CA2606587C - The use of polymer mixtures for the production of coated pharmaceutical formulations and pharmaceutical formulation with mixed polymeric coating - Google Patents
The use of polymer mixtures for the production of coated pharmaceutical formulations and pharmaceutical formulation with mixed polymeric coating Download PDFInfo
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- CA2606587C CA2606587C CA2606587A CA2606587A CA2606587C CA 2606587 C CA2606587 C CA 2606587C CA 2606587 A CA2606587 A CA 2606587A CA 2606587 A CA2606587 A CA 2606587A CA 2606587 C CA2606587 C CA 2606587C
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- polymer
- copolymer
- acrylate
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- 238000000576 coating method Methods 0.000 title claims abstract description 36
- 239000011248 coating agent Substances 0.000 title claims abstract description 33
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 19
- 239000008194 pharmaceutical composition Substances 0.000 title abstract description 8
- 229920002959 polymer blend Polymers 0.000 title description 9
- 229920000642 polymer Polymers 0.000 claims abstract description 164
- 229920001577 copolymer Polymers 0.000 claims abstract description 100
- 239000000203 mixture Substances 0.000 claims abstract description 61
- 239000000178 monomer Substances 0.000 claims abstract description 59
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims abstract description 48
- 150000004676 glycans Chemical class 0.000 claims abstract description 17
- 239000005017 polysaccharide Substances 0.000 claims abstract description 17
- 230000007935 neutral effect Effects 0.000 claims abstract description 16
- 125000000129 anionic group Chemical group 0.000 claims abstract description 15
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 15
- 229920002554 vinyl polymer Polymers 0.000 claims abstract description 14
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims abstract description 11
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims abstract description 9
- 239000004480 active ingredient Substances 0.000 claims description 107
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims description 55
- 229940102838 methylmethacrylate Drugs 0.000 claims description 49
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 claims description 48
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims description 43
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- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 15
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- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 12
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- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims description 10
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- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- 229920000578 graft copolymer Polymers 0.000 claims description 5
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 5
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 5
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 10
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- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
- 229960002381 vardenafil Drugs 0.000 description 1
- BGSZAXLLHYERSY-XQIGCQGXSA-N vecuronium Chemical compound N1([C@@H]2[C@@H](OC(C)=O)C[C@@H]3CC[C@H]4[C@@H]5C[C@@H]([C@@H]([C@]5(CC[C@@H]4[C@@]3(C)C2)C)OC(=O)C)[N+]2(C)CCCCC2)CCCCC1 BGSZAXLLHYERSY-XQIGCQGXSA-N 0.000 description 1
- 229960003819 vecuronium Drugs 0.000 description 1
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 description 1
- 229960004688 venlafaxine Drugs 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- 229960003636 vidarabine Drugs 0.000 description 1
- PJDFLNIOAUIZSL-UHFFFAOYSA-N vigabatrin Chemical compound C=CC(N)CCC(O)=O PJDFLNIOAUIZSL-UHFFFAOYSA-N 0.000 description 1
- 229960001255 viloxazine Drugs 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- 229960002726 vincamine Drugs 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 description 1
- 229960004355 vindesine Drugs 0.000 description 1
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
- 229960002066 vinorelbine Drugs 0.000 description 1
- 229960000744 vinpocetine Drugs 0.000 description 1
- 229960003353 viquidil Drugs 0.000 description 1
- DKRSEIPLAZTSFD-LSDHHAIUSA-N viquidil Chemical compound C12=CC(OC)=CC=C2N=CC=C1C(=O)CC[C@@H]1CCNC[C@@H]1C=C DKRSEIPLAZTSFD-LSDHHAIUSA-N 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 229960005080 warfarin Drugs 0.000 description 1
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
- 229960004855 xantinol nicotinate Drugs 0.000 description 1
- 229960001522 ximelagatran Drugs 0.000 description 1
- ZXIBCJHYVWYIKI-PZJWPPBQSA-N ximelagatran Chemical compound C1([C@@H](NCC(=O)OCC)C(=O)N2[C@@H](CC2)C(=O)NCC=2C=CC(=CC=2)C(\N)=N\O)CCCCC1 ZXIBCJHYVWYIKI-PZJWPPBQSA-N 0.000 description 1
- 229960000537 xipamide Drugs 0.000 description 1
- MTZBBNMLMNBNJL-UHFFFAOYSA-N xipamide Chemical compound CC1=CC=CC(C)=C1NC(=O)C1=CC(S(N)(=O)=O)=C(Cl)C=C1O MTZBBNMLMNBNJL-UHFFFAOYSA-N 0.000 description 1
- 229960004764 zafirlukast Drugs 0.000 description 1
- 229960000523 zalcitabine Drugs 0.000 description 1
- 229960004010 zaleplon Drugs 0.000 description 1
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- ARAIBEBZBOPLMB-UFGQHTETSA-N zanamivir Chemical compound CC(=O)N[C@@H]1[C@@H](N=C(N)N)C=C(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO ARAIBEBZBOPLMB-UFGQHTETSA-N 0.000 description 1
- 229960001028 zanamivir Drugs 0.000 description 1
- 229960002555 zidovudine Drugs 0.000 description 1
- HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 description 1
- 229960000607 ziprasidone Drugs 0.000 description 1
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 description 1
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- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 description 1
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- UTAZCRNOSWWEFR-ZDUSSCGKSA-N zolmitriptan Chemical compound C=1[C]2C(CCN(C)C)=CN=C2C=CC=1C[C@H]1COC(=O)N1 UTAZCRNOSWWEFR-ZDUSSCGKSA-N 0.000 description 1
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- ZAFYATHCZYHLPB-UHFFFAOYSA-N zolpidem Chemical compound N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 ZAFYATHCZYHLPB-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005024614.1 | 2005-05-25 | ||
| DE102005024614A DE102005024614A1 (de) | 2005-05-25 | 2005-05-25 | Verwendung von Polymermischungen zur Herstellung von überzogenen Arzneiformen sowie Arzneiform mit polymerem Mischüberzug |
| PCT/EP2006/001949 WO2006125483A1 (de) | 2005-05-25 | 2006-03-03 | Verwendung vom polymermischungen zur herstellung von überzogenen arzneiformen sowie arzneiform mit |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2606587A1 CA2606587A1 (en) | 2006-11-30 |
| CA2606587C true CA2606587C (en) | 2015-05-26 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2606587A Active CA2606587C (en) | 2005-05-25 | 2006-03-03 | The use of polymer mixtures for the production of coated pharmaceutical formulations and pharmaceutical formulation with mixed polymeric coating |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20080193522A1 (enExample) |
| EP (1) | EP1890682B1 (enExample) |
| JP (1) | JP5582701B2 (enExample) |
| KR (1) | KR101387835B1 (enExample) |
| CN (1) | CN101137354B (enExample) |
| BR (1) | BRPI0610206B8 (enExample) |
| CA (1) | CA2606587C (enExample) |
| DE (1) | DE102005024614A1 (enExample) |
| ES (1) | ES2628962T3 (enExample) |
| HU (1) | HUE032869T2 (enExample) |
| IL (1) | IL187535A0 (enExample) |
| MX (1) | MX363064B (enExample) |
| PL (1) | PL1890682T3 (enExample) |
| SI (1) | SI1890682T1 (enExample) |
| WO (1) | WO2006125483A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2570916C (en) | 2004-06-16 | 2013-06-11 | Tap Pharmaceutical Products, Inc. | Pulsed release dosage form of a ppi |
| WO2008070072A2 (en) * | 2006-12-01 | 2008-06-12 | Mutual Pharmaceutical Company, Inc. | Carvedilol forms, compositions, and methods of preparation thereof |
| AU2008210327B2 (en) * | 2007-01-31 | 2011-06-16 | Methylation Sciences International Srl | Extended release pharmaceutical formulations of S-adenosylmethionine |
| JP5204846B2 (ja) * | 2007-09-21 | 2013-06-05 | エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング | エタノールの影響に対して耐性を有する非オピオイド薬のｐＨ依存性制御放出医薬組成物 |
| SI2187876T1 (sl) * | 2007-09-21 | 2012-12-31 | Evonik Roehm Gmbh | Od pH odvisen opioidni farmacevtski sestavek z nadzorovanim sproščanjem z odpornostjo na vpliv etanola |
| JP5629581B2 (ja) * | 2007-10-12 | 2014-11-19 | タケダ ファーマシューティカルズ ユー．エス．エー． インコーポレイティド | 食物の摂取から独立した消化器疾患の治療方法 |
| NZ588407A (en) * | 2008-03-11 | 2012-07-27 | Takeda Pharmaceutical | Orally-disintegrating solid preparation |
| US8282957B2 (en) | 2008-06-26 | 2012-10-09 | Mcneil-Ppc, Inc. | Coated particles containing pharmaceutically active agents |
| KR101535701B1 (ko) * | 2008-09-24 | 2015-07-09 | 에보니크 룀 게엠베하 | 에탄올의 영향에 대하여 내성을 갖는 비-오피오이드용 ｐｈ-의존성 조절 방출 제약 조성물 |
| MX2011003047A (es) | 2008-09-24 | 2011-04-14 | Evonik Roehm Gmbh | Composicion farmaceutica de opioide de liberacion controlada ph dependiente con resistencia contra la influencia de etanol. |
| CN104984343B (zh) * | 2008-09-24 | 2019-04-02 | 赢创罗姆有限公司 | 耐受乙醇影响的非阿片类药物的pH依赖性受控释放的药物组合物 |
| EP2364138A2 (en) * | 2008-12-08 | 2011-09-14 | Teva Pharmaceutical Industries Ltd. | Palonosetron formulation |
| BRPI0924427A2 (pt) * | 2009-03-18 | 2016-01-26 | Evonik Roehm Gmbh | composição farmacêutica de liberação controlada, seu processo de preparação e uso da mesma |
| WO2010105672A1 (en) * | 2009-03-18 | 2010-09-23 | Evonik Röhm Gmbh | Controlled release pharmaceutical composition with resistance against the influence of ethanol employing a coating comprising neutral vinyl polymers and excipients |
| CN105287434A (zh) * | 2009-03-18 | 2016-02-03 | 赢创罗姆有限公司 | 采用含有中性乙烯基聚合物和赋形剂的包衣的具有耐乙醇影响的控释药物组合物 |
| US20100303920A1 (en) * | 2009-05-27 | 2010-12-02 | Johan Hjartstam | Aqueous Film Coating Composition / 841 |
| US8329208B2 (en) | 2009-07-28 | 2012-12-11 | Methylation Sciences International Srl | Pharmacokinetics of S-adenosylmethionine formulations |
| WO2011047700A1 (en) * | 2009-10-22 | 2011-04-28 | Synthon B.V. | Pharmaceutical compositions of sevelamer |
| US9775815B2 (en) * | 2011-06-17 | 2017-10-03 | Evonik Roehm Gmbh | Gastric resistant pharmaceutical or nutraceutical composition with resistance against the influence of ethanol |
| US9801896B2 (en) | 2012-10-17 | 2017-10-31 | Methylation Sciences International Srl | Compositions comprising S-adenosylmethionine and a gallic acid ester |
| CA3018328A1 (en) | 2014-10-31 | 2016-04-30 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
| US20170042806A1 (en) | 2015-04-29 | 2017-02-16 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
| SI3302444T1 (sl) | 2015-06-05 | 2021-01-29 | Evonik Operations Gmbh | Farmacevtski ali nutracevtski sestavek z odpornostjo na vpliv etanola |
| US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
| JP6739275B2 (ja) * | 2016-08-02 | 2020-08-12 | 日本化薬株式会社 | ゲフィチニブを有効成分とする医薬組成物 |
| IT201700032367A1 (it) * | 2017-03-23 | 2018-09-23 | Lamberti Spa | Dispersioni poliuretaniche acquose |
| MX2020009385A (es) | 2018-03-09 | 2020-10-28 | Evonik Operations Gmbh | Mezcla de polimeros con resistencia a la influencia del etanol. |
| US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
| JP7299595B2 (ja) * | 2019-06-07 | 2023-06-28 | 日本曹達株式会社 | 微粒子用の湿式コーティング剤 |
| US20220257517A1 (en) * | 2019-06-13 | 2022-08-18 | Evonik Operations Gmbh | Powder composition comprising a copolymer mixture and a water-soluble cellulose |
| CN111700871A (zh) * | 2020-06-24 | 2020-09-25 | 杭州巴洛特生物科技有限公司 | 一种美沙拉嗪组合物及其制备方法 |
| CN112237572A (zh) * | 2020-10-28 | 2021-01-19 | 海南卫康制药(潜山)有限公司 | 一种富马酸沃诺拉赞片剂及其制备方法 |
| CN114409998A (zh) * | 2021-12-24 | 2022-04-29 | 浙江普利特新材料有限公司 | 一种蜂窝状咖啡炭复合隔音降噪聚丙烯材料及其制备方法 |
| US12239623B2 (en) | 2023-05-15 | 2025-03-04 | Bonafide Health, Llc | Sleep-improving compositions and methods of use |
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| US5019397A (en) * | 1988-04-21 | 1991-05-28 | Alza Corporation | Aqueous emulsion for pharmaceutical dosage form |
| IT1227899B (it) * | 1988-12-23 | 1991-05-14 | Poli Ind Chimica Spa | Rivestimento totale o parziale di principi attivi farmaceutici e relative composizioni |
| DE9414066U1 (de) * | 1994-08-31 | 1994-11-03 | Röhm GmbH & Co. KG, 64293 Darmstadt | Überzugs- und Bindemittel für Arzneiformen sowie damit hergestellte Arzneiform |
| JPH09323926A (ja) * | 1996-03-15 | 1997-12-16 | Nikken Chem Co Ltd | バルプロ酸ナトリウムの徐放性錠剤 |
| CZ2002671A3 (cs) * | 1999-08-31 | 2002-06-12 | Grünenthal GmbH | Léková forma se zpoľděným účinkem obsahující tramadolsacharinát |
| DE10013029A1 (de) * | 2000-03-17 | 2001-09-20 | Roehm Gmbh | Mehrschichtige Arzneiform für die Colonfreigabe |
| PL367686A1 (en) * | 2001-07-16 | 2005-03-07 | Astrazeneca Ab | Pharmaceutical formulation comprising a proton pump inhibitor and antacids |
| KR20040047915A (ko) * | 2001-10-15 | 2004-06-05 | 룀 게엠베하 운트 콤파니 카게 | 활성제로서 펩타이드 또는 단백질을 함유하는 생약 형태를제조하기 위한 공중합체의 용도 |
| US20040091538A1 (en) * | 2002-10-31 | 2004-05-13 | Crystal Pollock-Dove | Dosage form providing ascending release of liquid formulation |
| EP1589951B1 (en) * | 2003-01-03 | 2017-08-09 | Supernus Pharmaceuticals, Inc. | Use of a mixture of two or more enteric materials to regulate drug release via membrane or matrix for systemic therapeutics |
| MXPA04010956A (es) * | 2003-01-30 | 2005-01-25 | Roehm Gmbh | Forma de dosis farmaceutica y metodo para la produccion de la misma. |
| WO2005041934A2 (de) * | 2003-10-31 | 2005-05-12 | Hexal Ag | Pharmazeutische wirkstoffhaltige formulierung mit überzug |
-
2005
- 2005-05-25 DE DE102005024614A patent/DE102005024614A1/de not_active Withdrawn
-
2006
- 2006-03-03 MX MX2007014024A patent/MX363064B/es unknown
- 2006-03-03 BR BRPI0610206A patent/BRPI0610206B8/pt not_active IP Right Cessation
- 2006-03-03 ES ES06723193.6T patent/ES2628962T3/es active Active
- 2006-03-03 HU HUE06723193A patent/HUE032869T2/en unknown
- 2006-03-03 PL PL06723193T patent/PL1890682T3/pl unknown
- 2006-03-03 CN CN200680007508.8A patent/CN101137354B/zh not_active Expired - Fee Related
- 2006-03-03 CA CA2606587A patent/CA2606587C/en active Active
- 2006-03-03 SI SI200632186T patent/SI1890682T1/sl unknown
- 2006-03-03 US US11/909,315 patent/US20080193522A1/en not_active Abandoned
- 2006-03-03 KR KR1020077027199A patent/KR101387835B1/ko not_active Expired - Fee Related
- 2006-03-03 WO PCT/EP2006/001949 patent/WO2006125483A1/de not_active Ceased
- 2006-03-03 EP EP06723193.6A patent/EP1890682B1/de active Active
- 2006-03-03 JP JP2008512703A patent/JP5582701B2/ja not_active Expired - Fee Related
-
2007
- 2007-11-21 IL IL187535A patent/IL187535A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007014024A (es) | 2008-04-09 |
| BRPI0610206A2 (pt) | 2010-06-01 |
| PL1890682T3 (pl) | 2017-10-31 |
| WO2006125483A1 (de) | 2006-11-30 |
| EP1890682A1 (de) | 2008-02-27 |
| HK1116341A1 (en) | 2008-12-19 |
| KR101387835B1 (ko) | 2014-04-25 |
| IL187535A0 (en) | 2008-03-20 |
| MX363064B (es) | 2019-03-06 |
| KR20080009213A (ko) | 2008-01-25 |
| CN101137354A (zh) | 2008-03-05 |
| CN101137354B (zh) | 2014-06-11 |
| BRPI0610206B8 (pt) | 2022-07-05 |
| CA2606587A1 (en) | 2006-11-30 |
| US20080193522A1 (en) | 2008-08-14 |
| ES2628962T3 (es) | 2017-08-04 |
| EP1890682B1 (de) | 2017-05-03 |
| JP5582701B2 (ja) | 2014-09-03 |
| SI1890682T1 (sl) | 2017-10-30 |
| BRPI0610206B1 (pt) | 2020-10-06 |
| JP2008542211A (ja) | 2008-11-27 |
| HUE032869T2 (en) | 2017-11-28 |
| DE102005024614A1 (de) | 2006-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |