CA2572743C - Methods for improving bioavailability of a renin inhibitor - Google Patents
Methods for improving bioavailability of a renin inhibitor Download PDFInfo
- Publication number
- CA2572743C CA2572743C CA2572743A CA2572743A CA2572743C CA 2572743 C CA2572743 C CA 2572743C CA 2572743 A CA2572743 A CA 2572743A CA 2572743 A CA2572743 A CA 2572743A CA 2572743 C CA2572743 C CA 2572743C
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- Prior art keywords
- amino
- inhibitor
- hydroxy
- aryl
- 4alkoxy
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59870004P | 2004-08-03 | 2004-08-03 | |
| US60/598,700 | 2004-08-03 | ||
| PCT/EP2005/008369 WO2006013094A1 (en) | 2004-08-03 | 2005-08-02 | Methods for improving bioavailability of a renin inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2572743A1 CA2572743A1 (en) | 2006-02-09 |
| CA2572743C true CA2572743C (en) | 2012-12-04 |
Family
ID=35056890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2572743A Expired - Fee Related CA2572743C (en) | 2004-08-03 | 2005-08-02 | Methods for improving bioavailability of a renin inhibitor |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US7709532B2 (https=) |
| EP (2) | EP1776099B1 (https=) |
| JP (1) | JP5134366B2 (https=) |
| KR (1) | KR20070040384A (https=) |
| CN (1) | CN1993116B (https=) |
| AR (1) | AR050043A1 (https=) |
| AT (1) | ATE449601T1 (https=) |
| AU (1) | AU2005268844B2 (https=) |
| BR (1) | BRPI0514021A (https=) |
| CA (1) | CA2572743C (https=) |
| CY (1) | CY1109826T1 (https=) |
| DE (1) | DE602005017905D1 (https=) |
| DK (1) | DK1776099T3 (https=) |
| EC (1) | ECSP077169A (https=) |
| ES (1) | ES2335597T3 (https=) |
| HR (1) | HRP20100064T1 (https=) |
| IL (1) | IL180678A (https=) |
| MA (1) | MA28821B1 (https=) |
| MX (1) | MX2007001339A (https=) |
| MY (1) | MY142180A (https=) |
| NO (1) | NO20071142L (https=) |
| NZ (1) | NZ552903A (https=) |
| PE (1) | PE20060416A1 (https=) |
| PL (1) | PL1776099T3 (https=) |
| PT (1) | PT1776099E (https=) |
| RU (1) | RU2404758C2 (https=) |
| SI (1) | SI1776099T1 (https=) |
| TN (1) | TNSN07038A1 (https=) |
| TW (1) | TW200616610A (https=) |
| WO (1) | WO2006013094A1 (https=) |
| ZA (1) | ZA200610639B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1891937A1 (en) * | 2006-08-25 | 2008-02-27 | Novartis AG | Galenic formulations of aliskiren |
| EP1927350A1 (en) * | 2006-11-24 | 2008-06-04 | Novartis AG | Methods for improving bioavailability of a renin inhibitor |
| CA2769392A1 (en) | 2009-07-31 | 2011-02-03 | Sandoz Ag | Method for the preparation of w-amino-alkaneamides and w-amino-alkanethioamides as well as intermediates of this method |
| WO2012010651A2 (en) | 2010-07-23 | 2012-01-26 | Sandoz Ag | Method for the preparation of omega-amino-alkaneamides and omega-amino-alkanethioamides as well as intermediates of this method |
| WO2014168255A1 (ja) * | 2013-04-12 | 2014-10-16 | 国立大学法人京都大学 | 巨核球の成熟化促進物質 |
| WO2015035218A1 (en) * | 2013-09-05 | 2015-03-12 | Howard University | Method of increasing the bioavailability of an hiv drug |
| JP6029621B2 (ja) * | 2014-07-14 | 2016-11-24 | ヤマサ醤油株式会社 | 血漿レニン活性の測定法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| IL108499A (en) | 1993-02-04 | 2000-02-29 | Lilly Co Eli | Mammalian influx peptide transporter |
| US5567592A (en) | 1994-02-02 | 1996-10-22 | Regents Of The University Of California | Screening method for the identification of bioenhancers through the inhibition of P-glycoprotein transport in the gut of a mammal |
| MY119161A (en) * | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
| CA2224227A1 (en) | 1995-06-07 | 1996-12-19 | Avmax, Inc. | Use of essential oils to increase bioavailability of oral pharmaceutical compounds |
| US5716928A (en) * | 1995-06-07 | 1998-02-10 | Avmax, Inc. | Use of essential oils to increase bioavailability of oral pharmaceutical compounds |
| US6245805B1 (en) * | 1995-10-26 | 2001-06-12 | Baker Norton Pharmaceuticals, Inc. | Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
| CN1143680C (zh) * | 1997-08-14 | 2004-03-31 | 阿旺蒂斯制药公司 | 增强非索非那定及其衍生物之生物利用度的方法 |
| JP2003512443A (ja) * | 1999-10-27 | 2003-04-02 | ベーカー ノートン ファーマシューティカルズ インコーポレイテッド | タキサンをヒト患者に経口投与するための方法及び組成物 |
| AU3808801A (en) * | 2000-02-11 | 2001-08-20 | Praecis Pharmaceuticals Incorporated | Methods for enhancing the bioavailability of a drug |
| WO2001092468A2 (en) * | 2000-05-31 | 2001-12-06 | Rutgers, The State University Of New Jersey | Novel compositions for the expression of the human peptide histidine transporter 1 and methods of use thereof |
| US7115565B2 (en) * | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
| GB0113663D0 (en) * | 2001-06-05 | 2001-07-25 | Novartis Ag | Use of organic compounds |
| KR20040066177A (ko) | 2001-12-19 | 2004-07-23 | 알자 코포레이션 | 친수성 거대분자의 경구 생체이용률을 증가시키기 위한제형 및 투여 형태 |
| US6869970B2 (en) * | 2002-02-04 | 2005-03-22 | Novartis Ag | Crystalline salt forms of valsartan |
| EP1501546B1 (de) * | 2002-05-03 | 2012-10-10 | Hexal AG | Stabile pharmazeutische formulierung für eine kombination aus einem statin mit einem ace-hemmer |
| PT1517682E (pt) * | 2002-06-28 | 2007-02-28 | Speedel Pharma Ag | Formulação farmacêutica compreendendo inibidor da renina não-peptídico e tensioactivo |
| NZ549535A (en) * | 2004-03-17 | 2010-11-26 | Novartis Ag | Use of aliskiren for treating renal and other disorders |
-
2005
- 2005-08-01 AR ARP050103198A patent/AR050043A1/es not_active Application Discontinuation
- 2005-08-01 PE PE2005000883A patent/PE20060416A1/es not_active Application Discontinuation
- 2005-08-02 BR BRPI0514021-8A patent/BRPI0514021A/pt not_active IP Right Cessation
- 2005-08-02 SI SI200530915T patent/SI1776099T1/sl unknown
- 2005-08-02 US US11/572,471 patent/US7709532B2/en not_active Expired - Fee Related
- 2005-08-02 MX MX2007001339A patent/MX2007001339A/es active IP Right Grant
- 2005-08-02 DE DE602005017905T patent/DE602005017905D1/de not_active Expired - Lifetime
- 2005-08-02 DK DK05769973.8T patent/DK1776099T3/da active
- 2005-08-02 AT AT05769973T patent/ATE449601T1/de active
- 2005-08-02 EP EP05769973A patent/EP1776099B1/en not_active Expired - Lifetime
- 2005-08-02 AU AU2005268844A patent/AU2005268844B2/en not_active Ceased
- 2005-08-02 WO PCT/EP2005/008369 patent/WO2006013094A1/en not_active Ceased
- 2005-08-02 JP JP2007524264A patent/JP5134366B2/ja not_active Expired - Fee Related
- 2005-08-02 CN CN2005800261744A patent/CN1993116B/zh not_active Expired - Fee Related
- 2005-08-02 TW TW094126194A patent/TW200616610A/zh unknown
- 2005-08-02 RU RU2007107850/15A patent/RU2404758C2/ru not_active IP Right Cessation
- 2005-08-02 PT PT05769973T patent/PT1776099E/pt unknown
- 2005-08-02 CA CA2572743A patent/CA2572743C/en not_active Expired - Fee Related
- 2005-08-02 HR HR20100064T patent/HRP20100064T1/hr unknown
- 2005-08-02 NZ NZ552903A patent/NZ552903A/en not_active IP Right Cessation
- 2005-08-02 PL PL05769973T patent/PL1776099T3/pl unknown
- 2005-08-02 MY MYPI20053584A patent/MY142180A/en unknown
- 2005-08-02 ES ES05769973T patent/ES2335597T3/es not_active Expired - Lifetime
- 2005-08-02 KR KR1020077002718A patent/KR20070040384A/ko not_active Abandoned
- 2005-08-02 EP EP09014648A patent/EP2191823A1/en not_active Withdrawn
-
2006
- 2006-12-18 ZA ZA200610639A patent/ZA200610639B/en unknown
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2007
- 2007-01-11 IL IL180678A patent/IL180678A/en not_active IP Right Cessation
- 2007-01-15 EC EC2007007169A patent/ECSP077169A/es unknown
- 2007-02-02 TN TNP2007000038A patent/TNSN07038A1/en unknown
- 2007-02-22 MA MA29709A patent/MA28821B1/fr unknown
- 2007-02-28 NO NO20071142A patent/NO20071142L/no not_active Application Discontinuation
-
2010
- 2010-01-05 CY CY20101100019T patent/CY1109826T1/el unknown
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20140804 |