CA2655205A1 - Pan-cell surface receptor- specific therapeutics - Google Patents
Pan-cell surface receptor- specific therapeutics Download PDFInfo
- Publication number
- CA2655205A1 CA2655205A1 CA002655205A CA2655205A CA2655205A1 CA 2655205 A1 CA2655205 A1 CA 2655205A1 CA 002655205 A CA002655205 A CA 002655205A CA 2655205 A CA2655205 A CA 2655205A CA 2655205 A1 CA2655205 A1 CA 2655205A1
- Authority
- CA
- Canada
- Prior art keywords
- ecd
- domain
- receptor
- polypeptide
- multimer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pain & Pain Management (AREA)
- Microbiology (AREA)
- Cardiology (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Plant Pathology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81326006P | 2006-06-12 | 2006-06-12 | |
| US60/813,260 | 2006-06-12 | ||
| US84854206P | 2006-09-29 | 2006-09-29 | |
| US60/848,542 | 2006-09-29 | ||
| US87894107P | 2007-01-05 | 2007-01-05 | |
| US60/878,941 | 2007-01-05 | ||
| PCT/US2007/071041 WO2007146959A2 (en) | 2006-06-12 | 2007-06-12 | Pan-cell surface receptor- specific therapeutics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2655205A1 true CA2655205A1 (en) | 2007-12-21 |
Family
ID=38832799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002655205A Abandoned CA2655205A1 (en) | 2006-06-12 | 2007-06-12 | Pan-cell surface receptor- specific therapeutics |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20100055093A1 (enExample) |
| EP (1) | EP2044115A2 (enExample) |
| JP (1) | JP2009539412A (enExample) |
| KR (1) | KR20090031897A (enExample) |
| AU (1) | AU2007257683A1 (enExample) |
| BR (1) | BRPI0713272A2 (enExample) |
| CA (1) | CA2655205A1 (enExample) |
| IL (1) | IL195909A0 (enExample) |
| NZ (1) | NZ574093A (enExample) |
| SG (1) | SG172692A1 (enExample) |
| WO (1) | WO2007146959A2 (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008312580A1 (en) * | 2007-10-16 | 2009-04-23 | Symphogen A/S | Compositions comprising optimized Her1 and Her3 multimers and methods of use thereof |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| JP2010006705A (ja) * | 2008-06-13 | 2010-01-14 | Atlas Antibodies Ab | Her2サブセット |
| US9198952B2 (en) | 2008-09-22 | 2015-12-01 | The Brigham And Women's Hospital, Inc. | Compositions of and methods of using ligand dimers |
| WO2010040029A1 (en) * | 2008-10-02 | 2010-04-08 | Celtaxsys, Inc. | Methods of modulating the negative chemotaxis of immune cells |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| RU2012105766A (ru) * | 2009-07-28 | 2013-09-10 | Лигацепт, Лимитед Лиабилити Компани | МОЛЕКУЛЫ, СВЯЗЫВАЮЩИЕ ШИРОКИЙ СПЕКТР ЛИГАНДОВ ErbB И СПОСОБЫ ИХ ПРИГОТОВЛЕНИЯ И ИСПОЛЬЗОВАНИЯ |
| ES2691717T3 (es) | 2009-10-30 | 2018-11-28 | Novartis Ag | Bibliotecas universales del dominio de unión del lado inferior de tipo iii de la fibronectina de tipo III |
| WO2011060242A2 (en) | 2009-11-13 | 2011-05-19 | Talecris Biotherapeutics, Inc. | Von willebrand factor (vwf)-containing preparations, and methods, kits, and uses related thereto |
| US9556249B2 (en) | 2010-02-18 | 2017-01-31 | Genentech, Inc. | Neuregulin antagonists and use thereof in treating cancer |
| WO2011119836A1 (en) | 2010-03-24 | 2011-09-29 | Massachusetts Institute Of Technology | Methods and compositions for cardioprotection and cardioregeneration |
| CN107903321A (zh) | 2010-07-30 | 2018-04-13 | 诺华有限公司 | 纤连蛋白摇篮分子和其库 |
| AU2011290672B2 (en) | 2010-08-20 | 2015-07-09 | Novartis Ag | Antibodies for epidermal growth factor receptor 3 (HER3) |
| EP2625196B1 (en) * | 2010-10-05 | 2016-03-23 | Kemijski Institut | Fusion polypeptides comprising tir and dimerization domain for modulation of tlr/innate immunity signaling |
| WO2012103114A2 (en) * | 2011-01-24 | 2012-08-02 | Jason Hill | Therapeutic chimeric ligand binding proteins and methods for their use |
| MX342034B (es) | 2011-02-28 | 2016-09-12 | Hoffmann La Roche | Proteinas monovalentes que se unen a antigenos. |
| AR085404A1 (es) | 2011-02-28 | 2013-09-25 | Hoffmann La Roche | Proteinas de union a antigeno |
| CN102219860B (zh) * | 2011-05-20 | 2012-09-12 | 烟台荣昌生物工程有限公司 | FGFR-Fc融合蛋白及其用途 |
| CN102219859B (zh) * | 2011-05-20 | 2012-09-12 | 烟台荣昌生物工程有限公司 | 拮抗血管新生诱导因子的融合蛋白及其用途 |
| WO2012162418A1 (en) * | 2011-05-23 | 2012-11-29 | The University Of North Carolina At Chapel Hill | Methods and compositions for heterodimeric targeting ligands |
| KR101397088B1 (ko) | 2011-06-10 | 2014-05-19 | 강원대학교산학협력단 | 암세포 증식 억제와 혈관신생 억제를 위한 융합 단백질 및 이를 포함한 항암 조성물 |
| WO2012169822A2 (ko) * | 2011-06-10 | 2012-12-13 | 강원대학교산학협력단 | 암세포 증식 억제와 혈관신생 억제를 위한 융합 단백질 및 이를 포함한 항암 조성물 |
| WO2013003647A2 (en) | 2011-06-28 | 2013-01-03 | Sea Lane Biotechnologies, Llc | Multispecific stacked variable domain binding proteins |
| JP2013040148A (ja) * | 2011-08-19 | 2013-02-28 | Asahi Kasei Corp | シアリルオリゴ糖ペプチド固定化ビーズ |
| ES2670651T3 (es) * | 2011-10-04 | 2018-05-31 | Expression Pathology, Inc. | Ensayo de SRM/MRM para determinar la proteína ERBB-4 del receptor de tirosina-proteína quinasa (HER4) |
| JP2015504038A (ja) | 2011-10-31 | 2015-02-05 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 低減した免疫原性を有するフィブロネクチン結合ドメイン |
| CN104105709A (zh) * | 2011-12-05 | 2014-10-15 | 诺华股份有限公司 | 抗her3的结构域ii的表皮生长因子受体3(her3)抗体 |
| EP3590538A1 (en) | 2011-12-05 | 2020-01-08 | Novartis AG | Antibodies for epidermal growth factor receptor 3 (her3) |
| WO2013110030A2 (en) | 2012-01-19 | 2013-07-25 | Duke University | Vaccines against antigens involved in therapy resistance and methods of using same |
| JP6224077B2 (ja) | 2012-04-17 | 2017-11-01 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 改変された核酸を用いてポリペプチドを発現させるための方法 |
| MX2014014162A (es) | 2012-05-24 | 2015-02-04 | Hoffmann La Roche | Anticuerpos multiespecificos. |
| EP2727941A1 (en) | 2012-11-05 | 2014-05-07 | MAB Discovery GmbH | Method for the production of multispecific antibodies |
| EP2914629A1 (en) | 2012-11-05 | 2015-09-09 | MAB Discovery GmbH | Method for the production of multispecific antibodies |
| EP2727943A1 (en) | 2012-11-05 | 2014-05-07 | MAB Discovery GmbH | Trispecific antibodies against human EGFR, HER2 and HER3 |
| EP2727942A1 (en) | 2012-11-05 | 2014-05-07 | MAB Discovery GmbH | Bispecific antibodies against human EGFR, HER2, and HER3 |
| AR093778A1 (es) | 2012-11-08 | 2015-06-24 | Hoffmann La Roche | PROTEINAS LIGANTES DE ANTIGENO ANTI-HER3/HER4 DE UNION A LA HORQUILLA b DE HER3 Y A LA HORQUILLA b DE HER4 |
| MA38165A1 (fr) | 2012-11-08 | 2018-07-31 | Hoffmann La Roche | Protéines de liaison à l'antigène her3 se liant à l'épingle à cheveux beta de her3 |
| EP3711484A1 (en) * | 2013-07-05 | 2020-09-23 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Soluble cd33 for treating myelodysplastic syndromes (mds) |
| BR112016006929A2 (pt) | 2013-10-11 | 2017-09-19 | Hoffmann La Roche | Anticorpo, ácido nucleico, vetor de expressão, célula hospedeira, métodos de preparação de anticorpo, de tratamento de pacientes e de geração de um anticorpo, composição farmacêutica e uso do anticorpo |
| JPWO2015099197A1 (ja) * | 2013-12-25 | 2017-03-23 | 国立大学法人佐賀大学 | 肺癌の検査方法 |
| US20160331853A1 (en) * | 2014-01-21 | 2016-11-17 | The Trustees Of Columbia University In The City Of New York | Compositions for radiotherapy and uses thereof |
| MX2016014416A (es) | 2014-05-14 | 2017-02-23 | Hoffmann La Roche | Anticuerpos anti-her3 que se unen a la horquilla beta de her3. |
| EP3166646A4 (en) | 2014-07-07 | 2018-03-07 | Duke University | Vaccines against an oncogenic isoform of her2 (erbb2) and methods of using the same |
| CA2954279C (en) | 2014-07-07 | 2023-11-14 | Duke University | Vaccines against an oncogenic isoform of esr1 and methods of using the same |
| WO2016011343A1 (en) * | 2014-07-17 | 2016-01-21 | The Trustees Of The University Of Pennsylvania | Her3 peptides and dendritic cell vaccines |
| WO2017003908A1 (en) | 2015-06-30 | 2017-01-05 | The Trustees Of Columbia University In The City Of New York | Talc-bound compositions and uses thereof |
| US11253580B2 (en) | 2016-01-07 | 2022-02-22 | Duke University | Cancer vaccines and methods of delivery |
| WO2018022929A1 (en) * | 2016-07-27 | 2018-02-01 | The Trustees Of Columbia University In The City Of New York | Gel-bound compositions for radiotherapy and uses thereof |
| US11224665B2 (en) | 2016-10-05 | 2022-01-18 | Duke University | Mitochondrial antiviral signaling (MAVS) protein compositions and methods of using the same |
| US10487143B2 (en) | 2016-10-05 | 2019-11-26 | Duke University | Vaccines against HER3 antigens and methods of using the same |
| EP3568474A1 (en) | 2017-01-10 | 2019-11-20 | Intrexon Corporation | Modulating expression of polypeptides via new gene switch expression systems |
| US11617797B2 (en) | 2017-04-28 | 2023-04-04 | David T. Tran | Multi-targeted multi-valent ligand drug particles for the treatment and prevention of diseases and conditions |
| CA3065930A1 (en) | 2017-06-07 | 2018-12-13 | Intrexon Corporation | Expression of novel cell tags |
| CN111406071B (zh) * | 2017-11-16 | 2024-01-16 | 成都硕德药业有限公司 | Pas化的vegfr/pdgfr融合蛋白及其在治疗中的用途 |
| US11548931B2 (en) | 2017-11-16 | 2023-01-10 | Xl-Protein Gmbh | PASylated VEGFR/PDGFR fusion proteins and their use in therapy |
| US20210346484A1 (en) * | 2017-12-11 | 2021-11-11 | Medizinische Universitaet Wien | Method of producing a vaccine composition and uses thereof |
| AR121035A1 (es) * | 2019-04-01 | 2022-04-13 | Lilly Co Eli | Compuestos de neuregulina-4 y métodos de uso |
| JP2022540245A (ja) * | 2019-07-11 | 2022-09-14 | ザ クリーヴランド クリニック ファウンデーション | モデルに基づくステントの設計及び配置のためのシステム及び方法 |
| US20210315870A1 (en) * | 2020-04-10 | 2021-10-14 | Postsurgical Therapeutics, Inc. | Combinatorial targeted therapy methods |
| US12268692B2 (en) | 2020-04-10 | 2025-04-08 | Postsurgical Therapeutics, Inc. | Combinatorial targeted therapy methods |
| CA3193273A1 (en) | 2020-08-27 | 2022-03-03 | Enosi Therapeutics Corporation | Methods and compositions to treat autoimmune diseases and cancer |
| WO2023168426A1 (en) | 2022-03-03 | 2023-09-07 | Enosi Therapeutics Corporation | Compositions and cells containing mixtures of oligo-trap fusion proteins (ofps) and uses thereof |
| WO2024186690A2 (en) | 2023-03-03 | 2024-09-12 | Enosi Therapeutics Corporation | Oligo-trap fusion proteins (ofps) and uses thereof |
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-
2007
- 2007-06-12 JP JP2009515614A patent/JP2009539412A/ja not_active Withdrawn
- 2007-06-12 EP EP07784419A patent/EP2044115A2/en not_active Withdrawn
- 2007-06-12 WO PCT/US2007/071041 patent/WO2007146959A2/en not_active Ceased
- 2007-06-12 US US12/304,467 patent/US20100055093A1/en not_active Abandoned
- 2007-06-12 BR BRPI0713272A patent/BRPI0713272A2/pt not_active IP Right Cessation
- 2007-06-12 SG SG2011041944A patent/SG172692A1/en unknown
- 2007-06-12 AU AU2007257683A patent/AU2007257683A1/en not_active Abandoned
- 2007-06-12 CA CA002655205A patent/CA2655205A1/en not_active Abandoned
- 2007-06-12 NZ NZ574093A patent/NZ574093A/en not_active IP Right Cessation
- 2007-06-12 KR KR1020097000615A patent/KR20090031897A/ko not_active Withdrawn
-
2008
- 2008-12-11 IL IL195909A patent/IL195909A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0713272A2 (pt) | 2017-05-02 |
| IL195909A0 (en) | 2011-08-01 |
| AU2007257683A1 (en) | 2007-12-21 |
| NZ574093A (en) | 2011-03-31 |
| WO2007146959A3 (en) | 2008-07-24 |
| WO2007146959A2 (en) | 2007-12-21 |
| JP2009539412A (ja) | 2009-11-19 |
| US20100055093A1 (en) | 2010-03-04 |
| EP2044115A2 (en) | 2009-04-08 |
| SG172692A1 (en) | 2011-07-28 |
| KR20090031897A (ko) | 2009-03-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20130612 |