CA2599650A1 - Method of sterilization - Google Patents
Method of sterilization Download PDFInfo
- Publication number
- CA2599650A1 CA2599650A1 CA002599650A CA2599650A CA2599650A1 CA 2599650 A1 CA2599650 A1 CA 2599650A1 CA 002599650 A CA002599650 A CA 002599650A CA 2599650 A CA2599650 A CA 2599650A CA 2599650 A1 CA2599650 A1 CA 2599650A1
- Authority
- CA
- Canada
- Prior art keywords
- column
- packed
- aqueous liquid
- chromatography column
- chromatography
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract description 84
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 67
- 238000004659 sterilization and disinfection Methods 0.000 title claims description 53
- 238000004587 chromatography analysis Methods 0.000 claims abstract description 85
- 239000007788 liquid Substances 0.000 claims abstract description 68
- 238000012856 packing Methods 0.000 claims abstract description 26
- 239000011159 matrix material Substances 0.000 claims abstract description 22
- 238000010438 heat treatment Methods 0.000 claims abstract description 21
- 238000000926 separation method Methods 0.000 claims abstract description 11
- 239000003446 ligand Substances 0.000 claims description 30
- 230000008569 process Effects 0.000 claims description 16
- 239000000872 buffer Substances 0.000 claims description 13
- 239000000306 component Substances 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 12
- 239000000126 substance Substances 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 241000700605 Viruses Species 0.000 claims description 9
- 239000002245 particle Substances 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 4
- 230000002209 hydrophobic effect Effects 0.000 claims description 3
- 238000005342 ion exchange Methods 0.000 claims description 3
- 238000012544 monitoring process Methods 0.000 claims description 2
- 238000005086 pumping Methods 0.000 claims description 2
- 229920001059 synthetic polymer Polymers 0.000 claims description 2
- 150000004676 glycans Chemical class 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 230000036512 infertility Effects 0.000 abstract description 2
- 238000000899 pressurised-fluid extraction Methods 0.000 description 19
- 210000004027 cell Anatomy 0.000 description 18
- 239000000047 product Substances 0.000 description 18
- 229920002684 Sepharose Polymers 0.000 description 17
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 17
- 238000012360 testing method Methods 0.000 description 17
- 108090000623 proteins and genes Proteins 0.000 description 14
- 102000004169 proteins and genes Human genes 0.000 description 13
- 239000000499 gel Substances 0.000 description 12
- 239000000523 sample Substances 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 9
- 239000012504 chromatography matrix Substances 0.000 description 8
- 239000011780 sodium chloride Substances 0.000 description 8
- 239000011521 glass Substances 0.000 description 7
- 239000011347 resin Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 229920005989 resin Polymers 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 238000004140 cleaning Methods 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 238000010828 elution Methods 0.000 description 5
- 238000000605 extraction Methods 0.000 description 5
- 239000008213 purified water Substances 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- 239000012539 chromatography resin Substances 0.000 description 4
- 239000013612 plasmid Substances 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
- 238000004448 titration Methods 0.000 description 4
- HNSDLXPSAYFUHK-UHFFFAOYSA-N 1,4-bis(2-ethylhexyl) sulfosuccinate Chemical compound CCCCC(CC)COC(=O)CC(S(O)(=O)=O)C(=O)OCC(CC)CCCC HNSDLXPSAYFUHK-UHFFFAOYSA-N 0.000 description 3
- 229920000936 Agarose Polymers 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000007795 chemical reaction product Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229960004756 ethanol Drugs 0.000 description 3
- 235000019441 ethanol Nutrition 0.000 description 3
- 238000004811 liquid chromatography Methods 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 238000010561 standard procedure Methods 0.000 description 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 2
- 102000008192 Lactoglobulins Human genes 0.000 description 2
- 108010060630 Lactoglobulins Proteins 0.000 description 2
- 239000012901 Milli-Q water Substances 0.000 description 2
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000005349 anion exchange Methods 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 238000011210 chromatographic step Methods 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000010432 diamond Substances 0.000 description 2
- 238000000855 fermentation Methods 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 208000021267 infertility disease Diseases 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000005498 polishing Methods 0.000 description 2
- 239000012460 protein solution Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 2
- 238000012414 sterilization procedure Methods 0.000 description 2
- 239000003206 sterilizing agent Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241001312219 Amorphophallus konjac Species 0.000 description 1
- 235000001206 Amorphophallus rivieri Nutrition 0.000 description 1
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical group C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 102100021935 C-C motif chemokine 26 Human genes 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 241000193155 Clostridium botulinum Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000004606 Fillers/Extenders Substances 0.000 description 1
- 230000005526 G1 to G0 transition Effects 0.000 description 1
- 229920002148 Gellan gum Polymers 0.000 description 1
- 101000897493 Homo sapiens C-C motif chemokine 26 Proteins 0.000 description 1
- 235000020853 Inedia Nutrition 0.000 description 1
- 229920002752 Konjac Polymers 0.000 description 1
- 102000007474 Multiprotein Complexes Human genes 0.000 description 1
- 108010085220 Multiprotein Complexes Proteins 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- SCKXCAADGDQQCS-UHFFFAOYSA-N Performic acid Chemical compound OOC=O SCKXCAADGDQQCS-UHFFFAOYSA-N 0.000 description 1
- 239000004696 Poly ether ether ketone Substances 0.000 description 1
- 108091006629 SLC13A2 Proteins 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 241000700618 Vaccinia virus Species 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000008351 acetate buffer Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 230000009830 antibody antigen interaction Effects 0.000 description 1
- 239000012062 aqueous buffer Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- JUPQTSLXMOCDHR-UHFFFAOYSA-N benzene-1,4-diol;bis(4-fluorophenyl)methanone Chemical compound OC1=CC=C(O)C=C1.C1=CC(F)=CC=C1C(=O)C1=CC=C(F)C=C1 JUPQTSLXMOCDHR-UHFFFAOYSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 238000010352 biotechnological method Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 238000002659 cell therapy Methods 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229940039227 diagnostic agent Drugs 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000003596 drug target Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000006052 feed supplement Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 230000009975 flexible effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 208000000509 infertility Diseases 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000000252 konjac Substances 0.000 description 1
- 235000010485 konjac Nutrition 0.000 description 1
- 239000012160 loading buffer Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000010587 phase diagram Methods 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920002530 polyetherether ketone Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000011012 sanitization Methods 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 230000003330 sporicidal effect Effects 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/50—Conditioning of the sorbent material or stationary liquid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0500554-1 | 2005-03-07 | ||
| SE0500554 | 2005-03-07 | ||
| PCT/SE2006/000284 WO2006096116A1 (en) | 2005-03-07 | 2006-03-06 | Method of sterilization |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2599650A1 true CA2599650A1 (en) | 2006-09-14 |
Family
ID=36953639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002599650A Abandoned CA2599650A1 (en) | 2005-03-07 | 2006-03-06 | Method of sterilization |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7682510B2 (enExample) |
| EP (1) | EP1855729B1 (enExample) |
| JP (1) | JP5021610B2 (enExample) |
| CN (1) | CN101137399B (enExample) |
| CA (1) | CA2599650A1 (enExample) |
| WO (1) | WO2006096116A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0614315D0 (en) | 2006-07-19 | 2006-08-30 | Ge Healthcare Bio Sciences Ab | Chromatography columns, systems and methods |
| US9597611B2 (en) * | 2007-03-09 | 2017-03-21 | Ge Healthcare Bioprocess R&D Ab | Packing system and method for chromatography columns |
| AU2013201133B2 (en) * | 2007-03-28 | 2014-02-27 | Patheon Holdings I B.V. | Expanded bed column and disposable chromatography |
| CA2682333C (en) * | 2007-03-28 | 2015-05-05 | Upfront Chromatography A/S | Expanded bed column and disposable chromatography |
| GB2452301A (en) * | 2007-08-30 | 2009-03-04 | Ge Healthcare Bio Sciences Ab | Sterilization Method |
| EP2237804B1 (en) * | 2007-12-21 | 2013-04-10 | GE Healthcare Bio-Sciences AB | Method for sterilization of chemically activated solid support materials |
| JP6348507B2 (ja) * | 2012-12-14 | 2018-06-27 | ジーイー・ヘルスケア・バイオプロセス・アールアンドディ・アクチボラグ | 充填ベッドクロマトグラフィーカラムの洗浄方法 |
| WO2014103787A1 (ja) * | 2012-12-27 | 2014-07-03 | 大日本印刷株式会社 | 飲料充填装置及びその殺菌方法 |
| HK1219964A1 (zh) | 2013-03-08 | 2017-04-21 | Genzyme Corporation | 治疗性蛋白药物物质的整合连续制造 |
| TWI671312B (zh) | 2014-01-17 | 2019-09-11 | 美商健臻公司 | 無菌層析法及製法 |
| TWI709569B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析樹脂及其用於製造方法的用途 |
| JP6684719B2 (ja) * | 2014-03-10 | 2020-04-22 | 株式会社スリー・ディー・マトリックス | ペプチド組成物の滅菌および濾過 |
| CA3073356A1 (en) | 2017-09-21 | 2019-03-28 | Repligen Corporation | Methods and systems for removing pressure and air from chromatography columns |
| US12029999B2 (en) | 2017-11-30 | 2024-07-09 | Corning Incorporated | Package for batch chromatography |
| AU2019332764B2 (en) | 2018-08-31 | 2025-05-29 | Genzyme Corporation | Sterile chromatography resin and use thereof in manufacturing processes |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2748057A (en) * | 1953-03-16 | 1956-05-29 | Kerr Mc Gee Oil Ind Inc | Cation exchange materials and their preparation |
| US4028242A (en) * | 1975-02-06 | 1977-06-07 | Kokurin Vyacheslav Alexandrovi | Method of thermal disinfection of sewage and plant realizing same |
| US4484061A (en) * | 1982-05-13 | 1984-11-20 | Sys-Tec, Inc. | Temperature control system for liquid chromatographic columns employing a thin film heater/sensor |
| FR2543410B1 (fr) * | 1983-03-29 | 1988-06-24 | Torterotot Roland | Procede de reconstitution et de traitement thermique de produits alimentaires liquides, et appareillage permettant de mettre en oeuvre ce procede |
| JPH0626568B2 (ja) * | 1986-03-27 | 1994-04-13 | 鐘淵化学工業株式会社 | 保存安定性の改良された体外循環治療用吸着カラム |
| US4865729A (en) * | 1985-11-04 | 1989-09-12 | Sepragen Corporation | Radial thin layer chromatography |
| US4676898A (en) * | 1985-11-04 | 1987-06-30 | Sepragen Corporation | Chromatography column using horizontal flow |
| US4627918A (en) * | 1985-11-04 | 1986-12-09 | Sepragen Corporation | Chromatography column using horizontal flow |
| US4923068A (en) * | 1989-02-07 | 1990-05-08 | Cdp Product Development Corporation | Automatic filter system |
| US5268144A (en) * | 1989-11-04 | 1993-12-07 | Fresenius Ag | Method for sterilizing a medical unit |
| US5242586A (en) | 1990-12-17 | 1993-09-07 | Biotage Inc. | Column protection system for liquid chromatography system |
| JPH04282162A (ja) * | 1991-03-08 | 1992-10-07 | Green Cross Corp:The | 輸液入りプラスチック容器の製造方法 |
| US5268097A (en) * | 1992-06-19 | 1993-12-07 | Sepracor Inc. | Passivated and stabilized porous mineral oxide supports and method for the preparation and use of same |
| JPH06125984A (ja) * | 1992-10-16 | 1994-05-10 | Asahi Medical Co Ltd | 吸着器とその滅菌方法 |
| US5367054A (en) * | 1993-04-12 | 1994-11-22 | Stolle Research & Development Corp. | Large-scale purification of egg immunoglobulin |
| JP3161604B2 (ja) * | 1994-05-13 | 2001-04-25 | プラズマセレクト ゲーエムベーハー テテロウ | 血液中の物質を結合してそれを除去するためのタンパク質を結合させた、無菌かつ発熱物質を含有しないカラム |
| US5423982A (en) * | 1994-05-31 | 1995-06-13 | Biosepra Inc. | Liquid chromatography column adapted for in situ chemical sterilization |
| EP0762919A4 (en) * | 1994-05-31 | 1997-07-02 | Biosepra Inc | STERILIZATION OF RESINS FOR LIQUID PHASE CHROMATOGRAPHY |
| US5906747A (en) * | 1995-11-13 | 1999-05-25 | Biosepra Inc. | Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates |
| US6103112A (en) * | 1996-11-13 | 2000-08-15 | Transgenomic, Inc. | MIPC chromatographic apparatus with improved temperature control |
| US5904663A (en) * | 1997-07-30 | 1999-05-18 | Braverman; Andrew | Method of removing beta-2 microglobulin from blood |
| US20020197249A1 (en) * | 2001-04-10 | 2002-12-26 | Renal Tech International | Devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood products |
| JPH11221094A (ja) * | 1997-12-01 | 1999-08-17 | Toray Ind Inc | インターロイキン−８の製造法 |
| US6406632B1 (en) | 1998-04-03 | 2002-06-18 | Symyx Technologies, Inc. | Rapid characterization of polymers |
| JP2001300308A (ja) * | 2000-04-28 | 2001-10-30 | Kuraray Co Ltd | エンドトキシン吸着材 |
| US6923936B2 (en) * | 2001-10-23 | 2005-08-02 | Medtronic Minimed, Inc. | Sterile device and method for producing same |
| WO2003072217A1 (en) * | 2002-02-22 | 2003-09-04 | Selerity Technologies, Inc. | Mobile phase treatment for chromatography |
| JP2004213514A (ja) * | 2003-01-08 | 2004-07-29 | Fuji Electric Holdings Co Ltd | 容器入り飲料の加熱装置及びこれを用いた自動販売機 |
| US6913695B2 (en) * | 2003-07-08 | 2005-07-05 | Bayer Healthcare Llc | Sanitization of chromatographic media |
-
2006
- 2006-03-06 WO PCT/SE2006/000284 patent/WO2006096116A1/en not_active Ceased
- 2006-03-06 CN CN2006800072681A patent/CN101137399B/zh active Active
- 2006-03-06 EP EP06716970.6A patent/EP1855729B1/en active Active
- 2006-03-06 JP JP2008500670A patent/JP5021610B2/ja active Active
- 2006-03-06 CA CA002599650A patent/CA2599650A1/en not_active Abandoned
- 2006-03-06 US US11/817,268 patent/US7682510B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1855729A4 (en) | 2010-07-21 |
| US7682510B2 (en) | 2010-03-23 |
| JP2008533464A (ja) | 2008-08-21 |
| WO2006096116A1 (en) | 2006-09-14 |
| EP1855729B1 (en) | 2013-10-30 |
| US20080142439A1 (en) | 2008-06-19 |
| EP1855729A1 (en) | 2007-11-21 |
| CN101137399A (zh) | 2008-03-05 |
| CN101137399B (zh) | 2012-08-29 |
| JP5021610B2 (ja) | 2012-09-12 |
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