CA2650616A1 - Hepatitis c virus infection biomarkers - Google Patents
Hepatitis c virus infection biomarkers Download PDFInfo
- Publication number
- CA2650616A1 CA2650616A1 CA002650616A CA2650616A CA2650616A1 CA 2650616 A1 CA2650616 A1 CA 2650616A1 CA 002650616 A CA002650616 A CA 002650616A CA 2650616 A CA2650616 A CA 2650616A CA 2650616 A1 CA2650616 A1 CA 2650616A1
- Authority
- CA
- Canada
- Prior art keywords
- activity
- binding
- subject
- protein
- genes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 208000010710 hepatitis C virus infection Diseases 0.000 title abstract description 12
- 239000000090 biomarker Substances 0.000 title description 4
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 392
- 238000011282 treatment Methods 0.000 claims abstract description 140
- 229960002935 telaprevir Drugs 0.000 claims abstract description 129
- 108010017101 telaprevir Proteins 0.000 claims abstract description 129
- 238000000034 method Methods 0.000 claims description 196
- 230000014509 gene expression Effects 0.000 claims description 180
- 241000711549 Hepacivirus C Species 0.000 claims description 177
- 208000015181 infectious disease Diseases 0.000 claims description 109
- -1 IFIL44L Proteins 0.000 claims description 73
- 102000014150 Interferons Human genes 0.000 claims description 67
- 108010050904 Interferons Proteins 0.000 claims description 67
- 101001082060 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 3 Proteins 0.000 claims description 62
- 102100027302 Interferon-induced protein with tetratricopeptide repeats 3 Human genes 0.000 claims description 62
- 239000003112 inhibitor Substances 0.000 claims description 57
- YMZPQKXPKZZSFV-CPWYAANMSA-N 2-[3-[(1r)-1-[(2s)-1-[(2s)-2-[(1r)-cyclohex-2-en-1-yl]-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid Chemical compound C1=C(OC)C(OC)=CC=C1CC[C@H](C=1C=C(OCC(O)=O)C=CC=1)OC(=O)[C@H]1N(C(=O)[C@@H]([C@H]2C=CCCC2)C=2C=C(OC)C(OC)=C(OC)C=2)CCCC1 YMZPQKXPKZZSFV-CPWYAANMSA-N 0.000 claims description 56
- 229940079322 interferon Drugs 0.000 claims description 48
- 101000840275 Homo sapiens Interferon alpha-inducible protein 27, mitochondrial Proteins 0.000 claims description 42
- 102100029604 Interferon alpha-inducible protein 27, mitochondrial Human genes 0.000 claims description 42
- GXAFMKJFWWBYNW-OWHBQTKESA-N 2-[3-[(1r)-1-[(2s)-1-[(2s)-3-cyclopropyl-2-(3,4,5-trimethoxyphenyl)propanoyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid Chemical compound C1=C(OC)C(OC)=CC=C1CC[C@H](C=1C=C(OCC(O)=O)C=CC=1)OC(=O)[C@H]1N(C(=O)[C@@H](CC2CC2)C=2C=C(OC)C(OC)=C(OC)C=2)CCCC1 GXAFMKJFWWBYNW-OWHBQTKESA-N 0.000 claims description 41
- 101001082058 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 2 Proteins 0.000 claims description 41
- 102100027303 Interferon-induced protein with tetratricopeptide repeats 2 Human genes 0.000 claims description 41
- 230000004044 response Effects 0.000 claims description 37
- 102100035389 2'-5'-oligoadenylate synthase 3 Human genes 0.000 claims description 33
- 101000597332 Homo sapiens 2'-5'-oligoadenylate synthase 3 Proteins 0.000 claims description 33
- 101100519283 Arabidopsis thaliana PDX13 gene Proteins 0.000 claims description 32
- 101150099040 GIP2 gene Proteins 0.000 claims description 32
- 101100218339 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) aurR1 gene Proteins 0.000 claims description 32
- 239000003814 drug Substances 0.000 claims description 29
- 229940079593 drug Drugs 0.000 claims description 26
- 230000028993 immune response Effects 0.000 claims description 26
- 108091005804 Peptidases Proteins 0.000 claims description 24
- 230000003612 virological effect Effects 0.000 claims description 24
- 102100039928 Gamma-interferon-inducible protein 16 Human genes 0.000 claims description 23
- 101000960209 Homo sapiens Gamma-interferon-inducible protein 16 Proteins 0.000 claims description 23
- 101000840293 Homo sapiens Interferon-induced protein 44 Proteins 0.000 claims description 23
- 102100029607 Interferon-induced protein 44 Human genes 0.000 claims description 23
- 230000002459 sustained effect Effects 0.000 claims description 23
- 102100040225 Gamma-interferon-inducible lysosomal thiol reductase Human genes 0.000 claims description 22
- 101001037132 Homo sapiens Gamma-interferon-inducible lysosomal thiol reductase Proteins 0.000 claims description 22
- 101000998500 Homo sapiens Interferon-induced 35 kDa protein Proteins 0.000 claims description 22
- 101001034842 Homo sapiens Interferon-induced transmembrane protein 2 Proteins 0.000 claims description 22
- 101001034846 Homo sapiens Interferon-induced transmembrane protein 3 Proteins 0.000 claims description 22
- 102100033273 Interferon-induced 35 kDa protein Human genes 0.000 claims description 22
- 102100040020 Interferon-induced transmembrane protein 2 Human genes 0.000 claims description 22
- 102100040035 Interferon-induced transmembrane protein 3 Human genes 0.000 claims description 22
- 101001082063 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 5 Proteins 0.000 claims description 19
- 101000657037 Homo sapiens Radical S-adenosyl methionine domain-containing protein 2 Proteins 0.000 claims description 19
- 102100027356 Interferon-induced protein with tetratricopeptide repeats 5 Human genes 0.000 claims description 19
- 102100033749 Radical S-adenosyl methionine domain-containing protein 2 Human genes 0.000 claims description 19
- 230000000840 anti-viral effect Effects 0.000 claims description 17
- 239000004365 Protease Substances 0.000 claims description 15
- 238000011156 evaluation Methods 0.000 claims description 15
- 230000008593 response to virus Effects 0.000 claims description 11
- 210000005259 peripheral blood Anatomy 0.000 claims description 10
- 239000011886 peripheral blood Substances 0.000 claims description 10
- 241000607479 Yersinia pestis Species 0.000 claims description 8
- 244000045947 parasite Species 0.000 claims description 8
- 244000052769 pathogen Species 0.000 claims description 8
- 230000001717 pathogenic effect Effects 0.000 claims description 8
- 230000003938 response to stress Effects 0.000 claims description 8
- 229960000517 boceprevir Drugs 0.000 claims description 7
- LHHCSNFAOIFYRV-DOVBMPENSA-N boceprevir Chemical compound O=C([C@@H]1[C@@H]2[C@@H](C2(C)C)CN1C(=O)[C@@H](NC(=O)NC(C)(C)C)C(C)(C)C)NC(C(=O)C(N)=O)CC1CCC1 LHHCSNFAOIFYRV-DOVBMPENSA-N 0.000 claims description 7
- PJZPDFUUXKKDNB-KNINVFKUSA-N ciluprevir Chemical compound N([C@@H]1C(=O)N2[C@H](C(N[C@@]3(C[C@H]3\C=C/CCCCC1)C(O)=O)=O)C[C@H](C2)OC=1C2=CC=C(C=C2N=C(C=1)C=1N=C(NC(C)C)SC=1)OC)C(=O)OC1CCCC1 PJZPDFUUXKKDNB-KNINVFKUSA-N 0.000 claims description 7
- 229950006631 ciluprevir Drugs 0.000 claims description 7
- 230000004665 defense response Effects 0.000 claims description 7
- 230000017734 multicellular organismal process Effects 0.000 claims description 6
- 230000024428 response to biotic stimulus Effects 0.000 claims description 6
- 230000021670 response to stimulus Effects 0.000 claims description 6
- 101001128393 Homo sapiens Interferon-induced GTP-binding protein Mx1 Proteins 0.000 claims description 5
- 101001067396 Homo sapiens Phospholipid scramblase 1 Proteins 0.000 claims description 5
- 102100031802 Interferon-induced GTP-binding protein Mx1 Human genes 0.000 claims description 5
- 102100034627 Phospholipid scramblase 1 Human genes 0.000 claims description 5
- GTVAUHXUMYENSK-RWSKJCERSA-N 2-[3-[(1r)-3-(3,4-dimethoxyphenyl)-1-[(2s)-1-[(2s)-2-(3,4,5-trimethoxyphenyl)pent-4-enoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acid Chemical compound C1=C(OC)C(OC)=CC=C1CC[C@H](C=1C=C(OCC(O)=O)C=CC=1)OC(=O)[C@H]1N(C(=O)[C@@H](CC=C)C=2C=C(OC)C(OC)=C(OC)C=2)CCCC1 GTVAUHXUMYENSK-RWSKJCERSA-N 0.000 claims description 3
- 101001082065 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 1 Proteins 0.000 claims description 3
- 102100027355 Interferon-induced protein with tetratricopeptide repeats 1 Human genes 0.000 claims description 3
- 101001034844 Homo sapiens Interferon-induced transmembrane protein 1 Proteins 0.000 claims 4
- 102100040021 Interferon-induced transmembrane protein 1 Human genes 0.000 claims 4
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
- 239000000902 placebo Substances 0.000 abstract description 6
- 229940068196 placebo Drugs 0.000 abstract description 6
- 230000000694 effects Effects 0.000 description 346
- 230000027455 binding Effects 0.000 description 330
- 102000004169 proteins and genes Human genes 0.000 description 150
- 235000018102 proteins Nutrition 0.000 description 139
- 239000012528 membrane Substances 0.000 description 103
- 230000035897 transcription Effects 0.000 description 101
- 238000013518 transcription Methods 0.000 description 101
- 210000004940 nucleus Anatomy 0.000 description 82
- 238000002560 therapeutic procedure Methods 0.000 description 79
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 78
- 239000000523 sample Substances 0.000 description 68
- 108020004414 DNA Proteins 0.000 description 55
- 102000039446 nucleic acids Human genes 0.000 description 55
- 108020004707 nucleic acids Proteins 0.000 description 55
- 150000007523 nucleic acids Chemical class 0.000 description 55
- 230000006870 function Effects 0.000 description 52
- 230000032258 transport Effects 0.000 description 52
- 230000033228 biological regulation Effects 0.000 description 51
- 102000005962 receptors Human genes 0.000 description 45
- 108020003175 receptors Proteins 0.000 description 45
- 230000001413 cellular effect Effects 0.000 description 39
- 230000008569 process Effects 0.000 description 37
- 230000004060 metabolic process Effects 0.000 description 32
- 210000002381 plasma Anatomy 0.000 description 32
- 239000002773 nucleotide Substances 0.000 description 31
- 108091000080 Phosphotransferase Proteins 0.000 description 27
- 229910021645 metal ion Inorganic materials 0.000 description 27
- 125000003729 nucleotide group Chemical group 0.000 description 27
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 27
- 102000020233 phosphotransferase Human genes 0.000 description 27
- 102000004157 Hydrolases Human genes 0.000 description 26
- 108090000604 Hydrolases Proteins 0.000 description 26
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 description 25
- 210000000805 cytoplasm Anatomy 0.000 description 25
- 239000003795 chemical substances by application Substances 0.000 description 24
- 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 description 23
- 241000282414 Homo sapiens Species 0.000 description 23
- 101710198130 NADPH-cytochrome P450 reductase Proteins 0.000 description 23
- 102000040945 Transcription factor Human genes 0.000 description 23
- 108091023040 Transcription factor Proteins 0.000 description 23
- 238000011161 development Methods 0.000 description 23
- 230000018109 developmental process Effects 0.000 description 23
- 208000005176 Hepatitis C Diseases 0.000 description 22
- 102000035195 Peptidases Human genes 0.000 description 22
- 230000015572 biosynthetic process Effects 0.000 description 22
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 21
- 230000001684 chronic effect Effects 0.000 description 21
- 229940047124 interferons Drugs 0.000 description 21
- 229920001184 polypeptide Polymers 0.000 description 21
- 108090000765 processed proteins & peptides Proteins 0.000 description 21
- 102000004196 processed proteins & peptides Human genes 0.000 description 21
- 230000019491 signal transduction Effects 0.000 description 21
- 230000003321 amplification Effects 0.000 description 20
- 230000001419 dependent effect Effects 0.000 description 20
- 238000003199 nucleic acid amplification method Methods 0.000 description 20
- 102000003960 Ligases Human genes 0.000 description 19
- 108090000364 Ligases Proteins 0.000 description 19
- 102000004357 Transferases Human genes 0.000 description 19
- 108090000992 Transferases Proteins 0.000 description 19
- 230000003834 intracellular effect Effects 0.000 description 19
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 description 18
- 238000009396 hybridization Methods 0.000 description 18
- 210000003660 reticulum Anatomy 0.000 description 17
- 102000009572 RNA Polymerase II Human genes 0.000 description 16
- 108010009460 RNA Polymerase II Proteins 0.000 description 16
- 239000000203 mixture Substances 0.000 description 16
- 241000700605 Viruses Species 0.000 description 15
- 230000006907 apoptotic process Effects 0.000 description 15
- 210000004027 cell Anatomy 0.000 description 15
- 108020004999 messenger RNA Proteins 0.000 description 15
- 238000011269 treatment regimen Methods 0.000 description 15
- 229940122604 HCV protease inhibitor Drugs 0.000 description 14
- 150000001875 compounds Chemical class 0.000 description 14
- 229960000329 ribavirin Drugs 0.000 description 14
- 239000003153 chemical reaction reagent Substances 0.000 description 13
- 238000002648 combination therapy Methods 0.000 description 13
- 230000001404 mediated effect Effects 0.000 description 13
- 230000004879 molecular function Effects 0.000 description 13
- 230000011664 signaling Effects 0.000 description 13
- 230000026683 transduction Effects 0.000 description 13
- 238000010361 transduction Methods 0.000 description 13
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 12
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 12
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 12
- 235000001014 amino acid Nutrition 0.000 description 12
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 12
- 235000019419 proteases Nutrition 0.000 description 12
- 108010047761 Interferon-alpha Proteins 0.000 description 11
- 102000006992 Interferon-alpha Human genes 0.000 description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 11
- 230000001965 increasing effect Effects 0.000 description 11
- 230000037425 regulation of transcription Effects 0.000 description 11
- 102000004316 Oxidoreductases Human genes 0.000 description 10
- 108090000854 Oxidoreductases Proteins 0.000 description 10
- 102000004389 Ribonucleoproteins Human genes 0.000 description 10
- 108010081734 Ribonucleoproteins Proteins 0.000 description 10
- 108090000848 Ubiquitin Proteins 0.000 description 10
- 102000044159 Ubiquitin Human genes 0.000 description 10
- 230000009471 action Effects 0.000 description 10
- 239000003443 antiviral agent Substances 0.000 description 10
- 230000003197 catalytic effect Effects 0.000 description 10
- 150000002500 ions Chemical class 0.000 description 10
- 239000002253 acid Substances 0.000 description 9
- 239000012190 activator Substances 0.000 description 9
- 230000003081 coactivator Effects 0.000 description 9
- 239000002552 dosage form Substances 0.000 description 9
- 230000003828 downregulation Effects 0.000 description 9
- 210000003470 mitochondria Anatomy 0.000 description 9
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 description 9
- 101710088194 Dehydrogenase Proteins 0.000 description 8
- 108010047956 Nucleosomes Proteins 0.000 description 8
- 150000001413 amino acids Chemical class 0.000 description 8
- 238000003491 array Methods 0.000 description 8
- 230000015556 catabolic process Effects 0.000 description 8
- 230000000295 complement effect Effects 0.000 description 8
- 238000001514 detection method Methods 0.000 description 8
- 230000036541 health Effects 0.000 description 8
- 208000019423 liver disease Diseases 0.000 description 8
- 238000010606 normalization Methods 0.000 description 8
- 210000001623 nucleosome Anatomy 0.000 description 8
- 238000003752 polymerase chain reaction Methods 0.000 description 8
- 235000019833 protease Nutrition 0.000 description 8
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 8
- 230000002103 transcriptional effect Effects 0.000 description 8
- 230000034512 ubiquitination Effects 0.000 description 8
- 102000057234 Acyl transferases Human genes 0.000 description 7
- 108700016155 Acyl transferases Proteins 0.000 description 7
- 108091034117 Oligonucleotide Proteins 0.000 description 7
- 208000037581 Persistent Infection Diseases 0.000 description 7
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 7
- 239000000427 antigen Substances 0.000 description 7
- 108091007433 antigens Proteins 0.000 description 7
- 102000036639 antigens Human genes 0.000 description 7
- 230000022131 cell cycle Effects 0.000 description 7
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 7
- 208000006454 hepatitis Diseases 0.000 description 7
- 230000026731 phosphorylation Effects 0.000 description 7
- 238000006366 phosphorylation reaction Methods 0.000 description 7
- 238000012545 processing Methods 0.000 description 7
- 239000000758 substrate Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 229910052725 zinc Inorganic materials 0.000 description 7
- 239000011701 zinc Substances 0.000 description 7
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 6
- 101150028074 2 gene Proteins 0.000 description 6
- 101150090724 3 gene Proteins 0.000 description 6
- 101150033839 4 gene Proteins 0.000 description 6
- 101150096316 5 gene Proteins 0.000 description 6
- 101150039504 6 gene Proteins 0.000 description 6
- 101150101112 7 gene Proteins 0.000 description 6
- 101150044182 8 gene Proteins 0.000 description 6
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 6
- 229940124143 Endopeptidase inhibitor Drugs 0.000 description 6
- 102000005593 Endopeptidases Human genes 0.000 description 6
- 108010059378 Endopeptidases Proteins 0.000 description 6
- 108091006027 G proteins Proteins 0.000 description 6
- 102000030782 GTP binding Human genes 0.000 description 6
- 108091000058 GTP-Binding Proteins 0.000 description 6
- 108010033040 Histones Proteins 0.000 description 6
- 101001032342 Homo sapiens Interferon regulatory factor 7 Proteins 0.000 description 6
- 102100038070 Interferon regulatory factor 7 Human genes 0.000 description 6
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 6
- 102000001253 Protein Kinase Human genes 0.000 description 6
- 230000001154 acute effect Effects 0.000 description 6
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 6
- 210000003719 b-lymphocyte Anatomy 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 230000036765 blood level Effects 0.000 description 6
- 229910001424 calcium ion Inorganic materials 0.000 description 6
- 210000000170 cell membrane Anatomy 0.000 description 6
- 229910001431 copper ion Inorganic materials 0.000 description 6
- 230000005860 defense response to virus Effects 0.000 description 6
- 208000035475 disorder Diseases 0.000 description 6
- 239000007850 fluorescent dye Substances 0.000 description 6
- 239000012634 fragment Substances 0.000 description 6
- 210000003494 hepatocyte Anatomy 0.000 description 6
- 150000002632 lipids Chemical class 0.000 description 6
- 108060006633 protein kinase Proteins 0.000 description 6
- 230000001105 regulatory effect Effects 0.000 description 6
- 229960003471 retinol Drugs 0.000 description 6
- 235000020944 retinol Nutrition 0.000 description 6
- 239000011607 retinol Substances 0.000 description 6
- 238000009097 single-agent therapy Methods 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- 102000040811 transporter activity Human genes 0.000 description 6
- 108091092194 transporter activity Proteins 0.000 description 6
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 6
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 5
- 102100034808 CCAAT/enhancer-binding protein alpha Human genes 0.000 description 5
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 5
- 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 5
- 101000945515 Homo sapiens CCAAT/enhancer-binding protein alpha Proteins 0.000 description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- 108010044467 Isoenzymes Proteins 0.000 description 5
- 102000004195 Isomerases Human genes 0.000 description 5
- 108090000769 Isomerases Proteins 0.000 description 5
- 108700020796 Oncogene Proteins 0.000 description 5
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 description 5
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 description 5
- 102000006275 Ubiquitin-Protein Ligases Human genes 0.000 description 5
- 108010083111 Ubiquitin-Protein Ligases Proteins 0.000 description 5
- JBPUGFODGPKTDW-SFHVURJKSA-N [(3s)-oxolan-3-yl] n-[[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]methyl]carbamate Chemical compound C=1C=C(C=2OC=NC=2)C(OC)=CC=1NC(=O)NC(C=1)=CC=CC=1CNC(=O)O[C@H]1CCOC1 JBPUGFODGPKTDW-SFHVURJKSA-N 0.000 description 5
- 238000003556 assay Methods 0.000 description 5
- 230000035605 chemotaxis Effects 0.000 description 5
- 210000004292 cytoskeleton Anatomy 0.000 description 5
- 230000007423 decrease Effects 0.000 description 5
- 230000030609 dephosphorylation Effects 0.000 description 5
- 238000006209 dephosphorylation reaction Methods 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 229940000406 drug candidate Drugs 0.000 description 5
- 238000010348 incorporation Methods 0.000 description 5
- 230000001939 inductive effect Effects 0.000 description 5
- 230000037427 ion transport Effects 0.000 description 5
- 238000012544 monitoring process Methods 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 150000003904 phospholipids Chemical class 0.000 description 5
- 230000012846 protein folding Effects 0.000 description 5
- 238000012163 sequencing technique Methods 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- 238000010798 ubiquitination Methods 0.000 description 5
- 108020005087 unfolded proteins Proteins 0.000 description 5
- 108010078791 Carrier Proteins Proteins 0.000 description 4
- 108091006146 Channels Proteins 0.000 description 4
- 208000003311 Cytochrome P-450 Enzyme Inhibitors Diseases 0.000 description 4
- 241000206602 Eukaryota Species 0.000 description 4
- 108010052285 Membrane Proteins Proteins 0.000 description 4
- 102000003939 Membrane transport proteins Human genes 0.000 description 4
- 108090000301 Membrane transport proteins Proteins 0.000 description 4
- 108060004795 Methyltransferase Proteins 0.000 description 4
- 229920000388 Polyphosphate Polymers 0.000 description 4
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 4
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 description 4
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 description 4
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 4
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 4
- 102000016611 Proteoglycans Human genes 0.000 description 4
- 108010067787 Proteoglycans Proteins 0.000 description 4
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 4
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 4
- 239000004473 Threonine Substances 0.000 description 4
- 102000003929 Transaminases Human genes 0.000 description 4
- 108090000340 Transaminases Proteins 0.000 description 4
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 4
- 235000014633 carbohydrates Nutrition 0.000 description 4
- 230000004663 cell proliferation Effects 0.000 description 4
- 235000012000 cholesterol Nutrition 0.000 description 4
- 210000000349 chromosome Anatomy 0.000 description 4
- 239000000470 constituent Substances 0.000 description 4
- 230000000875 corresponding effect Effects 0.000 description 4
- 230000003247 decreasing effect Effects 0.000 description 4
- 230000004069 differentiation Effects 0.000 description 4
- 238000006073 displacement reaction Methods 0.000 description 4
- 235000019152 folic acid Nutrition 0.000 description 4
- 239000011724 folic acid Substances 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 230000002068 genetic effect Effects 0.000 description 4
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Natural products OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 4
- 208000002672 hepatitis B Diseases 0.000 description 4
- 230000002519 immonomodulatory effect Effects 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 230000006698 induction Effects 0.000 description 4
- 230000002757 inflammatory effect Effects 0.000 description 4
- 230000000977 initiatory effect Effects 0.000 description 4
- 230000037356 lipid metabolism Effects 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 210000001589 microsome Anatomy 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 210000000653 nervous system Anatomy 0.000 description 4
- 230000037361 pathway Effects 0.000 description 4
- 108010092853 peginterferon alfa-2a Proteins 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 239000001205 polyphosphate Substances 0.000 description 4
- 235000011176 polyphosphates Nutrition 0.000 description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 4
- 230000017854 proteolysis Effects 0.000 description 4
- 239000007962 solid dispersion Substances 0.000 description 4
- 210000001324 spliceosome Anatomy 0.000 description 4
- 208000011580 syndromic disease Diseases 0.000 description 4
- 230000005758 transcription activity Effects 0.000 description 4
- 230000014616 translation Effects 0.000 description 4
- 101710169336 5'-deoxyadenosine deaminase Proteins 0.000 description 3
- 102100036664 Adenosine deaminase Human genes 0.000 description 3
- 108700028369 Alleles Proteins 0.000 description 3
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 3
- 108010060434 Co-Repressor Proteins Proteins 0.000 description 3
- 102000008169 Co-Repressor Proteins Human genes 0.000 description 3
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 3
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 3
- 238000002965 ELISA Methods 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 206010016654 Fibrosis Diseases 0.000 description 3
- 108010024636 Glutathione Proteins 0.000 description 3
- 206010019799 Hepatitis viral Diseases 0.000 description 3
- 101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 description 3
- 108010078049 Interferon alpha-2 Proteins 0.000 description 3
- 108091006671 Ion Transporter Proteins 0.000 description 3
- 102000037862 Ion Transporter Human genes 0.000 description 3
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 3
- 102000013566 Plasminogen Human genes 0.000 description 3
- 108010051456 Plasminogen Proteins 0.000 description 3
- 108010029485 Protein Isoforms Proteins 0.000 description 3
- 102000001708 Protein Isoforms Human genes 0.000 description 3
- NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 description 3
- 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 description 3
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 3
- 230000010632 Transcription Factor Activity Effects 0.000 description 3
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 3
- SIIZPVYVXNXXQG-KGXOGWRBSA-N [(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-4-[[(3s,4r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-3-hydroxyoxolan-2-yl]methyl [(2r,4r,5r)-2-(6-aminopurin-9-yl)-4-hydroxy-5-(phosphonooxymethyl)oxolan-3-yl] hydrogen phosphate Polymers C1=NC2=C(N)N=CN=C2N1[C@@H]1O[C@H](COP(O)(=O)OC2[C@@H](O[C@H](COP(O)(O)=O)[C@H]2O)N2C3=NC=NC(N)=C3N=C2)[C@@H](O)[C@H]1OP(O)(=O)OCC([C@@H](O)[C@H]1O)OC1N1C(N=CN=C2N)=C2N=C1 SIIZPVYVXNXXQG-KGXOGWRBSA-N 0.000 description 3
- GYCPCOJTCINIFZ-JXFKEZNVSA-N [(2s)-1-cyanobutan-2-yl] n-[(1s)-1-[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]ethyl]carbamate Chemical compound N#CC[C@H](CC)OC(=O)N[C@@H](C)C1=CC=CC(NC(=O)NC=2C=C(OC)C(C=3OC=NC=3)=CC=2)=C1 GYCPCOJTCINIFZ-JXFKEZNVSA-N 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 229960005305 adenosine Drugs 0.000 description 3
- 238000013475 authorization Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000031018 biological processes and functions Effects 0.000 description 3
- 230000023555 blood coagulation Effects 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 230000021164 cell adhesion Effects 0.000 description 3
- 230000009087 cell motility Effects 0.000 description 3
- 230000009134 cell regulation Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000007882 cirrhosis Effects 0.000 description 3
- 208000019425 cirrhosis of liver Diseases 0.000 description 3
- 238000003776 cleavage reaction Methods 0.000 description 3
- 238000012790 confirmation Methods 0.000 description 3
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 3
- 235000018417 cysteine Nutrition 0.000 description 3
- 210000000172 cytosol Anatomy 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 230000012202 endocytosis Effects 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- 229960000304 folic acid Drugs 0.000 description 3
- 102000018146 globin Human genes 0.000 description 3
- 108060003196 globin Proteins 0.000 description 3
- 229960003180 glutathione Drugs 0.000 description 3
- 231100000283 hepatitis Toxicity 0.000 description 3
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 3
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 3
- 230000013632 homeostatic process Effects 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 230000028709 inflammatory response Effects 0.000 description 3
- 108010044426 integrins Proteins 0.000 description 3
- 102000006495 integrins Human genes 0.000 description 3
- 108700027921 interferon tau Proteins 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 3
- 229910052742 iron Inorganic materials 0.000 description 3
- 230000003902 lesion Effects 0.000 description 3
- 201000007270 liver cancer Diseases 0.000 description 3
- 208000014018 liver neoplasm Diseases 0.000 description 3
- 210000003712 lysosome Anatomy 0.000 description 3
- 230000001868 lysosomic effect Effects 0.000 description 3
- 229910001425 magnesium ion Inorganic materials 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 238000002493 microarray Methods 0.000 description 3
- 230000035772 mutation Effects 0.000 description 3
- 230000017095 negative regulation of cell growth Effects 0.000 description 3
- 239000002777 nucleoside Substances 0.000 description 3
- 150000003833 nucleoside derivatives Chemical class 0.000 description 3
- 229940002988 pegasys Drugs 0.000 description 3
- 210000004976 peripheral blood cell Anatomy 0.000 description 3
- 229910001414 potassium ion Inorganic materials 0.000 description 3
- 230000003389 potentiating effect Effects 0.000 description 3
- 230000004952 protein activity Effects 0.000 description 3
- 230000009145 protein modification Effects 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 229960000311 ritonavir Drugs 0.000 description 3
- NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 description 3
- 230000007017 scission Effects 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 229910001415 sodium ion Inorganic materials 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000013519 translation Methods 0.000 description 3
- 230000003827 upregulation Effects 0.000 description 3
- 201000001862 viral hepatitis Diseases 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 description 2
- GZCWLCBFPRFLKL-UHFFFAOYSA-N 1-prop-2-ynoxypropan-2-ol Chemical compound CC(O)COCC#C GZCWLCBFPRFLKL-UHFFFAOYSA-N 0.000 description 2
- KVUXYQHEESDGIJ-UHFFFAOYSA-N 10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthrene-3,16-diol Chemical compound C1CC2CC(O)CCC2(C)C2C1C1CC(O)CC1(C)CC2 KVUXYQHEESDGIJ-UHFFFAOYSA-N 0.000 description 2
- 102000055416 ATPase-coupled transmembrane transporter activity proteins Human genes 0.000 description 2
- 108700013194 ATPase-coupled transmembrane transporter activity proteins Proteins 0.000 description 2
- 108010051457 Acid Phosphatase Proteins 0.000 description 2
- 102000013563 Acid Phosphatase Human genes 0.000 description 2
- 206010048998 Acute phase reaction Diseases 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 2
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 2
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 2
- 208000022309 Alcoholic Liver disease Diseases 0.000 description 2
- 108010090849 Amyloid beta-Peptides Proteins 0.000 description 2
- 102000013455 Amyloid beta-Peptides Human genes 0.000 description 2
- 102100036441 Amyloid-beta A4 precursor protein-binding family A member 2 Human genes 0.000 description 2
- 102100037435 Antiviral innate immune response receptor RIG-I Human genes 0.000 description 2
- 101710127675 Antiviral innate immune response receptor RIG-I Proteins 0.000 description 2
- 102100028218 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 Human genes 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000271566 Aves Species 0.000 description 2
- 101710125089 Bindin Proteins 0.000 description 2
- 102000000584 Calmodulin Human genes 0.000 description 2
- 108010041952 Calmodulin Proteins 0.000 description 2
- 102000009410 Chemokine receptor Human genes 0.000 description 2
- 108050000299 Chemokine receptor Proteins 0.000 description 2
- 102000019034 Chemokines Human genes 0.000 description 2
- 108010012236 Chemokines Proteins 0.000 description 2
- PCLITLDOTJTVDJ-UHFFFAOYSA-N Chlormethiazole Chemical compound CC=1N=CSC=1CCCl PCLITLDOTJTVDJ-UHFFFAOYSA-N 0.000 description 2
- 108010077544 Chromatin Proteins 0.000 description 2
- 206010008909 Chronic Hepatitis Diseases 0.000 description 2
- 208000006154 Chronic hepatitis C Diseases 0.000 description 2
- ZTDFZLVUIVPZDU-QGNHJMHWSA-N Cnicin Chemical compound OC[C@H](O)C(=C)C(=O)O[C@H]1CC(/C)=C/CC\C(CO)=C\[C@H]2OC(=O)C(=C)[C@@H]21 ZTDFZLVUIVPZDU-QGNHJMHWSA-N 0.000 description 2
- 108090000266 Cyclin-dependent kinases Proteins 0.000 description 2
- 102000003903 Cyclin-dependent kinases Human genes 0.000 description 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 2
- 229930105110 Cyclosporin A Natural products 0.000 description 2
- 108010036949 Cyclosporine Proteins 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 2
- 102100021238 Dynamin-2 Human genes 0.000 description 2
- 102100031780 Endonuclease Human genes 0.000 description 2
- 108010042407 Endonucleases Proteins 0.000 description 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
- 239000005715 Fructose Substances 0.000 description 2
- 102100022629 Fructose-2,6-bisphosphatase Human genes 0.000 description 2
- 102000042092 Glucose transporter family Human genes 0.000 description 2
- 108091052347 Glucose transporter family Proteins 0.000 description 2
- 108010056771 Glucosidases Proteins 0.000 description 2
- 102000004366 Glucosidases Human genes 0.000 description 2
- 102000016354 Glucuronosyltransferase Human genes 0.000 description 2
- 108010092364 Glucuronosyltransferase Proteins 0.000 description 2
- 102100029846 Glutaminyl-peptide cyclotransferase Human genes 0.000 description 2
- 102100034294 Glutathione synthetase Human genes 0.000 description 2
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 2
- 229920002683 Glycosaminoglycan Polymers 0.000 description 2
- 102100031415 Hepatic triacylglycerol lipase Human genes 0.000 description 2
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 2
- 102100038885 Histone acetyltransferase p300 Human genes 0.000 description 2
- 102100038719 Histone deacetylase 7 Human genes 0.000 description 2
- 102100030234 Homeobox protein cut-like 1 Human genes 0.000 description 2
- 101000928677 Homo sapiens Amyloid-beta A4 precursor protein-binding family A member 2 Proteins 0.000 description 2
- 101000724276 Homo sapiens Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 Proteins 0.000 description 2
- 101000817607 Homo sapiens Dynamin-2 Proteins 0.000 description 2
- 101000726740 Homo sapiens Homeobox protein cut-like 1 Proteins 0.000 description 2
- 101001011382 Homo sapiens Interferon regulatory factor 3 Proteins 0.000 description 2
- 101000761460 Homo sapiens Protein CASP Proteins 0.000 description 2
- 101000595548 Homo sapiens TIR domain-containing adapter molecule 1 Proteins 0.000 description 2
- 101710200424 Inosine-5'-monophosphate dehydrogenase Proteins 0.000 description 2
- 101710144867 Inositol monophosphatase Proteins 0.000 description 2
- 102100040018 Interferon alpha-2 Human genes 0.000 description 2
- 102100027354 Interferon alpha-inducible protein 6 Human genes 0.000 description 2
- 102100029843 Interferon regulatory factor 3 Human genes 0.000 description 2
- 108010074328 Interferon-gamma Proteins 0.000 description 2
- 102100039953 Interferon-induced protein 44-like Human genes 0.000 description 2
- 108090000862 Ion Channels Proteins 0.000 description 2
- 102000004310 Ion Channels Human genes 0.000 description 2
- 206010025323 Lymphomas Diseases 0.000 description 2
- 102100024295 Maltase-glucoamylase Human genes 0.000 description 2
- 101150024075 Mapk1 gene Proteins 0.000 description 2
- 102100023727 Mitochondrial antiviral-signaling protein Human genes 0.000 description 2
- 101710142315 Mitochondrial antiviral-signaling protein Proteins 0.000 description 2
- 238000000636 Northern blotting Methods 0.000 description 2
- 108091005461 Nucleic proteins Proteins 0.000 description 2
- 102000003832 Nucleotidyltransferases Human genes 0.000 description 2
- 108090000119 Nucleotidyltransferases Proteins 0.000 description 2
- 108700026244 Open Reading Frames Proteins 0.000 description 2
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 2
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 2
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 description 2
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 description 2
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 2
- 102000004879 Racemases and epimerases Human genes 0.000 description 2
- 108090001066 Racemases and epimerases Proteins 0.000 description 2
- 108091027981 Response element Proteins 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 206010039491 Sarcoma Diseases 0.000 description 2
- 108010090804 Streptavidin Proteins 0.000 description 2
- 102000005262 Sulfatase Human genes 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 102100036073 TIR domain-containing adapter molecule 1 Human genes 0.000 description 2
- 108010067390 Viral Proteins Proteins 0.000 description 2
- 208000036142 Viral infection Diseases 0.000 description 2
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 description 2
- 108020002494 acetyltransferase Proteins 0.000 description 2
- 102000005421 acetyltransferase Human genes 0.000 description 2
- 230000004658 acute-phase response Effects 0.000 description 2
- 239000003098 androgen Substances 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000035578 autophosphorylation Effects 0.000 description 2
- 230000008436 biogenesis Effects 0.000 description 2
- 125000005340 bisphosphate group Chemical group 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 230000024245 cell differentiation Effects 0.000 description 2
- 230000024856 cell surface receptor signaling pathway Effects 0.000 description 2
- 230000023549 cell-cell signaling Effects 0.000 description 2
- 230000005754 cellular signaling Effects 0.000 description 2
- 210000003483 chromatin Anatomy 0.000 description 2
- 229960001265 ciclosporin Drugs 0.000 description 2
- 229960004414 clomethiazole Drugs 0.000 description 2
- RGJOEKWQDUBAIZ-UHFFFAOYSA-N coenzime A Natural products OC1C(OP(O)(O)=O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-UHFFFAOYSA-N 0.000 description 2
- 239000005515 coenzyme Substances 0.000 description 2
- 239000005516 coenzyme A Substances 0.000 description 2
- 229940093530 coenzyme a Drugs 0.000 description 2
- 239000002299 complementary DNA Substances 0.000 description 2
- 229940055354 copegus Drugs 0.000 description 2
- 229930182912 cyclosporin Natural products 0.000 description 2
- 108010057085 cytokine receptors Proteins 0.000 description 2
- 102000003675 cytokine receptors Human genes 0.000 description 2
- 230000001086 cytosolic effect Effects 0.000 description 2
- 230000007123 defense Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- WHBIGIKBNXZKFE-UHFFFAOYSA-N delavirdine Chemical compound CC(C)NC1=CC=CN=C1N1CCN(C(=O)C=2NC3=CC=C(NS(C)(=O)=O)C=C3C=2)CC1 WHBIGIKBNXZKFE-UHFFFAOYSA-N 0.000 description 2
- 210000004443 dendritic cell Anatomy 0.000 description 2
- KDTSHFARGAKYJN-UHFFFAOYSA-N dephosphocoenzyme A Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 KDTSHFARGAKYJN-UHFFFAOYSA-N 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000002405 diagnostic procedure Methods 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 238000006471 dimerization reaction Methods 0.000 description 2
- 229910001882 dioxygen Inorganic materials 0.000 description 2
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 210000002472 endoplasmic reticulum Anatomy 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 230000029142 excretion Effects 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- RIKMMFOAQPJVMX-UHFFFAOYSA-N fomepizole Chemical compound CC=1C=NNC=1 RIKMMFOAQPJVMX-UHFFFAOYSA-N 0.000 description 2
- 229960004285 fomepizole Drugs 0.000 description 2
- 238000001415 gene therapy Methods 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 2
- 238000005734 heterodimerization reaction Methods 0.000 description 2
- 229960002751 imiquimod Drugs 0.000 description 2
- DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 230000002779 inactivation Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 229960000367 inositol Drugs 0.000 description 2
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 2
- 230000010468 interferon response Effects 0.000 description 2
- 230000010189 intracellular transport Effects 0.000 description 2
- 229960004125 ketoconazole Drugs 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 230000004576 lipid-binding Effects 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 102000006240 membrane receptors Human genes 0.000 description 2
- 108020004084 membrane receptors Proteins 0.000 description 2
- 230000009061 membrane transport Effects 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229930182817 methionine Natural products 0.000 description 2
- 230000002438 mitochondrial effect Effects 0.000 description 2
- 230000011278 mitosis Effects 0.000 description 2
- 210000001616 monocyte Anatomy 0.000 description 2
- 238000003499 nucleic acid array Methods 0.000 description 2
- 150000002892 organic cations Chemical class 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 229960003104 ornithine Drugs 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 108010092851 peginterferon alfa-2b Proteins 0.000 description 2
- 108010002205 phospholipase C1 Proteins 0.000 description 2
- 102000054765 polymorphisms of proteins Human genes 0.000 description 2
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 2
- ZDHURYWHEBEGHO-UHFFFAOYSA-N potassiopotassium Chemical compound [K].[K] ZDHURYWHEBEGHO-UHFFFAOYSA-N 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 238000003498 protein array Methods 0.000 description 2
- 230000022558 protein metabolic process Effects 0.000 description 2
- 238000009163 protein therapy Methods 0.000 description 2
- NGVDGCNFYWLIFO-UHFFFAOYSA-N pyridoxal 5'-phosphate Chemical compound CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O NGVDGCNFYWLIFO-UHFFFAOYSA-N 0.000 description 2
- 238000003127 radioimmunoassay Methods 0.000 description 2
- 102000016914 ras Proteins Human genes 0.000 description 2
- 108010014186 ras Proteins Proteins 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000012385 regulation of binding Effects 0.000 description 2
- 230000007155 regulation of transcription from RNA polymerase II promoter Effects 0.000 description 2
- 230000008399 response to wounding Effects 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 210000003705 ribosome Anatomy 0.000 description 2
- 238000005096 rolling process Methods 0.000 description 2
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- 230000007781 signaling event Effects 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 238000010922 spray-dried dispersion Methods 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 230000035882 stress Effects 0.000 description 2
- 108060007951 sulfatase Proteins 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 229960005041 troleandomycin Drugs 0.000 description 2
- LQCLVBQBTUVCEQ-QTFUVMRISA-N troleandomycin Chemical compound O1[C@@H](C)[C@H](OC(C)=O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](OC(C)=O)[C@@H](C)C(=O)[C@@]2(OC2)C[C@H](C)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)OC(C)=O)[C@H]1C LQCLVBQBTUVCEQ-QTFUVMRISA-N 0.000 description 2
- 241000712461 unidentified influenza virus Species 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- 210000003934 vacuole Anatomy 0.000 description 2
- 230000029812 viral genome replication Effects 0.000 description 2
- 230000009385 viral infection Effects 0.000 description 2
- 230000016776 visual perception Effects 0.000 description 2
- 238000001262 western blot Methods 0.000 description 2
- 150000003751 zinc Chemical class 0.000 description 2
- DIGQNXIGRZPYDK-WKSCXVIASA-N (2R)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2R,3S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[2-[[2-[[2-[(2-amino-1-hydroxyethylidene)amino]-3-carboxy-1-hydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]hexanoic acid Chemical compound C[C@@H]([C@@H](C(=N[C@@H](CS)C(=N[C@@H](C)C(=N[C@@H](CO)C(=NCC(=N[C@@H](CCC(=N)O)C(=NC(CS)C(=N[C@H]([C@H](C)O)C(=N[C@H](CS)C(=N[C@H](CO)C(=NCC(=N[C@H](CS)C(=NCC(=N[C@H](CCCCN)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C([C@H](CS)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](C)N=C(CN=C([C@H](CO)N=C([C@H](CS)N=C(CN=C(C(CS)N=C(C(CC(=O)O)N=C(CN)O)O)O)O)O)O)O)O)O)O)O)O DIGQNXIGRZPYDK-WKSCXVIASA-N 0.000 description 1
- WMYLYYNMCFINGV-CKCBUVOCSA-N (2s)-2-amino-5-[[(2r)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O.OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O WMYLYYNMCFINGV-CKCBUVOCSA-N 0.000 description 1
- XJPHGGXFBWOHFL-QMMMGPOBSA-N (2s)-2-hydrazinyl-3-(4-hydroxyphenyl)propanoic acid Chemical compound NN[C@H](C(O)=O)CC1=CC=C(O)C=C1 XJPHGGXFBWOHFL-QMMMGPOBSA-N 0.000 description 1
- SJTPYAOZAPSOLO-REOHCLBHSA-N (2s)-2-hydrazinyl-3-hydroxypropanoic acid Chemical compound NN[C@@H](CO)C(O)=O SJTPYAOZAPSOLO-REOHCLBHSA-N 0.000 description 1
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 description 1
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 1
- 102100038794 17-beta-hydroxysteroid dehydrogenase type 6 Human genes 0.000 description 1
- 102100027621 2'-5'-oligoadenylate synthase 2 Human genes 0.000 description 1
- 102100035473 2'-5'-oligoadenylate synthase-like protein Human genes 0.000 description 1
- 102100027962 2-5A-dependent ribonuclease Human genes 0.000 description 1
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 description 1
- KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 description 1
- 108010054479 3',5'-Cyclic-AMP Phosphodiesterases Proteins 0.000 description 1
- 102000001707 3',5'-Cyclic-AMP Phosphodiesterases Human genes 0.000 description 1
- 102100029103 3-ketoacyl-CoA thiolase Human genes 0.000 description 1
- 102100034147 39S ribosomal protein L44, mitochondrial Human genes 0.000 description 1
- 102100036116 60S ribosomal protein L35 Human genes 0.000 description 1
- SHGAZHPCJJPHSC-ZVCIMWCZSA-N 9-cis-retinoic acid Chemical compound OC(=O)/C=C(\C)/C=C/C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-ZVCIMWCZSA-N 0.000 description 1
- 108091005560 ADGRG3 Proteins 0.000 description 1
- 108010049290 ADP Ribose Transferases Proteins 0.000 description 1
- 102000009062 ADP Ribose Transferases Human genes 0.000 description 1
- 230000005730 ADP ribosylation Effects 0.000 description 1
- 102100022594 ATP-binding cassette sub-family G member 1 Human genes 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 108010003902 Acetyl-CoA C-acyltransferase Proteins 0.000 description 1
- 102000004672 Acetyl-CoA C-acyltransferase Human genes 0.000 description 1
- 102000005234 Adenosylhomocysteinase Human genes 0.000 description 1
- 108020002202 Adenosylhomocysteinase Proteins 0.000 description 1
- 102100040037 Adhesion G protein-coupled receptor G3 Human genes 0.000 description 1
- 102100036457 Akirin-1 Human genes 0.000 description 1
- 102100036472 Akirin-2 Human genes 0.000 description 1
- 102100040038 Amyloid beta precursor like protein 2 Human genes 0.000 description 1
- 102100037211 Aryl hydrocarbon receptor nuclear translocator-like protein 1 Human genes 0.000 description 1
- 102100039723 Aurora kinase A-interacting protein Human genes 0.000 description 1
- 102000003989 Aurora kinases Human genes 0.000 description 1
- 108090000433 Aurora kinases Proteins 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 102100021631 B-cell lymphoma 6 protein Human genes 0.000 description 1
- 230000003844 B-cell-activation Effects 0.000 description 1
- 241001598984 Bromius obscurus Species 0.000 description 1
- 102100031172 C-C chemokine receptor type 1 Human genes 0.000 description 1
- 101710149814 C-C chemokine receptor type 1 Proteins 0.000 description 1
- 102100025248 C-X-C motif chemokine 10 Human genes 0.000 description 1
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 1
- 102100034798 CCAAT/enhancer-binding protein beta Human genes 0.000 description 1
- 101150026353 CD46 gene Proteins 0.000 description 1
- 102100039553 CKLF-like MARVEL transmembrane domain-containing protein 8 Human genes 0.000 description 1
- QAGYKUNXZHXKMR-UHFFFAOYSA-N CPD000469186 Natural products CC1=C(O)C=CC=C1C(=O)NC(C(O)CN1C(CC2CCCCC2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 QAGYKUNXZHXKMR-UHFFFAOYSA-N 0.000 description 1
- 102100021975 CREB-binding protein Human genes 0.000 description 1
- 101100494319 Caenorhabditis elegans bub-3 gene Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 108010031425 Casein Kinases Proteins 0.000 description 1
- 102000005403 Casein Kinases Human genes 0.000 description 1
- 108010076667 Caspases Proteins 0.000 description 1
- 102000011727 Caspases Human genes 0.000 description 1
- 108010078140 Cation Transport Proteins Proteins 0.000 description 1
- 108091005462 Cation channels Proteins 0.000 description 1
- 102100024490 Cdc42 effector protein 3 Human genes 0.000 description 1
- 102100035954 Choline transporter-like protein 2 Human genes 0.000 description 1
- RGJOEKWQDUBAIZ-IBOSZNHHSA-N CoASH Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCS)O[C@H]1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-IBOSZNHHSA-N 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- 108091004554 Copper Transport Proteins Proteins 0.000 description 1
- 102000020856 Copper Transport Proteins Human genes 0.000 description 1
- 102000021421 Copper Transporter 1 Human genes 0.000 description 1
- 102100034528 Core histone macro-H2A.1 Human genes 0.000 description 1
- 102100029375 Crk-like protein Human genes 0.000 description 1
- 101710095468 Cyclase Proteins 0.000 description 1
- 102000016736 Cyclin Human genes 0.000 description 1
- 108050006400 Cyclin Proteins 0.000 description 1
- 229940122280 Cytochrome P450 inhibitor Drugs 0.000 description 1
- 102100031655 Cytochrome b5 Human genes 0.000 description 1
- 102000018832 Cytochromes Human genes 0.000 description 1
- 108010052832 Cytochromes Proteins 0.000 description 1
- 108010007167 Cytochromes b5 Proteins 0.000 description 1
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
- 102100033212 DAZ-associated protein 2 Human genes 0.000 description 1
- 102100029586 DDB1- and CUL4-associated factor 16 Human genes 0.000 description 1
- 102000010567 DNA Polymerase II Human genes 0.000 description 1
- 108010063113 DNA Polymerase II Proteins 0.000 description 1
- 230000007067 DNA methylation Effects 0.000 description 1
- 230000004543 DNA replication Effects 0.000 description 1
- 108010063362 DNA-(Apurinic or Apyrimidinic Site) Lyase Proteins 0.000 description 1
- 102000010719 DNA-(Apurinic or Apyrimidinic Site) Lyase Human genes 0.000 description 1
- 102100035619 DNA-(apurinic or apyrimidinic site) lyase Human genes 0.000 description 1
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
- 102100036504 Dehydrogenase/reductase SDR family member 9 Human genes 0.000 description 1
- 108010053770 Deoxyribonucleases Proteins 0.000 description 1
- 102000016911 Deoxyribonucleases Human genes 0.000 description 1
- 108010086291 Deubiquitinating Enzyme CYLD Proteins 0.000 description 1
- 238000009007 Diagnostic Kit Methods 0.000 description 1
- 102100029579 Diphosphoinositol polyphosphate phosphohydrolase 1 Human genes 0.000 description 1
- 102100029721 DnaJ homolog subfamily B member 1 Human genes 0.000 description 1
- 102100035425 DnaJ homolog subfamily B member 6 Human genes 0.000 description 1
- 102100027274 Dual specificity protein phosphatase 6 Human genes 0.000 description 1
- 102100039922 E3 ISG15-protein ligase HERC5 Human genes 0.000 description 1
- 102100023991 E3 ubiquitin-protein ligase DTX3L Human genes 0.000 description 1
- 102100031788 E3 ubiquitin-protein ligase MYLIP Human genes 0.000 description 1
- 102100036275 E3 ubiquitin-protein ligase RNF149 Human genes 0.000 description 1
- 102100027418 E3 ubiquitin-protein ligase RNF213 Human genes 0.000 description 1
- 102100039499 E3 ubiquitin-protein ligase RNF26 Human genes 0.000 description 1
- 102100039502 E3 ubiquitin-protein ligase RNF34 Human genes 0.000 description 1
- 102100021758 E3 ubiquitin-protein transferase MAEA Human genes 0.000 description 1
- 102100037249 Egl nine homolog 1 Human genes 0.000 description 1
- 102100029988 Endoplasmic reticulum-Golgi intermediate compartment protein 3 Human genes 0.000 description 1
- 102100030011 Endoribonuclease Human genes 0.000 description 1
- 108010093099 Endoribonucleases Proteins 0.000 description 1
- 108090000371 Esterases Proteins 0.000 description 1
- 102100039950 Eukaryotic initiation factor 4A-I Human genes 0.000 description 1
- 208000005917 Exostoses Diseases 0.000 description 1
- 102100029055 Exostosin-1 Human genes 0.000 description 1
- 108010023321 Factor VII Proteins 0.000 description 1
- 108010008177 Fd immunoglobulins Proteins 0.000 description 1
- 102100037362 Fibronectin Human genes 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- 201000008808 Fibrosarcoma Diseases 0.000 description 1
- 241000710781 Flaviviridae Species 0.000 description 1
- 102100035139 Folate receptor alpha Human genes 0.000 description 1
- 102100028121 Fos-related antigen 2 Human genes 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- YXWOAJXNVLXPMU-ZXXMMSQZSA-N Fructose 2,6-diphosphate Chemical compound OP(=O)(O)O[C@]1(CO)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O YXWOAJXNVLXPMU-ZXXMMSQZSA-N 0.000 description 1
- 230000027304 G-protein signaling, coupled to cyclic nucleotide second messenger Effects 0.000 description 1
- 108091006094 GTPase-accelerating proteins Proteins 0.000 description 1
- 102100031692 GTPase-activating protein and VPS9 domain-containing protein 1 Human genes 0.000 description 1
- 102100034004 Gamma-adducin Human genes 0.000 description 1
- 206010071602 Genetic polymorphism Diseases 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 description 1
- 102100022624 Glucoamylase Human genes 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102000058062 Glucose Transporter Type 3 Human genes 0.000 description 1
- 102100033398 Glutamate-cysteine ligase regulatory subunit Human genes 0.000 description 1
- 108010036164 Glutathione synthase Proteins 0.000 description 1
- 102100033415 Golgi resident protein GCP60 Human genes 0.000 description 1
- 102000004144 Green Fluorescent Proteins Human genes 0.000 description 1
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 1
- 102100025334 Guanine nucleotide-binding protein G(q) subunit alpha Human genes 0.000 description 1
- 102100028538 Guanylate-binding protein 4 Human genes 0.000 description 1
- 208000007698 Gyrate Atrophy Diseases 0.000 description 1
- 102100031547 HLA class II histocompatibility antigen, DO alpha chain Human genes 0.000 description 1
- 108010042283 HSP40 Heat-Shock Proteins Proteins 0.000 description 1
- 108010027992 HSP70 Heat-Shock Proteins Proteins 0.000 description 1
- 102000018932 HSP70 Heat-Shock Proteins Human genes 0.000 description 1
- 102100040352 Heat shock 70 kDa protein 1A Human genes 0.000 description 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 description 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 description 1
- 102100035961 Hematopoietically-expressed homeobox protein HHEX Human genes 0.000 description 1
- 229920002971 Heparan sulfate Polymers 0.000 description 1
- 102100028895 Heterogeneous nuclear ribonucleoprotein M Human genes 0.000 description 1
- 102100033994 Heterogeneous nuclear ribonucleoproteins C1/C2 Human genes 0.000 description 1
- 101710177330 Histone deacetylase 7 Proteins 0.000 description 1
- 102100032742 Histone-lysine N-methyltransferase SETD2 Human genes 0.000 description 1
- 102100023604 Homeobox and leucine zipper protein Homez Human genes 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101001008910 Homo sapiens 2'-5'-oligoadenylate synthase 2 Proteins 0.000 description 1
- 101000597360 Homo sapiens 2'-5'-oligoadenylate synthase-like protein Proteins 0.000 description 1
- 101001080057 Homo sapiens 2-5A-dependent ribonuclease Proteins 0.000 description 1
- 101000841262 Homo sapiens 3-ketoacyl-CoA thiolase Proteins 0.000 description 1
- 101000711597 Homo sapiens 39S ribosomal protein L44, mitochondrial Proteins 0.000 description 1
- 101000715818 Homo sapiens 60S ribosomal protein L35 Proteins 0.000 description 1
- 101000928511 Homo sapiens Akirin-1 Proteins 0.000 description 1
- 101000928488 Homo sapiens Akirin-2 Proteins 0.000 description 1
- 101000890401 Homo sapiens Amyloid beta precursor like protein 2 Proteins 0.000 description 1
- 101000793430 Homo sapiens Apolipoprotein L2 Proteins 0.000 description 1
- 101000740484 Homo sapiens Aryl hydrocarbon receptor nuclear translocator-like protein 1 Proteins 0.000 description 1
- 101000959551 Homo sapiens Aurora kinase A-interacting protein Proteins 0.000 description 1
- 101000971234 Homo sapiens B-cell lymphoma 6 protein Proteins 0.000 description 1
- 101000984926 Homo sapiens Butyrophilin subfamily 2 member A1 Proteins 0.000 description 1
- 101000984925 Homo sapiens Butyrophilin subfamily 2 member A2 Proteins 0.000 description 1
- 101000945963 Homo sapiens CCAAT/enhancer-binding protein beta Proteins 0.000 description 1
- 101000888512 Homo sapiens CKLF-like MARVEL transmembrane domain-containing protein 8 Proteins 0.000 description 1
- 101000896987 Homo sapiens CREB-binding protein Proteins 0.000 description 1
- 101000741014 Homo sapiens Caspase-7 Proteins 0.000 description 1
- 101000762414 Homo sapiens Cdc42 effector protein 3 Proteins 0.000 description 1
- 101001067929 Homo sapiens Core histone macro-H2A.1 Proteins 0.000 description 1
- 101000919315 Homo sapiens Crk-like protein Proteins 0.000 description 1
- 101000871240 Homo sapiens DAZ-associated protein 2 Proteins 0.000 description 1
- 101000917435 Homo sapiens DDB1- and CUL4-associated factor 16 Proteins 0.000 description 1
- 101001137256 Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Proteins 0.000 description 1
- 101000928746 Homo sapiens Dehydrogenase/reductase SDR family member 9 Proteins 0.000 description 1
- 101000632920 Homo sapiens Diphosphoinositol polyphosphate phosphohydrolase 1 Proteins 0.000 description 1
- 101000804112 Homo sapiens DnaJ homolog subfamily B member 6 Proteins 0.000 description 1
- 101001057587 Homo sapiens Dual specificity protein phosphatase 6 Proteins 0.000 description 1
- 101001035145 Homo sapiens E3 ISG15-protein ligase HERC5 Proteins 0.000 description 1
- 101000904542 Homo sapiens E3 ubiquitin-protein ligase DTX3L Proteins 0.000 description 1
- 101001128447 Homo sapiens E3 ubiquitin-protein ligase MYLIP Proteins 0.000 description 1
- 101000650316 Homo sapiens E3 ubiquitin-protein ligase RNF213 Proteins 0.000 description 1
- 101001103590 Homo sapiens E3 ubiquitin-protein ligase RNF26 Proteins 0.000 description 1
- 101001103581 Homo sapiens E3 ubiquitin-protein ligase RNF34 Proteins 0.000 description 1
- 101000616009 Homo sapiens E3 ubiquitin-protein transferase MAEA Proteins 0.000 description 1
- 101000881648 Homo sapiens Egl nine homolog 1 Proteins 0.000 description 1
- 101001010804 Homo sapiens Endoplasmic reticulum-Golgi intermediate compartment protein 3 Proteins 0.000 description 1
- 101000959666 Homo sapiens Eukaryotic initiation factor 4A-I Proteins 0.000 description 1
- 101000918311 Homo sapiens Exostosin-1 Proteins 0.000 description 1
- 101001023230 Homo sapiens Folate receptor alpha Proteins 0.000 description 1
- 101001059934 Homo sapiens Fos-related antigen 2 Proteins 0.000 description 1
- 101000823463 Homo sapiens Fructose-2,6-bisphosphatase Proteins 0.000 description 1
- 101001066325 Homo sapiens GTPase-activating protein and VPS9 domain-containing protein 1 Proteins 0.000 description 1
- 101000799011 Homo sapiens Gamma-adducin Proteins 0.000 description 1
- 101000870644 Homo sapiens Glutamate-cysteine ligase regulatory subunit Proteins 0.000 description 1
- 101000585315 Homo sapiens Glutaminyl-peptide cyclotransferase Proteins 0.000 description 1
- 101000926911 Homo sapiens Golgi resident protein GCP60 Proteins 0.000 description 1
- 101000857888 Homo sapiens Guanine nucleotide-binding protein G(q) subunit alpha Proteins 0.000 description 1
- 101001058851 Homo sapiens Guanylate-binding protein 4 Proteins 0.000 description 1
- 101000866278 Homo sapiens HLA class II histocompatibility antigen, DO alpha chain Proteins 0.000 description 1
- 101001037759 Homo sapiens Heat shock 70 kDa protein 1A Proteins 0.000 description 1
- 101001021503 Homo sapiens Hematopoietically-expressed homeobox protein HHEX Proteins 0.000 description 1
- 101000839073 Homo sapiens Heterogeneous nuclear ribonucleoprotein M Proteins 0.000 description 1
- 101001017574 Homo sapiens Heterogeneous nuclear ribonucleoproteins C1/C2 Proteins 0.000 description 1
- 101001032113 Homo sapiens Histone deacetylase 7 Proteins 0.000 description 1
- 101000654725 Homo sapiens Histone-lysine N-methyltransferase SETD2 Proteins 0.000 description 1
- 101001048457 Homo sapiens Homeobox and leucine zipper protein Homez Proteins 0.000 description 1
- 101001035135 Homo sapiens Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein Proteins 0.000 description 1
- 101001003310 Homo sapiens Immediate early response gene 5 protein Proteins 0.000 description 1
- 101001044094 Homo sapiens Inositol monophosphatase 2 Proteins 0.000 description 1
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 description 1
- 101001082070 Homo sapiens Interferon alpha-inducible protein 6 Proteins 0.000 description 1
- 101001011393 Homo sapiens Interferon regulatory factor 2 Proteins 0.000 description 1
- 101000959664 Homo sapiens Interferon-induced protein 44-like Proteins 0.000 description 1
- 101001056699 Homo sapiens Intersectin-2 Proteins 0.000 description 1
- 101001047041 Homo sapiens Kelch repeat and BTB domain-containing protein 7 Proteins 0.000 description 1
- 101001139146 Homo sapiens Krueppel-like factor 2 Proteins 0.000 description 1
- 101001139126 Homo sapiens Krueppel-like factor 6 Proteins 0.000 description 1
- 101000941892 Homo sapiens Leucine-rich repeat and calponin homology domain-containing protein 4 Proteins 0.000 description 1
- 101001017833 Homo sapiens Leucine-rich repeat-containing protein 4 Proteins 0.000 description 1
- 101001010513 Homo sapiens Leukocyte elastase inhibitor Proteins 0.000 description 1
- 101000984199 Homo sapiens Leukocyte immunoglobulin-like receptor subfamily A member 4 Proteins 0.000 description 1
- 101000984196 Homo sapiens Leukocyte immunoglobulin-like receptor subfamily A member 5 Proteins 0.000 description 1
- 101000966257 Homo sapiens Limb region 1 protein homolog Proteins 0.000 description 1
- 101001044093 Homo sapiens Lipopolysaccharide-induced tumor necrosis factor-alpha factor Proteins 0.000 description 1
- 101001018028 Homo sapiens Lymphocyte antigen 86 Proteins 0.000 description 1
- 101000958225 Homo sapiens LysM and putative peptidoglycan-binding domain-containing protein 2 Proteins 0.000 description 1
- 101000969581 Homo sapiens MOB kinase activator 1A Proteins 0.000 description 1
- 101000950648 Homo sapiens Malectin Proteins 0.000 description 1
- 101001052076 Homo sapiens Maltase-glucoamylase Proteins 0.000 description 1
- 101001005667 Homo sapiens Mastermind-like protein 2 Proteins 0.000 description 1
- 101001005668 Homo sapiens Mastermind-like protein 3 Proteins 0.000 description 1
- 101000956320 Homo sapiens Membrane-spanning 4-domains subfamily A member 6A Proteins 0.000 description 1
- 101000581428 Homo sapiens Mini-chromosome maintenance complex-binding protein Proteins 0.000 description 1
- 101000988591 Homo sapiens Minor histocompatibility antigen H13 Proteins 0.000 description 1
- 101000602922 Homo sapiens Mitochondrial sodium/calcium exchanger protein Proteins 0.000 description 1
- 101001052493 Homo sapiens Mitogen-activated protein kinase 1 Proteins 0.000 description 1
- 101001018196 Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Proteins 0.000 description 1
- 101000896484 Homo sapiens Mitotic checkpoint protein BUB3 Proteins 0.000 description 1
- 101000969594 Homo sapiens Modulator of apoptosis 1 Proteins 0.000 description 1
- 101000955254 Homo sapiens Multiple epidermal growth factor-like domains protein 9 Proteins 0.000 description 1
- 101000604054 Homo sapiens Neuroplastin Proteins 0.000 description 1
- 101000578295 Homo sapiens NmrA-like family domain-containing protein 1 Proteins 0.000 description 1
- 101000973177 Homo sapiens Nuclear factor interleukin-3-regulated protein Proteins 0.000 description 1
- 101001137535 Homo sapiens Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 Proteins 0.000 description 1
- 101001098175 Homo sapiens P2X purinoceptor 7 Proteins 0.000 description 1
- 101000579354 Homo sapiens PHD finger protein 21A Proteins 0.000 description 1
- 101000586632 Homo sapiens PWWP domain-containing protein 2A Proteins 0.000 description 1
- 101000981502 Homo sapiens Pantothenate kinase 2, mitochondrial Proteins 0.000 description 1
- 101000878253 Homo sapiens Peptidyl-prolyl cis-trans isomerase FKBP5 Proteins 0.000 description 1
- 101001102158 Homo sapiens Phosphatidylserine synthase 1 Proteins 0.000 description 1
- 101000609532 Homo sapiens Phosphoinositide-3-kinase-interacting protein 1 Proteins 0.000 description 1
- 101000929845 Homo sapiens Phospholipase ABHD3 Proteins 0.000 description 1
- 101000974715 Homo sapiens Potassium voltage-gated channel subfamily E member 3 Proteins 0.000 description 1
- 101000705759 Homo sapiens Proteasome activator complex subunit 2 Proteins 0.000 description 1
- 101000933601 Homo sapiens Protein BTG1 Proteins 0.000 description 1
- 101001021281 Homo sapiens Protein HEXIM1 Proteins 0.000 description 1
- 101000994471 Homo sapiens Protein Jade-1 Proteins 0.000 description 1
- 101000983140 Homo sapiens Protein associated with UVRAG as autophagy enhancer Proteins 0.000 description 1
- 101001098769 Homo sapiens Protein disulfide-isomerase A6 Proteins 0.000 description 1
- 101000735459 Homo sapiens Protein mono-ADP-ribosyltransferase PARP9 Proteins 0.000 description 1
- 101000685914 Homo sapiens Protein transport protein Sec23B Proteins 0.000 description 1
- 101000830696 Homo sapiens Protein tyrosine phosphatase type IVA 1 Proteins 0.000 description 1
- 101000830691 Homo sapiens Protein tyrosine phosphatase type IVA 2 Proteins 0.000 description 1
- 101000605118 Homo sapiens Protein-glucosylgalactosylhydroxylysine glucosidase Proteins 0.000 description 1
- 101001100309 Homo sapiens RNA-binding protein 47 Proteins 0.000 description 1
- 101000743264 Homo sapiens RNA-binding protein 6 Proteins 0.000 description 1
- 101001132549 Homo sapiens Ras-related protein Rab-9A Proteins 0.000 description 1
- 101001130458 Homo sapiens Ras-related protein Ral-B Proteins 0.000 description 1
- 101000580351 Homo sapiens Respirasome Complex Assembly Factor 1 Proteins 0.000 description 1
- 101000727472 Homo sapiens Reticulon-4 Proteins 0.000 description 1
- 101001111655 Homo sapiens Retinol dehydrogenase 11 Proteins 0.000 description 1
- 101000651709 Homo sapiens SCO-spondin Proteins 0.000 description 1
- 101000825377 Homo sapiens SPRY domain-containing SOCS box protein 3 Proteins 0.000 description 1
- 101000834853 Homo sapiens SUZ domain-containing protein 1 Proteins 0.000 description 1
- 101000879840 Homo sapiens Serglycin Proteins 0.000 description 1
- 101001038335 Homo sapiens Serine/threonine-protein kinase LMTK2 Proteins 0.000 description 1
- 101000783404 Homo sapiens Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Proteins 0.000 description 1
- 101000654500 Homo sapiens Signal-induced proliferation-associated 1-like protein 2 Proteins 0.000 description 1
- 101000657845 Homo sapiens Small nuclear ribonucleoprotein-associated proteins B and B' Proteins 0.000 description 1
- 101000974834 Homo sapiens Sodium/potassium-transporting ATPase subunit beta-3 Proteins 0.000 description 1
- 101000689199 Homo sapiens Src-like-adapter Proteins 0.000 description 1
- 101000822540 Homo sapiens Sterile alpha motif domain-containing protein 9-like Proteins 0.000 description 1
- 101000617830 Homo sapiens Sterol O-acyltransferase 1 Proteins 0.000 description 1
- 101000652300 Homo sapiens Synaptosomal-associated protein 23 Proteins 0.000 description 1
- 101000800493 Homo sapiens Talin rod domain-containing protein 1 Proteins 0.000 description 1
- 101000819111 Homo sapiens Trans-acting T-cell-specific transcription factor GATA-3 Proteins 0.000 description 1
- 101000962473 Homo sapiens Transcription factor MafG Proteins 0.000 description 1
- 101000904499 Homo sapiens Transcription regulator protein BACH2 Proteins 0.000 description 1
- 101000764622 Homo sapiens Transmembrane and immunoglobulin domain-containing protein 2 Proteins 0.000 description 1
- 101000895030 Homo sapiens Transmembrane ascorbate-dependent reductase CYB561 Proteins 0.000 description 1
- 101000763474 Homo sapiens Transmembrane protein 140 Proteins 0.000 description 1
- 101000763472 Homo sapiens Transmembrane protein 141 Proteins 0.000 description 1
- 101000749407 Homo sapiens UV-stimulated scaffold protein A Proteins 0.000 description 1
- 101001057508 Homo sapiens Ubiquitin-like protein ISG15 Proteins 0.000 description 1
- 101000760337 Homo sapiens Urokinase plasminogen activator surface receptor Proteins 0.000 description 1
- 101000631907 Homo sapiens Vesicle-trafficking protein SEC22b Proteins 0.000 description 1
- 101000955105 Homo sapiens WAS protein family homolog 2 Proteins 0.000 description 1
- 101000814514 Homo sapiens XIAP-associated factor 1 Proteins 0.000 description 1
- 101001022836 Homo sapiens c-Myc-binding protein Proteins 0.000 description 1
- 101000988424 Homo sapiens cAMP-specific 3',5'-cyclic phosphodiesterase 4B Proteins 0.000 description 1
- 102100039926 Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein Human genes 0.000 description 1
- 238000009015 Human TaqMan MicroRNA Assay kit Methods 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 102100020688 Immediate early response gene 5 protein Human genes 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
- 102100021608 Inositol monophosphatase 2 Human genes 0.000 description 1
- 102100025304 Integrin beta-1 Human genes 0.000 description 1
- 102000002227 Interferon Type I Human genes 0.000 description 1
- 108010014726 Interferon Type I Proteins 0.000 description 1
- 101710169201 Interferon alpha-inducible protein 6 Proteins 0.000 description 1
- 102100026720 Interferon beta Human genes 0.000 description 1
- 102100037850 Interferon gamma Human genes 0.000 description 1
- 102100036157 Interferon gamma receptor 2 Human genes 0.000 description 1
- 102100029838 Interferon regulatory factor 2 Human genes 0.000 description 1
- 102100038251 Interferon regulatory factor 9 Human genes 0.000 description 1
- 108010079944 Interferon-alpha2b Proteins 0.000 description 1
- 108090000467 Interferon-beta Proteins 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 101710142533 Interferon-induced protein 44-like Proteins 0.000 description 1
- 102000013462 Interleukin-12 Human genes 0.000 description 1
- 108010065805 Interleukin-12 Proteins 0.000 description 1
- 102000000588 Interleukin-2 Human genes 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 102000000646 Interleukin-3 Human genes 0.000 description 1
- 108010002386 Interleukin-3 Proteins 0.000 description 1
- 102000004889 Interleukin-6 Human genes 0.000 description 1
- 108090001005 Interleukin-6 Proteins 0.000 description 1
- 102100025505 Intersectin-2 Human genes 0.000 description 1
- SHGAZHPCJJPHSC-NUEINMDLSA-N Isotretinoin Chemical compound OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NUEINMDLSA-N 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- KJHKTHWMRKYKJE-SUGCFTRWSA-N Kaletra Chemical compound N1([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=2C=CC=CC=2)NC(=O)COC=2C(=CC=CC=2C)C)CC=2C=CC=CC=2)CCCNC1=O KJHKTHWMRKYKJE-SUGCFTRWSA-N 0.000 description 1
- 102100022835 Kelch repeat and BTB domain-containing protein 7 Human genes 0.000 description 1
- 102100020675 Krueppel-like factor 2 Human genes 0.000 description 1
- 102100020679 Krueppel-like factor 6 Human genes 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- 239000002211 L-ascorbic acid Substances 0.000 description 1
- 235000000069 L-ascorbic acid Nutrition 0.000 description 1
- AEMOLEFTQBMNLQ-HNFCZKTMSA-N L-idopyranuronic acid Chemical compound OC1O[C@@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-HNFCZKTMSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- 241000288904 Lemur Species 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 108010006444 Leucine-Rich Repeat Proteins Proteins 0.000 description 1
- 102100032680 Leucine-rich repeat and calponin homology domain-containing protein 4 Human genes 0.000 description 1
- 102100033304 Leucine-rich repeat-containing protein 4 Human genes 0.000 description 1
- 102100030635 Leukocyte elastase inhibitor Human genes 0.000 description 1
- 102100025555 Leukocyte immunoglobulin-like receptor subfamily A member 4 Human genes 0.000 description 1
- 102100025574 Leukocyte immunoglobulin-like receptor subfamily A member 5 Human genes 0.000 description 1
- 102100040547 Limb region 1 protein homolog Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 102100021607 Lipopolysaccharide-induced tumor necrosis factor-alpha factor Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090000856 Lyases Proteins 0.000 description 1
- 102000004317 Lyases Human genes 0.000 description 1
- 102100033485 Lymphocyte antigen 86 Human genes 0.000 description 1
- 102100038229 LysM and putative peptidoglycan-binding domain-containing protein 2 Human genes 0.000 description 1
- 108020002496 Lysophospholipase Proteins 0.000 description 1
- 108091007767 MALAT1 Proteins 0.000 description 1
- 102000001291 MAP Kinase Kinase Kinase Human genes 0.000 description 1
- 108060006687 MAP kinase kinase kinase Proteins 0.000 description 1
- 102000017274 MDM4 Human genes 0.000 description 1
- 108050005300 MDM4 Proteins 0.000 description 1
- 101150007128 MDM4 gene Proteins 0.000 description 1
- 102100021437 MOB kinase activator 1A Human genes 0.000 description 1
- 101150020396 MSRB2 gene Proteins 0.000 description 1
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
- 102100037750 Malectin Human genes 0.000 description 1
- 102100025130 Mastermind-like protein 2 Human genes 0.000 description 1
- 102100025134 Mastermind-like protein 3 Human genes 0.000 description 1
- 108010090314 Member 1 Subfamily G ATP Binding Cassette Transporter Proteins 0.000 description 1
- 102100038555 Membrane-spanning 4-domains subfamily A member 6A Human genes 0.000 description 1
- 102000003792 Metallothionein Human genes 0.000 description 1
- 108090000157 Metallothionein Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102100024862 Methionine-R-sulfoxide reductase B2, mitochondrial Human genes 0.000 description 1
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 description 1
- 102000029749 Microtubule Human genes 0.000 description 1
- 108091022875 Microtubule Proteins 0.000 description 1
- 102000009664 Microtubule-Associated Proteins Human genes 0.000 description 1
- 108010020004 Microtubule-Associated Proteins Proteins 0.000 description 1
- 102100027372 Mini-chromosome maintenance complex-binding protein Human genes 0.000 description 1
- 102100029083 Minor histocompatibility antigen H13 Human genes 0.000 description 1
- 102100037227 Mitochondrial sodium/calcium exchanger protein Human genes 0.000 description 1
- 102100024193 Mitogen-activated protein kinase 1 Human genes 0.000 description 1
- 102100033127 Mitogen-activated protein kinase kinase kinase 5 Human genes 0.000 description 1
- 102100021718 Mitotic checkpoint protein BUB3 Human genes 0.000 description 1
- 102100021440 Modulator of apoptosis 1 Human genes 0.000 description 1
- 102100038989 Multiple epidermal growth factor-like domains protein 9 Human genes 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 101100178288 Mus musculus Homez gene Proteins 0.000 description 1
- 101100023508 Mus musculus Mlec gene Proteins 0.000 description 1
- 101100085608 Mus musculus Pwwp2a gene Proteins 0.000 description 1
- 101100420730 Mus musculus Sec23a gene Proteins 0.000 description 1
- 108060008487 Myosin Proteins 0.000 description 1
- 102000003505 Myosin Human genes 0.000 description 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 1
- 108010071382 NF-E2-Related Factor 2 Proteins 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 108090000189 Neuropeptides Proteins 0.000 description 1
- 102000003797 Neuropeptides Human genes 0.000 description 1
- 102100038434 Neuroplastin Human genes 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 102100028083 NmrA-like family domain-containing protein 1 Human genes 0.000 description 1
- 101800001020 Non-structural protein 4A Proteins 0.000 description 1
- 108091092724 Noncoding DNA Proteins 0.000 description 1
- 230000005913 Notch signaling pathway Effects 0.000 description 1
- 102000007999 Nuclear Proteins Human genes 0.000 description 1
- 108010089610 Nuclear Proteins Proteins 0.000 description 1
- 102100031701 Nuclear factor erythroid 2-related factor 2 Human genes 0.000 description 1
- 102100022163 Nuclear factor interleukin-3-regulated protein Human genes 0.000 description 1
- 102100021007 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 Human genes 0.000 description 1
- 101710163270 Nuclease Proteins 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 102000035028 Nucleic proteins Human genes 0.000 description 1
- 102000008021 Nucleoside-Triphosphatase Human genes 0.000 description 1
- 108010075285 Nucleoside-Triphosphatase Proteins 0.000 description 1
- 102100039306 Nucleotide pyrophosphatase Human genes 0.000 description 1
- 108010078627 Oncogene Protein v-crk Proteins 0.000 description 1
- 108010058846 Ovalbumin Proteins 0.000 description 1
- 102100037602 P2X purinoceptor 7 Human genes 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 102100028222 PHD finger protein 21A Human genes 0.000 description 1
- 102100029733 PWWP domain-containing protein 2A Human genes 0.000 description 1
- 241000282579 Pan Species 0.000 description 1
- 108010021592 Pantothenate kinase Proteins 0.000 description 1
- 102100024122 Pantothenate kinase 1 Human genes 0.000 description 1
- 102100024127 Pantothenate kinase 2, mitochondrial Human genes 0.000 description 1
- 241000232971 Passer domesticus Species 0.000 description 1
- 229940122344 Peptidase inhibitor Drugs 0.000 description 1
- 108010044843 Peptide Initiation Factors Proteins 0.000 description 1
- 102000005877 Peptide Initiation Factors Human genes 0.000 description 1
- 102100037026 Peptidyl-prolyl cis-trans isomerase FKBP5 Human genes 0.000 description 1
- 102100039298 Phosphatidylserine synthase 1 Human genes 0.000 description 1
- 108010022678 Phosphofructokinase-2 Proteins 0.000 description 1
- 102100035907 Phospholipase ABHD3 Human genes 0.000 description 1
- 108010089430 Phosphoproteins Proteins 0.000 description 1
- 102000007982 Phosphoproteins Human genes 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 102000004257 Potassium Channel Human genes 0.000 description 1
- 102100022753 Potassium voltage-gated channel subfamily E member 3 Human genes 0.000 description 1
- 102100026036 Protein BTG1 Human genes 0.000 description 1
- 102000006010 Protein Disulfide-Isomerase Human genes 0.000 description 1
- 102100036307 Protein HEXIM1 Human genes 0.000 description 1
- 102100032706 Protein Jade-1 Human genes 0.000 description 1
- 108700040121 Protein Methyltransferases Proteins 0.000 description 1
- 102000055027 Protein Methyltransferases Human genes 0.000 description 1
- 102000002727 Protein Tyrosine Phosphatase Human genes 0.000 description 1
- 102100026827 Protein associated with UVRAG as autophagy enhancer Human genes 0.000 description 1
- 102100037061 Protein disulfide-isomerase A6 Human genes 0.000 description 1
- 102100034930 Protein mono-ADP-ribosyltransferase PARP9 Human genes 0.000 description 1
- 229940116193 Protein phosphatase inhibitor Drugs 0.000 description 1
- 102100030908 Protein shisa-5 Human genes 0.000 description 1
- 102100023366 Protein transport protein Sec23B Human genes 0.000 description 1
- 102100024599 Protein tyrosine phosphatase type IVA 1 Human genes 0.000 description 1
- 102100024602 Protein tyrosine phosphatase type IVA 2 Human genes 0.000 description 1
- 102100038278 Protein-glucosylgalactosylhydroxylysine glucosidase Human genes 0.000 description 1
- 238000002123 RNA extraction Methods 0.000 description 1
- 230000006819 RNA synthesis Effects 0.000 description 1
- 102100038822 RNA-binding protein 47 Human genes 0.000 description 1
- 102100038150 RNA-binding protein 6 Human genes 0.000 description 1
- 108090000740 RNA-binding protein EWS Proteins 0.000 description 1
- 102000004229 RNA-binding protein EWS Human genes 0.000 description 1
- 108091007335 RNF149 Proteins 0.000 description 1
- 238000011529 RT qPCR Methods 0.000 description 1
- 102100031426 Ras GTPase-activating protein 1 Human genes 0.000 description 1
- 102100039767 Ras-related protein Rab-27A Human genes 0.000 description 1
- 102100033966 Ras-related protein Rab-9A Human genes 0.000 description 1
- 102100031425 Ras-related protein Ral-B Human genes 0.000 description 1
- 101100222379 Rattus norvegicus Cxcl10 gene Proteins 0.000 description 1
- 108010012770 Rebetron Proteins 0.000 description 1
- 102100027558 Respirasome Complex Assembly Factor 1 Human genes 0.000 description 1
- 102100029831 Reticulon-4 Human genes 0.000 description 1
- 102100023916 Retinol dehydrogenase 11 Human genes 0.000 description 1
- 108010083644 Ribonucleases Proteins 0.000 description 1
- 102000006382 Ribonucleases Human genes 0.000 description 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
- 108010000605 Ribosomal Proteins Proteins 0.000 description 1
- 102000002278 Ribosomal Proteins Human genes 0.000 description 1
- 229930001406 Ryanodine Natural products 0.000 description 1
- MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 description 1
- 108091006207 SLC-Transporter Proteins 0.000 description 1
- 102000037054 SLC-Transporter Human genes 0.000 description 1
- 108091006737 SLC22A4 Proteins 0.000 description 1
- 108091006298 SLC2A3 Proteins 0.000 description 1
- 108091006565 SLC31A1 Proteins 0.000 description 1
- 108091007001 SLC44A2 Proteins 0.000 description 1
- 102100022310 SPRY domain-containing SOCS box protein 3 Human genes 0.000 description 1
- 102100026877 SUZ domain-containing protein 1 Human genes 0.000 description 1
- 102100037344 Serglycin Human genes 0.000 description 1
- 102100040292 Serine/threonine-protein kinase LMTK2 Human genes 0.000 description 1
- 102100036122 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Human genes 0.000 description 1
- 102100031451 Signal-induced proliferation-associated 1-like protein 2 Human genes 0.000 description 1
- 108010003165 Small Nuclear Ribonucleoproteins Proteins 0.000 description 1
- 102000004598 Small Nuclear Ribonucleoproteins Human genes 0.000 description 1
- 108020003224 Small Nucleolar RNA Proteins 0.000 description 1
- 102000042773 Small Nucleolar RNA Human genes 0.000 description 1
- 102100034683 Small nuclear ribonucleoprotein-associated proteins B and B' Human genes 0.000 description 1
- 102100022792 Sodium/potassium-transporting ATPase subunit beta-3 Human genes 0.000 description 1
- 102100030435 Sp110 nuclear body protein Human genes 0.000 description 1
- 102100030056 Splicing factor 1 Human genes 0.000 description 1
- 102100024519 Src-like-adapter Human genes 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 102100022459 Sterile alpha motif domain-containing protein 9-like Human genes 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 102000001494 Sterol O-Acyltransferase Human genes 0.000 description 1
- 108010054082 Sterol O-acyltransferase Proteins 0.000 description 1
- 102100021993 Sterol O-acyltransferase 1 Human genes 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 108090000088 Symporters Proteins 0.000 description 1
- 102000003673 Symporters Human genes 0.000 description 1
- 102100030545 Synaptosomal-associated protein 23 Human genes 0.000 description 1
- 230000006044 T cell activation Effects 0.000 description 1
- 230000005867 T cell response Effects 0.000 description 1
- 102100033130 T-box transcription factor T Human genes 0.000 description 1
- 101710086566 T-box transcription factor T Proteins 0.000 description 1
- 102100033112 Talin rod domain-containing protein 1 Human genes 0.000 description 1
- 108010046075 Thymosin Proteins 0.000 description 1
- 102000007501 Thymosin Human genes 0.000 description 1
- 102100021386 Trans-acting T-cell-specific transcription factor GATA-3 Human genes 0.000 description 1
- 102100039188 Transcription factor MafG Human genes 0.000 description 1
- 102100023998 Transcription regulator protein BACH2 Human genes 0.000 description 1
- 102100026224 Transmembrane and immunoglobulin domain-containing protein 2 Human genes 0.000 description 1
- 102100021338 Transmembrane ascorbate-dependent reductase CYB561 Human genes 0.000 description 1
- 102100027030 Transmembrane protein 140 Human genes 0.000 description 1
- 102100027029 Transmembrane protein 141 Human genes 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 101710102500 Tryptophan 2,3-dioxygenase-like protein Proteins 0.000 description 1
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 1
- 108010079194 Type C Phospholipases Proteins 0.000 description 1
- 102000014384 Type C Phospholipases Human genes 0.000 description 1
- 102100024250 Ubiquitin carboxyl-terminal hydrolase CYLD Human genes 0.000 description 1
- 102100027266 Ubiquitin-like protein ISG15 Human genes 0.000 description 1
- 108091023045 Untranslated Region Proteins 0.000 description 1
- 102100024689 Urokinase plasminogen activator surface receptor Human genes 0.000 description 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 1
- 102100028753 Vesicle-trafficking protein SEC22b Human genes 0.000 description 1
- 102100038949 WAS protein family homolog 2 Human genes 0.000 description 1
- 210000001766 X chromosome Anatomy 0.000 description 1
- 102100039488 XIAP-associated factor 1 Human genes 0.000 description 1
- 210000002593 Y chromosome Anatomy 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 102100026487 Zinc finger protein 862 Human genes 0.000 description 1
- KOHUATWNGBDXMV-UHFFFAOYSA-N [Mg]N Chemical compound [Mg]N KOHUATWNGBDXMV-UHFFFAOYSA-N 0.000 description 1
- 229940100228 acetyl coenzyme a Drugs 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 231100000354 acute hepatitis Toxicity 0.000 description 1
- 102000019997 adhesion receptor Human genes 0.000 description 1
- 108010013985 adhesion receptor Proteins 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 108010062065 albumin interferon Proteins 0.000 description 1
- 229960001445 alitretinoin Drugs 0.000 description 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
- 108010028144 alpha-Glucosidases Proteins 0.000 description 1
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 description 1
- 229960003805 amantadine Drugs 0.000 description 1
- 229960001830 amprenavir Drugs 0.000 description 1
- YMARZQAQMVYCKC-OEMFJLHTSA-N amprenavir Chemical compound C([C@@H]([C@H](O)CN(CC(C)C)S(=O)(=O)C=1C=CC(N)=CC=1)NC(=O)O[C@@H]1COCC1)C1=CC=CC=C1 YMARZQAQMVYCKC-OEMFJLHTSA-N 0.000 description 1
- 230000000798 anti-retroviral effect Effects 0.000 description 1
- 230000030741 antigen processing and presentation Effects 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 230000012785 antimicrobial humoral response Effects 0.000 description 1
- 230000001640 apoptogenic effect Effects 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 230000004900 autophagic degradation Effects 0.000 description 1
- 230000002886 autophagic effect Effects 0.000 description 1
- 210000003050 axon Anatomy 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 150000001556 benzimidazoles Chemical class 0.000 description 1
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000005460 biophysical method Methods 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 102100035161 c-Myc-binding protein Human genes 0.000 description 1
- WLZRMCYVCSSEQC-UHFFFAOYSA-N cadmium(2+) Chemical compound [Cd+2] WLZRMCYVCSSEQC-UHFFFAOYSA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 108010086826 calponin Proteins 0.000 description 1
- 102000006783 calponin Human genes 0.000 description 1
- 238000005251 capillar electrophoresis Methods 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 230000034303 cell budding Effects 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000002032 cellular defenses Effects 0.000 description 1
- 229940106189 ceramide Drugs 0.000 description 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 108091006090 chromatin-associated proteins Proteins 0.000 description 1
- 229960001380 cimetidine Drugs 0.000 description 1
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 description 1
- 230000027288 circadian rhythm Effects 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 238000011284 combination treatment Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000027326 copulation Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000009223 counseling Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- GYOZYWVXFNDGLU-XLPZGREQSA-N dTMP Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)C1 GYOZYWVXFNDGLU-XLPZGREQSA-N 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- 229960005319 delavirdine Drugs 0.000 description 1
- 238000007435 diagnostic evaluation Methods 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000001177 diphosphate Substances 0.000 description 1
- 231100000676 disease causative agent Toxicity 0.000 description 1
- 230000032671 dosage compensation Effects 0.000 description 1
- 239000000890 drug combination Substances 0.000 description 1
- 230000036267 drug metabolism Effects 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 210000001163 endosome Anatomy 0.000 description 1
- 244000309457 enveloped RNA virus Species 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 238000001976 enzyme digestion Methods 0.000 description 1
- 102000027412 enzyme-linked receptors Human genes 0.000 description 1
- 108091008592 enzyme-linked receptors Proteins 0.000 description 1
- 229960003276 erythromycin Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000006846 excision repair Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000010195 expression analysis Methods 0.000 description 1
- 208000008805 familial cylindromatosis Diseases 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 description 1
- 229960004884 fluconazole Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229960002464 fluoxetine Drugs 0.000 description 1
- CJOFXWAVKWHTFT-XSFVSMFZSA-N fluvoxamine Chemical compound COCCCC\C(=N/OCCN)C1=CC=C(C(F)(F)F)C=C1 CJOFXWAVKWHTFT-XSFVSMFZSA-N 0.000 description 1
- 229960004038 fluvoxamine Drugs 0.000 description 1
- 229940014144 folate Drugs 0.000 description 1
- 229960003142 fosamprenavir Drugs 0.000 description 1
- MLBVMOWEQCZNCC-OEMFJLHTSA-N fosamprenavir Chemical compound C([C@@H]([C@H](OP(O)(O)=O)CN(CC(C)C)S(=O)(=O)C=1C=CC(N)=CC=1)NC(=O)O[C@@H]1COCC1)C1=CC=CC=C1 MLBVMOWEQCZNCC-OEMFJLHTSA-N 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 108010067667 gamma Subunit Interferon-Stimulated Gene Factor 3 Proteins 0.000 description 1
- 238000003500 gene array Methods 0.000 description 1
- 238000003633 gene expression assay Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000006377 glucose transport Effects 0.000 description 1
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 description 1
- 108010081484 glutaminyl-peptide cyclotransferase Proteins 0.000 description 1
- 125000003147 glycosyl group Chemical group 0.000 description 1
- 210000002288 golgi apparatus Anatomy 0.000 description 1
- 210000003652 golgi cell Anatomy 0.000 description 1
- RQFCJASXJCIDSX-UUOKFMHZSA-N guanosine 5'-monophosphate Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O RQFCJASXJCIDSX-UUOKFMHZSA-N 0.000 description 1
- 210000002443 helper t lymphocyte Anatomy 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 description 1
- 238000007417 hierarchical cluster analysis Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000005745 host immune response Effects 0.000 description 1
- 230000028996 humoral immune response Effects 0.000 description 1
- 230000008348 humoral response Effects 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 102000013167 hydrolase activity, acting on glycosyl bonds Human genes 0.000 description 1
- 108040007813 hydrolase activity, acting on glycosyl bonds Proteins 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 230000005965 immune activity Effects 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 102000027596 immune receptors Human genes 0.000 description 1
- 108091008915 immune receptors Proteins 0.000 description 1
- 238000003119 immunoblot Methods 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 230000004957 immunoregulator effect Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 229960001936 indinavir Drugs 0.000 description 1
- CBVCZFGXHXORBI-PXQQMZJSSA-N indinavir Chemical compound C([C@H](N(CC1)C[C@@H](O)C[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H]2C3=CC=CC=C3C[C@H]2O)C(=O)NC(C)(C)C)N1CC1=CC=CN=C1 CBVCZFGXHXORBI-PXQQMZJSSA-N 0.000 description 1
- 230000006882 induction of apoptosis Effects 0.000 description 1
- 229940090438 infergen Drugs 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229950000038 interferon alfa Drugs 0.000 description 1
- 229960003521 interferon alfa-2a Drugs 0.000 description 1
- 229960003507 interferon alfa-2b Drugs 0.000 description 1
- 108010006088 interferon alfa-n1 Proteins 0.000 description 1
- 108010010648 interferon alfacon-1 Proteins 0.000 description 1
- 108010085650 interferon gamma receptor Proteins 0.000 description 1
- 239000002799 interferon inducing agent Substances 0.000 description 1
- 229940117681 interleukin-12 Drugs 0.000 description 1
- 229940076264 interleukin-3 Drugs 0.000 description 1
- 229940100601 interleukin-6 Drugs 0.000 description 1
- 102000027411 intracellular receptors Human genes 0.000 description 1
- 108091008582 intracellular receptors Proteins 0.000 description 1
- 230000031146 intracellular signal transduction Effects 0.000 description 1
- 230000004068 intracellular signaling Effects 0.000 description 1
- 229960004130 itraconazole Drugs 0.000 description 1
- 150000004715 keto acids Chemical class 0.000 description 1
- 210000002415 kinetochore Anatomy 0.000 description 1
- 210000004901 leucine-rich repeat Anatomy 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 238000007834 ligase chain reaction Methods 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000008604 lipoprotein metabolism Effects 0.000 description 1
- 206010024627 liposarcoma Diseases 0.000 description 1
- 238000012317 liver biopsy Methods 0.000 description 1
- 208000018191 liver inflammation Diseases 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229960004525 lopinavir Drugs 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000002132 lysosomal effect Effects 0.000 description 1
- 230000013227 macrophage apoptotic process Effects 0.000 description 1
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000010297 mechanical methods and process Methods 0.000 description 1
- 230000034217 membrane fusion Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 239000003475 metalloproteinase inhibitor Substances 0.000 description 1
- 229960002509 miconazole Drugs 0.000 description 1
- HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 description 1
- 210000004688 microtubule Anatomy 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 108091064355 mitochondrial RNA Proteins 0.000 description 1
- 230000017205 mitotic cell cycle checkpoint Effects 0.000 description 1
- 230000000394 mitotic effect Effects 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 239000003068 molecular probe Substances 0.000 description 1
- 210000005087 mononuclear cell Anatomy 0.000 description 1
- 238000007837 multiplex assay Methods 0.000 description 1
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 description 1
- 229960000951 mycophenolic acid Drugs 0.000 description 1
- OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- VRBKIVRKKCLPHA-UHFFFAOYSA-N nefazodone Chemical compound O=C1N(CCOC=2C=CC=CC=2)C(CC)=NN1CCCN(CC1)CCN1C1=CC=CC(Cl)=C1 VRBKIVRKKCLPHA-UHFFFAOYSA-N 0.000 description 1
- 229960001800 nefazodone Drugs 0.000 description 1
- 230000035407 negative regulation of cell proliferation Effects 0.000 description 1
- 230000031744 negative regulation of protein catabolic process Effects 0.000 description 1
- 230000029246 negative regulation of transcription, DNA-dependent Effects 0.000 description 1
- 230000009522 negative regulation of tyrosine phosphorylation of Stat3 protein Effects 0.000 description 1
- 229960000884 nelfinavir Drugs 0.000 description 1
- QAGYKUNXZHXKMR-HKWSIXNMSA-N nelfinavir Chemical compound CC1=C(O)C=CC=C1C(=O)N[C@H]([C@H](O)CN1[C@@H](C[C@@H]2CCCC[C@@H]2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 QAGYKUNXZHXKMR-HKWSIXNMSA-N 0.000 description 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 238000001151 non-parametric statistical test Methods 0.000 description 1
- 210000003924 normoblast Anatomy 0.000 description 1
- 210000000633 nuclear envelope Anatomy 0.000 description 1
- 108010067588 nucleotide pyrophosphatase Proteins 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 208000014380 ornithine aminotransferase deficiency Diseases 0.000 description 1
- 201000008968 osteosarcoma Diseases 0.000 description 1
- 229940092253 ovalbumin Drugs 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 229940014662 pantothenate Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 230000025733 passive induction of host immune response by virus Effects 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- 229960003930 peginterferon alfa-2a Drugs 0.000 description 1
- 229960003931 peginterferon alfa-2b Drugs 0.000 description 1
- 229940106366 pegintron Drugs 0.000 description 1
- 239000000816 peptidomimetic Substances 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 150000003905 phosphatidylinositols Chemical class 0.000 description 1
- 239000003934 phosphoprotein phosphatase inhibitor Substances 0.000 description 1
- 108091008695 photoreceptors Proteins 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 230000010118 platelet activation Effects 0.000 description 1
- 235000020004 porter Nutrition 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000018767 positive regulation of catalytic activity Effects 0.000 description 1
- 230000009098 positive regulation of endothelial cell differentiation Effects 0.000 description 1
- 230000022206 positive regulation of myoblast differentiation Effects 0.000 description 1
- 230000034383 positive regulation of proteolysis Effects 0.000 description 1
- 230000021514 positive regulation of transcription from RNA polymerase II promoter Effects 0.000 description 1
- BITYAPCSNKJESK-UHFFFAOYSA-N potassiosodium Chemical compound [Na].[K] BITYAPCSNKJESK-UHFFFAOYSA-N 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 108020001213 potassium channel Proteins 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 108091005629 prenylated proteins Proteins 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 238000002331 protein detection Methods 0.000 description 1
- 108020003519 protein disulfide isomerase Proteins 0.000 description 1
- 230000009822 protein phosphorylation Effects 0.000 description 1
- 230000005451 protein repair Effects 0.000 description 1
- 238000000734 protein sequencing Methods 0.000 description 1
- 230000029983 protein stabilization Effects 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 108020000494 protein-tyrosine phosphatase Proteins 0.000 description 1
- 239000002213 purine nucleotide Substances 0.000 description 1
- 230000001696 purinergic effect Effects 0.000 description 1
- 150000003212 purines Chemical class 0.000 description 1
- 235000007682 pyridoxal 5'-phosphate Nutrition 0.000 description 1
- 239000011589 pyridoxal 5'-phosphate Substances 0.000 description 1
- 229960001327 pyridoxal phosphate Drugs 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 108010033990 rab27 GTP-Binding Proteins Proteins 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 108700042226 ras Genes Proteins 0.000 description 1
- 108091006084 receptor activators Proteins 0.000 description 1
- 210000003370 receptor cell Anatomy 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000033018 regulation of I-kappaB kinase/NF-kappaB cascade Effects 0.000 description 1
- 230000033390 regulation of RNA export from nucleus Effects 0.000 description 1
- 230000007250 regulation of Wnt receptor signaling pathway Effects 0.000 description 1
- 230000024155 regulation of cell adhesion Effects 0.000 description 1
- 230000009703 regulation of cell differentiation Effects 0.000 description 1
- 230000026267 regulation of growth Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000028617 response to DNA damage stimulus Effects 0.000 description 1
- 230000024977 response to activity Effects 0.000 description 1
- 230000020874 response to hypoxia Effects 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 108010035291 retinol dehydrogenase Proteins 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 238000012502 risk assessment Methods 0.000 description 1
- JJSYXNQGLHBRRK-SFEDZAPPSA-N ryanodine Chemical compound O([C@@H]1[C@]([C@@]2([C@]3(O)[C@]45O[C@@]2(O)C[C@]([C@]4(CC[C@H](C)[C@H]5O)O)(C)[C@@]31O)C)(O)C(C)C)C(=O)C1=CC=CN1 JJSYXNQGLHBRRK-SFEDZAPPSA-N 0.000 description 1
- 229960001852 saquinavir Drugs 0.000 description 1
- QWAXKHKRTORLEM-UGJKXSETSA-N saquinavir Chemical compound C([C@@H]([C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)C=1N=C2C=CC=CC2=CC=1)C1=CC=CC=C1 QWAXKHKRTORLEM-UGJKXSETSA-N 0.000 description 1
- 230000015692 second-messenger-mediated signaling Effects 0.000 description 1
- 230000013707 sensory perception of sound Effects 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 description 1
- 229960002073 sertraline Drugs 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000029003 signal transducer activity Effects 0.000 description 1
- 102000034285 signal transducing proteins Human genes 0.000 description 1
- 108091006024 signal transducing proteins Proteins 0.000 description 1
- 108091029842 small nuclear ribonucleic acid Proteins 0.000 description 1
- MIXCUJKCXRNYFM-UHFFFAOYSA-M sodium;diiodomethanesulfonate;n-propyl-n-[2-(2,4,6-trichlorophenoxy)ethyl]imidazole-1-carboxamide Chemical compound [Na+].[O-]S(=O)(=O)C(I)I.C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl MIXCUJKCXRNYFM-UHFFFAOYSA-M 0.000 description 1
- 229940043517 specific immunoglobulins Drugs 0.000 description 1
- 230000021595 spermatogenesis Effects 0.000 description 1
- 230000019130 spindle checkpoint Effects 0.000 description 1
- 230000027039 spliceosomal complex assembly Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000000528 statistical test Methods 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 210000003699 striated muscle Anatomy 0.000 description 1
- 210000002536 stromal cell Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 230000000946 synaptic effect Effects 0.000 description 1
- 210000003568 synaptosome Anatomy 0.000 description 1
- 230000033772 system development Effects 0.000 description 1
- IQFYYKKMVGJFEH-CSMHCCOUSA-N telbivudine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1O[C@@H](CO)[C@H](O)C1 IQFYYKKMVGJFEH-CSMHCCOUSA-N 0.000 description 1
- 229960005311 telbivudine Drugs 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000011285 therapeutic regimen Methods 0.000 description 1
- LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 description 1
- 102000004217 thyroid hormone receptors Human genes 0.000 description 1
- 108090000721 thyroid hormone receptors Proteins 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229960000707 tobramycin Drugs 0.000 description 1
- NLVFBUXFDBBNBW-PBSUHMDJSA-S tobramycin(5+) Chemical compound [NH3+][C@@H]1C[C@H](O)[C@@H](C[NH3+])O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H]([NH3+])[C@H](O)[C@@H](CO)O2)O)[C@H]([NH3+])C[C@@H]1[NH3+] NLVFBUXFDBBNBW-PBSUHMDJSA-S 0.000 description 1
- 108091006106 transcriptional activators Proteins 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000014621 translational initiation Effects 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 230000011713 vesicle targeting Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 101150000251 xiap gene Proteins 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/706—Specific hybridization probes for hepatitis
- C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2545/00—Reactions characterised by their quantitative nature
- C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
- C12Q2545/114—Reactions characterised by their quantitative nature the purpose being quantitative analysis involving a quantitation step
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Communicable Diseases (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79552006P | 2006-04-26 | 2006-04-26 | |
| US60/795,520 | 2006-04-26 | ||
| PCT/US2007/067421 WO2007127801A2 (en) | 2006-04-26 | 2007-04-25 | Hepatitis c virus infection biomarkers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2650616A1 true CA2650616A1 (en) | 2007-11-08 |
Family
ID=38656353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002650616A Abandoned CA2650616A1 (en) | 2006-04-26 | 2007-04-25 | Hepatitis c virus infection biomarkers |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20100028874A1 (enExample) |
| EP (1) | EP2016195A4 (enExample) |
| JP (1) | JP2009535036A (enExample) |
| KR (1) | KR20090023360A (enExample) |
| CN (1) | CN101479389A (enExample) |
| AU (1) | AU2007244824A1 (enExample) |
| CA (1) | CA2650616A1 (enExample) |
| IL (1) | IL194920A0 (enExample) |
| MX (1) | MX2008013796A (enExample) |
| NO (1) | NO20084954L (enExample) |
| NZ (1) | NZ573052A (enExample) |
| RU (1) | RU2008146518A (enExample) |
| WO (1) | WO2007127801A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8399615B2 (en) | 2005-08-19 | 2013-03-19 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
| JP2009178057A (ja) * | 2008-01-29 | 2009-08-13 | Miyazakiken Sangyo Shien Zaidan | インターフェロンとリバビリンとの併用治療効果の検出方法および検出キット |
| KR20110074870A (ko) * | 2008-09-24 | 2011-07-04 | 버텍스 파마슈티칼스 인코포레이티드 | 간염을 치료하기 위한 ｐｅｇ-인터페론, 리바비린 및 ｖｘ-950을 포함하는 치료 요법 |
| WO2011132086A2 (en) | 2010-04-21 | 2011-10-27 | MeMed Diagnostics, Ltd. | Signatures and determinants for distinguishing between a bacterial and viral infection and methods of use thereof |
| CN102178927A (zh) * | 2011-03-01 | 2011-09-14 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 干扰素诱导跨膜蛋白3在制备抗乙型肝炎病毒感染药物中的用途 |
| CN102323426A (zh) * | 2011-08-08 | 2012-01-18 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 用于诊断或筛查丙型肝炎病毒感染的试剂 |
| AU2013217935B2 (en) | 2012-02-09 | 2018-05-17 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections and methods of use thereof |
| CA2948803A1 (en) * | 2014-04-11 | 2015-10-15 | Globeimmune, Inc. | Yeast-based immunotherapy and type i interferon sensitivity |
| RU2730836C2 (ru) | 2014-08-14 | 2020-08-26 | Мемед Диагностикс Лтд. | Вычислительный анализ биологических данных с применением многообразия и гиперплоскости |
| CN115054687A (zh) * | 2014-08-22 | 2022-09-16 | 广州英恩迈生物医药科技有限公司 | 治疗和/或预防与ifp35蛋白家族的异常水平和/或活性相关的疾病或不适的方法和组合物 |
| US20170234873A1 (en) | 2014-10-14 | 2017-08-17 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof |
| EP3230740B1 (en) | 2014-12-11 | 2025-05-21 | Memed Diagnostics Ltd. | Marker combinations for diagnosing infections and methods of use thereof |
| CA3015046A1 (en) | 2016-03-03 | 2017-09-08 | Memed Diagnostics Ltd. | Rna determinants for distinguishing between bacterial and viral infections |
| WO2017149547A1 (en) | 2016-03-03 | 2017-09-08 | Memed Diagnostics Ltd. | Analyzing rna for diagnosing infection type |
| US11274345B2 (en) | 2016-06-07 | 2022-03-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for diagnosis of bacterial and viral infections |
| WO2018011796A1 (en) | 2016-07-10 | 2018-01-18 | Memed Diagnostics Ltd. | Early diagnosis of infections |
| WO2018011795A1 (en) | 2016-07-10 | 2018-01-18 | Memed Diagnostics Ltd. | Protein signatures for distinguishing between bacterial and viral infections |
| WO2018060999A1 (en) | 2016-09-29 | 2018-04-05 | Memed Diagnostics Ltd. | Methods of risk assessment and disease classification |
| WO2018060998A1 (en) | 2016-09-29 | 2018-04-05 | Memed Diagnostics Ltd. | Methods of prognosis and treatment |
| US10209260B2 (en) | 2017-07-05 | 2019-02-19 | Memed Diagnostics Ltd. | Signatures and determinants for diagnosing infections and methods of use thereof |
| CN108379584B (zh) * | 2018-04-12 | 2020-08-11 | 上海交复生物医药科技有限公司 | RSAD2通过wnt通路影响肿瘤细胞替莫唑胺耐药性 |
| CN110448548B (zh) * | 2018-05-08 | 2023-05-05 | 四川大学华西医院 | Ifitm2抑制剂在制备治疗乙型肝炎的药物中的用途 |
| KR102289533B1 (ko) * | 2019-08-19 | 2021-08-17 | 주식회사 테라젠바이오 | 특정 약물의 타겟 유전자와 관련된 시그니처를 기초로 타겟 유전자와 관련된 유전자들을 판단하는 전자 장치, 방법 및 상기 방법을 실행하기 위한 컴퓨터 프로그램 |
| CN111333710B (zh) * | 2020-03-04 | 2021-12-03 | 暨南大学 | C20orf24蛋白缺失突变体及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006517960A (ja) * | 2003-02-18 | 2006-08-03 | ファイザー インコーポレイテッド | Ｃ型肝炎ウイルスの阻害剤、それを使用する組成物および治療法 |
| US20050282179A1 (en) * | 2003-12-05 | 2005-12-22 | Applera Corporation | Biomarkers for interferon-alpha response in hepatitis C virus infected patients |
| US7892735B2 (en) * | 2004-12-30 | 2011-02-22 | University Of Louisville Research Foundation, Inc. | Genetic markers of schizophrenia spectrum disorders in the sulfotransferase 4a (sult4a) gene |
-
2007
- 2007-04-25 KR KR1020087028981A patent/KR20090023360A/ko not_active Ceased
- 2007-04-25 US US12/298,353 patent/US20100028874A1/en not_active Abandoned
- 2007-04-25 NZ NZ573052A patent/NZ573052A/en not_active IP Right Cessation
- 2007-04-25 CA CA002650616A patent/CA2650616A1/en not_active Abandoned
- 2007-04-25 JP JP2009507945A patent/JP2009535036A/ja active Pending
- 2007-04-25 EP EP07761284A patent/EP2016195A4/en not_active Withdrawn
- 2007-04-25 RU RU2008146518/13A patent/RU2008146518A/ru not_active Application Discontinuation
- 2007-04-25 CN CNA200780023526XA patent/CN101479389A/zh active Pending
- 2007-04-25 MX MX2008013796A patent/MX2008013796A/es not_active Application Discontinuation
- 2007-04-25 WO PCT/US2007/067421 patent/WO2007127801A2/en not_active Ceased
- 2007-04-25 AU AU2007244824A patent/AU2007244824A1/en not_active Abandoned
-
2008
- 2008-10-26 IL IL194920A patent/IL194920A0/en unknown
- 2008-11-25 NO NO20084954A patent/NO20084954L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007127801A2 (en) | 2007-11-08 |
| KR20090023360A (ko) | 2009-03-04 |
| CN101479389A (zh) | 2009-07-08 |
| NO20084954L (no) | 2009-01-22 |
| AU2007244824A1 (en) | 2007-11-08 |
| JP2009535036A (ja) | 2009-10-01 |
| EP2016195A4 (en) | 2010-03-10 |
| WO2007127801A3 (en) | 2008-09-12 |
| MX2008013796A (es) | 2009-03-31 |
| IL194920A0 (en) | 2009-08-03 |
| NZ573052A (en) | 2012-03-30 |
| RU2008146518A (ru) | 2010-06-10 |
| EP2016195A2 (en) | 2009-01-21 |
| US20100028874A1 (en) | 2010-02-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20100028874A1 (en) | Hepatitis c virus infection biomarkers | |
| Meissner et al. | Endogenous intrahepatic IFNs and association with IFN-free HCV treatment outcome | |
| EP2115169B1 (en) | Methods for determining drug sensitivity in patients infected with hcv | |
| Welzel et al. | Variants in interferon‐alpha pathway genes and response to pegylated interferon‐Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long‐term treatment against cirrhosis trial | |
| Manry et al. | Deciphering the genetic control of gene expression following Mycobacterium leprae antigen stimulation | |
| JP2007529714A (ja) | 遺伝子分析のための方法 | |
| US20130059749A1 (en) | Method for predicting the response of a subject suffering from a viral infection of the liver to an antiviral therapy | |
| US20110117563A1 (en) | Antiviral therapy | |
| US10072296B2 (en) | Compositions and methods for sjögren's syndrome | |
| JP7855586B2 (ja) | コロナウイルス感染症を発症するリスクが高い対象を特定する方法及びその治療法 | |
| CN115066505A (zh) | 生物标记物及其在治疗慢性乙型肝炎感染中的用途 | |
| JP2023055222A (ja) | クロストリジウム・ディフィシレ毒素ｂを標的化する治療に対する応答に関連したヒト遺伝的マーカー | |
| US20090047245A1 (en) | Prognostic chronic hepatitis C biomarkers | |
| Macartney et al. | Telaprevir or boceprevir based therapy for chronic hepatitis C infection: Development of resistance-associated variants in treatment failure | |
| Ren et al. | Polymorphisms of interferon-inducible genes OAS associated with interferon-α treatment response in chronic HBV infection | |
| KR20180107013A (ko) | 인슐린 저항성 진단용 조성물 및 이의 용도 | |
| Jain | Personalized therapy of infectious diseases | |
| WO2018107388A1 (en) | Human genetic markers associated with response to treatments that target clostridium difficile toxin b | |
| HK1130843A (en) | Hepatitis c virus infection biomarkers | |
| Benish et al. | Comparative description of haplotype structure and genetic diversity of MDR1 (ABCB1) in HIV-positive and HIV-negative populations | |
| ARDYANTO et al. | Vitamin K Epoxide Reductase Complex, Subunit 1 Gene-1639 Polymorphism in Surakarta, Indonesia and South East Asia. | |
| CN117363799A (zh) | 用于预测干扰素药物治疗慢性乙型肝炎效果的组合物、产品及系统 | |
| WO2021092703A1 (en) | Methods for using low-dose colchicine after myocardial infarction | |
| Ansari et al. | Interferon lambda 4 impacts broadly on hepatitis C virus diversity | |
| Reid et al. | Variants in Interferon-α Pathway Genes and Response to Pegylated-Interferon-α2a plus Ribavirin for Treatment of Chronic HCV Infection in the HALT-C Trial |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20140425 |