CA2648196A1 - Use of biarylcarboxamides in the treatment of hedgehog pathway-related disorders - Google Patents
Use of biarylcarboxamides in the treatment of hedgehog pathway-related disorders Download PDFInfo
- Publication number
- CA2648196A1 CA2648196A1 CA002648196A CA2648196A CA2648196A1 CA 2648196 A1 CA2648196 A1 CA 2648196A1 CA 002648196 A CA002648196 A CA 002648196A CA 2648196 A CA2648196 A CA 2648196A CA 2648196 A1 CA2648196 A1 CA 2648196A1
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- Prior art keywords
- alkyl
- aryl
- hydrogen
- optionally substituted
- substituted alkyl
- Prior art date
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- Abandoned
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79216206P | 2006-04-14 | 2006-04-14 | |
| US60/792,162 | 2006-04-14 | ||
| PCT/US2007/009138 WO2007120827A2 (en) | 2006-04-14 | 2007-04-12 | Use of biarylcarboxamides in the treatment of hedgehog pathway-related disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2648196A1 true CA2648196A1 (en) | 2007-10-25 |
Family
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Family Applications (1)
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|---|---|---|---|
| CA002648196A Abandoned CA2648196A1 (en) | 2006-04-14 | 2007-04-12 | Use of biarylcarboxamides in the treatment of hedgehog pathway-related disorders |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20090306149A1 (enExample) |
| EP (1) | EP2010170A2 (enExample) |
| JP (1) | JP2009536156A (enExample) |
| KR (1) | KR20090006089A (enExample) |
| CN (1) | CN101420949A (enExample) |
| AU (1) | AU2007238676A1 (enExample) |
| BR (1) | BRPI0710723A2 (enExample) |
| CA (1) | CA2648196A1 (enExample) |
| MX (1) | MX2008013204A (enExample) |
| RU (1) | RU2008144805A (enExample) |
| WO (1) | WO2007120827A2 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類 |
| CA2710858A1 (en) | 2007-12-27 | 2009-07-09 | Infinity Pharmaceuticals, Inc. | Methods for stereoselective reduction |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| GEP20125664B (en) * | 2008-02-26 | 2012-10-10 | Takeda Pharmaceuticals Co | Condensed heterocyclic derivatives and application thereof |
| AU2009286528B2 (en) | 2008-08-29 | 2014-07-17 | Msd Italia S.R.L. | Saturated bicyclic heterocyclic derivatives as Smo antagonists |
| RU2519200C2 (ru) | 2008-10-01 | 2014-06-10 | Новартис Аг | Применение антагонистов smoothened для лечения связанных с путем hedgehog нарушений |
| EP2462115B1 (en) | 2009-08-05 | 2016-01-06 | Infinity Pharmaceuticals, Inc. | Enzymatic transamination of cyclopamine analogs |
| US8604032B2 (en) | 2010-05-21 | 2013-12-10 | Infinity Pharmaceuticals, Inc. | Chemical compounds, compositions and methods for kinase modulation |
| US9376447B2 (en) | 2010-09-14 | 2016-06-28 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
| EP2637669A4 (en) | 2010-11-10 | 2014-04-02 | Infinity Pharmaceuticals Inc | Heterocyclic compounds and their use |
| FR2967498B1 (fr) | 2010-11-16 | 2015-01-02 | Centre Nat Rech Scient | Utilisation de derives de quinolinone comme outil de recherche |
| NZ612909A (en) | 2011-01-10 | 2015-09-25 | Infinity Pharmaceuticals Inc | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
| CA2834049C (en) * | 2011-04-25 | 2018-05-22 | Usher Iii Initiative, Inc. | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome |
| TWI565709B (zh) | 2011-07-19 | 2017-01-11 | 英菲尼提製藥股份有限公司 | 雜環化合物及其用途 |
| EP2734520B1 (en) | 2011-07-19 | 2016-09-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| RU2014111823A (ru) | 2011-08-29 | 2015-10-10 | Инфинити Фармасьютикалз, Инк. | Гетероциклические соединения и их применения |
| US9630979B2 (en) | 2011-09-29 | 2017-04-25 | Infinity Pharmaceuticals, Inc. | Inhibitors of monoacylglycerol lipase and methods of their use |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US9227976B2 (en) | 2012-10-25 | 2016-01-05 | Usher Iii Initiative, Inc. | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome |
| CA2890105C (en) | 2012-11-01 | 2023-03-21 | Infinity Pharmaceuticals, Inc. | Treatment of cancers using pi3 kinase isoform modulators |
| US9844541B2 (en) | 2012-11-29 | 2017-12-19 | Strasspharma, Llc | Methods of modulating follicle stimulating hormone activity |
| WO2014151386A1 (en) | 2013-03-15 | 2014-09-25 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
| US9192609B2 (en) | 2013-04-17 | 2015-11-24 | Hedgepath Pharmaceuticals, Inc. | Treatment and prognostic monitoring of proliferation disorders using hedgehog pathway inhibitors |
| BR112015029969A2 (pt) | 2013-05-30 | 2017-07-25 | Infinity Pharmaceuticals Inc | tratamento de câncer usando moduladores de isoformas quinase pi3 |
| WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| SG10201902074UA (en) | 2013-10-04 | 2019-04-29 | Infinity Pharmaceuticals Inc | Heterocyclic compounds and uses thereof |
| WO2015061204A1 (en) | 2013-10-21 | 2015-04-30 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| CN113616656B (zh) | 2014-03-19 | 2023-02-17 | 无限药品股份有限公司 | 用于治疗PI3K-γ介导的障碍的杂环化合物 |
| WO2015160986A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| WO2015168079A1 (en) | 2014-04-29 | 2015-11-05 | Infinity Pharmaceuticals, Inc. | Pyrimidine or pyridine derivatives useful as pi3k inhibitors |
| WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| BR112017026103B1 (pt) | 2015-06-04 | 2023-10-03 | Sol-Gel Technologies Ltd | Composições tópicas com composto inibidor de hedgehog, sistema de entrega tópica e seus usos |
| AU2016322552B2 (en) | 2015-09-14 | 2021-03-25 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
| WO2017139497A1 (en) | 2016-02-11 | 2017-08-17 | PellePharm, Inc. | Hedgehog inhibitor for use in relief of and treatment of pruritus or itching |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| WO2017223422A1 (en) | 2016-06-24 | 2017-12-28 | Infinity Pharmaceuticals, Inc. | Combination therapies |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6333337B1 (en) * | 1998-01-27 | 2001-12-25 | Icagen, Inc. | Potassium channel inhibitors |
| GB9807903D0 (en) * | 1998-04-14 | 1998-06-10 | Smithkline Beecham Plc | Novel compounds |
| US6197798B1 (en) * | 1998-07-21 | 2001-03-06 | Novartis Ag | Amino-benzocycloalkane derivatives |
| CO5090829A1 (es) * | 1998-07-21 | 2001-10-30 | Novartis Ag | Compuestos organicos de la formula i, utiles como inhibido res de la proteina de transferencia de triglicerido microso mal y de la secrecion de la apolipoproteina b. |
| JP2002538167A (ja) * | 1999-03-03 | 2002-11-12 | バイオジェン インコーポレイテッド | 脂質の代謝および貯蔵を調節する方法 |
| WO2001005767A1 (en) * | 1999-07-20 | 2001-01-25 | Novartis Ag | Organic compounds |
| WO2001053260A1 (en) * | 2000-01-18 | 2001-07-26 | Novartis Ag | Carboxamides useful as inhibitors of microsomal triglyceride transfer protein and of apolipoprotein b secretion |
-
2007
- 2007-04-12 JP JP2009505499A patent/JP2009536156A/ja not_active Withdrawn
- 2007-04-12 RU RU2008144805/14A patent/RU2008144805A/ru not_active Application Discontinuation
- 2007-04-12 WO PCT/US2007/009138 patent/WO2007120827A2/en not_active Ceased
- 2007-04-12 CN CNA2007800134377A patent/CN101420949A/zh active Pending
- 2007-04-12 AU AU2007238676A patent/AU2007238676A1/en not_active Abandoned
- 2007-04-12 MX MX2008013204A patent/MX2008013204A/es not_active Application Discontinuation
- 2007-04-12 EP EP07755420A patent/EP2010170A2/en not_active Withdrawn
- 2007-04-12 BR BRPI0710723-4A patent/BRPI0710723A2/pt not_active IP Right Cessation
- 2007-04-12 US US12/297,158 patent/US20090306149A1/en not_active Abandoned
- 2007-04-12 KR KR1020087024972A patent/KR20090006089A/ko not_active Withdrawn
- 2007-04-12 CA CA002648196A patent/CA2648196A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MX2008013204A (es) | 2008-10-22 |
| US20090306149A1 (en) | 2009-12-10 |
| RU2008144805A (ru) | 2010-05-20 |
| WO2007120827A3 (en) | 2007-12-13 |
| AU2007238676A1 (en) | 2007-10-25 |
| CN101420949A (zh) | 2009-04-29 |
| JP2009536156A (ja) | 2009-10-08 |
| BRPI0710723A2 (pt) | 2012-01-31 |
| WO2007120827A2 (en) | 2007-10-25 |
| KR20090006089A (ko) | 2009-01-14 |
| EP2010170A2 (en) | 2009-01-07 |
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