1985-12-11 | 1988-10-12 | Sloan-Kettering Institute For Cancer Research | Isolation of a gene encoding human thyrotropin beta subunit |
| US5595756A (en) * | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| US5968895A (en) * | 1996-12-11 | 1999-10-19 | Praecis Pharmaceuticals, Inc. | Pharmaceutical formulations for sustained drug delivery |
| KR100642599B1 (ko) * | 1997-09-22 | 2006-11-10 | 유니버시티 어브 메릴랜드, 발티모어 | 갑상선 자극 호르몬의 변이체 및 이에 근거한 방법 |
| CN1321092A (zh) * | 1998-06-30 | 2001-11-07 | 安姆根有限公司 | 用于生物活性剂的延缓给药的热敏生物可降解水凝胶 |
| ITMI20011401A1 (it) * | 2001-07-02 | 2003-01-02 | Altergon Sa | Formulazioni farmaceutiche per ormoni tiroidei |
| US20080167223A1 (en) * | 2004-04-16 | 2008-07-10 | Mount Sinai School Of Medicine | Methods and Compositions for Using Tsh in the Inhibition of Tnf Activity |
-
2007
- 2007-09-18 ES ES07838433T patent/ES2396502T3/es active Active
- 2007-09-18 EP EP07838433A patent/EP2063909B1/en not_active Not-in-force
- 2007-09-18 CA CA002663323A patent/CA2663323A1/en not_active Abandoned
- 2007-09-18 DK DK07838433.6T patent/DK2063909T3/da active
- 2007-09-18 PT PT78384336T patent/PT2063909E/pt unknown
- 2007-09-18 MX MX2009002985A patent/MX2009002985A/es active IP Right Grant
- 2007-09-18 SI SI200731102T patent/SI2063909T1/sl unknown
- 2007-09-18 PL PL07838433T patent/PL2063909T3/pl unknown
- 2007-09-18 US US12/441,836 patent/US20100048455A1/en not_active Abandoned
- 2007-09-18 BR BRPI0717077-7A patent/BRPI0717077A2/pt active Search and Examination
- 2007-09-18 JP JP2009528340A patent/JP2010503689A/ja active Pending
- 2007-09-18 WO PCT/US2007/020221 patent/WO2008036271A1/en not_active Ceased
- 2007-09-19 AR ARP070104133A patent/AR062894A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2396502T3 (es) | 2013-02-22 |
| JP2010503689A (ja) | 2010-02-04 |
| SI2063909T1 (sl) | 2013-02-28 |
| EP2063909B1 (en) | 2012-10-24 |
| US20100048455A1 (en) | 2010-02-25 |
| MX2009002985A (es) | 2009-04-01 |
| DK2063909T3 (da) | 2013-01-02 |
| BRPI0717077A2 (pt) | 2013-11-26 |
| AR062894A1 (es) | 2008-12-10 |
| PT2063909E (pt) | 2013-01-15 |
| EP2063909A1 (en) | 2009-06-03 |
| WO2008036271A1 (en) | 2008-03-27 |
| PL2063909T3 (pl) | 2013-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Dead |
Effective date: 20150203 |