CA2612006A1 - Compositions phospholipidiques, procede de fabrication et methode d'utilisation - Google Patents
Compositions phospholipidiques, procede de fabrication et methode d'utilisation Download PDFInfo
- Publication number
- CA2612006A1 CA2612006A1 CA002612006A CA2612006A CA2612006A1 CA 2612006 A1 CA2612006 A1 CA 2612006A1 CA 002612006 A CA002612006 A CA 002612006A CA 2612006 A CA2612006 A CA 2612006A CA 2612006 A1 CA2612006 A1 CA 2612006A1
- Authority
- CA
- Canada
- Prior art keywords
- phospholipid
- composition
- agents
- tissue
- poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 242
- 150000003904 phospholipids Chemical class 0.000 title claims abstract description 196
- 238000000034 method Methods 0.000 title claims description 35
- 238000002360 preparation method Methods 0.000 title description 12
- 239000012530 fluid Substances 0.000 claims abstract description 67
- 239000000945 filler Substances 0.000 claims abstract description 54
- 230000003190 augmentative effect Effects 0.000 claims abstract description 6
- 229940112824 paste Drugs 0.000 claims description 48
- 210000001519 tissue Anatomy 0.000 claims description 43
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 41
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 39
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 34
- 239000013543 active substance Substances 0.000 claims description 29
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims description 26
- 239000000499 gel Substances 0.000 claims description 23
- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 claims description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 19
- 108010035532 Collagen Proteins 0.000 claims description 18
- 102000008186 Collagen Human genes 0.000 claims description 18
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 18
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 18
- 239000000243 solution Substances 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 229920001436 collagen Polymers 0.000 claims description 16
- 239000008347 soybean phospholipid Substances 0.000 claims description 15
- -1 polyethylene Polymers 0.000 claims description 14
- 235000011187 glycerol Nutrition 0.000 claims description 13
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 claims description 12
- 239000002246 antineoplastic agent Substances 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- 229920001577 copolymer Polymers 0.000 claims description 12
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 claims description 12
- 229940093471 ethyl oleate Drugs 0.000 claims description 12
- 229920000642 polymer Polymers 0.000 claims description 12
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- 239000003589 local anesthetic agent Substances 0.000 claims description 10
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- 150000004665 fatty acids Chemical class 0.000 claims description 8
- 229920001223 polyethylene glycol Polymers 0.000 claims description 8
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- 208000000094 Chronic Pain Diseases 0.000 claims description 5
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 5
- 229960005015 local anesthetics Drugs 0.000 claims description 5
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 5
- 230000001954 sterilising effect Effects 0.000 claims description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 4
- PQUXFUBNSYCQAL-UHFFFAOYSA-N 1-(2,3-difluorophenyl)ethanone Chemical compound CC(=O)C1=CC=CC(F)=C1F PQUXFUBNSYCQAL-UHFFFAOYSA-N 0.000 claims description 4
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 4
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- 229940024606 amino acid Drugs 0.000 claims description 4
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 4
- 230000001684 chronic effect Effects 0.000 claims description 4
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- 229940047670 sodium acrylate Drugs 0.000 claims description 4
- 238000012546 transfer Methods 0.000 claims description 4
- WWUZIQQURGPMPG-UHFFFAOYSA-N (-)-D-erythro-Sphingosine Natural products CCCCCCCCCCCCCC=CC(O)C(N)CO WWUZIQQURGPMPG-UHFFFAOYSA-N 0.000 claims description 3
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- 239000012062 aqueous buffer Substances 0.000 claims description 3
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- 239000003433 contraceptive agent Substances 0.000 claims description 3
- 229940124558 contraceptive agent Drugs 0.000 claims description 3
- 239000008344 egg yolk phospholipid Substances 0.000 claims description 3
- 239000002871 fertility agent Substances 0.000 claims description 3
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- 229940096919 glycogen Drugs 0.000 claims description 3
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- 229940124535 smoking cessation aid Drugs 0.000 claims description 3
- WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 claims description 3
- 238000001356 surgical procedure Methods 0.000 claims description 3
- 239000002996 urinary tract agent Substances 0.000 claims description 3
- 239000013598 vector Substances 0.000 claims description 3
- 230000037303 wrinkles Effects 0.000 claims description 3
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims description 2
- CTPDSKVQLSDPLC-UHFFFAOYSA-N 2-(oxolan-2-ylmethoxy)ethanol Chemical compound OCCOCC1CCCO1 CTPDSKVQLSDPLC-UHFFFAOYSA-N 0.000 claims description 2
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- 108010088751 Albumins Proteins 0.000 claims description 2
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- 229920000945 Amylopectin Polymers 0.000 claims description 2
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- 108010076119 Caseins Proteins 0.000 claims description 2
- 229920002101 Chitin Polymers 0.000 claims description 2
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- 229920002567 Chondroitin Polymers 0.000 claims description 2
- 229920000858 Cyclodextrin Polymers 0.000 claims description 2
- AERBNCYCJBRYDG-UHFFFAOYSA-N D-ribo-phytosphingosine Natural products CCCCCCCCCCCCCCC(O)C(O)C(N)CO AERBNCYCJBRYDG-UHFFFAOYSA-N 0.000 claims description 2
- 229920002307 Dextran Polymers 0.000 claims description 2
- 239000001856 Ethyl cellulose Substances 0.000 claims description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- 229920002683 Glycosaminoglycan Polymers 0.000 claims description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 2
- SUHOOTKUPISOBE-UHFFFAOYSA-N O-phosphoethanolamine Chemical class NCCOP(O)(O)=O SUHOOTKUPISOBE-UHFFFAOYSA-N 0.000 claims description 2
- 239000004698 Polyethylene Substances 0.000 claims description 2
- 229920002675 Polyoxyl Polymers 0.000 claims description 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 2
- 206010040925 Skin striae Diseases 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 208000031439 Striae Distensae Diseases 0.000 claims description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 2
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- 229930003427 Vitamin E Natural products 0.000 claims description 2
- 206010052428 Wound Diseases 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- 150000003926 acrylamides Chemical class 0.000 claims description 2
- 239000008272 agar Substances 0.000 claims description 2
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- 229920000615 alginic acid Polymers 0.000 claims description 2
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- 239000001506 calcium phosphate Substances 0.000 claims description 2
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- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
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- 239000005018 casein Substances 0.000 claims description 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 2
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- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 2
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- A61K38/18—Growth factors; Growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
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- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58018304P | 2004-06-15 | 2004-06-15 | |
| US60/580,183 | 2004-06-15 | ||
| PCT/US2005/020960 WO2006002050A1 (fr) | 2004-06-15 | 2005-06-14 | Compositions phospholipidiques, procede de fabrication et methode d'utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2612006A1 true CA2612006A1 (fr) | 2006-01-05 |
Family
ID=35782118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002612006A Abandoned CA2612006A1 (fr) | 2004-06-15 | 2005-06-14 | Compositions phospholipidiques, procede de fabrication et methode d'utilisation |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20050287180A1 (fr) |
| EP (1) | EP1765367A4 (fr) |
| JP (1) | JP2008502690A (fr) |
| KR (1) | KR20070057767A (fr) |
| CN (1) | CN101027065A (fr) |
| CA (1) | CA2612006A1 (fr) |
| WO (1) | WO2006002050A1 (fr) |
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|---|---|---|---|---|
| MXPA05009429A (es) | 2003-03-05 | 2005-12-12 | Halozyme Inc | Glicoproteina hialuronidasa soluble (shasegp), proceso para preparar la misma, usos y composiciones farmaceuticas que la comprenden. |
| FR2861734B1 (fr) | 2003-04-10 | 2006-04-14 | Corneal Ind | Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus |
| KR101376895B1 (ko) | 2004-05-03 | 2014-03-25 | 헤르메스 바이오사이언스, 인코포레이티드 | 약물 전달에 유용한 리포좀 |
| FR2885491B1 (fr) * | 2005-05-16 | 2020-03-06 | Nutricos Technologies | Traitement de la secheresse keratinique par des glycerides |
| US9017709B2 (en) * | 2005-08-11 | 2015-04-28 | Promedon S.A. | Composition comprising polymeric, water-insoluble, anionic particles, processes and uses |
| US20070212385A1 (en) * | 2006-03-13 | 2007-09-13 | David Nathaniel E | Fluidic Tissue Augmentation Compositions and Methods |
| WO2007115134A2 (fr) * | 2006-03-29 | 2007-10-11 | Wayne State University | Nanoparticules de liposome et autres formulations de fenrétinide utiles en thérapie et pour l'apport de médicament |
| US9119902B2 (en) * | 2006-06-22 | 2015-09-01 | Ethicon, Inc. | Semi-crystalline absorbable microspheres |
| JP5189093B2 (ja) * | 2006-07-31 | 2013-04-24 | ラボラトワール・ベザン・ザンテルナショナル | 過剰瘢痕化の治療および予防 |
| WO2008039472A2 (fr) | 2006-09-26 | 2008-04-03 | Taro Pharmaceuticals North America, Inc. | Compositions stabilisatrices pour antibiotiques et leurs méthodes d'utilisation |
| KR100759091B1 (ko) * | 2006-12-13 | 2007-09-17 | 조강선 | 피부 충전제 조성물 |
| CA2687983A1 (fr) * | 2007-05-23 | 2008-12-04 | Allergan, Inc. | Particules d'acide hyaluronique revetues |
| US20080293637A1 (en) | 2007-05-23 | 2008-11-27 | Allergan, Inc. | Cross-linked collagen and uses thereof |
| GB0712905D0 (en) * | 2007-07-04 | 2007-08-15 | Reckitt Benckiser Uk Ltd | Hard surface treatment compositions with improved mold or fungi remediation properties |
| PL2170287T3 (pl) * | 2007-07-26 | 2014-04-30 | Aqtis Ip Bv | Mikrocząstki zawierające PCL i ich zastosowania |
| US8318695B2 (en) | 2007-07-30 | 2012-11-27 | Allergan, Inc. | Tunably crosslinked polysaccharide compositions |
| US8697044B2 (en) * | 2007-10-09 | 2014-04-15 | Allergan, Inc. | Crossed-linked hyaluronic acid and collagen and uses thereof |
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| JP5860409B2 (ja) | 2010-01-19 | 2016-02-16 | ポリピッド リミテッド | 徐放性核酸マトリックス組成物 |
| WO2011109730A2 (fr) | 2010-03-04 | 2011-09-09 | The General Hospital Corporation | Procédés et systèmes de compensation des déficiences vocales au moyen d'un implant de muqueuse adaptable permettant de rétablir et renforcer la production sonore et vocale humaine individualisée |
| JP5749283B2 (ja) | 2010-03-12 | 2015-07-15 | アラーガン・アンデュストリー・ソシエテ・パール・アクシオン・サンプリフィエＡｌｌｅｒｇａｎ Ｉｎｄｕｓｔｒｉｅ Ｓａｓ | 皮膚状態を改善するための流体組成物 |
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| US20130089585A1 (en) * | 2010-04-08 | 2013-04-11 | Merz Pharma Gmbh & Co., Kgaa | Filler comprising beads |
| KR101003331B1 (ko) | 2010-05-11 | 2010-12-23 | 조강선 | 피부 충전제 조성물 |
| BR112012029040A2 (pt) * | 2010-05-14 | 2016-08-02 | Archer Daniels Midland Co | composição de organogel de fosfolipideo estruturado termorreversível comestível para uso em produto alimentício, método de estruturar uma fase orgânica comestível, produto ou ingrediente alimentício, composição, método de carregar um organogel de fosfolipídeo estruturado termorreversível comestível, método de revestir um alimento e composição de organogel de fosfolipídeo estruturado termorreversivel comestível para uso em um produto alimentício |
| CA2840339A1 (fr) * | 2010-06-23 | 2011-12-29 | Brightside Innovations, Inc. | Vesicules porteuses de lecithine et leurs procedes de fabrication |
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| SI2787974T1 (sl) * | 2011-12-05 | 2017-10-30 | Camurus Ab | Robustno kontrolirano-sproščujoče peptidne formulacije |
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| RU2678433C2 (ru) | 2012-05-10 | 2019-01-29 | Пейнреформ Лтд. | Депо-составы гидрофобного активного ингредиента и способы их получения |
| CN102688153A (zh) * | 2012-06-05 | 2012-09-26 | 东南大学 | 由磷脂复配制成的空白脂质体及其制备方法 |
| US11458199B2 (en) * | 2012-08-21 | 2022-10-04 | Opko Pharmaceuticals, Llc | Liposome formulations |
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| CN103705439B (zh) * | 2012-09-28 | 2017-11-28 | 上海恒瑞医药有限公司 | 脂质凝胶药物制剂及其制备方法和用途 |
| CN103705442B (zh) * | 2012-09-28 | 2017-12-01 | 上海恒瑞医药有限公司 | 原位脂质凝胶药物制剂及其制备方法和用途 |
| CN103007339B (zh) * | 2012-12-06 | 2014-11-26 | 浙江医鼎医用敷料有限公司 | 生物粉体医用敷料及其制备方法 |
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| CN104304646A (zh) * | 2014-10-21 | 2015-01-28 | 宣城柏维力生物工程有限公司 | 一种卵磷脂软胶囊及其制备方法 |
| WO2016128783A1 (fr) | 2015-02-09 | 2016-08-18 | Allergan Industrie Sas | Compositions et méthodes pour améliorer l'apparence de la peau |
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| CA3001467A1 (fr) | 2015-10-16 | 2017-04-20 | Ipsen Biopharm Ltd. | Stabilisation de compositions pharmaceutiques de camptothecine |
| WO2018235079A1 (fr) | 2017-06-20 | 2018-12-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Compositions d'esters d'acide cannabidiolique et leurs utilisations |
| IL272630B2 (en) | 2017-08-22 | 2023-09-01 | Moebius Medical Ltd | Liposomal formulations for joint lubrication |
| ES2754476B2 (es) * | 2018-10-15 | 2020-09-14 | Consejo Superior Investigacion | Gel lipidico nanoestructurado, procedimiento de preparacion y uso |
| CN111840553A (zh) * | 2019-04-15 | 2020-10-30 | 湖州依诺唯新药物制剂有限公司 | 脂性药物制剂及其应用 |
| CN113018248B (zh) * | 2019-12-23 | 2022-07-22 | 南京清普生物科技有限公司 | 一种缓释递药系统 |
| CN111388744B (zh) * | 2020-01-15 | 2021-05-18 | 华中科技大学 | 一种凝胶贮库及其制法与制备术后止血制剂的应用 |
| CN114848795B (zh) * | 2021-02-03 | 2023-04-14 | 四川大学 | RORa蛋白及其激动剂在制备抗衰老药物中的应用 |
| US11992483B2 (en) | 2021-03-31 | 2024-05-28 | Cali Biosciences Us, Llc | Emulsions for local anesthetics |
| CN114699562B (zh) * | 2022-02-28 | 2023-03-24 | 南方科技大学 | 一种水凝胶及其制备方法与应用 |
| KR20230145624A (ko) * | 2022-04-08 | 2023-10-18 | (주)아크로스 | 안전성이 우수한 조직수복용 생체재료의 제조 방법 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4208552A1 (de) * | 1992-03-17 | 1993-09-23 | Liedtke Pharmed Gmbh | Topische arzneiformen mit insulin |
| SI9300468A (en) * | 1992-10-14 | 1994-06-30 | Hoffmann La Roche | Injectable composition for the sustained release of biologically active compounds |
| US5716614A (en) * | 1994-08-05 | 1998-02-10 | Molecular/Structural Biotechnologies, Inc. | Method for delivering active agents to mammalian brains in a complex with eicosapentaenoic acid or docosahexaenoic acid-conjugated polycationic carrier |
| US5945409A (en) * | 1995-03-10 | 1999-08-31 | Wilson T. Crandall | Topical moisturizing composition and method |
| US5955451A (en) * | 1995-05-12 | 1999-09-21 | The University Of Texas System Board Of Regents | Methods of enhancing the therapeutic activity of NSAIDS and compositions of zwitterionic phospholipids useful therein |
| AUPN723395A0 (en) * | 1995-12-19 | 1996-01-18 | Macnaught Medical Pty Limited | Lubrication methods |
| MXPA03008975A (es) * | 2001-04-03 | 2004-02-17 | Bristol Myers Squibb Pharma Co | Estabilizacion y esterilizacion terminal de formulaciones de fosfolipidos. |
| US20040109893A1 (en) * | 2002-06-25 | 2004-06-10 | Guohua Chen | Sustained release dosage forms of anesthetics for pain management |
| WO2005087221A1 (fr) * | 2004-03-15 | 2005-09-22 | Christine Allen | Implant biocompatible et biodegradable et procede de fabrication de cet implant |
| US7858115B2 (en) * | 2004-06-24 | 2010-12-28 | Idexx Laboratories | Phospholipid gel compositions for drug delivery and methods of treating conditions using same |
-
2005
- 2005-06-14 WO PCT/US2005/020960 patent/WO2006002050A1/fr active Application Filing
- 2005-06-14 US US11/152,855 patent/US20050287180A1/en not_active Abandoned
- 2005-06-14 CA CA002612006A patent/CA2612006A1/fr not_active Abandoned
- 2005-06-14 EP EP05771368A patent/EP1765367A4/fr not_active Withdrawn
- 2005-06-14 JP JP2007516643A patent/JP2008502690A/ja active Pending
- 2005-06-14 CN CNA2005800253644A patent/CN101027065A/zh active Pending
- 2005-06-14 KR KR1020077000998A patent/KR20070057767A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008502690A (ja) | 2008-01-31 |
| EP1765367A1 (fr) | 2007-03-28 |
| EP1765367A4 (fr) | 2010-08-11 |
| WO2006002050A1 (fr) | 2006-01-05 |
| CN101027065A (zh) | 2007-08-29 |
| US20050287180A1 (en) | 2005-12-29 |
| KR20070057767A (ko) | 2007-06-07 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20130611 |