CA2593432A1 - Fast-disintegrating dosage forms of 5,8,14-triazatetracyclo[10.3.1.02,11.04,9]-hexadeca-2(11),3,5,7,9-pentaene - Google Patents
Fast-disintegrating dosage forms of 5,8,14-triazatetracyclo[10.3.1.02,11.04,9]-hexadeca-2(11),3,5,7,9-pentaene Download PDFInfo
- Publication number
- CA2593432A1 CA2593432A1 CA002593432A CA2593432A CA2593432A1 CA 2593432 A1 CA2593432 A1 CA 2593432A1 CA 002593432 A CA002593432 A CA 002593432A CA 2593432 A CA2593432 A CA 2593432A CA 2593432 A1 CA2593432 A1 CA 2593432A1
- Authority
- CA
- Canada
- Prior art keywords
- varenicline
- dosage form
- fast disintegrating
- disintegrating dosage
- fast
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000002552 dosage form Substances 0.000 title claims abstract description 109
- JQSHBVHOMNKWFT-UHFFFAOYSA-N varenicline Chemical compound C12=CC3=NC=CN=C3C=C2C2CC1CNC2 JQSHBVHOMNKWFT-UHFFFAOYSA-N 0.000 title description 2
- 229960004751 varenicline Drugs 0.000 claims abstract description 130
- JQSHBVHOMNKWFT-DTORHVGOSA-N varenicline Chemical compound C12=CC3=NC=CN=C3C=C2[C@H]2C[C@@H]1CNC2 JQSHBVHOMNKWFT-DTORHVGOSA-N 0.000 claims abstract description 130
- 238000000034 method Methods 0.000 claims abstract description 60
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 42
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 33
- -1 Brij.TM.35 Polymers 0.000 claims description 32
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 29
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 7
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- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 6
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- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical class OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 5
- 150000001860 citric acid derivatives Chemical class 0.000 claims description 5
- 235000019868 cocoa butter Nutrition 0.000 claims description 5
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- BLILOGGUTRWFNI-UHFFFAOYSA-N Monomenthyl succinate Chemical compound CC(C)C1CCC(C)CC1OC(=O)CCC(O)=O BLILOGGUTRWFNI-UHFFFAOYSA-N 0.000 claims description 4
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- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 3
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- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 3
- GUBGYTABKSRVRQ-UHFFFAOYSA-N 2-(hydroxymethyl)-6-[4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol Chemical compound OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O GUBGYTABKSRVRQ-UHFFFAOYSA-N 0.000 claims description 3
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- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64208305P | 2005-01-07 | 2005-01-07 | |
US60/642,083 | 2005-01-07 | ||
PCT/IB2005/003979 WO2006072832A1 (en) | 2005-01-07 | 2005-12-22 | Fast-disintegrating dosage forms of 5,8,14-triazatetracyclo[10.3.1.02,11.04,9]-hexadeca-2(11),3,5,7,9-pentaene |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2593432A1 true CA2593432A1 (en) | 2006-07-13 |
Family
ID=36129747
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002593432A Abandoned CA2593432A1 (en) | 2005-01-07 | 2005-12-22 | Fast-disintegrating dosage forms of 5,8,14-triazatetracyclo[10.3.1.02,11.04,9]-hexadeca-2(11),3,5,7,9-pentaene |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1843769A1 (ja) |
JP (1) | JP2008526827A (ja) |
CA (1) | CA2593432A1 (ja) |
WO (1) | WO2006072832A1 (ja) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110086086A1 (en) * | 2005-07-26 | 2011-04-14 | Pfizer Inc | Transdermal system for varenicline |
JP5228359B2 (ja) * | 2007-04-12 | 2013-07-03 | ニプロ株式会社 | 主薬粒子及びその製造方法ならびに口腔内崩壊錠 |
CA2686035C (en) * | 2007-05-08 | 2016-01-05 | Hercules Incorporated | Robust rapid disintegration tablet formulation |
WO2009111623A2 (en) * | 2008-03-06 | 2009-09-11 | Dr. Reddy's Laboratories Ltd. | Amorphous varenicline tartrate |
JP2012509321A (ja) * | 2008-11-21 | 2012-04-19 | ミレニアム ファーマシューティカルズ, インコーポレイテッド | 癌および他の疾患または障害の処置のための、4−[6−メトキシ−7−(3−ピペリジン−1−イル−プロポキシ)キナゾリン−4−イル]ピペラジン−1−カルボン酸(4−イソプロポキシフェニル)−アミドの乳酸塩およびその薬学的組成物 |
CN103919742B (zh) * | 2008-11-25 | 2017-04-12 | 田边三菱制药株式会社 | 口腔速崩片及其制备方法 |
JP5637624B2 (ja) * | 2009-02-12 | 2014-12-10 | 富士化学工業株式会社 | 崩壊性粒子組成物及びそれを用いた速崩壊性圧縮成型物 |
JP2010285415A (ja) * | 2009-06-15 | 2010-12-24 | Hisamitsu Pharmaceut Co Inc | バレニクリン又は薬学的に許容されるバレニクリン酸付加塩を含有する経皮薬物送達システムの包装体 |
KR101828630B1 (ko) * | 2010-07-09 | 2018-02-12 | 데이진 화-마 가부시키가이샤 | 구강 내 붕괴 정제 |
JP6045237B2 (ja) * | 2012-07-27 | 2016-12-14 | 旭化成株式会社 | 錠剤型の増粘化剤 |
JP6045238B2 (ja) * | 2012-07-27 | 2016-12-14 | 旭化成株式会社 | 増粘多糖類を含む錠剤 |
US10413516B2 (en) * | 2013-05-09 | 2019-09-17 | Cure Pharmaceutical Corporation | Thin film with high load of active ingredient |
CN104548113B (zh) * | 2014-12-11 | 2017-12-01 | 天津博科林药品包装技术有限公司 | 一种薄膜包衣剂的生产工艺 |
CN105434383B (zh) * | 2015-12-31 | 2021-08-03 | 山东新时代药业有限公司 | 一种苯磺酸左旋氨氯地平片剂及其制备方法 |
CN106943367B (zh) * | 2016-01-06 | 2020-07-14 | 山东新时代药业有限公司 | 一种马来酸阿法替尼片及其制备方法 |
IT201600078683A1 (it) * | 2016-07-27 | 2018-01-27 | Mattia Saporiti | Matrice edibile per uso veterinario e zootecnico e relativo metodo di produzione |
US11266658B2 (en) * | 2017-03-03 | 2022-03-08 | Ctc Bio, Inc. | Preparation, comprising inclusion complex of varenicline or pharmaceutically acceptable salt thereof, for oral administration |
WO2018154395A2 (en) | 2018-06-11 | 2018-08-30 | Alvogen Malta Operations (Row) Ltd | Controlled release pharmaceutical composition of varenicline |
CN109432022B (zh) * | 2018-12-10 | 2021-07-06 | 江苏豪森药业集团有限公司 | 一种含酒石酸伐尼克兰的药物组合物及其制备方法 |
WO2022230925A1 (ja) * | 2021-04-28 | 2022-11-03 | アスパック企業株式会社 | 膿皮症改善剤 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1448235T1 (sl) * | 2001-11-30 | 2007-08-31 | Pfizer Prod Inc | Peroralni farmacevtski sestavki s podaljšanim sproščanjem 5,8,14-triazatetraciklo (10.3.1.0(2,11).0(4,9)) -heksadeka-2(11)3,5,7,9-pentaena |
-
2005
- 2005-12-22 JP JP2007549963A patent/JP2008526827A/ja not_active Abandoned
- 2005-12-22 EP EP05826405A patent/EP1843769A1/en not_active Withdrawn
- 2005-12-22 CA CA002593432A patent/CA2593432A1/en not_active Abandoned
- 2005-12-22 WO PCT/IB2005/003979 patent/WO2006072832A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
EP1843769A1 (en) | 2007-10-17 |
WO2006072832A1 (en) | 2006-07-13 |
JP2008526827A (ja) | 2008-07-24 |
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