MX363064B - Uso de mezclas polimericas para la produccion de formulaciones farmaceuticas recubiertas y formulacion farmaceutica con recubrimiento polimerico mezclado. - Google Patents

Uso de mezclas polimericas para la produccion de formulaciones farmaceuticas recubiertas y formulacion farmaceutica con recubrimiento polimerico mezclado.

Info

Publication number
MX363064B
MX363064B MX2007014024A MX2007014024A MX363064B MX 363064 B MX363064 B MX 363064B MX 2007014024 A MX2007014024 A MX 2007014024A MX 2007014024 A MX2007014024 A MX 2007014024A MX 363064 B MX363064 B MX 363064B
Authority
MX
Mexico
Prior art keywords
polymer
pharmaceutical formulation
production
polymers
polymeric coating
Prior art date
Application number
MX2007014024A
Other languages
English (en)
Other versions
MX2007014024A (es
Inventor
Petereit Hans-Ulrich
Meier Christian
Knuppen Karin
Original Assignee
Evonik Roehm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Roehm Gmbh filed Critical Evonik Roehm Gmbh
Publication of MX2007014024A publication Critical patent/MX2007014024A/es
Publication of MX363064B publication Critical patent/MX363064B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

La invención se refiere al uso de una mezcla de 2 a 60% en peso de uno o varios polímeros (I) con 40 a 98% en peso de uno o varios polímeros (II), siendo que el polímero (I) es un copolímero de (met)acrilato que contiene 90 a 100% en peso de unidades polimerizadas por radicales libres de 40 a 95% en peso de C1 a C4 alquilésteres del ácido acrílico o metacrílico, y 5 a 60% en peso de unidades de monómeros de (met)acrilato con un grupo aniónico, y 0 a 10% en peso de otros monómeros polimerizables vinílicamente, y el polímero (II), es un vinilpolímero distinto al polímero (I) o un polisacárido o un derivado de un polisacárido, que contiene 88 a 100% de unidades monoméricas neutrales y hasta 12% en peso de unidades monoméricas polimerizadas con radicales iónicos, para la producción de una formulación farmacéutica revestida que contiene un núcleo que presenta el ingrediente activo y un revestimiento polimérico de una mezcla de los polímeros (I) y (II), caracterizado porque la temperatura de transición vítrea del polímero (I) no es mayor a 70 °C y se obtiene un perfil de liberación de ingrediente activo en el que, en comparación con una formulación farmacéutica revestida únicamente con el polímero (I), el ingrediente activo se libera empezando en el mismo valor de pH pero más lentamente. La invención también se refiere a una formulación farmacéutica con un polímero (I) selecto.
MX2007014024A 2005-05-25 2006-03-03 Uso de mezclas polimericas para la produccion de formulaciones farmaceuticas recubiertas y formulacion farmaceutica con recubrimiento polimerico mezclado. MX363064B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005024614A DE102005024614A1 (de) 2005-05-25 2005-05-25 Verwendung von Polymermischungen zur Herstellung von überzogenen Arzneiformen sowie Arzneiform mit polymerem Mischüberzug
PCT/EP2006/001949 WO2006125483A1 (de) 2005-05-25 2006-03-03 Verwendung vom polymermischungen zur herstellung von überzogenen arzneiformen sowie arzneiform mit

Publications (2)

Publication Number Publication Date
MX2007014024A MX2007014024A (es) 2008-04-09
MX363064B true MX363064B (es) 2019-03-06

Family

ID=36607494

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007014024A MX363064B (es) 2005-05-25 2006-03-03 Uso de mezclas polimericas para la produccion de formulaciones farmaceuticas recubiertas y formulacion farmaceutica con recubrimiento polimerico mezclado.

Country Status (15)

Country Link
US (1) US20080193522A1 (es)
EP (1) EP1890682B1 (es)
JP (1) JP5582701B2 (es)
KR (1) KR101387835B1 (es)
CN (1) CN101137354B (es)
BR (1) BRPI0610206B8 (es)
CA (1) CA2606587C (es)
DE (1) DE102005024614A1 (es)
ES (1) ES2628962T3 (es)
HU (1) HUE032869T2 (es)
IL (1) IL187535A0 (es)
MX (1) MX363064B (es)
PL (1) PL1890682T3 (es)
SI (1) SI1890682T1 (es)
WO (1) WO2006125483A1 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1768668A2 (en) 2004-06-16 2007-04-04 Tap Pharmaceutical Products, Inc. Multiple ppi dosage form
WO2008070072A2 (en) * 2006-12-01 2008-06-12 Mutual Pharmaceutical Company, Inc. Carvedilol forms, compositions, and methods of preparation thereof
AU2008210327B2 (en) * 2007-01-31 2011-06-16 Methylation Sciences International Srl Extended release pharmaceutical formulations of S-adenosylmethionine
CN101801356B (zh) * 2007-09-21 2016-10-19 赢创罗姆有限公司 耐受乙醇影响的非阿片类的pH依赖性受控释放的药物组合物
MX2010003032A (es) 2007-09-21 2010-04-09 Evonik R Hm Gmbh Composicion farmaceutica opioide de liberacion controlada ph dependiente con resistencia contra la influencia del etanol.
KR20100116165A (ko) * 2007-10-12 2010-10-29 다케다 파마슈티칼스 노쓰 어메리카, 인코포레이티드 음식 섭취와 관계없이 위장 장애를 치료하는 방법
MY173730A (en) 2008-03-11 2020-02-18 Takeda Pharmaceuticals Co Orally-disintegrating solid preparation
CA2729015A1 (en) * 2008-06-26 2009-12-30 Mcneil-Ppc, Inc. Coated particles containing pharmaceutically active agents
CA2738078C (en) * 2008-09-24 2015-12-29 Evonik Operations Gmbh Ph-dependent controlled release pharmaceutical opioid composition with resistance against the influence of ethanol
ES2537622T3 (es) * 2008-09-24 2015-06-10 Evonik Röhm Gmbh Composición farmacéutica de liberación controlada dependiente del pH para compuestos no opioides con resistencia frente a la influencia del etanol
CN104984343B (zh) * 2008-09-24 2019-04-02 赢创罗姆有限公司 耐受乙醇影响的非阿片类药物的pH依赖性受控释放的药物组合物
EP2364138A2 (en) * 2008-12-08 2011-09-14 Teva Pharmaceutical Industries Ltd. Palonosetron formulation
CA2755814A1 (en) * 2009-03-18 2010-09-23 Evonik Roehm Gmbh Controlled release pharmaceutical composition with resistance against the influence of ethanol employing a coating comprising a polymer mixture and excipients
CN105287434A (zh) * 2009-03-18 2016-02-03 赢创罗姆有限公司 采用含有中性乙烯基聚合物和赋形剂的包衣的具有耐乙醇影响的控释药物组合物
JP5619130B2 (ja) * 2009-03-18 2014-11-05 エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツングＥｖｏｎｉｋ ＲｏｅｈｍＧｍｂＨ 中性ビニルポリマーおよび賦形剤を含むコーティングを使用するエタノールの影響に対する耐性を有する制御放出性医薬組成物
US20100303920A1 (en) * 2009-05-27 2010-12-02 Johan Hjartstam Aqueous Film Coating Composition / 841
US8329208B2 (en) 2009-07-28 2012-12-11 Methylation Sciences International Srl Pharmacokinetics of S-adenosylmethionine formulations
ES2720869T3 (es) * 2009-10-22 2019-07-25 Synthon Bv Composiciones farmacéuticas de sevelámero
CN103501768B (zh) * 2011-06-17 2016-11-09 赢创罗姆有限公司 具有抗乙醇影响抗性的抗胃酸的药物或营养组合物
WO2014059522A1 (en) 2012-10-17 2014-04-24 Methylation Sciences International Srl Compositions comprising s-adenosylmethionine and a gallic acid ester
CA2936746C (en) 2014-10-31 2017-06-27 Purdue Pharma Methods and compositions particularly for treatment of attention deficit disorder
EP3288556A4 (en) 2015-04-29 2018-09-19 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
ES2838816T3 (es) 2015-06-05 2021-07-02 Evonik Operations Gmbh Composición farmacéutica o nutracéutica con resistencia contra la influencia de etanol
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
JP6739275B2 (ja) * 2016-08-02 2020-08-12 日本化薬株式会社 ゲフィチニブを有効成分とする医薬組成物
IT201700032367A1 (it) * 2017-03-23 2018-09-23 Lamberti Spa Dispersioni poliuretaniche acquose
CN112469399A (zh) * 2018-03-09 2021-03-09 赢创运营有限公司 耐受乙醇影响的聚合物混合物
US10722473B2 (en) 2018-11-19 2020-07-28 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder
JP7299595B2 (ja) * 2019-06-07 2023-06-28 日本曹達株式会社 微粒子用の湿式コーティング剤
MX2021010904A (es) * 2019-06-13 2021-10-01 Evonik Operations Gmbh Composicion en polvo que comprende una mezcla de copolimeros y una celulosa soluble en agua.
WO2021252951A1 (en) 2020-06-12 2021-12-16 Vanderbilt University Methods of treatment for gastrointestinal motility disorders
CN111700871A (zh) * 2020-06-24 2020-09-25 杭州巴洛特生物科技有限公司 一种美沙拉嗪组合物及其制备方法
CN112237572A (zh) * 2020-10-28 2021-01-19 海南卫康制药(潜山)有限公司 一种富马酸沃诺拉赞片剂及其制备方法
CN114409998A (zh) * 2021-12-24 2022-04-29 浙江普利特新材料有限公司 一种蜂窝状咖啡炭复合隔音降噪聚丙烯材料及其制备方法
KR20260020944A (ko) 2023-05-15 2026-02-12 보나파이드 헬스, 엘엘씨 수면 개선 조성물 및 이용 방법
CN120204161A (zh) * 2025-04-08 2025-06-27 江西英特科胜动保科技有限公司 一种氟尼辛葡甲胺颗粒及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5019397A (en) * 1988-04-21 1991-05-28 Alza Corporation Aqueous emulsion for pharmaceutical dosage form
IT1227899B (it) * 1988-12-23 1991-05-14 Poli Ind Chimica Spa Rivestimento totale o parziale di principi attivi farmaceutici e relative composizioni
DE9414066U1 (de) * 1994-08-31 1994-11-03 Röhm GmbH & Co. KG, 64293 Darmstadt Überzugs- und Bindemittel für Arzneiformen sowie damit hergestellte Arzneiform
JPH09323926A (ja) * 1996-03-15 1997-12-16 Nikken Chem Co Ltd バルプロ酸ナトリウムの徐放性錠剤
NZ517559A (en) * 1999-08-31 2004-08-27 Gruenenthal Chemie Sustained release pharmaceutical composition containing tramadol saccharinate
DE10013029A1 (de) * 2000-03-17 2001-09-20 Roehm Gmbh Mehrschichtige Arzneiform für die Colonfreigabe
HUP0401941A3 (en) * 2001-07-16 2008-04-28 Astrazeneca Ab Pharmaceutical formulation comprising a proton pomp inhibitor and antacids and process for its preparation
US20030091637A1 (en) * 2001-10-15 2003-05-15 Hans-Ulrich Petereit Use of a copolymer to prepare a pharmaceutical form that contains a peptide of protein as active principle
EP1556017A1 (en) * 2002-10-31 2005-07-27 ALZA Corporation Dosage form providing ascending release of liquid formulation
US7910128B2 (en) * 2003-01-03 2011-03-22 Supernus Pharmaceuticals, Inc. Use of a mixture of two or more enteric materials to regulate drug release via membrane or matrix for systemic therapeutics
MXPA04010956A (es) * 2003-01-30 2005-01-25 Roehm Gmbh Forma de dosis farmaceutica y metodo para la produccion de la misma.
ATE549015T1 (de) * 2003-10-31 2012-03-15 Hexal Ag Pharmazeutische wirkstoffhaltige formulierung mit überzug

Also Published As

Publication number Publication date
CN101137354A (zh) 2008-03-05
HK1116341A1 (en) 2008-12-19
WO2006125483A1 (de) 2006-11-30
EP1890682A1 (de) 2008-02-27
CN101137354B (zh) 2014-06-11
KR20080009213A (ko) 2008-01-25
US20080193522A1 (en) 2008-08-14
DE102005024614A1 (de) 2006-11-30
HUE032869T2 (en) 2017-11-28
MX2007014024A (es) 2008-04-09
JP2008542211A (ja) 2008-11-27
JP5582701B2 (ja) 2014-09-03
BRPI0610206B8 (pt) 2022-07-05
IL187535A0 (en) 2008-03-20
PL1890682T3 (pl) 2017-10-31
BRPI0610206B1 (pt) 2020-10-06
SI1890682T1 (sl) 2017-10-30
BRPI0610206A2 (pt) 2010-06-01
KR101387835B1 (ko) 2014-04-25
CA2606587C (en) 2015-05-26
ES2628962T3 (es) 2017-08-04
EP1890682B1 (de) 2017-05-03
CA2606587A1 (en) 2006-11-30

Similar Documents

Publication Publication Date Title
MX363064B (es) Uso de mezclas polimericas para la produccion de formulaciones farmaceuticas recubiertas y formulacion farmaceutica con recubrimiento polimerico mezclado.
WO2007006353A3 (de) Verwendung eines teilneutralisierten, anionischen (meth) acrylat-copolymers als uberzug fur die herstellung einer arzneiform mit einer wirkstofffreisetzung bei erniedrigten ph-werten
AU2003266351A1 (en) Multilayer dosage forms, which contain active substances and which comprise a neutral core, and an inner and outer coating consisting of methacrylate copolymers and methacrylate monomers
ATE438693T1 (de) Wässriges überzugsmittel, verfahren zu seiner herstellung und seine verwendung
DK1685186T3 (da) Formmasse indeholdende et matteringsmiddel
WO2002022754A8 (en) Adhesive compositions containing low molecular weight polymeric additives
CN101787231A (zh) 憎水改性缔合型增稠剂及其制备方法
IL180849A0 (en) Medicament in a multilayer form
DE502004001110D1 (de) Redispersionspulver-zusammensetzung mit abbindebesschleunigender wirkung
DE602004016293D1 (de) Polymerische dispergiermittel als verflüssigungsmittel in zusammensetzungen von hydraulischen bindemitteln und verfahren zu deren herstellung
MX2008016485A (es) Procedimiento de polimerización por radicales libres en dispersión acuosa para la preparación de polímeros.
KR20190124318A (ko) 경화성 조성물, 시트, 그것을 이용한 적층체, 화상 표시 장치
CN103154041B (zh) 通过在溶液中的自由基聚合制备含叔氨基的(甲基)丙烯酸酯共聚物的方法
ATE273333T1 (de) (co-)polymerisate von hydroxyalkyl(meth)acrylaten,verfahren zu deren herstellung sowie deren verwendung in pharmazeutischen darreichungsformen
DE10346973A1 (de) Modifizierte Polyvinylalkohole enthaltende Polymerzusammensetzungen
BR0308892A (pt) Copolìmero, dispersão polimérica aquosa, pelìcula, formulação farmacêutica, e, processos para a preparação de um polìmero e de uma formulação
CN103154056A (zh) 通过在溶液中的自由基聚合制备含季铵基的（甲基）丙烯酸酯共聚物的方法
ATE432966T1 (de) Verwendung von mit schutzkolloid stabilisierten mischpolymerisaten in zementfreien beschichtungsmitteln
JPS62270608A (ja) 水溶性アクリル系共重合体の製造方法
JP2008525547A5 (es)
AU2002232434A1 (en) Water-based coating composition having carbonate-amine cross-linking, method of preparing the same, and a cured film thereof
WO2024238275A3 (en) Release coating compositions for adhesive tape and methods
KR20120078553A (ko) 아크릴계 미립자 및 이를 포함하는 확산필름
ATE173286T1 (de) Wässrige überzugsmittel
HK1222327B (zh) 低拉丝性增稠剂和混合有该增稠剂的化妆品