CA2631236A1 - Methodes et appareils pour identifier des biomarqueurs de reponse a un traitement et leur utilisation pour predire l'efficacite d'un traitement - Google Patents

Methodes et appareils pour identifier des biomarqueurs de reponse a un traitement et leur utilisation pour predire l'efficacite d'un traitement Download PDF

Info

Publication number
CA2631236A1
CA2631236A1 CA002631236A CA2631236A CA2631236A1 CA 2631236 A1 CA2631236 A1 CA 2631236A1 CA 002631236 A CA002631236 A CA 002631236A CA 2631236 A CA2631236 A CA 2631236A CA 2631236 A1 CA2631236 A1 CA 2631236A1
Authority
CA
Canada
Prior art keywords
gene
treatment
expression
patient
level
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002631236A
Other languages
English (en)
Other versions
CA2631236C (fr
Inventor
Steen Knudsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allarity Therapeutics Europe ApS
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2631236A1 publication Critical patent/CA2631236A1/fr
Application granted granted Critical
Publication of CA2631236C publication Critical patent/CA2631236C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hospice & Palliative Care (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La présente invention a pour objet des méthodes et des appareils pour prédire la sensibilité d'un patient à un composé ou à un traitement médical. L'invention concerne aussi des méthodes pour identifier des biomarqueurs de gène dont l'expression correspond à une sensibilité ou une résistance à un traitement dans une population ou sous-population de patients.
CA2631236A 2005-12-01 2006-12-01 Methodes et appareils pour identifier des biomarqueurs de reponse a un traitement et leur utilisation pour predire l'efficacite d'un traitement Active CA2631236C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200501696 2005-12-01
DKPA200501696 2005-12-01
PCT/IB2006/004048 WO2007072225A2 (fr) 2005-12-01 2006-12-01 Méthodes et appareils pour identifier des biomarqueurs de réponse à un traitement et leur utilisation pour prédire l'efficacité d’un traitement

Publications (2)

Publication Number Publication Date
CA2631236A1 true CA2631236A1 (fr) 2007-06-28
CA2631236C CA2631236C (fr) 2019-10-29

Family

ID=38189039

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2631236A Active CA2631236C (fr) 2005-12-01 2006-12-01 Methodes et appareils pour identifier des biomarqueurs de reponse a un traitement et leur utilisation pour predire l'efficacite d'un traitement

Country Status (5)

Country Link
EP (1) EP1960551A2 (fr)
JP (3) JP5984324B2 (fr)
CN (1) CN101365806B (fr)
CA (1) CA2631236C (fr)
WO (1) WO2007072225A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10181008B2 (en) 2013-05-30 2019-01-15 Genomic Health, Inc. Gene expression profile algorithm for calculating a recurrence score for a patient with kidney cancer
US10892038B2 (en) 2010-01-11 2021-01-12 Genomic Health, Inc. Method to use gene expression to determine likelihood of clinical outcome of renal cancer
EP3674416A4 (fr) * 2017-09-29 2021-05-26 Kyushu University, National University Corporation Procédé et kit de prédiction de l'efficacité thérapeutique d'une chimiothérapie pour des patients atteints d'un lymphome diffus à grandes cellules b
CN113593700A (zh) * 2021-08-06 2021-11-02 江苏师范大学 分析肺癌进展的方法、装置、设备、介质及程序产品

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010535518A (ja) * 2007-08-14 2010-11-25 エフ.ホフマン−ラ ロシュ アーゲー Egfr阻害剤治療のための予測マーカー
ES2605237T3 (es) * 2007-09-17 2017-03-13 Mdxhealth Sa Novedosos marcadores para la detección del cáncer de vejiga
JP5592793B2 (ja) * 2008-08-29 2014-09-17 学校法人北里研究所 Dnaメチル化阻害剤の薬剤効果検出方法
GB0816867D0 (en) * 2008-09-15 2008-10-22 Glaxosmithkline Biolog Sa Method
SG10201402288RA (en) 2009-05-11 2014-07-30 Berg Llc Methods for the diagnosis of oncological disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
DK177532B1 (en) 2009-09-17 2013-09-08 Bio Bedst Aps Medical use of sPLA2 hydrolysable liposomes
TW201136604A (en) 2009-12-14 2011-11-01 Oncotherapy Science Inc TMEM22 peptides and vaccines including the same
KR101853511B1 (ko) * 2009-12-31 2018-06-20 큐알엔에이, 인크. 인슐린 수용체 기질 2 및 전사 인자 e3(tfe3)에 대한 천연 안티센스 전사체의 억제에 의한 irs2 관련된 질환의 치료
AU2011246976B2 (en) 2010-04-29 2016-01-28 Allarity Therapeutics Europe ApS Methods and devices for predicting treatment efficacy
TR201903026T4 (tr) 2010-06-14 2019-04-22 Lykera Biomed S A S100a4 anti̇korlari ve bunlarin terapöti̇k kullanimlari.
CA2841142C (fr) 2010-06-23 2020-12-15 Ryan D. Morin Biomarqueurs pour lymphomes non hodgkiniens et leurs utilisations
SG10201505769PA (en) 2010-07-27 2015-09-29 Genomic Health Inc Method for using gene expression to determine prognosis of prostate cancer
US9175331B2 (en) 2010-09-10 2015-11-03 Epizyme, Inc. Inhibitors of human EZH2, and methods of use thereof
KR102061353B1 (ko) * 2010-09-10 2020-01-02 에피자임, 인코포레이티드 인간 ezh2의 억제제 및 이의 사용 방법
CN102408478A (zh) * 2010-09-21 2012-04-11 复旦大学 一种人少突神经胶质瘤标志物map2蛋白及其用途
AU2011343954A1 (en) * 2010-12-15 2013-07-11 Medimmune, Llc Melanoma treatments
PT2666015T (pt) * 2011-01-21 2017-03-22 Basilea Pharmaceutica Ag Utilização de estatmina como um biomarcador da resposta farmacológica a furazanobenzimidazolos
CN103608323B (zh) 2011-04-04 2016-08-17 博格有限责任公司 治疗中枢神经系统肿瘤的方法
JO3438B1 (ar) 2011-04-13 2019-10-20 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
KR101439856B1 (ko) * 2011-06-02 2014-09-17 한국생명공학연구원 항-atic 자가면역항체를 포함하는 간암 진단 마커 및 이의 항원을 포함하는 간암 진단용 조성물
CN104024851A (zh) * 2011-11-28 2014-09-03 加拿大国家研究委员会 针对癌症的紫杉醇反应标志物
EP2809812A4 (fr) 2012-01-31 2016-01-27 Genomic Health Inc Algorithme de profil d'expression génique et test de détermination du pronostic du cancer de la prostate
WO2013158984A1 (fr) 2012-04-19 2013-10-24 Acetylon Pharmaceuticals, Inc. Biomarqueurs permettant d'identifier des patients qui réagiront à un traitement, et traitement desdits patients
SG11201406837TA (en) * 2012-05-04 2014-11-27 Novartis Ag Biomarkers for iap inhibitor therapy
US11242564B2 (en) * 2012-07-12 2022-02-08 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for predicting the survival time and treatment responsiveness of a patient suffering from a solid cancer with a signature of at least 7 genes
AU2013331380B2 (en) 2012-10-15 2018-03-22 Epizyme, Inc. Substituted benzene compounds
CN113797343A (zh) 2013-04-08 2021-12-17 博格有限责任公司 使用辅酶q10联合疗法治疗癌症
HUE050060T2 (hu) 2013-09-04 2020-11-30 Berg Llc Eljárások rák kezelésére koenzim Q10 folyamatos infúziójával
JP2017508469A (ja) * 2014-03-11 2017-03-30 ザ・カウンシル・オヴ・ザ・クイーンズランド・インスティテュート・オヴ・メディカル・リサーチ 癌悪性度、予後及び治療に対する反応性の決定
CN104945496B (zh) * 2014-03-31 2019-05-03 天津市应世博科技发展有限公司 一种多肽及其在制备与纯化对ehd2特异的抗体中的应用
CN103923212A (zh) * 2014-03-31 2014-07-16 天津市应世博科技发展有限公司 Ehd2抗体及其在制备乳腺癌免疫组化检测试剂中的应用
FR3025028A1 (fr) * 2014-08-22 2016-02-26 Acobiom Procede pour determiner le pronostic de survie d'un patient atteint d'un cancer du pancreas
US10570457B2 (en) 2014-09-26 2020-02-25 Medical Prognosis Institute A/S Methods for predicting drug responsiveness
KR101674874B1 (ko) * 2014-10-21 2016-11-22 한국원자력의학원 항암제 내성 예측용 바이오마커로서의 icam-3 및 이의 용도
CN105777901B (zh) * 2014-12-25 2019-07-09 中国科学院上海生命科学研究院 一种抗qki-5单克隆抗体及其制备与应用
WO2016121715A1 (fr) * 2015-01-26 2016-08-04 国立大学法人名古屋大学 Procédé de fourniture d'informations pour évaluer le pronostic d'un patient atteint de cancer du poumon, procédé de prédiction de pronostic de patient atteint de cancer du poumon, standard interne, anticorps, dispositif pour prédire le pronostic d'un patient atteint de cancer du poumon, programme pour dispositif de prédiction de pronostic, et support d'enregistrement
GB201503371D0 (en) * 2015-02-27 2015-04-15 Mission Therapeutics Ltd Methods of screening and treatment
CN104749381B (zh) * 2015-03-30 2017-03-15 石河子大学 组装抑制蛋白pfn2在制备食管癌诊断试剂中的用途
CN105132415A (zh) * 2015-08-19 2015-12-09 天津市康婷生物工程有限公司 锰超氧化物歧化酶sod2的体外分子检测方法及引物
CN105132429A (zh) * 2015-10-10 2015-12-09 华东理工大学 靶向人KPNB1基因的siRNA及其应用
CN105424935B (zh) * 2015-11-09 2017-08-25 吉林大学 多聚谷氨酰化dnajc7的新应用
CN105506107A (zh) * 2015-12-30 2016-04-20 杭州艾迪康医学检验中心有限公司 检测dock2基因多态热点突变情况的引物和方法
CA3234176A1 (fr) * 2016-02-05 2017-08-10 Antje Margret Wengner Composes, compositions et methodes pour la stratification de patients cancereux et le traitement d'un cancer
CN105787297A (zh) * 2016-03-12 2016-07-20 云南圣清环境监测科技有限公司 一种微生物修复系统活性评价的方法
WO2017167788A1 (fr) * 2016-03-29 2017-10-05 Universite Paris Diderot Paris 7 Compositions comprenant des vésicules extracellulaires sécrétées de cellules exprimant nfatc4 utiles pour le traitement du cancer
WO2018039490A1 (fr) * 2016-08-24 2018-03-01 Genomedx Biosciences, Inc. Utilisation de signatures génomiques en vue d'une prédiction de la réactivité de patients atteints d'un cancer de la prostate à une radiothérapie postopératoire
JP6779517B2 (ja) * 2016-09-02 2020-11-04 国立大学法人 鹿児島大学 抗癌剤の感受性及び癌の予後に対する診断マーカー
US9725769B1 (en) 2016-10-07 2017-08-08 Oncology Venture ApS Methods for predicting drug responsiveness in cancer patients
CN106399582B (zh) * 2016-12-20 2019-12-24 上海杏园瑞民生物工程有限公司 一种检测与结直肠癌靶向用药西妥昔单抗治疗敏感性相关基因的多态性的试剂盒及其应用
AU2017258901A1 (en) 2016-12-30 2018-07-19 Allarity Therapeutics Europe ApS Methods for predicting drug responsiveness in cancer patients
AU2018202878A1 (en) * 2017-05-16 2018-12-06 Allarity Therapeutics Europe ApS Methods for predicting drug responsiveness in cancer patients
CN107266567B (zh) * 2017-06-05 2021-06-04 高新 Lcrmp4单克隆抗体及其制备方法与应用
CN109207589A (zh) * 2017-07-05 2019-01-15 安徽普元生物科技股份有限公司 一步法实时荧光定量逆转录聚合酶链反应检测人细胞角蛋白7的试剂盒
JP2020527569A (ja) * 2017-07-17 2020-09-10 ザ・リージエンツ・オブ・ザ・ユニバーシテイ・オブ・コロラド、ア・ボデイー・コーポレイト 放射線または放射線療法によって引き起こされた放射線誘発性バイスタンダ効果を防止および治療するための組成物および方法
CN109387630A (zh) * 2017-08-14 2019-02-26 杭州源昶医药科技有限公司 用于预测吉西他滨药物敏感性的生物标记物及其用途
CN109470854B (zh) * 2017-09-08 2022-02-11 广州市丹蓝生物科技有限公司 肺癌诊断用蛋白芯片及试剂盒
WO2019144275A1 (fr) * 2018-01-23 2019-08-01 北京艾克伦医疗科技有限公司 Méthode et kit pour identifier l'état d'un cancer du poumon
US20220324835A1 (en) * 2018-01-26 2022-10-13 Nurix Therapeutics, Inc. Inhibitors of cbl-b and methods of use thereof
CN108796077B (zh) * 2018-05-30 2021-11-09 朱运峰 在cfDNA中检测胞嘧啶脱氨酶及相关分子基因修饰差异的引物对组及试剂盒
CN113039290A (zh) * 2018-09-06 2021-06-25 昆士兰医学研究所理事会 用于癌症治疗的生物标志物
CN113412259B (zh) 2018-10-15 2024-07-16 紐力克斯治疗公司 通过泛素蛋白酶体途径降解btk的双官能化合物
SG11202106398WA (en) * 2018-11-04 2021-07-29 Pfs Genomics Inc Methods and genomic classifiers for prognosis of breast cancer and predicting benefit from adjuvant radiotherapy
CN109402260A (zh) * 2018-11-28 2019-03-01 陕西中医药大学 Rims3基因作为肝癌检测的生物标志物及应用
US20220081727A1 (en) * 2019-01-17 2022-03-17 Geninus Inc. Biomarker for predicting response to anticancer agent and use thereof
WO2020210508A1 (fr) 2019-04-09 2020-10-15 Nurix Therapeutics, Inc. Composés de pipéridine substitués en position 3 pour l'inhibition de cbl-b, et utilisation d'un inhibiteur de cbl-b en combinaison avec un vaccin contre le cancer et/ou un virus oncolytique
MX2021013751A (es) 2019-05-17 2022-01-26 Nurix Therapeutics Inc Compuestos de ciano ciclobutilo para la inhibicion del protooncogen b de linfoma de linaje b de casitas (cbl-b) y usos de los mismos.
EP3990117A1 (fr) 2019-06-26 2022-05-04 Nurix Therapeutics, Inc. Composés benzyl-triazoles substitués pour l'inhibition de cbl-b et autres utilisations de ces composés
CN110331200A (zh) * 2019-06-28 2019-10-15 中山大学附属第六医院 Cd47检测试剂在制备结直肠癌对抗egfr单抗耐药诊断剂方面的应用
WO2021050490A1 (fr) * 2019-09-13 2021-03-18 The Trustees Of Columbia University In The City Of New York Procédés d'amélioration de la radiothérapie au moyen d'inducteurs de ferroptose en tant que radiosensibilisateurs
CA3152293A1 (fr) 2019-09-24 2021-04-01 Arthur T. Sands Inhibiteurs de cbl et compositions destines a etre utilises dans une therapie cellulaire adoptive
US11820781B2 (en) 2019-12-04 2023-11-21 Nurix Therapeutics, Inc. Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway
CN110951876A (zh) * 2019-12-17 2020-04-03 蔡清清 一种淋巴瘤预后试剂盒
CN111321228B (zh) * 2020-03-13 2021-03-05 中国医学科学院肿瘤医院 抗pd-1治疗敏感性相关基因及其应用
KR102363980B1 (ko) * 2020-04-13 2022-02-15 전남대학교산학협력단 전이성 뇌종양의 진단 또는 예후 분석용 바이오마커 및 이를 이용한 진단방법
KR20230167407A (ko) 2021-04-08 2023-12-08 누릭스 테라퓨틱스 인코포레이티드 Cbl-b 억제제 화합물을 이용한 조합 요법
TW202307203A (zh) * 2021-07-15 2023-02-16 日商富士軟片股份有限公司 特定細胞的品質管理方法及製造特定細胞之方法
CN113493840A (zh) * 2021-09-07 2021-10-12 北京泱深生物信息技术有限公司 子宫内膜癌诊断用标志物及其衍生产品和应用
GB202117299D0 (en) * 2021-11-30 2022-01-12 Queens Univ Of Belfast Method of prognosis
KR102701566B1 (ko) * 2021-12-29 2024-09-04 인하대학교 산학협력단 Ifi44의 발현 또는 활성 억제제를 유효성분으로 포함하는 방사선 민감성 증진용 약학 조성물

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040072722A1 (en) * 2002-10-10 2004-04-15 Kornblith Paul L. Methods for assessing efficacy of chemotherapeutic agents
EP1127070A2 (fr) * 1998-11-05 2001-08-29 Parker Hughes Institute ISOFORMES ET MUTANTS $i(IKAROS)
CA2354084A1 (fr) * 1998-12-08 2000-06-15 Sue Hilsenbeck Procedes de detection du cancer du sein resistant aux anti-oestrogenes
US6647341B1 (en) * 1999-04-09 2003-11-11 Whitehead Institute For Biomedical Research Methods for classifying samples and ascertaining previously unknown classes
US7324926B2 (en) * 1999-04-09 2008-01-29 Whitehead Institute For Biomedical Research Methods for predicting chemosensitivity or chemoresistance
US8722331B2 (en) * 2002-03-28 2014-05-13 University Of Toledo Method for selecting a treatment for non-small cell lung cancer using gene expression profiles
JP2004043446A (ja) * 2002-05-15 2004-02-12 Schering Ag ヒストンデアセチラーゼ抑制剤及びその使用
EP2272512A1 (fr) * 2002-05-17 2011-01-12 Celgene Corporation Compositions pharmaceutiques pour le traitement du cancer
JP2007501608A (ja) * 2003-08-08 2007-02-01 株式会社 キャンバス 抗癌治療の効力を推定するための感受性試験
US20080113344A1 (en) * 2003-10-28 2008-05-15 Ralph Wirtz Methods and Compositions for the Response Prediction of Malignant Neoplasia to Treatment
US20050147978A1 (en) * 2003-12-30 2005-07-07 Jose Remacle Method for quantitative determination of multi-drug resistance in tumors
US7700280B2 (en) * 2003-12-31 2010-04-20 The Penn State Research Foundation Methods for assessing cisplatin resistance, disease progression, and treatment efficacy in ovarian cancer
US20070270488A1 (en) * 2004-03-12 2007-11-22 The Queen's University Of Belfast Treatment and Assays
CN1972703A (zh) * 2004-03-30 2007-05-30 丹麦皇家兽医和农业学院 通过阻断和检测蛋白酶抑制剂改进癌症的治疗和癌症治疗效率的预测
AU2005233593B2 (en) * 2004-04-09 2010-08-26 Fondazione Irccs Istituto Nazionale Dei Tumori Gene expression markers for predicting response to chemotherapy

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10892038B2 (en) 2010-01-11 2021-01-12 Genomic Health, Inc. Method to use gene expression to determine likelihood of clinical outcome of renal cancer
US11776664B2 (en) 2010-01-11 2023-10-03 Genomic Health, Inc. Method to use gene expression to determine likelihood of clinical outcome of renal cancer
US10181008B2 (en) 2013-05-30 2019-01-15 Genomic Health, Inc. Gene expression profile algorithm for calculating a recurrence score for a patient with kidney cancer
US11551782B2 (en) 2013-05-30 2023-01-10 Genomic Health, Inc. Gene expression profile algorithm for calculating a recurrence score for a patient with kidney cancer
EP3674416A4 (fr) * 2017-09-29 2021-05-26 Kyushu University, National University Corporation Procédé et kit de prédiction de l'efficacité thérapeutique d'une chimiothérapie pour des patients atteints d'un lymphome diffus à grandes cellules b
CN113593700A (zh) * 2021-08-06 2021-11-02 江苏师范大学 分析肺癌进展的方法、装置、设备、介质及程序产品
CN113593700B (zh) * 2021-08-06 2024-02-27 江苏师范大学 分析肺癌进展的方法、装置、设备、介质及程序产品

Also Published As

Publication number Publication date
CN101365806A (zh) 2009-02-11
WO2007072225A3 (fr) 2008-07-10
EP1960551A2 (fr) 2008-08-27
JP2016026496A (ja) 2016-02-18
JP5984324B2 (ja) 2016-09-06
CN101365806B (zh) 2016-11-16
JP2009523011A (ja) 2009-06-18
JP2014147386A (ja) 2014-08-21
WO2007072225A8 (fr) 2008-11-06
WO2007072225A2 (fr) 2007-06-28
CA2631236C (fr) 2019-10-29

Similar Documents

Publication Publication Date Title
CA2631236A1 (fr) Methodes et appareils pour identifier des biomarqueurs de reponse a un traitement et leur utilisation pour predire l'efficacite d'un traitement
US8445198B2 (en) Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
WO2008138578A2 (fr) Procédés, coffrets et dispositifs pour identifier des biomarqueurs de réponse à un traitement et utilisation de ceux-ci pour prédire l'efficacité du traitement
EP2563936B1 (fr) Méthodes et dispositifs permettant de prédire l'efficacité d'un traitement
US20230381231A1 (en) Compositions for cancer treatment and methods and uses for cancer treatment and prognosis
US10570457B2 (en) Methods for predicting drug responsiveness
JP6923291B2 (ja) 少なくとも7個の遺伝子のサインを用いて、固形癌を患う患者の生存期間および処置に対する応答性を予測するための方法
EP4428157A2 (fr) Utilisation de l'expression génique spécifique de cellules immunitaires pour le pronostic du cancer de la prostate et la prédiction de la réactivité à une radiothérapie
US20080280779A1 (en) Gene expression profiling based identification of genomic signatures of multiple myeloma and uses thereof
WO2009029266A2 (fr) Outil de diagnostic pour diagnostiquer des lésions de la thyroïde bénignes versus malignes
US10774387B2 (en) Methods for identifying androgen receptor splice variants in subjects having castration resistant prostate cancer
US20210164056A1 (en) Use of metastases-specific signatures for treatment of cancer
US20210293820A1 (en) Methods of activating dysfunctional immune cells and treatment of cancer
US20210164054A1 (en) Biomarkers for cancer immunotherapy outcomes
US10689708B2 (en) Methods for treating diffuse large B-cell lymphoma and the use of biomarkers as a predictor of responsiveness to drugs
Harima et al. Identification of genes associated with progression and metastasis of advanced cervical cancers after radiotherapy by cDNA microarray analysis
US20180238886A1 (en) Methods for treating hematological cancer and the use of biomarkers as a predictor for responsiveness to treatment compounds
US20100055686A1 (en) Methods for diagnosis of pediatric common acute lymphoblastic leukemia by determining the level of gene expression
Szczepanek et al. Gene expression signatures and ex vivo drug sensitivity profiles in children with acute lymphoblastic leukemia
Chen et al. Identification of the Roles of Coagulation-related Signature and its Key Factor RABIF in Hepatoma Cell Malignancy
US12111317B2 (en) Flow cytometry-based platform for the detection, enumeration, and isolation of disseminated tumor cells in bone marrow aspirates
US20240254565A1 (en) Unique cancer associated fibroblast subsets predict response to immunotherapy
US11709164B2 (en) Approach for universal monitoring of minimal residual disease in acute myeloid leukemia
Saleem et al. Gene expression profiling in B-cell non-Hodgkin lymphomas
CN118679268A (zh) 肿瘤突变负荷作为针对癌症治疗中的免疫检查点抑制剂与化学疗法有效性的预测性生物标志物的用途

Legal Events

Date Code Title Description
EEER Examination request