CA2569183A1 - Methods and compositions for the inhibition of gene expression - Google Patents
Methods and compositions for the inhibition of gene expression Download PDFInfo
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- CA2569183A1 CA2569183A1 CA002569183A CA2569183A CA2569183A1 CA 2569183 A1 CA2569183 A1 CA 2569183A1 CA 002569183 A CA002569183 A CA 002569183A CA 2569183 A CA2569183 A CA 2569183A CA 2569183 A1 CA2569183 A1 CA 2569183A1
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Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/33—Chemical structure of the base
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Landscapes
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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| US10/858,164 US7524827B2 (en) | 2004-06-01 | 2004-06-01 | Methods and compositions for the inhibition of gene expression |
| US10/858,094 | 2004-06-01 | ||
| US10/858,146 | 2004-06-01 | ||
| US10/858,145 US7498315B2 (en) | 2004-06-01 | 2004-06-01 | Methods and compositions for the inhibition of gene expression |
| US10/858,094 US20080152700A1 (en) | 2004-06-01 | 2004-06-01 | Methods and compositions for the inhibition of gene expression |
| US10/858,013 | 2004-06-01 | ||
| US10/858,341 US20050287667A1 (en) | 2004-06-01 | 2004-06-01 | Methods and compositions for the inhibition of gene expression |
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| US7498315B2 (en) * | 2004-06-01 | 2009-03-03 | Pronai Therapeutics, Inc. | Methods and compositions for the inhibition of gene expression |
| US8815599B2 (en) | 2004-06-01 | 2014-08-26 | Pronai Therapeutics, Inc. | Methods and compositions for the inhibition of gene expression |
| CA2631677C (en) * | 2005-12-01 | 2014-08-12 | Pronai Therapeutics, Inc. | Amphoteric liposome formulation |
| EP1971371B1 (en) * | 2005-12-01 | 2015-08-05 | Pronai Therapeutics, Inc. | Cancer therapies and pharmaceutical compositions used therein |
| EP2302395B1 (en) * | 2006-06-07 | 2015-04-15 | Health Diagnostic Laboratory, Inc. | Markers associated with arteriovascular events and methods of use thereof |
| EP2121925A2 (en) * | 2007-03-02 | 2009-11-25 | MDRNA, Inc. | Nucleic acid compounds for inhibiting ras gene expression and uses thereof |
| US9023819B2 (en) * | 2008-06-09 | 2015-05-05 | National Chung Cheng University | Treatment of a disease or a condition associated with aberrant gene hypomethylation by a method involving tailored epigenomic modification |
| WO2011078301A1 (ja) * | 2009-12-25 | 2011-06-30 | ファーマロジカルズ・リサーチ プライベート リミテッド | Nog樹立癌細胞株が移植された非ヒト動物モデルを用いた抗癌剤ターゲット探索及びスクリーニング法 |
| JP6230789B2 (ja) | 2010-10-06 | 2017-11-15 | 中外製薬株式会社 | 癌幹細胞集団及びその作製方法 |
| US9095606B1 (en) | 2010-11-13 | 2015-08-04 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
| US9066974B1 (en) | 2010-11-13 | 2015-06-30 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
| US8597695B1 (en) | 2010-11-13 | 2013-12-03 | Sirbal Ltd. | Herbal combinations for treatment of a skin condition |
| US8541382B2 (en) | 2010-11-13 | 2013-09-24 | Sirbal Ltd. | Cardiac glycoside analogs in combination with emodin for cancer therapy |
| US20170049687A1 (en) | 2015-07-29 | 2017-02-23 | Sirbal Ltd. | Herbal Combinations For Treating Scalp Conditions |
| JP6077997B2 (ja) | 2011-09-07 | 2017-02-08 | 中外製薬株式会社 | 癌幹細胞の分離 |
| US20140302511A1 (en) | 2011-10-28 | 2014-10-09 | Pharmalogicals Research Pte. Ltd. | Cancer stem cell-specific molecule |
| ITMI20120275A1 (it) * | 2012-02-24 | 2013-08-25 | Biogenera Societa A Responsabilita Limitata | Oligonucleotidi per la modulazione dell'espressione genica e loro usi |
| WO2013183964A1 (ko) * | 2012-06-07 | 2013-12-12 | 한양대학교 산학협력단 | 폐암 진단 및 치료를 위한 표적 단백질 |
| LT4406594T (lt) | 2012-09-17 | 2025-12-29 | Madrigal Pharmaceuticals, Inc. | Skydliaukės hormono analogai |
| BR112015010220A2 (pt) | 2012-11-05 | 2017-12-05 | Pronai Therapeutics Inc | métodos de utilização de biomarcadores para tratamento de câncer |
| US20160040163A1 (en) * | 2013-03-15 | 2016-02-11 | Pronai Therapeutics, Inc. | Dnai for the modulation of genes |
| EP3076984B1 (en) | 2013-12-02 | 2018-11-14 | Sirbal Ltd. | Herbal combinations for treatment of a skin condition |
| US10266828B2 (en) | 2013-12-16 | 2019-04-23 | Syddansk Universitet | RAS exon 2 skipping for cancer treatment |
| CN105581979A (zh) * | 2016-02-24 | 2016-05-18 | 南京大学 | 一种抑制her-2表达的核酸脂质体纳米药物及其制备方法和应用 |
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| US20210100828A1 (en) * | 2017-05-04 | 2021-04-08 | Sanofi | Methods for Treatment of Alport Syndrome |
| JP7427227B2 (ja) * | 2020-01-21 | 2024-02-05 | 学校法人産業医科大学 | 腫瘍細胞の生存を低下させるｋｒａｓアンチセンスオリゴヌクレオチド及びその用途 |
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2004
- 2004-06-01 US US10/858,145 patent/US7498315B2/en not_active Expired - Fee Related
- 2004-06-01 US US10/858,094 patent/US20080152700A1/en not_active Abandoned
- 2004-06-01 US US10/858,341 patent/US20050287667A1/en not_active Abandoned
- 2004-06-01 US US10/858,013 patent/US20060135455A1/en not_active Abandoned
- 2004-06-01 US US10/858,146 patent/US20060229267A1/en not_active Abandoned
- 2004-06-01 US US10/858,164 patent/US7524827B2/en not_active Expired - Fee Related
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- 2005-06-01 JP JP2007515472A patent/JP4906717B2/ja not_active Expired - Fee Related
- 2005-06-01 CA CA002569183A patent/CA2569183A1/en not_active Abandoned
- 2005-06-01 EP EP09171679A patent/EP2141173B1/en not_active Expired - Lifetime
- 2005-06-01 WO PCT/US2005/018993 patent/WO2005118824A2/en not_active Ceased
- 2005-06-01 EP EP05804859A patent/EP1773859A4/en not_active Withdrawn
- 2005-06-01 PL PL09171679T patent/PL2141173T3/pl unknown
- 2005-06-01 ES ES09171679T patent/ES2402532T3/es not_active Expired - Lifetime
- 2005-06-01 CN CN200580025490XA patent/CN101014608B/zh not_active Expired - Fee Related
- 2005-06-01 AU AU2005250453A patent/AU2005250453B2/en not_active Ceased
- 2005-06-01 BR BRPI0511770-4A patent/BRPI0511770A/pt not_active IP Right Cessation
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| ES2402532T3 (es) | 2013-05-06 |
| EP1773859A4 (en) | 2008-03-26 |
| BRPI0511770A (pt) | 2008-01-08 |
| HK1107098A1 (en) | 2008-03-28 |
| JP2012085642A (ja) | 2012-05-10 |
| WO2005118824A3 (en) | 2006-11-09 |
| AU2005250453A1 (en) | 2005-12-15 |
| EP2141173A1 (en) | 2010-01-06 |
| PL2141173T3 (pl) | 2013-08-30 |
| US20080152700A1 (en) | 2008-06-26 |
| JP4906717B2 (ja) | 2012-03-28 |
| US7498315B2 (en) | 2009-03-03 |
| JP5922913B2 (ja) | 2016-05-24 |
| US20060198828A1 (en) | 2006-09-07 |
| JP2015133967A (ja) | 2015-07-27 |
| WO2005118824A2 (en) | 2005-12-15 |
| WO2005118824A8 (en) | 2007-01-25 |
| US7524827B2 (en) | 2009-04-28 |
| US20060229267A1 (en) | 2006-10-12 |
| US20060073596A1 (en) | 2006-04-06 |
| CN101014608A (zh) | 2007-08-08 |
| EP1773859A2 (en) | 2007-04-18 |
| JP2008500838A (ja) | 2008-01-17 |
| WO2005118824A9 (en) | 2006-06-15 |
| CN101014608B (zh) | 2011-07-06 |
| US20060135455A1 (en) | 2006-06-22 |
| EP2141173B1 (en) | 2013-01-02 |
| US20050287667A1 (en) | 2005-12-29 |
| AU2005250453B2 (en) | 2012-02-23 |
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