CA2628193C - Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties - Google Patents

Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties Download PDF

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Publication number
CA2628193C
CA2628193C CA2628193A CA2628193A CA2628193C CA 2628193 C CA2628193 C CA 2628193C CA 2628193 A CA2628193 A CA 2628193A CA 2628193 A CA2628193 A CA 2628193A CA 2628193 C CA2628193 C CA 2628193C
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Canada
Prior art keywords
compound
condition
compounds
cells
benzodiazepine
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Expired - Fee Related
Application number
CA2628193A
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English (en)
French (fr)
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CA2628193A1 (en
Inventor
Gary D. Glick
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University of Michigan System
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University of Michigan System
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Priority to CA2779041A priority Critical patent/CA2779041A1/en
Publication of CA2628193A1 publication Critical patent/CA2628193A1/en
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Publication of CA2628193C publication Critical patent/CA2628193C/en
Expired - Fee Related legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2628193A 2005-11-01 2006-11-01 Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties Expired - Fee Related CA2628193C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2779041A CA2779041A1 (en) 2005-11-01 2006-11-01 Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73204505P 2005-11-01 2005-11-01
US60/732,045 2005-11-01
PCT/US2006/042753 WO2007053725A2 (en) 2005-11-01 2006-11-01 Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2779041A Division CA2779041A1 (en) 2005-11-01 2006-11-01 Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties

Publications (2)

Publication Number Publication Date
CA2628193A1 CA2628193A1 (en) 2007-05-10
CA2628193C true CA2628193C (en) 2012-08-14

Family

ID=38006506

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2628193A Expired - Fee Related CA2628193C (en) 2005-11-01 2006-11-01 Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties
CA2779041A Abandoned CA2779041A1 (en) 2005-11-01 2006-11-01 Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2779041A Abandoned CA2779041A1 (en) 2005-11-01 2006-11-01 Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties

Country Status (8)

Country Link
US (3) US8088759B2 (OSRAM)
EP (2) EP2604269B1 (OSRAM)
JP (1) JP5241501B2 (OSRAM)
AU (2) AU2006308655B2 (OSRAM)
CA (2) CA2628193C (OSRAM)
IL (1) IL191175A (OSRAM)
NZ (1) NZ568254A (OSRAM)
WO (1) WO2007053725A2 (OSRAM)

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JP5127096B2 (ja) 1999-04-30 2013-01-23 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン アポトーシスにより誘導される自己免疫疾患を処置するためのベンゾジアゼピンの使用
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CA2611031A1 (en) 2005-06-01 2007-05-10 The Regents Of The University Of Michigan Unsolvated benzodiazepine compositions and methods
AU2006308655B2 (en) 2005-11-01 2010-09-23 The Regents Of The University Of Michigan Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties
US7759338B2 (en) * 2006-04-27 2010-07-20 The Regents Of The University Of Michigan Soluble 1,4 benzodiazepine compounds and stable salts thereof
JP5264716B2 (ja) 2006-06-09 2013-08-14 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 化合物およびその標的に関連する組成物および方法
AU2008226532B2 (en) 2007-03-09 2011-09-22 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
ES2614498T3 (es) 2007-09-14 2017-05-31 The Regents Of The University Of Michigan Inhibidores de ATPasa F1F0 y métodos relacionados
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WO2010030891A2 (en) 2008-09-11 2010-03-18 The Regents Of The University Of Michigan Aryl guanidine f1f0-atpase inhibitors and related methods
US8604023B2 (en) 2009-04-17 2013-12-10 The Regents Of The University Of Michigan 1,4-benzodiazepinone compounds and their use in treating cancer
KR101784674B1 (ko) 2009-05-22 2017-10-12 애브비 인코포레이티드 5-ｈｔ 수용체의 조절제 및 이의 사용방법
JP2013505258A (ja) 2009-09-18 2013-02-14 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン ベンゾジアゼピノン化合物およびそれを使用する治療方法
AU2010322287B2 (en) * 2009-11-17 2014-04-03 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
US9126978B2 (en) 2009-11-17 2015-09-08 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
BR112012030534A2 (pt) 2010-05-21 2015-09-29 Abbott Gmbh & Co Kg moduladores de receptores 5-ht e métodos de uso dos mesmos
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CN105693634B (zh) * 2016-03-17 2018-12-11 清华大学 化合物及其用途

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IL191175A0 (en) 2009-02-11
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US8088759B2 (en) 2012-01-03
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AU2010241505A1 (en) 2010-12-09
US8791104B2 (en) 2014-07-29
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US20070111994A1 (en) 2007-05-17
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US20120088757A1 (en) 2012-04-12
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