CA2606815C - Polymer conjugate enhanced bioassays - Google Patents

Polymer conjugate enhanced bioassays Download PDF

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Publication number
CA2606815C
CA2606815C CA2606815A CA2606815A CA2606815C CA 2606815 C CA2606815 C CA 2606815C CA 2606815 A CA2606815 A CA 2606815A CA 2606815 A CA2606815 A CA 2606815A CA 2606815 C CA2606815 C CA 2606815C
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CA
Canada
Prior art keywords
reporter
solid phase
antibody
polymer
molecule
Prior art date
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Expired - Lifetime
Application number
CA2606815A
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English (en)
French (fr)
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CA2606815A1 (en
Inventor
Ray Yin
Dujie Qin
Jing Pan
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ANP Technologies Inc
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ANP Technologies Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37308573&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2606815(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ANP Technologies Inc filed Critical ANP Technologies Inc
Publication of CA2606815A1 publication Critical patent/CA2606815A1/en
Application granted granted Critical
Publication of CA2606815C publication Critical patent/CA2606815C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/545—Synthetic resin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Nanotechnology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mathematical Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CA2606815A 2005-05-02 2006-05-02 Polymer conjugate enhanced bioassays Expired - Lifetime CA2606815C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67721805P 2005-05-02 2005-05-02
US60/677,218 2005-05-02
PCT/US2006/016580 WO2006119160A2 (en) 2005-05-02 2006-05-02 Polymer conjugate enhanced bioassays

Publications (2)

Publication Number Publication Date
CA2606815A1 CA2606815A1 (en) 2006-11-09
CA2606815C true CA2606815C (en) 2017-03-07

Family

ID=37308573

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2606815A Expired - Lifetime CA2606815C (en) 2005-05-02 2006-05-02 Polymer conjugate enhanced bioassays

Country Status (7)

Country Link
US (3) US8563329B2 (https=)
EP (2) EP2208998A3 (https=)
AT (1) ATE496297T1 (https=)
AU (1) AU2006242303A1 (https=)
CA (1) CA2606815C (https=)
DE (1) DE602006019709D1 (https=)
WO (1) WO2006119160A2 (https=)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008510829A (ja) * 2004-08-25 2008-04-10 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン デンドリマーに基づく組成物およびそれらの使用法
ATE496297T1 (de) * 2005-05-02 2011-02-15 Anp Technologies Inc Polymerkonjugat-verbesserte bioassays
CN101479604B (zh) * 2006-06-30 2016-06-01 Jnc株式会社 检测对象的检测、定量用试剂盒及检测、定量方法
CA2704768A1 (en) 2006-11-03 2008-10-23 Trustees Of Tufts College Biopolymer sensor and method of manufacturing the same
WO2008127403A2 (en) 2006-11-03 2008-10-23 Trustees Of Tufts College Biopolymer optofluidic device and method of manufacturing the same
JP5240945B2 (ja) 2006-11-28 2013-07-17 ピクター リミテッド アッセイ膜およびその使用法
WO2009151687A2 (en) 2008-03-12 2009-12-17 The Regents Of The University Of Michigan Dendrimer conjugates
WO2010039861A2 (en) 2008-09-30 2010-04-08 The Regents Of The University Of Michigan Dendrimer conjugates
US9017644B2 (en) 2008-11-07 2015-04-28 The Regents Of The University Of Michigan Methods of treating autoimmune disorders and/or inflammatory disorders
US20100158850A1 (en) * 2008-12-23 2010-06-24 The Regents Of The University Of Michigan Dendrimer based modular platforms
WO2011059609A2 (en) * 2009-10-13 2011-05-19 The Regents Of The University Of Michigan Dendrimer compositions and methods of synthesis
WO2011059586A2 (en) 2009-10-30 2011-05-19 The Regents Of The University Of Michigan Multifunctional small molecules
US8658702B2 (en) * 2009-12-17 2014-02-25 Mamadou Diallo Soluble anion exchangers from hyperbranched macromolecules
BR112013007311A2 (pt) 2010-10-01 2016-07-05 Hologic Inc tira de teste de imunoensaio para uso em um sistema de diagnóstico
JP6092121B2 (ja) * 2011-01-09 2017-03-08 エイエヌピー テクノロジーズ， インコーポレイテッド 疎水性分子に誘起された分岐ポリマー凝集体及びその使用
KR20120128440A (ko) * 2011-05-17 2012-11-27 삼성전자주식회사 표적 물질 검출용 키트 및 이를 이용한 표적 물질 검출 방법
WO2013085718A1 (en) 2011-12-08 2013-06-13 The Regents Of The University Of Michigan Multifunctional small molecules
US20160153973A1 (en) * 2013-07-09 2016-06-02 Lucas David Smith Device and method of rapid linker mediated label-based immunoassays
EP3052936A4 (en) * 2013-09-23 2017-05-24 Assaypro, LLC Immunoassays using over-labeled fluorescent probes
EP2982987A1 (en) 2014-08-08 2016-02-10 Proteomika, S.L. Lateral flow immunoassays for the detection of antibodies against biological drugs
BR112018016337A2 (pt) 2016-02-11 2019-02-26 Massachusetts Institute Of Technology anticorpos monoclonais da proteína ns1 de vírus antidengue
WO2018221920A1 (ko) * 2017-05-29 2018-12-06 경희대학교 산학협력단 글라스-코팅 미세와이어를 이용한 비구형/비대칭 미립자의 제조방법
KR102082187B1 (ko) 2017-05-29 2020-02-27 경희대학교 산학협력단 글라스-코팅 미세와이어를 이용한 비구형/비대칭 미립자의 제조방법
CN109615625A (zh) * 2018-12-11 2019-04-12 厦门盈趣科技股份有限公司 一种颜色感应判断方法及装置
CN111381026A (zh) * 2018-12-29 2020-07-07 深圳市帝迈生物技术有限公司 多重检测免疫试剂及其制备方法、试剂盒、系统及应用
CN109867797B (zh) * 2019-02-20 2021-07-06 青岛大学 一种近红外响应发光的树枝状大分子复合物及其制备方法与应用
KR20210146915A (ko) * 2019-03-29 2021-12-06 세키스이 메디칼 가부시키가이샤 면역 측정 시약 및 면역 측정 방법
CN116547537A (zh) 2020-07-29 2023-08-04 皮克托有限公司 SARS-CoV-2抗体免疫测定
CN112433048A (zh) * 2020-11-17 2021-03-02 深圳上泰生物工程有限公司 一种用于化学发光免疫法的试剂盒及其制备方法和应用
CN114235807B (zh) 2021-12-20 2022-11-01 中国农业科学院油料作物研究所 一种真菌毒素量子点试纸条智能即时定量检测装置
CN114264654B (zh) * 2021-12-20 2023-06-02 中国农业科学院油料作物研究所 一种真菌毒素、辣椒素、苯并[α]芘混合污染物智能微阵列检测设备及方法
TWI896469B (zh) * 2024-12-30 2025-09-01 光大科技股份有限公司 快篩試劑裝置及聚醯胺基胺-膠金-抗體複合物之製造方法

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4360646A (en) 1979-04-06 1982-11-23 Allied Corporation Preparation of lysine based macromolecular highly branched homogeneous compound
US4289872A (en) 1979-04-06 1981-09-15 Allied Corporation Macromolecular highly branched homogeneous compound based on lysine units
US4435548A (en) 1981-04-27 1984-03-06 The Dow Chemical Company Branched polyamidoamines
US4410688A (en) 1981-04-29 1983-10-18 Allied Corporation Macromolecular highly branched homogeneous compound
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4631337A (en) 1983-01-07 1986-12-23 The Dow Chemical Company Hydrolytically-stable dense star polyamine
US4507466A (en) 1983-01-07 1985-03-26 The Dow Chemical Corporation Dense star polymers having core, core branches, terminal groups
US4558120A (en) 1983-01-07 1985-12-10 The Dow Chemical Company Dense star polymer
US4737550A (en) 1983-01-07 1988-04-12 The Dow Chemical Company Bridged dense star polymers
US4568737A (en) 1983-01-07 1986-02-04 The Dow Chemical Company Dense star polymers and dendrimers
US4587329A (en) 1984-08-17 1986-05-06 The Dow Chemical Company Dense star polymers having two dimensional molecular diameter
US4599400A (en) 1984-12-18 1986-07-08 The Dow Chemical Company Star/comb-branched polyamide
US4694064A (en) 1986-02-28 1987-09-15 The Dow Chemical Company Rod-shaped dendrimer
US4713975A (en) 1986-05-30 1987-12-22 The Dow Chemical Company Dense star polymers for calibrating/characterizing sub-micron apertures
US5527524A (en) 1986-08-18 1996-06-18 The Dow Chemical Company Dense star polymer conjugates
US5338532A (en) 1986-08-18 1994-08-16 The Dow Chemical Company Starburst conjugates
US4857599A (en) 1988-02-08 1989-08-15 The Dow Chemical Company Modified dense star polymers
US4917495A (en) 1988-12-20 1990-04-17 E. I. Du Pont De Nemours And Company Portable colorimeter and method for characterization of a colored surface
US6274713B1 (en) 1989-04-07 2001-08-14 Salutar, Inc. Polychelants
US5631329A (en) 1990-08-27 1997-05-20 Dendritech, Inc. Process for producing hyper-comb-branched polymers
US5773527A (en) 1990-08-27 1998-06-30 Dendritech, Inc. Non-crosslinked, polybranched polymers
US5083868A (en) 1991-02-15 1992-01-28 Hach Company Colorimeter
US5610268A (en) 1992-01-13 1997-03-11 Dsm N.V. Dendritic macromolecule and the preparation thereof
US5530092A (en) 1992-01-13 1996-06-25 Dsm N.V. Dendritic macromolecule and the preparation thereof
AU687755B2 (en) 1992-08-21 1998-03-05 Genentech Inc. Method for treating an LFA-1-mediated disorder
US5387617A (en) 1993-01-22 1995-02-07 The Dow Chemical Company Small cell foams and blends and a process for their preparation
JP3366978B2 (ja) 1993-02-24 2003-01-14 デイド、ベーリング、インコーポレイテッド 特異的結合性アッセイ試薬の固定化
US5898005A (en) 1993-02-24 1999-04-27 Dade Behring Inc. Rapid detection of analytes with receptors immobilized on soluble submicron particles
US6121056A (en) 1993-02-24 2000-09-19 Dade Behring Inc. Random detection of antigens with antibodies immobilized on soluble submicron particles
US5494798A (en) 1993-12-09 1996-02-27 Gerdt; David W. Fiber optic evanscent wave sensor for immunoassay
JPH09508170A (ja) 1994-01-28 1997-08-19 デーエスエム ナムローゼ フェンノートシャップ 樹枝状高分子物質およびその製造法
IL112920A (en) 1994-03-07 2003-04-10 Dow Chemical Co Composition comprising a dendritic polymer complexed with at least one unit of biological response modifier and a process for the preparation thereof
US5543920A (en) 1994-08-10 1996-08-06 Kollmorgen Corporation System and method for sensing color and preventing use of unauthorized color formulation software
CA2199868C (en) 1994-09-14 2000-05-16 David R. Bowden Compact spectrophotometer
USH1563H (en) 1994-09-23 1996-07-02 The United States Of America As Represented By The Secretary Of The Army Chemical agent monitor for immunoassay detection
DE4435893C1 (de) 1994-10-07 1996-03-07 Techkon Elektronik Gmbh Handmeßgerät für densitometrische und farbmetrische Reflexionsmessungen
US5589932A (en) 1995-02-08 1996-12-31 University Of South Florida Spectrophotometric method and apparatus for the characterization of blood and blood types
US6083708A (en) 1995-08-11 2000-07-04 Dade Behring Inc. Polypeptide: dendrimer complexes
CA2226299A1 (en) 1995-08-11 1997-02-27 Dendritech, Inc. Hyper comb-branched polymer conjugates
US6096508A (en) * 1995-08-16 2000-08-01 Kirkegaard & Perry Laboratoies, Inc. Method of reducing background in biotin-based assays
US6575368B1 (en) 1996-01-31 2003-06-10 Psc Scanning, Inc. Multiple aperture data reader for multi-mode operation
US5900379A (en) 1996-04-11 1999-05-04 Mizuho Usa, Inc. Analytical device
US5885529A (en) 1996-06-28 1999-03-23 Dpc Cirrus, Inc. Automated immunoassay analyzer
US5962838A (en) 1996-07-15 1999-10-05 Psc Scanning, Inc. Barcode scanner with manually switchable scan patterns
US6043336A (en) 1996-07-25 2000-03-28 Dendritech, Inc. Electrically conducting dendrimers
US6020457A (en) 1996-09-30 2000-02-01 Dendritech Inc. Disulfide-containing dendritic polymers
US5731095A (en) 1996-10-23 1998-03-24 Oxazogen, Inc. Dendritic polymer coatings
WO1998036001A1 (en) 1997-02-18 1998-08-20 Oxazogen, Inc. Convergent self-branching polymerization
HUP0003296A3 (en) 1997-07-22 2001-09-28 Qiagen Genomics Inc Bothell Apparatus and methods for arraying solution onto a solid support
CA2297175A1 (en) 1997-07-22 1999-02-04 Jeffrey Van Ness Polyethylenimine-based biomolecule arrays
US6306642B1 (en) 1997-11-24 2001-10-23 Quidel Corporation Enzyme substrate delivery and product registration in one step enzyme immunoassays
US6267722B1 (en) 1998-02-03 2001-07-31 Adeza Biomedical Corporation Point of care diagnostic systems
US6394952B1 (en) 1998-02-03 2002-05-28 Adeza Biomedical Corporation Point of care diagnostic systems
WO1999043287A2 (en) 1998-02-25 1999-09-02 Biotraces, Inc. Phosphate-based dendrimers for bioassays
WO1999046591A2 (en) 1998-03-10 1999-09-16 Strategic Diagnostics, Inc. Integrated assay device and methods of production and use
US6259373B1 (en) 1998-05-12 2001-07-10 Bahador Ghahramani Multiple hazard marker system, components therefor and methods of making the same
US6099469A (en) 1998-06-02 2000-08-08 Armstrong; E. Glenn Reflex algorithm for early and cost effective diagnosis of myocardial infractions suitable for automated diagnostic platforms
AU4562599A (en) * 1998-06-12 1999-12-30 New Horizons Diagnostics, Inc. Colloidal colorimetric flow through and lateral flow assays utilizing soluble submicron particles
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
WO2000043044A1 (en) 1999-01-19 2000-07-27 The Children's Hospital Of Philadelphia Compositions and methods for controlled delivery of virus vectors
WO2000043552A2 (en) 1999-01-25 2000-07-27 Ut-Battelle, Llc Multifunctional and multispectral biosensor devices and methods of use
US20010055766A1 (en) * 1999-04-02 2001-12-27 Alexander Aristarkhov Immunosorbant assay using branched bis-biotin/avidin/multiple label complex as a detection reagent
US6285452B1 (en) 2000-11-01 2001-09-04 X-Rite Incorporated Portable scanning spectrophotometer
US6773928B1 (en) 1999-09-22 2004-08-10 The United States Of America As Represented By The Secretary Of The Army Compositions and methods for enhancing bioassay performance
US6458387B1 (en) 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
FR2804046B1 (fr) 2000-01-21 2002-07-05 Bio Merieux Procede de preparation de particules colloidales stables fonctionnalisees et particules obtenues
EP1259786A4 (en) 2000-02-07 2006-05-03 Applied Color Systems Inc PORTABLE COLORIMETRIC MEASURING DEVICE
US20020051981A1 (en) * 2000-03-08 2002-05-02 Robert Getts Methods for assay and detection on a microarray
YU27701A (sh) 2000-04-28 2003-04-30 Pfizer Products Inc. Postupak za dobijanje trihidrata mezilatne soli 1-(4- hidroksifenil)-2-(4-hidroksi-4-fenilpiperidin-1-il)1-propanola
US6716450B1 (en) 2000-05-18 2004-04-06 The United States Of America As Represented By The Secretary Of The Army Enhancing protein activity through nanoencapsulation
US6656745B1 (en) 2000-06-02 2003-12-02 Francis X. Cole Devices and methods for a multi-level, semi-quantitative immunodiffusion assay
JP2004500867A (ja) * 2000-06-07 2004-01-15 ベイラー　カレッジ　オブ　メディシン アレイ利用型核酸ハイブリダイゼーションのための新規な組成物および方法
JP3544962B2 (ja) * 2000-08-21 2004-07-21 エフ．ホフマン−ラ ロシュ アーゲー 改良された結合アッセイ
US6583880B2 (en) 2001-04-27 2003-06-24 International Business Machines Corporation Portable colorimeter
WO2002087508A2 (en) 2001-05-02 2002-11-07 Nitromed, Inc. Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use
AU2002365115A1 (en) * 2001-07-20 2003-09-02 North Carolina State University Light addressable electrochemical detection of duplex structures
IL160126A0 (en) 2001-07-31 2004-06-20 Immunomedics Inc A kit for targeting a target site containing a polymer conjugate
EP1429783A4 (en) 2001-09-04 2006-08-09 Univ Texas Tech VERSATILE CHELTS FOR MULTIMODAL PICTURE SETTING
EP1446438A2 (en) 2001-11-07 2004-08-18 Nektar Therapeutics Al, Corporation Branched polymers and their conjugates
KR100407822B1 (ko) 2001-12-04 2003-12-01 한국전자통신연구원 전기화학식 면역 센서와 이를 이용한 생화학 시료검출장치 및 방법
US20040023248A1 (en) * 2001-12-07 2004-02-05 Whitehead Institiute For Biomedical Research Methods and reagents for improving nucleic acid detection
US20030148379A1 (en) * 2002-02-06 2003-08-07 Roitman Daniel B. Methods for making microbar encoders for bioprobes
AU2003223491A1 (en) 2002-04-05 2003-10-27 Nitromed, Inc. Nitric oxide donors, compositions and methods of use
US8188116B2 (en) 2002-09-04 2012-05-29 Vanderbilt University Agents for therapy efficacy monitoring and deep tissue imaging
US7754884B2 (en) 2005-01-03 2010-07-13 Vanderbilt University Targeted, NIR imaging agents for therapy efficacy monitoring, deep tissue disease demarcation and deep tissue imaging
DE10322912A1 (de) * 2003-05-21 2004-12-16 Bayer Technology Services Gmbh Verfahren zum Nachweis von Nukleinsäuren
US7754500B2 (en) * 2003-11-21 2010-07-13 Anp Technologies, Inc. Asymmetrically branched polymer conjugates and microarray assays
EP1600213B1 (en) * 2004-05-21 2012-05-02 Schott AG Apparatus with microtiter plate format for multiplexed arraying
WO2006102484A2 (en) 2005-03-21 2006-09-28 Anp Technologies, Inc. Symmetrically branched polymer conjugates and microarray assays
ATE496297T1 (de) 2005-05-02 2011-02-15 Anp Technologies Inc Polymerkonjugat-verbesserte bioassays

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US20080200562A1 (en) 2008-08-21
EP2208998A3 (en) 2011-03-16
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US20160054309A1 (en) 2016-02-25
AU2006242303A1 (en) 2006-11-09
EP1877553B1 (en) 2011-01-19
US20140045727A1 (en) 2014-02-13
EP1877553A4 (en) 2009-02-18
US9360477B2 (en) 2016-06-07
CA2606815A1 (en) 2006-11-09
EP1877553A2 (en) 2008-01-16
EP2208998A2 (en) 2010-07-21
ATE496297T1 (de) 2011-02-15
US9176142B2 (en) 2015-11-03
WO2006119160A3 (en) 2007-04-19
US8563329B2 (en) 2013-10-22
WO2006119160A2 (en) 2006-11-09

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