CA2624781A1 - Nanobodies' et polypeptides diriges contre l'egfr et l'igf-1r - Google Patents
Nanobodies' et polypeptides diriges contre l'egfr et l'igf-1r Download PDFInfo
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- CA2624781A1 CA2624781A1 CA002624781A CA2624781A CA2624781A1 CA 2624781 A1 CA2624781 A1 CA 2624781A1 CA 002624781 A CA002624781 A CA 002624781A CA 2624781 A CA2624781 A CA 2624781A CA 2624781 A1 CA2624781 A1 CA 2624781A1
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- 230000005945 translocation Effects 0.000 description 1
- 230000005751 tumor progression Effects 0.000 description 1
- 108010087967 type I signal peptidase Proteins 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 description 1
- 229960004355 vindesine Drugs 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72593905P | 2005-10-11 | 2005-10-11 | |
US60/725,939 | 2005-10-11 | ||
PCT/EP2006/009840 WO2007042289A2 (fr) | 2005-10-11 | 2006-10-11 | Nanobodies™ et polypeptides diriges contre l'egfr et l'igf-1r |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2624781A1 true CA2624781A1 (fr) | 2007-04-19 |
Family
ID=37837037
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002624781A Abandoned CA2624781A1 (fr) | 2005-10-11 | 2006-10-11 | Nanobodies' et polypeptides diriges contre l'egfr et l'igf-1r |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1934259A2 (fr) |
JP (1) | JP2009511032A (fr) |
CN (1) | CN101321784A (fr) |
AU (1) | AU2006301426A1 (fr) |
CA (1) | CA2624781A1 (fr) |
WO (1) | WO2007042289A2 (fr) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
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CA2666599A1 (fr) | 2006-08-18 | 2008-02-21 | Ablynx N.V. | Sequences d'acides amines dirigees contre l'il-6r et polypeptides les contenant utilises pour le traitement de maladies et de troubles associes au signal medie par il-6 |
US9512236B2 (en) | 2006-12-19 | 2016-12-06 | Ablynx N.V. | Amino acid sequences directed against GPCRS and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders |
CA2588106A1 (fr) * | 2007-05-18 | 2008-11-18 | Nrc - Institute For Biological Sciences | Anticorps a domaine unique et anticorps a chaines lourdes ciblant le recepteur du facteur de croissance epidermique et utilisations connexes |
NZ581097A (en) * | 2007-05-24 | 2012-03-30 | Ablynx Nv | Amino acid sequences directed against rank-l and polypeptides comprising the same for the treatment of bone diseases and disorders |
CA2687633A1 (fr) * | 2007-05-24 | 2008-11-27 | Ablynx N.V. | Sequences d'acides amines dirigees contre les recepteurs des facteurs de croissance et polypeptides renfermant ces dernieres, destines au traitement de maladies et affections associees aux facteurs de croissance et a leurs recepteurs |
US20110053865A1 (en) * | 2007-11-27 | 2011-03-03 | Ablynx N.V. | Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same |
JP2011516603A (ja) | 2008-04-17 | 2011-05-26 | アブリンクス エン.ヴェー. | 血清タンパク質と結合することが可能なペプチド、並びにこれを含む化合物、構築物及びポリペプチド |
ES2620285T3 (es) | 2008-05-02 | 2017-06-28 | Novartis Ag | Moléculas de unión con base en fibronectina mejorada y usos de las mismas |
RU2010151725A (ru) * | 2008-05-16 | 2012-06-27 | Аблинкс Нв (Be) | Аминокислотные последовательности, направленные против cхcr4 и других gpcr, и соединения, включаюшие их |
US8444976B2 (en) | 2008-07-02 | 2013-05-21 | Argen-X B.V. | Antigen binding polypeptides |
EP2143735A1 (fr) * | 2008-07-10 | 2010-01-13 | Institut Pasteur | Domaines variables d'anticorps de camélidé à chaîne lourde dirigés contre les protéines acides fibrillaires gliales |
GB0814960D0 (en) * | 2008-08-15 | 2008-09-24 | Ge Healthcare As | Method for detecting dysplasia |
HUE042919T2 (hu) | 2008-12-19 | 2019-07-29 | Ablynx Nv | Genetikai immunizáció sejthez kapcsolódó antigének - például P2X7, CXCR7 vagy CXCR4 - elleni immunglobulinok elõállítására |
US9265834B2 (en) | 2009-03-05 | 2016-02-23 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
WO2010100135A1 (fr) * | 2009-03-05 | 2010-09-10 | Ablynx N.V. | Nouveaux complexes dimères de liaison antigénique, méthodes d'obtention/non obtention et leurs utilisations |
EP2408817B1 (fr) * | 2009-03-20 | 2016-03-16 | F.Hoffmann-La Roche Ag | Anticorps anti-her di-spécifiques |
WO2010112194A1 (fr) * | 2009-04-02 | 2010-10-07 | F. Hoffmann-La Roche Ag | Polypeptides se liant à un antigène et anticorps multispécifiques les renfermant |
NZ595461A (en) | 2009-04-10 | 2013-01-25 | Ablynx Nv | Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders |
EP2417162A2 (fr) | 2009-04-10 | 2012-02-15 | Ablynx N.V. | Séquences d'acides aminés améliorées dirigées contre l'il-6r et polypeptides les comprenant pour le traitement des maladies et des troubles liés à l'il-6r |
US20100316639A1 (en) | 2009-06-16 | 2010-12-16 | Genentech, Inc. | Biomarkers for igf-1r inhibitor therapy |
EP2473528B1 (fr) | 2009-09-03 | 2014-12-03 | Ablynx N.V. | Formulations stables de polypeptides et leurs utilisations |
WO2011051327A2 (fr) | 2009-10-30 | 2011-05-05 | Novartis Ag | Petites protéines à chaîne unique de type anticorps |
WO2011051333A1 (fr) | 2009-10-30 | 2011-05-05 | Novartis Ag | Bibliothèques de domaines de liaison à la face inférieure de la fibronectine universelle de type 3 |
WO2011051466A1 (fr) | 2009-11-02 | 2011-05-05 | Novartis Ag | Molécules de liaison anti-idiotypiques à base de fibronectine et leurs utilisations |
DK2513290T3 (en) * | 2009-12-18 | 2016-01-25 | Novozymes Inc | Methods for Preparation of Polypeptides in Trichoderma Mutants with Protease Deficiency |
WO2011083141A2 (fr) | 2010-01-08 | 2011-07-14 | Ablynx Nv | Procédé de production de séquences d'immunoglobulines par utilisation de particules de lipoprotéines |
EP2531523A1 (fr) | 2010-02-05 | 2012-12-12 | Ablynx N.V. | Peptides capables de se lier à la sérumalbumine, et composés, constructions, et polypeptides comprenant de tels peptides |
WO2011117423A1 (fr) | 2010-03-26 | 2011-09-29 | Ablynx N.V. | Domaines variables uniques de l'immunoglobuline dirigés contre cxcr7 |
NZ603570A (en) | 2010-05-20 | 2014-12-24 | Ablynx Nv | Biological materials related to her3 |
GB201014715D0 (en) * | 2010-09-06 | 2010-10-20 | Vib Vzw | Nanobodies stabilizing functional conformational states of GPCRS |
EP2621953B1 (fr) | 2010-09-30 | 2017-04-05 | Ablynx N.V. | Matières biologiques associées à c-met |
CN102153650B (zh) * | 2011-01-27 | 2012-07-04 | 中国人民解放军军事医学科学院生物工程研究所 | 一种抗egfr人源化抗体l2-h3及其编码基因与应用 |
AU2012234284B2 (en) | 2011-03-28 | 2015-10-08 | Ablynx Nv | Bispecific anti-CXCR7 immunoglobulin single variable domains |
UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
CA2835340A1 (fr) | 2011-05-27 | 2012-12-06 | Ablynx Nv | Inhibition de la resorption osseuse a l'aide de peptides se liant a rankl |
CN102321175B (zh) * | 2011-09-21 | 2013-08-07 | 天津胜发生物技术有限公司 | 针对乳腺癌Her2/new的纳米抗体或多肽 |
WO2013041722A1 (fr) | 2011-09-23 | 2013-03-28 | Ablynx Nv | Inhibition prolongée d'une signalisation à médiation par l'interleukine-6 |
CN103889451B (zh) | 2011-09-30 | 2016-06-29 | 埃博灵克斯股份有限公司 | 与C-Met相关的生物物质 |
TW201843172A (zh) * | 2012-06-25 | 2018-12-16 | 美商再生元醫藥公司 | 抗-egfr抗體及其用途 |
WO2014010758A1 (fr) | 2012-07-13 | 2014-01-16 | 学校法人帝京平成大学 | Agent antitumoral, marqueur de détection de tumeur, et agent vaccinal à usage oral |
WO2014106527A1 (fr) | 2013-01-03 | 2014-07-10 | Merck Patent Gmbh | Procédé de production d'anticorps sécrétables par expression dans saccharomyces cerevisiae |
CN105814082A (zh) * | 2013-09-26 | 2016-07-27 | 埃博灵克斯股份有限公司 | 双特异性纳米抗体 |
BR112016020643B1 (pt) * | 2014-03-06 | 2023-05-02 | National Research Council Of Canada | Anticorpos específicos para receptor de fator de crescimento semelhante à insulina tipo 1 e uso dos mesmos |
WO2015131256A1 (fr) * | 2014-03-06 | 2015-09-11 | National Research Council Of Canada | Anticorps analogues à l'insuline spécifiques du récepteur du facteur de croissance 1 et leurs utilisations |
CA2942154C (fr) * | 2014-03-06 | 2023-06-27 | National Research Council Of Canada | Anticorps specifiques du recepteur du facteur de croissance 1 analogues a l'insuline et leurs utilisations |
CN107002119A (zh) | 2014-03-24 | 2017-08-01 | 豪夫迈·罗氏有限公司 | 使用c‑met拮抗剂的癌症治疗及前者与hgf表达的关联 |
CN107074954A (zh) | 2014-10-21 | 2017-08-18 | 埃博灵克斯股份有限公司 | Il‑6r相关疾病的治疗 |
KR101679245B1 (ko) | 2014-12-09 | 2016-11-25 | 전남대학교산학협력단 | 상피성장인자 수용체를 표적으로 하는 암 진단 또는 영상화용 조성물 |
AU2015366284B2 (en) * | 2014-12-19 | 2021-07-22 | Ablynx N.V. | Cysteine linked nanobody dimers |
CN106854244B (zh) * | 2015-12-09 | 2020-05-22 | 南京英瀚斯生物科技有限公司 | 一种针对her3的纳米抗体及其临床应用 |
CN109843325B (zh) * | 2016-09-14 | 2023-10-03 | 特尼奥生物股份有限公司 | Cd3结合抗体 |
CN106492216A (zh) * | 2016-10-28 | 2017-03-15 | 山西纳安生物科技有限公司 | 经头颈部内外表皮的纳米抗体给药制剂系统及制备方法和应用 |
JP7241731B2 (ja) * | 2017-07-19 | 2023-03-17 | フエー・イー・ベー・フエー・ゼツト・ウエー | 血清アルブミン結合剤 |
WO2019014891A1 (fr) * | 2017-07-20 | 2019-01-24 | 深圳普瑞金生物药业有限公司 | Cart d'anticorps à domaine unique egfr destinée au traitement de tumeur et son application |
PE20212205A1 (es) * | 2017-09-08 | 2021-11-18 | Maverick Therapeutics Inc | Proteinas de union condicionalmente activadas restringidas |
CN111886251A (zh) * | 2017-12-14 | 2020-11-03 | Abl生物公司 | 抗a-syn/igf1r的双特异性抗体及其用途 |
GB201721802D0 (en) | 2017-12-22 | 2018-02-07 | Almac Discovery Ltd | Ror1-specific antigen binding molecules |
WO2019151865A1 (fr) * | 2018-02-05 | 2019-08-08 | Stichting Vu | Anticorps anti-us28 agonistes inverses |
CN109336976B (zh) * | 2018-09-27 | 2021-04-02 | 暨南大学 | 抗人egfr的纳米抗体及其应用 |
WO2020181140A1 (fr) | 2019-03-05 | 2020-09-10 | Maverick Therapeutics, Inc. | Protéines de liaison à activation conditionnelle limitée |
CN114096556A (zh) * | 2019-07-10 | 2022-02-25 | 南洋理工大学 | 表皮生长因子受体(egfr)配体 |
CN111171151B (zh) * | 2019-12-26 | 2021-09-14 | 佛山汉腾生物科技有限公司 | 抗egfr纳米抗体及其应用 |
CN112375135B (zh) * | 2020-07-06 | 2022-12-23 | 上海大学 | 一种人工表皮生长因子与设计多肽及其应用 |
EP4247850A1 (fr) | 2020-11-20 | 2023-09-27 | Simcere Innovation, Inc. | Compositions de car-t double segmenté et méthodes pour l'immuno-cancérothérapie |
CN112646034B (zh) * | 2020-12-25 | 2022-06-24 | 暨南大学 | Egfr的亲和力成熟结合蛋白及其应用 |
CN112646035B (zh) * | 2020-12-25 | 2022-06-24 | 暨南大学 | Egfr的亲和力成熟结合蛋白及应用 |
CA3225252A1 (fr) | 2021-07-14 | 2023-01-19 | Jordan JARJOUR | Recepteurs de lymphocytes t modifies fusionnes a des domaines de liaison d'anticorps |
EP4377352A2 (fr) | 2021-07-30 | 2024-06-05 | Vib Vzw | Liants du récepteur mannose-6-phosphate indépendants des cations pour la dégradation ciblée de protéines |
CA3232216A1 (fr) * | 2021-10-18 | 2023-04-27 | Tavotek Biotherapeutics (Hong Kong) Limited | Anticorps anti-egfr, anticorps anti-cmet, anticorps anti-vegf, anticorps multispecifiques et leurs utilisations |
WO2023143484A1 (fr) * | 2022-01-29 | 2023-08-03 | 明慧医药(杭州)有限公司 | Protéine de liaison à l'antigène et son utilisation |
CN114621349B (zh) * | 2022-02-09 | 2023-12-01 | 青岛大学附属医院 | 靶向pd-l1/hsa/ccl5三特异性纳米抗体及其衍生物和应用 |
WO2023196997A2 (fr) | 2022-04-08 | 2023-10-12 | 2Seventy Bio, Inc. | Récepteur multipartite et complexes de signalisation |
WO2024109949A1 (fr) * | 2022-11-25 | 2024-05-30 | 明慧医药(杭州)有限公司 | Composé antitumoral et son utilisation |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
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US20030165502A1 (en) * | 2000-06-13 | 2003-09-04 | City Of Hope | Single-chain antibodies against human insulin-like growth factor I receptor: expression, purification, and effect on tumor growth |
US20060228355A1 (en) * | 2003-11-07 | 2006-10-12 | Toon Laeremans | Camelidae single domain antibodies vhh directed against epidermal growth factor receptor and uses therefor |
WO2005016970A2 (fr) * | 2003-05-01 | 2005-02-24 | Imclone Systems Incorporated | Anticorps entierement humains diriges contre le recepteur du facteur de croissance 1 de type insuline |
-
2006
- 2006-10-11 CN CNA2006800449688A patent/CN101321784A/zh active Pending
- 2006-10-11 CA CA002624781A patent/CA2624781A1/fr not_active Abandoned
- 2006-10-11 AU AU2006301426A patent/AU2006301426A1/en not_active Abandoned
- 2006-10-11 EP EP06792421A patent/EP1934259A2/fr not_active Withdrawn
- 2006-10-11 JP JP2008534933A patent/JP2009511032A/ja not_active Withdrawn
- 2006-10-11 WO PCT/EP2006/009840 patent/WO2007042289A2/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
JP2009511032A (ja) | 2009-03-19 |
AU2006301426A1 (en) | 2007-04-19 |
EP1934259A2 (fr) | 2008-06-25 |
CN101321784A (zh) | 2008-12-10 |
WO2007042289A2 (fr) | 2007-04-19 |
WO2007042289A3 (fr) | 2007-10-04 |
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