AU2006285145A1 - 3,5-disubstituted pyrid-2-ones useful as inhibitors of Tec family of non-.receptor tyrosine kinases - Google Patents

3,5-disubstituted pyrid-2-ones useful as inhibitors of Tec family of non-.receptor tyrosine kinases Download PDF

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Publication number
AU2006285145A1
AU2006285145A1 AU2006285145A AU2006285145A AU2006285145A1 AU 2006285145 A1 AU2006285145 A1 AU 2006285145A1 AU 2006285145 A AU2006285145 A AU 2006285145A AU 2006285145 A AU2006285145 A AU 2006285145A AU 2006285145 A1 AU2006285145 A1 AU 2006285145A1
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Prior art keywords
aliphatic
alkyl
compound
ring
optionally substituted
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Abandoned
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AU2006285145A
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Inventor
Jean-Damien Charrier
Steven Durrant
Julian M.C. Golec
Juan-Miguel Jimenez
Michael Mortimore
Sharn Ramaya
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Publication of AU2006285145A1 publication Critical patent/AU2006285145A1/en
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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AU2006285145A 2005-08-29 2006-08-25 3,5-disubstituted pyrid-2-ones useful as inhibitors of Tec family of non-.receptor tyrosine kinases Abandoned AU2006285145A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71245705P 2005-08-29 2005-08-29
US60/712,457 2005-08-29
PCT/US2006/033282 WO2007027528A2 (en) 2005-08-29 2006-08-25 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-.receptor tyrosine kinases

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AU2006285145A1 true AU2006285145A1 (en) 2007-03-08

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ID=37565557

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AU2006285145A Abandoned AU2006285145A1 (en) 2005-08-29 2006-08-25 3,5-disubstituted pyrid-2-ones useful as inhibitors of Tec family of non-.receptor tyrosine kinases

Country Status (10)

Country Link
US (1) US7786120B2 (enExample)
EP (1) EP1919905B1 (enExample)
JP (2) JP5112317B2 (enExample)
CN (1) CN101291926A (enExample)
AT (1) ATE499362T1 (enExample)
AU (1) AU2006285145A1 (enExample)
CA (1) CA2620631A1 (enExample)
DE (1) DE602006020293D1 (enExample)
ES (1) ES2361338T3 (enExample)
WO (1) WO2007027528A2 (enExample)

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* Cited by examiner, † Cited by third party
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WO2007027729A1 (en) 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3, 5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases
AU2006285038A1 (en) * 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3,5-disubstituted pyrid-2-ones useful as inhibitors of Tec family of non-receptor tyrosine kinases
JP5587193B2 (ja) 2007-10-23 2014-09-10 エフ．ホフマン−ラ ロシュ アーゲー 新規なキナーゼ阻害剤
US7683064B2 (en) 2008-02-05 2010-03-23 Roche Palo Alto Llc Inhibitors of Bruton's tyrosine kinase
PE20100851A1 (es) 2008-06-24 2011-01-31 Hoffmann La Roche PIRIDIN-2-ONAS Y PIRIDAZIN-3-ONAS SUSTITUIDAS COMO INHIBIDORES DE Btk
PL2300459T3 (pl) 2008-07-02 2013-10-31 Hoffmann La Roche Nowe fenylopirazynony jako inhibitory kinazy
AR082590A1 (es) 2010-08-12 2012-12-19 Hoffmann La Roche Inhibidores de la tirosina-quinasa de bruton
WO2013153539A1 (en) 2012-04-13 2013-10-17 Glenmark Pharmaceuticals S.A. Tricyclic compounds as tec kinase inhibitors

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JP2012184260A (ja) 2012-09-27
ES2361338T3 (es) 2011-06-16
WO2007027528A3 (en) 2007-05-03
JP5112317B2 (ja) 2013-01-09
EP1919905A2 (en) 2008-05-14
CA2620631A1 (en) 2007-03-08
US7786120B2 (en) 2010-08-31
CN101291926A (zh) 2008-10-22
WO2007027528A2 (en) 2007-03-08
DE602006020293D1 (de) 2011-04-07
ATE499362T1 (de) 2011-03-15
EP1919905B1 (en) 2011-02-23
JP2009507790A (ja) 2009-02-26

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