CA2610474C - Methode permettant de produire une dent, un ensemble de dents et des tissus - Google Patents

Methode permettant de produire une dent, un ensemble de dents et des tissus Download PDF

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Publication number
CA2610474C
CA2610474C CA2610474A CA2610474A CA2610474C CA 2610474 C CA2610474 C CA 2610474C CA 2610474 A CA2610474 A CA 2610474A CA 2610474 A CA2610474 A CA 2610474A CA 2610474 C CA2610474 C CA 2610474C
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Prior art keywords
tooth
cells
cell
tissue
epithelial cells
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Expired - Fee Related
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CA2610474A
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CA2610474A1 (fr
Inventor
Takashi Tsuji
Kazuhisa Nakao
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Organ Technologies Inc
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Organ Technologies Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3865—Dental/periodontal tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0627—Hair cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/097—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells oral mucosa cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L~invention permet d~obtenir une dent à lieu cellulaire spécifique en mettant en contact une première masse cellulaire qui comprend substantiellement soit des cellules mésenchymateuses soit des cellules épithéliales, et une deuxième masse cellulaire qui comprend substantiellement d~autres cellules, dans un support capable de maintenir ces masses cellulaires en contact les unes avec les autres et ensuite de les cultiver. Dans une représentation préférée, le support contenant les masses cellulaires individuelles reçoit encore la culture de cellules rénales, une fois la culture achevée.
CA2610474A 2005-05-30 2006-05-30 Methode permettant de produire une dent, un ensemble de dents et des tissus Expired - Fee Related CA2610474C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2005157885 2005-05-30
JP2005-157885 2005-05-30
JP2006-055569 2006-03-01
JP2006055569 2006-03-01
PCT/JP2006/310805 WO2006129672A1 (fr) 2005-05-30 2006-05-30 Méthode pour produire une dent et méthode pour produire des dents et du tissu

Publications (2)

Publication Number Publication Date
CA2610474A1 CA2610474A1 (fr) 2006-12-07
CA2610474C true CA2610474C (fr) 2015-02-24

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2610474A Expired - Fee Related CA2610474C (fr) 2005-05-30 2006-05-30 Methode permettant de produire une dent, un ensemble de dents et des tissus

Country Status (11)

Country Link
US (2) US8361709B2 (fr)
EP (1) EP1905459B8 (fr)
JP (2) JP4991531B2 (fr)
KR (1) KR101232342B1 (fr)
CN (1) CN101189033B (fr)
AU (1) AU2006253406B2 (fr)
CA (1) CA2610474C (fr)
ES (1) ES2599532T3 (fr)
NO (1) NO20076573L (fr)
RU (1) RU2428140C2 (fr)
WO (1) WO2006129672A1 (fr)

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US8574904B2 (en) 2007-01-22 2013-11-05 Organ Technologies Inc. Method for production of mesenchymal cell, method for production of tooth, and mesenchymal cell for formation of tooth
JP2008206500A (ja) 2007-02-28 2008-09-11 Tokyo Univ Of Science 歯の製造方法及びこれにより得られた歯
AU2009283516B2 (en) * 2008-08-20 2014-02-13 Organ Technologies Inc. Method for restoring missing tooth and method for producing restorative material
WO2010027829A2 (fr) * 2008-08-25 2010-03-11 Laser Abrasive Technologies, Llc Procédé et appareil de régénération de tissus de la cavité buccale
US8927284B2 (en) 2009-01-28 2015-01-06 Organ Technologies, Inc. Method for producing tooth
US10022202B2 (en) 2013-03-15 2018-07-17 Triagenics, Llc Therapeutic tooth bud ablation
CA2761652C (fr) * 2009-05-11 2019-10-01 Leigh E. Colby Ablation therapeutique de bourgeon dentaire
WO2014143014A1 (fr) 2013-03-15 2014-09-18 Triagenics, Llc Ablation thérapeutique de bourgeon dentaire
JP5868844B2 (ja) * 2010-04-07 2016-02-24 株式会社オーガンテクノロジーズ 再生歯ユニットの製造方法
RU2012146365A (ru) * 2010-04-07 2014-05-10 Орган Текнолоджиз, Инк. Способ восстановления альвеолярной кости путем трансплантации регенированной зубной единицы
US9597359B2 (en) 2010-10-01 2017-03-21 The Trustees Of Columbia University In The City Of New York Production of dentin, cementum and enamel by cells
US9982238B2 (en) * 2011-02-09 2018-05-29 Organ Technologies, Inc. Method for producing regenerative organ primordium provided with guide for transplantation, composition containing regenerative organ primordium provided with guide for transplantation produced thereby, and method for transplanting regenerative organ primordium provided with guide for transplantation
SG10201600631SA (en) 2011-02-24 2016-02-26 Organ Technologies Inc Method of preparing regenerated hair follicle germ for transplantation in which hair color is controlled, composition including regenerated hair follicle germ for transplantation, and method of transplanting regenerated hair follicle germ
CN103857787B (zh) * 2011-09-27 2019-05-17 公立大学法人横滨市立大学 组织和器官的制作方法
EP2823787B1 (fr) * 2012-02-01 2019-01-09 Organ Technologies, Inc. Implant dentaire et son procédé de fabrication
EP2633870B1 (fr) * 2012-02-29 2018-08-01 Technische Universität Berlin Procédé de préparation d'ébauche de dent artificielle in vitro et ébauche de dent artificielle dérivée de celui-ci
AU2013312924A1 (en) * 2012-09-04 2015-03-19 Anthrogenesis Corporation Methods of tissue generation
KR101858648B1 (ko) * 2012-12-07 2018-05-16 한화파워시스템 주식회사 다단 압축 시스템의 서지 제어 방법
US20150366916A1 (en) * 2013-02-13 2015-12-24 Organ Technologies, Inc. Method for producing a plurality of teeth from one isolated tooth germ
US9438264B1 (en) 2015-09-10 2016-09-06 Realtek Semiconductor Corp. High-speed capacitive digital-to-analog converter and method thereof
CA2936258A1 (fr) 2014-02-07 2015-08-13 Medimmune, Llc Nouvelle analyse permettant de detecter la periostine humaine
JP7142840B2 (ja) * 2018-05-16 2022-09-28 国立大学法人横浜国立大学 細胞含有ハイドロゲル体及びその製造方法
WO2019235375A1 (fr) 2018-06-04 2019-12-12 株式会社オーガンテクノロジーズ Procédé de production de germes de follicules pileux régénératifs
CN111197027A (zh) * 2018-11-16 2020-05-26 中国科学院广州生物医药与健康研究院 分离牙胚单细胞的方法及应用
RU2716485C1 (ru) * 2019-02-15 2020-03-11 федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный медико-стоматологический университет имени А.И. Евдокимова" Министерства здравоохранения Российской Федерации (ФГБОУ ВО МГМСУ им. А.И. Евдокимова Минздрава России) Способ выращивания эмали в эксперименте
EP3979938A4 (fr) 2019-06-06 2023-06-28 TriAgenics, Inc. Systèmes de sonde d'ablation
KR20240036890A (ko) * 2022-09-14 2024-03-21 연세대학교 산학협력단 줄기세포의 경조직으로의 분화 방법

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Also Published As

Publication number Publication date
KR101232342B1 (ko) 2013-02-13
AU2006253406A1 (en) 2006-12-07
US8679755B2 (en) 2014-03-25
US20100021866A1 (en) 2010-01-28
CN101189033B (zh) 2012-03-28
JP5666490B2 (ja) 2015-02-12
EP1905459B1 (fr) 2016-08-03
NO20076573L (no) 2008-02-15
JPWO2006129672A1 (ja) 2009-01-08
EP1905459A4 (fr) 2012-03-14
JP4991531B2 (ja) 2012-08-01
US20130109093A1 (en) 2013-05-02
EP1905459B8 (fr) 2016-10-12
RU2007148138A (ru) 2009-07-20
US8361709B2 (en) 2013-01-29
ES2599532T3 (es) 2017-02-02
AU2006253406B2 (en) 2012-06-14
EP1905459A1 (fr) 2008-04-02
KR20080032044A (ko) 2008-04-14
CN101189033A (zh) 2008-05-28
CA2610474A1 (fr) 2006-12-07
WO2006129672A1 (fr) 2006-12-07
JP2012135313A (ja) 2012-07-19
RU2428140C2 (ru) 2011-09-10

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AU2009283516B2 (en) Method for restoring missing tooth and method for producing restorative material
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