CA2562151C - Oligonucleotides comprising a c5-modified pyrimidine - Google Patents

Oligonucleotides comprising a c5-modified pyrimidine Download PDF

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Publication number
CA2562151C
CA2562151C CA2562151A CA2562151A CA2562151C CA 2562151 C CA2562151 C CA 2562151C CA 2562151 A CA2562151 A CA 2562151A CA 2562151 A CA2562151 A CA 2562151A CA 2562151 C CA2562151 C CA 2562151C
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occurrence
represents independently
alkyl
gene
independently
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CA2562151A
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English (en)
French (fr)
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CA2562151A1 (en
Inventor
Muthiah Manoharan
Kallanthottathil G. Rajeev
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Alnylam Pharmaceuticals Inc
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Alnylam Pharmaceuticals Inc
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    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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CA2562151A 2004-04-30 2005-04-29 Oligonucleotides comprising a c5-modified pyrimidine Expired - Lifetime CA2562151C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US56671004P 2004-04-30 2004-04-30
US60/566,710 2004-04-30
US62027604P 2004-10-20 2004-10-20
US60/620,276 2004-10-20
PCT/US2005/015305 WO2006073458A2 (en) 2004-04-30 2005-04-29 Oligonucleotides comprising a c5-modified pyrimidine

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CA2562151A1 CA2562151A1 (en) 2006-04-13
CA2562151C true CA2562151C (en) 2016-09-06

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CA2562151A Expired - Lifetime CA2562151C (en) 2004-04-30 2005-04-29 Oligonucleotides comprising a c5-modified pyrimidine

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US (1) US7674778B2 (enExample)
EP (2) EP1750776A2 (enExample)
JP (1) JP4584987B2 (enExample)
AU (1) AU2005323437B2 (enExample)
CA (1) CA2562151C (enExample)
WO (1) WO2006073458A2 (enExample)

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WO2006078278A2 (en) 2004-04-27 2006-07-27 Alnylam Pharmaceuticals, Inc. Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety
HUE037173T2 (hu) * 2006-08-08 2018-08-28 Univ Bonn Rheinische Friedrich Wilhelms 5'-Foszfát-oligonukleotidok szerkezete és alkalmazása
EP2088865B1 (en) * 2006-11-06 2015-10-21 Jina Pharmaceuticals Inc. Guggulphospholipid methods and compositions
CA2711003C (en) * 2006-12-29 2017-02-21 Georgetown University Targeting of ews-fli1 as anti-tumor therapy
US8232310B2 (en) 2006-12-29 2012-07-31 Georgetown University Targeting of EWS-FLI1 as anti-tumor therapy
US7964356B2 (en) * 2007-01-16 2011-06-21 Somalogic, Inc. Method for generating aptamers with improved off-rates
US7947447B2 (en) 2007-01-16 2011-05-24 Somalogic, Inc. Method for generating aptamers with improved off-rates
US20110136099A1 (en) 2007-01-16 2011-06-09 Somalogic, Inc. Multiplexed Analyses of Test Samples
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WO2006073458A8 (en) 2006-11-16
AU2005323437B2 (en) 2011-10-06
US20050288244A1 (en) 2005-12-29
JP4584987B2 (ja) 2010-11-24
CA2562151A1 (en) 2006-04-13
JP2007535922A (ja) 2007-12-13
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EP1750776A2 (en) 2007-02-14
AU2005323437A2 (en) 2008-06-19

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