CA2627630A1 - Nicotinic acid derivatives as modulators of metabotropic glutamate receptors - Google Patents

Nicotinic acid derivatives as modulators of metabotropic glutamate receptors Download PDF

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Publication number
CA2627630A1
CA2627630A1 CA002627630A CA2627630A CA2627630A1 CA 2627630 A1 CA2627630 A1 CA 2627630A1 CA 002627630 A CA002627630 A CA 002627630A CA 2627630 A CA2627630 A CA 2627630A CA 2627630 A1 CA2627630 A1 CA 2627630A1
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Canada
Prior art keywords
pyridin
methanone
chloro
methyl
piperidin
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Abandoned
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CA002627630A
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English (en)
French (fr)
Inventor
Ralf Glatthar
David Orain
Carsten Spanka
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Novartis AG
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Individual
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Publication of CA2627630A1 publication Critical patent/CA2627630A1/en
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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  • Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
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  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Addiction (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
CA002627630A 2005-12-20 2006-12-18 Nicotinic acid derivatives as modulators of metabotropic glutamate receptors Abandoned CA2627630A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP05027934.8 2005-12-20
EP05027934 2005-12-20
EP06120424.4 2006-09-11
EP06120424 2006-09-11
PCT/EP2006/012181 WO2007071358A1 (en) 2005-12-20 2006-12-18 Nicotinic acid derivatives as modulators of metabotropic glutamate receptors

Publications (1)

Publication Number Publication Date
CA2627630A1 true CA2627630A1 (en) 2007-06-28

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ID=37744569

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002627630A Abandoned CA2627630A1 (en) 2005-12-20 2006-12-18 Nicotinic acid derivatives as modulators of metabotropic glutamate receptors

Country Status (12)

Country Link
US (1) US20090005363A1 (https=)
EP (1) EP1966144A1 (https=)
JP (1) JP2009519986A (https=)
KR (1) KR20080076962A (https=)
AR (1) AR058554A1 (https=)
AU (1) AU2006329007A1 (https=)
BR (1) BRPI0620066A2 (https=)
CA (1) CA2627630A1 (https=)
PE (1) PE20071171A1 (https=)
RU (1) RU2008129622A (https=)
TW (1) TW200732323A (https=)
WO (1) WO2007071358A1 (https=)

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JP2010502664A (ja) 2006-09-11 2010-01-28 ノバルティス アクチエンゲゼルシャフト 代謝型グルタミン酸受容体の調節剤としてのニコチン酸誘導体
JP5341084B2 (ja) * 2007-08-03 2013-11-13 エフ．ホフマン−ラ ロシュ アーゲー Ｔａａｒ１リガンドとしてのピリジンカルボキシアミド及びベンズアミド誘導体
AU2008309621A1 (en) * 2007-10-12 2009-04-16 Novartis Ag Metabotropic glutamate receptor modulators for the treatment of Parkinson's Disease
WO2009047303A2 (en) * 2007-10-12 2009-04-16 Novartis Ag Metabotropic glutamate receptor modulators for the treatment of pervasive developmental disorder
MX2010014222A (es) * 2008-06-30 2011-03-29 Novartis Ag Star Combinaciones que comprenden moduladores de mglur para el tratamiento de enfermedad de parkinson.
CN102256963B (zh) * 2008-12-19 2014-06-11 贝林格尔.英格海姆国际有限公司 作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺
US8748623B2 (en) 2009-02-17 2014-06-10 Syntrix Biosystems, Inc. Pyridinecarboxamides as CXCR2 modulators
EP2959902A1 (en) 2009-07-23 2015-12-30 Novartis AG Use of azabicycloalkyl derivatives for the treatment or prevention of ataxia
NZ598891A (en) * 2009-08-24 2014-05-30 Neuralstem Inc Synthesis of a neurostimulative piperazine
RU2012116124A (ru) * 2009-09-21 2013-10-27 Вандербилт Юниверсити О-БЕНЗИЛ НИКОТИНАМИДНЫЕ АНАЛОГИ КАК ПОЗИТИВНЫЕ АЛЛОСТЕРИЧЕСКИЕ МОДУЛЯТОРЫ mGluR5
JO3250B1 (ar) 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
EP2490691A1 (en) 2009-10-20 2012-08-29 Novartis AG Use of 1h-quinazoline-2,4-diones
ES2674275T3 (es) 2009-12-17 2018-06-28 Centrexion Therapeutics Corporation Antagonistas del receptor CCR2 y usos de los mismos
WO2011149963A1 (en) * 2010-05-24 2011-12-01 Vanderbilt University Substituted-6-methylnicotinamides as mglur5 positive allosteric modulators
AU2011268865A1 (en) 2010-06-24 2013-01-31 Novartis Ag Use of 1H-quinazoline-2,4-diones
EP2608672B1 (en) 2010-08-23 2020-12-16 Syntrix Biosystems, Inc. Aminopyridine- and aminopyrimidinecarboxamides as cxcr2 modulators
AR084515A1 (es) * 2010-12-22 2013-05-22 Merz Pharma Gmbh & Co Kgaa Derivados heterociclicos nitrogenados, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades asociadas al sistema nervioso central tales como parkinson y alzheimer, entre otras
AR084516A1 (es) * 2010-12-22 2013-05-22 Merz Pharma Gmbh & Co Kgaa Moduladores de receptores de glutamato metabotropicos
WO2012101060A1 (en) 2011-01-27 2012-08-02 Novartis Ag Use of nicotinic acetylcholine receptor alpha 7 activators
MX2014002693A (es) 2011-09-07 2014-06-04 Novartis Ag Uso de 1h-quinazolina-2,4-dionas para usarse en la prevencion o el tratamiento de epilepsia fotosensible.
RU2672468C1 (ru) * 2011-12-22 2018-11-15 Конекшис Лайф Сайенсиз Пвт. Лтд. Производные аза-адамантанов и их применение
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US20090005363A1 (en) 2009-01-01
WO2007071358A1 (en) 2007-06-28
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JP2009519986A (ja) 2009-05-21
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AU2006329007A1 (en) 2007-06-28

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