DE602006020293D1 - 3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin-kinasen nützlich sind - Google Patents

3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin-kinasen nützlich sind

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Publication number
DE602006020293D1
DE602006020293D1 DE602006020293T DE602006020293T DE602006020293D1 DE 602006020293 D1 DE602006020293 D1 DE 602006020293D1 DE 602006020293 T DE602006020293 T DE 602006020293T DE 602006020293 T DE602006020293 T DE 602006020293T DE 602006020293 D1 DE602006020293 D1 DE 602006020293D1
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Germany
Prior art keywords
inhibitors
receptor tyrosine
tyrosine kinases
tec family
pyrid
Prior art date
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Active
Application number
DE602006020293T
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German (de)
English (en)
Inventor
Jean-Damien Charrier
Sharn Ramaya
Steven Durrant
Juan-Miguel Jimenez
Julian M C Golec
Michael Mortimore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of DE602006020293D1 publication Critical patent/DE602006020293D1/de
Anticipated expiration legal-status Critical
Active legal-status Critical Current

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    • C07—ORGANIC CHEMISTRY
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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DE602006020293T 2005-08-29 2006-08-25 3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin-kinasen nützlich sind Active DE602006020293D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71245705P 2005-08-29 2005-08-29
PCT/US2006/033282 WO2007027528A2 (en) 2005-08-29 2006-08-25 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-.receptor tyrosine kinases

Publications (1)

Publication Number Publication Date
DE602006020293D1 true DE602006020293D1 (de) 2011-04-07

Family

ID=37565557

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DE602006020293T Active DE602006020293D1 (de) 2005-08-29 2006-08-25 3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin-kinasen nützlich sind

Country Status (10)

Country Link
US (1) US7786120B2 (enExample)
EP (1) EP1919905B1 (enExample)
JP (2) JP5112317B2 (enExample)
CN (1) CN101291926A (enExample)
AT (1) ATE499362T1 (enExample)
AU (1) AU2006285145A1 (enExample)
CA (1) CA2620631A1 (enExample)
DE (1) DE602006020293D1 (enExample)
ES (1) ES2361338T3 (enExample)
WO (1) WO2007027528A2 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007027729A1 (en) 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3, 5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases
AU2006285038A1 (en) * 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3,5-disubstituted pyrid-2-ones useful as inhibitors of Tec family of non-receptor tyrosine kinases
JP5587193B2 (ja) 2007-10-23 2014-09-10 エフ．ホフマン−ラ ロシュ アーゲー 新規なキナーゼ阻害剤
US7683064B2 (en) 2008-02-05 2010-03-23 Roche Palo Alto Llc Inhibitors of Bruton's tyrosine kinase
PE20100851A1 (es) 2008-06-24 2011-01-31 Hoffmann La Roche PIRIDIN-2-ONAS Y PIRIDAZIN-3-ONAS SUSTITUIDAS COMO INHIBIDORES DE Btk
PL2300459T3 (pl) 2008-07-02 2013-10-31 Hoffmann La Roche Nowe fenylopirazynony jako inhibitory kinazy
AR082590A1 (es) 2010-08-12 2012-12-19 Hoffmann La Roche Inhibidores de la tirosina-quinasa de bruton
WO2013153539A1 (en) 2012-04-13 2013-10-17 Glenmark Pharmaceuticals S.A. Tricyclic compounds as tec kinase inhibitors

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JP2012184260A (ja) 2012-09-27
ES2361338T3 (es) 2011-06-16
WO2007027528A3 (en) 2007-05-03
JP5112317B2 (ja) 2013-01-09
EP1919905A2 (en) 2008-05-14
CA2620631A1 (en) 2007-03-08
US7786120B2 (en) 2010-08-31
CN101291926A (zh) 2008-10-22
AU2006285145A1 (en) 2007-03-08
WO2007027528A2 (en) 2007-03-08
ATE499362T1 (de) 2011-03-15
EP1919905B1 (en) 2011-02-23
JP2009507790A (ja) 2009-02-26

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