CA2620631A1 - 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-.receptor tyrosine kinases - Google Patents
3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-.receptor tyrosine kinases Download PDFInfo
- Publication number
- CA2620631A1 CA2620631A1 CA002620631A CA2620631A CA2620631A1 CA 2620631 A1 CA2620631 A1 CA 2620631A1 CA 002620631 A CA002620631 A CA 002620631A CA 2620631 A CA2620631 A CA 2620631A CA 2620631 A1 CA2620631 A1 CA 2620631A1
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- Prior art keywords
- compound
- 6alkyl
- ring
- aliphatic
- 4aliphatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71245705P | 2005-08-29 | 2005-08-29 | |
| US60/712,457 | 2005-08-29 | ||
| PCT/US2006/033282 WO2007027528A2 (en) | 2005-08-29 | 2006-08-25 | 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-.receptor tyrosine kinases |
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| CA2620631A1 true CA2620631A1 (en) | 2007-03-08 |
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| DE (1) | DE602006020293D1 (enExample) |
| ES (1) | ES2361338T3 (enExample) |
| WO (1) | WO2007027528A2 (enExample) |
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| WO2007027729A1 (en) | 2005-08-29 | 2007-03-08 | Vertex Pharmaceuticals Incorporated | 3, 5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases |
| AU2006285038A1 (en) * | 2005-08-29 | 2007-03-08 | Vertex Pharmaceuticals Incorporated | 3,5-disubstituted pyrid-2-ones useful as inhibitors of Tec family of non-receptor tyrosine kinases |
| JP5587193B2 (ja) | 2007-10-23 | 2014-09-10 | エフ．ホフマン−ラ ロシュ アーゲー | 新規なキナーゼ阻害剤 |
| US7683064B2 (en) | 2008-02-05 | 2010-03-23 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
| PE20100851A1 (es) | 2008-06-24 | 2011-01-31 | Hoffmann La Roche | PIRIDIN-2-ONAS Y PIRIDAZIN-3-ONAS SUSTITUIDAS COMO INHIBIDORES DE Btk |
| PL2300459T3 (pl) | 2008-07-02 | 2013-10-31 | Hoffmann La Roche | Nowe fenylopirazynony jako inhibitory kinazy |
| AR082590A1 (es) | 2010-08-12 | 2012-12-19 | Hoffmann La Roche | Inhibidores de la tirosina-quinasa de bruton |
| WO2013153539A1 (en) | 2012-04-13 | 2013-10-17 | Glenmark Pharmaceuticals S.A. | Tricyclic compounds as tec kinase inhibitors |
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| US5308854A (en) | 1990-06-18 | 1994-05-03 | Merck & Co., Inc. | Inhibitors of HIV reverse transcriptase |
| NZ238576A (en) * | 1990-06-18 | 1994-12-22 | Merck & Co Inc | Pyridinone derivatives, preparation and pharmaceutical compositions thereof |
| KR100196559B1 (ko) | 1990-06-19 | 1999-06-15 | 기따사또 이찌로 | 안지오텐신ii 길항작용을 함유하는 피리딘 유도체 |
| IL99731A0 (en) * | 1990-10-18 | 1992-08-18 | Merck & Co Inc | Hydroxylated pyridine derivatives,their preparation and pharmaceutical compositions containing them |
| DE4221583A1 (de) | 1991-11-12 | 1993-05-13 | Bayer Ag | Substituierte biphenylpyridone |
| US5290941A (en) | 1992-10-14 | 1994-03-01 | Merck & Co., Inc. | Facile condensation of methylbenzoxazoles with aromatic aldehydes |
| DE4314964A1 (de) | 1993-05-06 | 1994-11-10 | Bayer Ag | Pyridinylmethyl-substiutierte Pyridine und Pyridone |
| DE4314963A1 (de) | 1993-05-06 | 1994-11-10 | Bayer Ag | Substituierte Pyridine und 2-Oxo-1,2-dihydropyridine |
| DE4316077A1 (de) | 1993-05-13 | 1994-11-17 | Bayer Ag | Substituierte Mono- und Bihydridylmethylpyridone |
| US6979695B2 (en) | 1996-04-23 | 2005-12-27 | Targacept, Inc. | Compounds capable of activating cholinergic receptors |
| CZ20003978A3 (cs) | 1998-04-27 | 2001-09-12 | Centre National De La Recherche Scientifique | Deriváty 3-(amino- nebo aminoalkyl) pyridinonu a jejich použití |
| US6774138B2 (en) | 1999-08-31 | 2004-08-10 | Merck & Co., Inc. | Thiazolyl(pyridyl)ethyne compounds |
| IL150650A0 (en) | 2000-01-20 | 2003-02-12 | Eisai Co Ltd | Piperidine derivatives and pharmaceutical compositions containing the same |
| WO2001096308A1 (en) * | 2000-06-12 | 2001-12-20 | Eisai Co., Ltd. | 1,2-dihydropyridine compounds, process for preparation of the same and use thereof |
| ATE319706T1 (de) * | 2000-09-19 | 2006-03-15 | Centre Nat Rech Scient | Pyridinon und pyridinethion-derivate mit hiv- hemmenden eigenschaften |
| EP1343763A1 (en) | 2000-11-20 | 2003-09-17 | Bristol-Myers Squibb Company | Pyrodone derivatives as ap2 inhibitors |
| DE60139506D1 (de) | 2000-12-28 | 2009-09-17 | Shionogi & Co | 2-pyridonderivate mit affinität für den cannabinoid-typ-2-rezeptor |
| CA2442428A1 (en) | 2001-03-28 | 2002-10-10 | Mark D. Wittman | Novel tyrosine kinase inhibitors |
| JP2002371078A (ja) * | 2001-06-12 | 2002-12-26 | Sankyo Co Ltd | キノリン誘導体及びキノロン誘導体 |
| GB0129260D0 (en) | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
| US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
| AP1822A (en) * | 2002-02-14 | 2008-01-30 | Pharmacia Corp | Substituted pyridinones as modulators of P38 MAP kinase. |
| JP4208512B2 (ja) | 2002-07-23 | 2009-01-14 | 株式会社クラレ | ５−（２’−ピリジル）−２−ピリドン誘導体の製造方法 |
| AU2003274025A1 (en) | 2002-10-17 | 2004-05-04 | Syngenta Participations Ag | Pyridine derivatives useful as herbicides |
| WO2004035563A1 (en) | 2002-10-17 | 2004-04-29 | Syngenta Participations Ag | 3-heterocyclylpyridine derivatives useful as herbicides |
| CA2506741A1 (en) | 2002-11-27 | 2004-06-17 | Artesian Therapeutics, Inc. | Compounds with mixed pde-inhibitory and .beta.-adrenergic antagonist or partial agonist activity for treatment of heart failure |
| AU2003300297A1 (en) | 2002-12-23 | 2004-07-22 | Artesian Therapeutics, Inc. | CARDIOTONIC COMPOUNDS WITH INHIBITORY ACTIVITY AGAINST Beta-ADRENERGIC RECEPTORS AND PHOSPHODIESTERASE |
| WO2005007159A1 (en) | 2003-07-14 | 2005-01-27 | The General Hospital Corporation | Methods for treating vascular diseases |
| CL2004002050A1 (es) * | 2003-08-13 | 2005-06-03 | Pharmacia Corp Sa Organizada B | Compuestos derivados de piridinonas sustituidas; su uso en el tratamiento de afecciones causadas o exacerbadas por actividad p38 map kinasa y/o tnf no regulada, tales como inflamaciones, tumores, sida y otros. |
| PE20060285A1 (es) * | 2004-03-30 | 2006-05-08 | Aventis Pharma Inc | Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp) |
| MX2007001399A (es) | 2004-08-02 | 2007-04-18 | Osi Pharm Inc | Compuestos que inhiben pirrolopirimidina multi-cinasa aril-amino sustituidas. |
| MX2007007330A (es) * | 2004-12-16 | 2007-10-04 | Vertex Pharma | Piridonas de utilidad como inhibidores de quinasas . |
| AU2006223409B2 (en) | 2005-03-10 | 2011-07-21 | Gilead Connecticut, Inc. | Certain substituted amides, method of making, and method of use thereof |
| AU2006285038A1 (en) | 2005-08-29 | 2007-03-08 | Vertex Pharmaceuticals Incorporated | 3,5-disubstituted pyrid-2-ones useful as inhibitors of Tec family of non-receptor tyrosine kinases |
| WO2007027729A1 (en) | 2005-08-29 | 2007-03-08 | Vertex Pharmaceuticals Incorporated | 3, 5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases |
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- 2006-08-25 AU AU2006285145A patent/AU2006285145A1/en not_active Abandoned
- 2006-08-25 EP EP06813771A patent/EP1919905B1/en not_active Not-in-force
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- 2006-08-25 US US11/510,126 patent/US7786120B2/en not_active Expired - Fee Related
- 2006-08-25 AT AT06813771T patent/ATE499362T1/de not_active IP Right Cessation
- 2006-08-25 CN CNA2006800393748A patent/CN101291926A/zh active Pending
- 2006-08-25 CA CA002620631A patent/CA2620631A1/en not_active Abandoned
- 2006-08-25 ES ES06813771T patent/ES2361338T3/es active Active
- 2006-08-25 WO PCT/US2006/033282 patent/WO2007027528A2/en not_active Ceased
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2012
- 2012-06-20 JP JP2012138966A patent/JP2012184260A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
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| US20070185125A1 (en) | 2007-08-09 |
| JP2012184260A (ja) | 2012-09-27 |
| ES2361338T3 (es) | 2011-06-16 |
| WO2007027528A3 (en) | 2007-05-03 |
| JP5112317B2 (ja) | 2013-01-09 |
| EP1919905A2 (en) | 2008-05-14 |
| US7786120B2 (en) | 2010-08-31 |
| CN101291926A (zh) | 2008-10-22 |
| AU2006285145A1 (en) | 2007-03-08 |
| WO2007027528A2 (en) | 2007-03-08 |
| DE602006020293D1 (de) | 2011-04-07 |
| ATE499362T1 (de) | 2011-03-15 |
| EP1919905B1 (en) | 2011-02-23 |
| JP2009507790A (ja) | 2009-02-26 |
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20130827 |