CA2574966A1 - Isoindoline compounds and methods of their use - Google Patents
Isoindoline compounds and methods of their use Download PDFInfo
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- CA2574966A1 CA2574966A1 CA002574966A CA2574966A CA2574966A1 CA 2574966 A1 CA2574966 A1 CA 2574966A1 CA 002574966 A CA002574966 A CA 002574966A CA 2574966 A CA2574966 A CA 2574966A CA 2574966 A1 CA2574966 A1 CA 2574966A1
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
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- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- Organic Chemistry (AREA)
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- Animal Behavior & Ethology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US10/900,332 US7405237B2 (en) | 2004-07-28 | 2004-07-28 | Isoindoline compounds and methods of their use |
| US10/900,332 | 2004-07-28 | ||
| PCT/US2005/026679 WO2006015060A2 (en) | 2004-07-28 | 2005-07-27 | Isoindoline compounds and methods of their use |
Publications (1)
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| CA2574966A1 true CA2574966A1 (en) | 2006-02-09 |
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Family Applications (1)
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| CA002574966A Abandoned CA2574966A1 (en) | 2004-07-28 | 2005-07-27 | Isoindoline compounds and methods of their use |
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| EP (1) | EP1781610A2 (enExample) |
| JP (1) | JP2008508298A (enExample) |
| KR (1) | KR20070047807A (enExample) |
| CN (1) | CN101031545A (enExample) |
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| IL (1) | IL180978A0 (enExample) |
| MX (1) | MX2007000842A (enExample) |
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| WO (1) | WO2006015060A2 (enExample) |
| ZA (1) | ZA200701660B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009039635A1 (en) * | 2007-09-24 | 2009-04-02 | Painceptor Pharma Corporation | Methods of modulating neurotrophin-mediated activity |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003228509B2 (en) * | 2002-10-15 | 2008-06-26 | Celgene Corporation | Selective cytokine inhibitory drugs for treating myelodysplastic syndrome |
| WO2004043336A2 (en) * | 2002-11-06 | 2004-05-27 | Celgene Corporation | Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of myeloproliferative diseases |
| US20080213213A1 (en) * | 2004-04-14 | 2008-09-04 | Zeldis Jerome B | Method For the Treatment of Myelodysplastic Syndromes Using (+)-2-[1-(3-Ethoxy-4-Methoxyphenyl)-2-Methylsulfonylethyl]-4-Acetylaminoisoindoline-1,3-Dione |
| US7405237B2 (en) * | 2004-07-28 | 2008-07-29 | Celgene Corporation | Isoindoline compounds and methods of their use |
| US7244759B2 (en) * | 2004-07-28 | 2007-07-17 | Celgene Corporation | Isoindoline compounds and methods of making and using the same |
| JP5700909B2 (ja) * | 2005-05-04 | 2015-04-15 | メディゲーネ アクチエンゲゼルシャフトＭｅｄｉＧｅｎｅ ＡＧ | パクリタキセルを含む陽イオン性リポソーム製剤を投与する方法 |
| CA2823088C (en) * | 2005-06-30 | 2015-10-06 | Celgene Corporation | Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds |
| CA2922029C (en) | 2006-03-22 | 2017-11-28 | Medigene Ag | A combination of a cationic liposomal preparation comprising an antimitotic agent and a non-liposomal preparation comprising an antimitotic agent |
| US20080064876A1 (en) * | 2006-05-16 | 2008-03-13 | Muller George W | Process for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione |
| TW200806625A (en) * | 2006-05-26 | 2008-02-01 | Astrazeneca Ab | Therapeutic compounds |
| BRPI1007500A2 (pt) | 2009-02-10 | 2016-02-16 | Celgene Corp | métodos de uso e composições que compreendem moduladores de pde4 para tratamento, prevenção e gerenciamento de tuberculose |
| RU2592668C2 (ru) * | 2009-05-12 | 2016-07-27 | Конинклейке Филипс Электроникс Н.В. | Фосфодиэстераза 9а в качестве маркера злокачественной опухоли предстательной железы |
| CN101580501B (zh) * | 2009-06-01 | 2011-03-09 | 南京卡文迪许生物工程技术有限公司 | 3-(取代二氢异吲哚酮-2-基)-2,6-哌啶二酮的合成方法及其中间体 |
| WO2011027326A1 (en) * | 2009-09-03 | 2011-03-10 | Ranbaxy Laboratories Limited | Process for the preparation of lenalidomide |
| GB2474120B (en) * | 2009-10-01 | 2011-12-21 | Amira Pharmaceuticals Inc | Compounds as Lysophosphatidic acid receptor antagonists |
| CN101747255B (zh) * | 2009-12-22 | 2011-11-23 | 上海大学 | 含烯炔结构的异吲哚酮类化合物及其合成方法 |
| RS59275B1 (sr) | 2010-02-11 | 2019-10-31 | Celgene Corp | Derivati arilmetoksi izoindolina i kompozicije koje ih obuhvataju i postupci njihove primene |
| AU2011268450B2 (en) | 2010-06-15 | 2015-07-16 | Amgen (Europe) GmbH | Biomarkers for the treatment of psoriasis |
| CN102603610B (zh) * | 2012-02-21 | 2014-07-09 | 四川大学 | 1,3-二氢-1-氧-2h-异吲哚类化合物、其制备方法和用途 |
| CN104045594B (zh) * | 2012-02-21 | 2016-08-17 | 四川大学 | 一类1,3-二氢-1-氧-2h-异吲哚类化合物及其用途 |
| KR101441096B1 (ko) * | 2012-11-27 | 2014-09-25 | 가톨릭대학교 산학협력단 | 제피티닙을 포함하는 톡소포자충 감염증의 예방 및 치료용 조성물 |
| CN105358177B (zh) | 2013-04-17 | 2018-11-23 | 西格诺药品有限公司 | 包含tor激酶抑制剂和imid化合物的联合疗法用于治疗癌症 |
| CN104721820A (zh) * | 2013-12-24 | 2015-06-24 | 信达生物制药(苏州)有限公司 | 双特异性单克隆抗体在治疗葡萄膜炎中的用途 |
| EP3142663A1 (en) | 2014-05-16 | 2017-03-22 | Celgene Corporation | Compositions and methods for the treatment of atherosclerotic cardiovascular diseases with pde4 modulators |
| ES2667793T3 (es) * | 2014-07-08 | 2018-05-14 | Viiv Healthcare Uk Limited | Derivados de isoindolina para su uso en el tratamiento de una infección vírica |
| EP3324962A4 (en) | 2015-07-23 | 2018-12-19 | Temple University Of The Commonwealth System Of Higher Education | Novel aminothiazole compounds and methods using same |
| WO2017070291A1 (en) | 2015-10-21 | 2017-04-27 | Celgene Corporation | Pde4 modulators for treating and preventing immune reconstitution inflammatory syndrome (iris) |
| US10941126B2 (en) | 2017-01-19 | 2021-03-09 | Temple University-Of The Commonwealth System Of Higher Education | Bridged bicycloalkyl-substituted aminothiazoles and their methods of use |
| MX2020002010A (es) | 2017-08-21 | 2020-07-13 | Celgene Corp | Procesos para la preparacion de 4,5-diamino-5-oxopentanoato de (s)-terc-butilo. |
| US11976059B2 (en) | 2018-08-16 | 2024-05-07 | Korea Research Institute Of Chemical Technology | Isoindolin-1-on derivative, method for preparing same, and pharmaceutical composition comprising same as effective component for preventing or treating cancer |
| KR20220133198A (ko) * | 2019-12-26 | 2022-10-04 | 오하이오 스테이트 이노베이션 파운데이션 | 디하이드로오로테이트 탈수소효소를 항-cd38 치료제와 조합하여 억제하는 방법 및 조성물 |
| CN114644586A (zh) * | 2022-04-12 | 2022-06-21 | 江苏豪森药业集团有限公司 | 一种来那度胺有关物质的制备方法 |
| WO2025118133A1 (zh) * | 2023-12-05 | 2025-06-12 | 浙江普洛家园药业有限公司 | 一种(s)-来那度胺-5-位衍生物及其合成方法和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2199530C2 (ru) | 1997-07-31 | 2003-02-27 | Селджин Корпорейшн | ЗАМЕЩЕННЫЕ ГИДРОКСАМОВЫЕ КИСЛОТЫ, ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ НА ИХ ОСНОВЕ И СПОСОБ СНИЖЕНИЯ УРОВНЕЙ TNFα |
| NZ513953A (en) * | 1999-03-18 | 2001-09-28 | Celgene Corp | Substituted 1-oxo- and 1,3-dioxoisoindolines and their use in pharmaceutical compositions for reducing inflammatory cytokine levels |
| US6326388B1 (en) * | 1999-12-21 | 2001-12-04 | Celgene Corporation | Substituted 1,3,4-oxadiazoles and a method of reducing TNF-alpha level |
| ES2325916T3 (es) | 2001-08-06 | 2009-09-24 | The Children's Medical Center Corporation | Actividad antiangiogenica de analogos de talidomida sustituidos con nitrogeno. |
| US7405237B2 (en) * | 2004-07-28 | 2008-07-29 | Celgene Corporation | Isoindoline compounds and methods of their use |
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2004
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2005
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- 2005-07-27 ZA ZA200701660A patent/ZA200701660B/xx unknown
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2009
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009039635A1 (en) * | 2007-09-24 | 2009-04-02 | Painceptor Pharma Corporation | Methods of modulating neurotrophin-mediated activity |
Also Published As
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| US7569597B2 (en) | 2009-08-04 |
| MX2007000842A (es) | 2007-04-17 |
| JP2008508298A (ja) | 2008-03-21 |
| EP1781610A2 (en) | 2007-05-09 |
| KR20070047807A (ko) | 2007-05-07 |
| AU2005269367A1 (en) | 2006-02-09 |
| US20090291991A1 (en) | 2009-11-26 |
| AU2005269367B2 (en) | 2011-12-01 |
| IL180978A0 (en) | 2007-07-04 |
| US20080145336A1 (en) | 2008-06-19 |
| US7816393B2 (en) | 2010-10-19 |
| CN101031545A (zh) | 2007-09-05 |
| WO2006015060A3 (en) | 2006-07-20 |
| WO2006015060A2 (en) | 2006-02-09 |
| NZ553029A (en) | 2010-12-24 |
| BRPI0513836A (pt) | 2008-05-20 |
| ZA200701660B (en) | 2008-09-25 |
| US20060025457A1 (en) | 2006-02-02 |
| US7405237B2 (en) | 2008-07-29 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |
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| FZDE | Discontinued |
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