CA2587158C - Immunoglobulin variable region cassette exchange - Google Patents

Immunoglobulin variable region cassette exchange Download PDF

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Publication number
CA2587158C
CA2587158C CA2587158A CA2587158A CA2587158C CA 2587158 C CA2587158 C CA 2587158C CA 2587158 A CA2587158 A CA 2587158A CA 2587158 A CA2587158 A CA 2587158A CA 2587158 C CA2587158 C CA 2587158C
Authority
CA
Canada
Prior art keywords
antibody
variable region
human
cdr2
regions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2587158A
Other languages
English (en)
French (fr)
Other versions
CA2587158A1 (en
Inventor
Christopher R. Bebbington
Kenneth R. Luehrsen
Geoffrey T. Yarranton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Humanigen Inc
Original Assignee
Kalobios Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36407771&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2587158(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kalobios Pharmaceuticals Inc filed Critical Kalobios Pharmaceuticals Inc
Publication of CA2587158A1 publication Critical patent/CA2587158A1/en
Application granted granted Critical
Publication of CA2587158C publication Critical patent/CA2587158C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2587158A 2004-11-16 2005-11-16 Immunoglobulin variable region cassette exchange Expired - Lifetime CA2587158C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62858104P 2004-11-16 2004-11-16
US60/628,581 2004-11-16
PCT/US2005/041825 WO2006055778A2 (en) 2004-11-16 2005-11-16 Immunoglobulin variable region cassette exchange

Publications (2)

Publication Number Publication Date
CA2587158A1 CA2587158A1 (en) 2006-05-26
CA2587158C true CA2587158C (en) 2016-01-12

Family

ID=36407771

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2587158A Expired - Lifetime CA2587158C (en) 2004-11-16 2005-11-16 Immunoglobulin variable region cassette exchange

Country Status (10)

Country Link
US (2) US20060134098A1 (enExample)
EP (3) EP2343380B1 (enExample)
JP (1) JP2008520586A (enExample)
AU (1) AU2005306502B2 (enExample)
CA (1) CA2587158C (enExample)
DK (2) DK3540062T3 (enExample)
ES (3) ES2881353T3 (enExample)
PL (2) PL3540062T3 (enExample)
PT (2) PT3540062T (enExample)
WO (1) WO2006055778A2 (enExample)

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Also Published As

Publication number Publication date
EP3540062B1 (en) 2021-05-12
DK2343380T3 (da) 2019-09-09
EP2343380B1 (en) 2019-06-12
PL3540062T3 (pl) 2021-12-27
US10919983B2 (en) 2021-02-16
AU2005306502A1 (en) 2006-05-26
AU2005306502B2 (en) 2012-11-15
EP2343380A1 (en) 2011-07-13
EP3540062A1 (en) 2019-09-18
JP2008520586A (ja) 2008-06-19
US20160102152A1 (en) 2016-04-14
ES2744149T3 (es) 2020-02-21
ES2881353T3 (es) 2021-11-29
PT3540062T (pt) 2021-07-06
US20060134098A1 (en) 2006-06-22
PT2343380T (pt) 2019-09-18
WO2006055778A3 (en) 2006-11-23
EP1824987A4 (en) 2008-03-19
PL2343380T3 (pl) 2020-03-31
ES2429541T3 (es) 2013-11-15
EP1824987A2 (en) 2007-08-29
CA2587158A1 (en) 2006-05-26
WO2006055778A2 (en) 2006-05-26
DK3540062T3 (da) 2021-06-28
EP1824987B1 (en) 2013-08-21

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