CA2561685C - Method of soft tissue augmentation - Google Patents
Method of soft tissue augmentation Download PDFInfo
- Publication number
- CA2561685C CA2561685C CA2561685A CA2561685A CA2561685C CA 2561685 C CA2561685 C CA 2561685C CA 2561685 A CA2561685 A CA 2561685A CA 2561685 A CA2561685 A CA 2561685A CA 2561685 C CA2561685 C CA 2561685C
- Authority
- CA
- Canada
- Prior art keywords
- particles
- implant
- soft tissue
- range
- tissue augmentation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000003416 augmentation Effects 0.000 title claims abstract description 64
- 210000004872 soft tissue Anatomy 0.000 title claims abstract description 54
- 238000000034 method Methods 0.000 title claims abstract description 36
- 239000002245 particle Substances 0.000 claims abstract description 101
- 239000007943 implant Substances 0.000 claims abstract description 64
- 239000007863 gel particle Substances 0.000 claims abstract description 54
- 239000012266 salt solution Substances 0.000 claims abstract description 28
- 241000124008 Mammalia Species 0.000 claims abstract description 25
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 35
- 229920002674 hyaluronan Polymers 0.000 claims description 35
- 229960003160 hyaluronic acid Drugs 0.000 claims description 35
- 210000001519 tissue Anatomy 0.000 claims description 19
- 239000003814 drug Substances 0.000 claims description 18
- 230000001225 therapeutic effect Effects 0.000 claims description 15
- 238000004519 manufacturing process Methods 0.000 claims description 11
- 230000001815 facial effect Effects 0.000 claims description 10
- 238000007920 subcutaneous administration Methods 0.000 claims description 6
- 239000002365 multiple layer Substances 0.000 claims description 2
- 239000000499 gel Substances 0.000 description 33
- 239000000243 solution Substances 0.000 description 14
- 238000011282 treatment Methods 0.000 description 13
- 150000004676 glycans Chemical class 0.000 description 12
- 239000000463 material Substances 0.000 description 12
- 229920001282 polysaccharide Polymers 0.000 description 12
- 239000005017 polysaccharide Substances 0.000 description 12
- 238000002513 implantation Methods 0.000 description 11
- 238000002347 injection Methods 0.000 description 11
- 239000007924 injection Substances 0.000 description 11
- 229940090044 injection Drugs 0.000 description 10
- 238000013508 migration Methods 0.000 description 9
- 230000005012 migration Effects 0.000 description 9
- 239000003431 cross linking reagent Substances 0.000 description 8
- 230000004962 physiological condition Effects 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 229920001954 Restylane Polymers 0.000 description 7
- 238000001727 in vivo Methods 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 239000002537 cosmetic Substances 0.000 description 6
- 238000004132 cross linking Methods 0.000 description 6
- 238000006073 displacement reaction Methods 0.000 description 6
- 210000000481 breast Anatomy 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 4
- 210000004207 dermis Anatomy 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 210000003491 skin Anatomy 0.000 description 4
- 239000002002 slurry Substances 0.000 description 4
- SHKUUQIDMUMQQK-UHFFFAOYSA-N 2-[4-(oxiran-2-ylmethoxy)butoxymethyl]oxirane Chemical compound C1OC1COCCCCOCC1CO1 SHKUUQIDMUMQQK-UHFFFAOYSA-N 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000012937 correction Methods 0.000 description 3
- 230000002500 effect on skin Effects 0.000 description 3
- 238000000855 fermentation Methods 0.000 description 3
- 230000004151 fermentation Effects 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
- 238000005360 mashing Methods 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 239000003190 viscoelastic substance Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 2
- 229920001287 Chondroitin sulfate Polymers 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 229920002683 Glycosaminoglycan Polymers 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 241000194017 Streptococcus Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 238000001949 anaesthesia Methods 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000003146 anticoagulant agent Substances 0.000 description 2
- 229940127219 anticoagulant drug Drugs 0.000 description 2
- 238000006065 biodegradation reaction Methods 0.000 description 2
- 229940059329 chondroitin sulfate Drugs 0.000 description 2
- 238000002316 cosmetic surgery Methods 0.000 description 2
- GYZLOYUZLJXAJU-UHFFFAOYSA-N diglycidyl ether Chemical class C1OC1COCC1CO1 GYZLOYUZLJXAJU-UHFFFAOYSA-N 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 229920000669 heparin Polymers 0.000 description 2
- 229960002897 heparin Drugs 0.000 description 2
- 230000002163 immunogen Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 229960004194 lidocaine Drugs 0.000 description 2
- 229960005015 local anesthetics Drugs 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 206010033675 panniculitis Diseases 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 238000010254 subcutaneous injection Methods 0.000 description 2
- 239000007929 subcutaneous injection Substances 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 108030001720 Bontoxilysin Proteins 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 229920001076 Cutan Polymers 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 229920001605 Dextranomer Polymers 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010024604 Lipoatrophy Diseases 0.000 description 1
- 208000006735 Periostitis Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 229940127218 antiplatelet drug Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 229940053031 botulinum toxin Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000009109 curative therapy Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 229960002864 dextranomer Drugs 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical class C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000007515 enzymatic degradation Effects 0.000 description 1
- 150000002118 epoxides Chemical class 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 230000000762 glandular Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 229940072322 hylan Drugs 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 238000009607 mammography Methods 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000002976 pectoralis muscle Anatomy 0.000 description 1
- 210000003460 periosteum Anatomy 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000000106 platelet aggregation inhibitor Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000002278 reconstructive surgery Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000003319 supportive effect Effects 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 229940006076 viscoelastic substance Drugs 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/52—Water-repellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/58—Adhesives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56025804P | 2004-04-08 | 2004-04-08 | |
| US60/560258 | 2004-04-08 | ||
| PCT/SE2005/000504 WO2005097218A2 (en) | 2004-04-08 | 2005-04-07 | Particles for soft tissue augmentation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2561685A1 CA2561685A1 (en) | 2005-10-20 |
| CA2561685C true CA2561685C (en) | 2013-03-12 |
Family
ID=34964714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2561685A Expired - Lifetime CA2561685C (en) | 2004-04-08 | 2005-04-07 | Method of soft tissue augmentation |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US20050226936A1 (https=) |
| EP (1) | EP1734894B2 (https=) |
| JP (2) | JP5074182B2 (https=) |
| KR (1) | KR101236363B1 (https=) |
| CN (2) | CN101897993A (https=) |
| AU (1) | AU2005231674B2 (https=) |
| BR (1) | BRPI0509678A (https=) |
| CA (1) | CA2561685C (https=) |
| ES (1) | ES2599329T3 (https=) |
| MX (1) | MXPA06011386A (https=) |
| RU (1) | RU2363496C2 (https=) |
| WO (1) | WO2005097218A2 (https=) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7338433B2 (en) | 2002-08-13 | 2008-03-04 | Allergan, Inc. | Remotely adjustable gastric banding method |
| ES2617452T3 (es) | 2002-08-28 | 2017-06-19 | Apollo Endosurgery, Inc | Dispositivo de banda gástrica resistente a la fatiga |
| FR2850282B1 (fr) | 2003-01-27 | 2007-04-06 | Jerome Asius | Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation |
| FR2861734B1 (fr) | 2003-04-10 | 2006-04-14 | Corneal Ind | Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus |
| WO2005087147A1 (en) | 2004-03-08 | 2005-09-22 | Endoart S.A. | Closure system for tubular organs |
| AU2004317849B2 (en) | 2004-03-18 | 2011-03-31 | Allergan, Inc. | Apparatus and method for volume adjustment of intragastric balloons |
| US20050226936A1 (en) | 2004-04-08 | 2005-10-13 | Q-Med Ab | Method of soft tissue augmentation |
| US8251888B2 (en) | 2005-04-13 | 2012-08-28 | Mitchell Steven Roslin | Artificial gastric valve |
| US8043206B2 (en) | 2006-01-04 | 2011-10-25 | Allergan, Inc. | Self-regulating gastric band with pressure data processing |
| US7798954B2 (en) | 2006-01-04 | 2010-09-21 | Allergan, Inc. | Hydraulic gastric band with collapsible reservoir |
| KR100820151B1 (ko) | 2007-02-20 | 2008-04-08 | 엘지전자 주식회사 | 덕트리스 건조기 |
| US20080293637A1 (en) | 2007-05-23 | 2008-11-27 | Allergan, Inc. | Cross-linked collagen and uses thereof |
| US7942930B2 (en) | 2007-06-15 | 2011-05-17 | Q-Med Ab | Biocompatible implant system and method |
| FR2918377B1 (fr) | 2007-07-05 | 2010-10-08 | Estelle Piron | Gel co-reticule de polysaccharides |
| US8318695B2 (en) | 2007-07-30 | 2012-11-27 | Allergan, Inc. | Tunably crosslinked polysaccharide compositions |
| WO2009044403A2 (en) * | 2007-10-05 | 2009-04-09 | Juvenis Ltd. | Injectable biodegradable polymer compositions for soft tissue repair and augmentation |
| US8697044B2 (en) | 2007-10-09 | 2014-04-15 | Allergan, Inc. | Crossed-linked hyaluronic acid and collagen and uses thereof |
| JP5670196B2 (ja) | 2007-11-16 | 2015-02-18 | バイセプト セラピューティクス、インク． | 紫斑を治療する組成物および方法 |
| US8394782B2 (en) | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having increased longevity |
| WO2009079555A2 (en) | 2007-12-17 | 2009-06-25 | Anna Love | Soft tissue filler |
| CN101502675B (zh) * | 2008-02-04 | 2013-02-13 | 山东省药学科学院 | 一种注射用含大分子水凝胶的透明质酸或其盐的混悬液及其制备方法 |
| US8357795B2 (en) | 2008-08-04 | 2013-01-22 | Allergan, Inc. | Hyaluronic acid-based gels including lidocaine |
| ES2658609T3 (es) | 2008-09-02 | 2018-03-12 | Tautona Group Lp | Hilos de ácido hialurónico y/o derivados de los mismos, métodos para fabricar los mismos, y usos de los mismos |
| CN101366978B (zh) * | 2008-09-03 | 2013-06-05 | 陕西瑞盛生物科技有限公司 | 可注射用的微粒组织充填材料及其制备方法 |
| EP2362762A1 (en) | 2008-10-06 | 2011-09-07 | Allergan Medical Sàrl | Mechanical gastric band with cushions |
| US20100185049A1 (en) | 2008-10-22 | 2010-07-22 | Allergan, Inc. | Dome and screw valves for remotely adjustable gastric banding systems |
| US20110172180A1 (en) | 2010-01-13 | 2011-07-14 | Allergan Industrie. Sas | Heat stable hyaluronic acid compositions for dermatological use |
| US8758221B2 (en) | 2010-02-24 | 2014-06-24 | Apollo Endosurgery, Inc. | Source reservoir with potential energy for remotely adjustable gastric banding system |
| US8840541B2 (en) | 2010-02-25 | 2014-09-23 | Apollo Endosurgery, Inc. | Pressure sensing gastric banding system |
| KR101764451B1 (ko) | 2010-03-12 | 2017-08-02 | 알러간 인더스트리 에스에이에스 | 피부 상태 개선을 위한 히알루론안 폴리머 및 만니톨을 포함하는 유체 조성물 |
| EP3078388B1 (en) | 2010-03-22 | 2019-02-20 | Allergan, Inc. | Cross-linked hydrogels for soft tissue augmentation |
| US20110270024A1 (en) | 2010-04-29 | 2011-11-03 | Allergan, Inc. | Self-adjusting gastric band having various compliant components |
| US9028394B2 (en) | 2010-04-29 | 2015-05-12 | Apollo Endosurgery, Inc. | Self-adjusting mechanical gastric band |
| US20110270025A1 (en) | 2010-04-30 | 2011-11-03 | Allergan, Inc. | Remotely powered remotely adjustable gastric band system |
| US8517915B2 (en) | 2010-06-10 | 2013-08-27 | Allergan, Inc. | Remotely adjustable gastric banding system |
| US9005605B2 (en) | 2010-08-19 | 2015-04-14 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US8697057B2 (en) | 2010-08-19 | 2014-04-15 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US8883139B2 (en) | 2010-08-19 | 2014-11-11 | Allergan Inc. | Compositions and soft tissue replacement methods |
| US20120059216A1 (en) | 2010-09-07 | 2012-03-08 | Allergan, Inc. | Remotely adjustable gastric banding system |
| US8961393B2 (en) | 2010-11-15 | 2015-02-24 | Apollo Endosurgery, Inc. | Gastric band devices and drive systems |
| FR2968305B1 (fr) * | 2010-12-06 | 2014-02-28 | Teoxane | Procede de preparation d'un gel reticule |
| US9393263B2 (en) | 2011-06-03 | 2016-07-19 | Allergan, Inc. | Dermal filler compositions including antioxidants |
| KR102238406B1 (ko) | 2011-06-03 | 2021-04-08 | 알러간 인더스트리 에스에이에스 | 항산화제를 포함하는 피부 충전제 조성물 |
| US9408797B2 (en) | 2011-06-03 | 2016-08-09 | Allergan, Inc. | Dermal filler compositions for fine line treatment |
| US20130096081A1 (en) | 2011-06-03 | 2013-04-18 | Allergan, Inc. | Dermal filler compositions |
| US20130244943A1 (en) | 2011-09-06 | 2013-09-19 | Allergan, Inc. | Hyaluronic acid-collagen matrices for dermal filling and volumizing applications |
| US9662422B2 (en) | 2011-09-06 | 2017-05-30 | Allergan, Inc. | Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation |
| US8876694B2 (en) | 2011-12-07 | 2014-11-04 | Apollo Endosurgery, Inc. | Tube connector with a guiding tip |
| KR20210071106A (ko) * | 2011-12-08 | 2021-06-15 | 알러간 인더스트리 에스에이에스 | 진피 필러 조성물 |
| US8961394B2 (en) | 2011-12-20 | 2015-02-24 | Apollo Endosurgery, Inc. | Self-sealing fluid joint for use with a gastric band |
| EP2827914B1 (en) * | 2012-03-22 | 2019-05-08 | TRB Chemedica International S.A. | Method for repair of ligament or tendon |
| BR112014031412B1 (pt) * | 2012-06-15 | 2021-01-05 | Merz Pharma Gmbh & Co. Kgaa | método de preparação de uma composição |
| US9907740B2 (en) * | 2013-01-17 | 2018-03-06 | Jeffrey Hagel | Increasing muscular volume in a human using hyaluronic acid |
| WO2015112907A1 (en) * | 2014-01-27 | 2015-07-30 | Allergan Holdings France S.A.S. | Spherical forms of cross-linked hyaluronic acid and methods of use thereof |
| US9164280B1 (en) * | 2014-06-25 | 2015-10-20 | Topray Mems Inc. | Dust-proof assembly for lens driving device |
| EP3200838B1 (en) | 2014-09-30 | 2019-09-18 | Allergan Industrie, SAS | Stable hydrogel compositions including additives |
| WO2016128783A1 (en) | 2015-02-09 | 2016-08-18 | Allergan Industrie Sas | Compositions and methods for improving skin appearance |
| HUE047971T2 (hu) | 2015-02-13 | 2020-05-28 | Allergan Ind Sas | Az arcelemek - például az áll - formázására, megnagyobbítására vagy korrekciójára szolgáló implantátumok |
| US9737395B2 (en) | 2015-06-26 | 2017-08-22 | Phi Nguyen | Systems and methods for reducing scarring |
| DE102015009271A1 (de) * | 2015-07-19 | 2017-01-19 | Tracey Lennemann | Neue Verwendung von Hyaluronsäure |
| EP3328351A1 (en) * | 2015-07-27 | 2018-06-06 | Galderma S.A. | A process for efficient cross-linking of hyaluronic acid |
| RU2601918C2 (ru) * | 2015-08-25 | 2016-11-10 | Частное учреждение образовательная организация высшего образования "Медицинский университет "Реавиз" | Способ увеличения объема мягких тканей с использованием свободного соединительнотканного аутотрансплантата при установке формирователей десны на дентальные имплантаты |
| CA2961868A1 (en) * | 2016-04-08 | 2017-10-08 | Johnson & Johnson Consumer Inc. | Topical compositions containing cross-linked glycosaminoglycans |
| RU2638711C1 (ru) * | 2016-12-14 | 2017-12-15 | Частное учреждение образовательная организация высшего образования "Медицинский университет "Реавиз" | Способ восстановления десневого сосочка при установке формирователей десны на дентальные имплантаты |
| RU2691538C1 (ru) * | 2018-04-13 | 2019-06-14 | Частное учреждение образовательная организация высшего образования "Медицинский университет "Реавиз" | Способ пластики мягких тканей в области адентии при одномоментной установке дентального имплантата и постоянного индивидуального абатмента в условиях толстого биотипа десны |
| EP3787702B1 (en) | 2018-05-03 | 2024-08-07 | CollPlant Ltd. | Dermal fillers and applications thereof |
| RU2691566C1 (ru) * | 2018-09-24 | 2019-06-14 | Частное учреждение образовательная организация высшего образования "Медицинский университет "Реавиз" | Способ устранения недостаточности мягких тканей вокруг установленного имплантата на верхней челюсти |
| CN113226388B (zh) | 2018-12-21 | 2023-07-25 | 株式会社Lg化学 | 具有优异的填充性能的包含透明质酸水凝胶的填充剂 |
| JP2022530895A (ja) * | 2019-05-03 | 2022-07-04 | パレット ライフ サイエンシーズ，インク． | 改善された組織スペーサー |
| AR128245A1 (es) | 2022-01-11 | 2024-04-10 | Gpq S R L | Nuevos derivados de ácido hialurónico como rellenos innovadores |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US402031A (en) * | 1889-04-23 | Scarf-protector | ||
| JPS60502087A (ja) * | 1983-08-31 | 1985-12-05 | キングストン・テクノロジーズ・インコーポレーテッド | 注入可能な、生理学的に受容できるポリマ−組成物 |
| SE442820B (sv) | 1984-06-08 | 1986-02-03 | Pharmacia Ab | Gel av tverbunden hyaluronsyra for anvendning som glaskroppssubstitut |
| US4657548A (en) * | 1984-09-11 | 1987-04-14 | Helitrex, Inc. | Delivery system for implantation of fine particles in surgical procedures |
| US4642117A (en) | 1985-03-22 | 1987-02-10 | Collagen Corporation | Mechanically sheared collagen implant material and method |
| US4803075A (en) * | 1986-06-25 | 1989-02-07 | Collagen Corporation | Injectable implant composition having improved intrudability |
| US4969901A (en) * | 1988-06-28 | 1990-11-13 | Binder William J | Plastic surgery implant |
| US5007940A (en) * | 1989-06-09 | 1991-04-16 | American Medical Systems, Inc. | Injectable polymeric bodies |
| US5246698A (en) * | 1990-07-09 | 1993-09-21 | Biomatrix, Inc. | Biocompatible viscoelastic gel slurries, their preparation and use |
| US6537574B1 (en) * | 1992-02-11 | 2003-03-25 | Bioform, Inc. | Soft tissue augmentation material |
| IT1260148B (it) * | 1992-04-17 | 1996-03-28 | Fidia Spa | Impiego di preparazioni di acido ialuronico per la formazione di tessuto osseo |
| JP3107726B2 (ja) | 1994-05-13 | 2000-11-13 | 株式会社クラレ | 水膨潤性高分子ゲル |
| US5658592A (en) | 1994-05-13 | 1997-08-19 | Kuraray Co., Ltd. | Medical crosslinked polymer gel of carboxylic polysaccharide and diaminoalkane |
| US5451406A (en) * | 1994-07-14 | 1995-09-19 | Advanced Uroscience, Inc. | Tissue injectable composition and method of use |
| UA10911C2 (uk) * | 1994-08-10 | 1996-12-25 | Мале Впроваджувальне Підприємство "Іhтерфалл" | Біосумісhий гідрогель |
| ES2161825T3 (es) * | 1995-03-07 | 2001-12-16 | Ethicon Inc | Medio para aumentar la funcion del esfinter de expansion controlada. |
| US5827937A (en) * | 1995-07-17 | 1998-10-27 | Q Med Ab | Polysaccharide gel composition |
| IT1288290B1 (it) * | 1996-06-21 | 1998-09-11 | Fidia Spa In Amministrazione S | Acido ialuronico autoreticolato e relative composizioni farmaceutiche per il trattamento delle artropatie |
| US6066325A (en) | 1996-08-27 | 2000-05-23 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
| US6063061A (en) * | 1996-08-27 | 2000-05-16 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
| BG102375A (en) * | 1997-08-26 | 1999-11-30 | Пегас Оод | Inoculation biocompatible hydrophilic gel, method for its preparation and application |
| JP2000239147A (ja) * | 1999-02-18 | 2000-09-05 | Naris Cosmetics Co Ltd | 化粧料 |
| US6277392B1 (en) * | 1999-09-16 | 2001-08-21 | Carbon Medical Technologies, Inc. | Tissue injectable composition |
| US6436424B1 (en) * | 2000-03-20 | 2002-08-20 | Biosphere Medical, Inc. | Injectable and swellable microspheres for dermal augmentation |
| WO2002011696A2 (en) * | 2000-08-08 | 2002-02-14 | Ev & M | Active tissue augmentation materials and method |
| US6679012B1 (en) | 2002-06-26 | 2004-01-20 | Ching-Shyang Chen | Earthquake energy eliminator |
| NZ538266A (en) | 2002-08-16 | 2007-05-31 | Denki Kagaku Kogyo Kk | Separate type medical material |
| JP2004181121A (ja) * | 2002-12-06 | 2004-07-02 | Denki Kagaku Kogyo Kk | 軟骨組織再生用注入剤組成物 |
| FR2850282B1 (fr) * | 2003-01-27 | 2007-04-06 | Jerome Asius | Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation |
| EP1610674A4 (en) * | 2003-03-13 | 2008-05-21 | Cheryl M Burgess | METHODS OF ADMINISTERING MATERIAL TO PATIENT TO OBTAIN DERMAL IMPROVEMENT |
| SE526878C2 (sv) * | 2003-06-18 | 2005-11-15 | Q Med Ab | Medicinsk pump |
| US8124120B2 (en) * | 2003-12-22 | 2012-02-28 | Anika Therapeutics, Inc. | Crosslinked hyaluronic acid compositions for tissue augmentation |
| US20050226936A1 (en) | 2004-04-08 | 2005-10-13 | Q-Med Ab | Method of soft tissue augmentation |
| US7942930B2 (en) | 2007-06-15 | 2011-05-17 | Q-Med Ab | Biocompatible implant system and method |
| US8357795B2 (en) | 2008-08-04 | 2013-01-22 | Allergan, Inc. | Hyaluronic acid-based gels including lidocaine |
-
2005
- 2005-03-28 US US11/090,141 patent/US20050226936A1/en not_active Abandoned
- 2005-04-07 ES ES05732235.6T patent/ES2599329T3/es not_active Expired - Lifetime
- 2005-04-07 RU RU2006139141/15A patent/RU2363496C2/ru active
- 2005-04-07 MX MXPA06011386A patent/MXPA06011386A/es active IP Right Grant
- 2005-04-07 EP EP05732235.6A patent/EP1734894B2/en not_active Expired - Lifetime
- 2005-04-07 KR KR1020067023389A patent/KR101236363B1/ko not_active Expired - Lifetime
- 2005-04-07 BR BRPI0509678-2A patent/BRPI0509678A/pt not_active Application Discontinuation
- 2005-04-07 CN CN2010101140542A patent/CN101897993A/zh active Pending
- 2005-04-07 CA CA2561685A patent/CA2561685C/en not_active Expired - Lifetime
- 2005-04-07 CN CN2005800141032A patent/CN1950039B/zh not_active Expired - Lifetime
- 2005-04-07 JP JP2007507278A patent/JP5074182B2/ja not_active Expired - Lifetime
- 2005-04-07 AU AU2005231674A patent/AU2005231674B2/en not_active Expired
- 2005-04-07 WO PCT/SE2005/000504 patent/WO2005097218A2/en not_active Ceased
-
2012
- 2012-06-28 JP JP2012145051A patent/JP2012179467A/ja active Pending
-
2014
- 2014-01-31 US US14/169,381 patent/US20140147479A1/en not_active Abandoned
-
2017
- 2017-11-02 US US15/801,931 patent/US20180093017A1/en not_active Abandoned
-
2019
- 2019-10-04 US US16/593,941 patent/US11458226B2/en not_active Expired - Lifetime
-
2022
- 2022-09-09 US US17/941,713 patent/US11992580B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070017172A (ko) | 2007-02-08 |
| AU2005231674A1 (en) | 2005-10-20 |
| WO2005097218A2 (en) | 2005-10-20 |
| RU2006139141A (ru) | 2008-05-20 |
| JP2007532173A (ja) | 2007-11-15 |
| US20050226936A1 (en) | 2005-10-13 |
| JP5074182B2 (ja) | 2012-11-14 |
| US20140147479A1 (en) | 2014-05-29 |
| JP2012179467A (ja) | 2012-09-20 |
| CN1950039B (zh) | 2010-05-05 |
| EP1734894B1 (en) | 2016-08-03 |
| BRPI0509678A (pt) | 2007-10-09 |
| AU2005231674B2 (en) | 2010-09-09 |
| CA2561685A1 (en) | 2005-10-20 |
| CN101897993A (zh) | 2010-12-01 |
| EP1734894A2 (en) | 2006-12-27 |
| EP1734894B2 (en) | 2023-05-17 |
| US20230211051A1 (en) | 2023-07-06 |
| ES2599329T3 (es) | 2017-02-01 |
| US20200030494A1 (en) | 2020-01-30 |
| US11458226B2 (en) | 2022-10-04 |
| US20180093017A1 (en) | 2018-04-05 |
| MXPA06011386A (es) | 2006-12-20 |
| CN1950039A (zh) | 2007-04-18 |
| KR101236363B1 (ko) | 2013-02-22 |
| RU2363496C2 (ru) | 2009-08-10 |
| US11992580B2 (en) | 2024-05-28 |
| WO2005097218A3 (en) | 2005-12-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11992580B2 (en) | Method of soft tissue augmentation | |
| JP7074951B2 (ja) | 注入可能な充填剤として及びコラーゲン成長のための足場として有用な水中シリコーン油型組成物 | |
| EP3049055B1 (en) | Method for obtaining an injectable hydrogel based on hyaluronic acid containing lidocaine added in powder form, and an alkaline agent, sterilized with heat | |
| AU2010303414B2 (en) | Methods and compositions for skin regeneration | |
| KR101279812B1 (ko) | 연골조직 수복용 조성물의 제조방법 | |
| TW201427697A (zh) | 用於治療用途之含有交聯玻尿酸及羥磷灰石的無菌可注射水性調配物 | |
| RU2674478C2 (ru) | Гиалуроновая кислота и ее применение в лечении венозной недостаточности и варикозного расширения вен | |
| Thioly-Bensoussan | Non–hyaluronic acid fillers | |
| KR20230131875A (ko) | 콜라겐 성장을 위한 주사 가능한 필러 (filler) 및스케폴드(scaffold)로서 유용한 다중점도 수중 오일 (OIL-IN-WATER) 조성물 | |
| HK1150984A (en) | Particles for soft tissue augmentation | |
| Burgess | Soft tissue augmentation | |
| Flynn et al. | Fillers and fat transfer for treatment of acne scarring | |
| Ellis et al. | Soft Tissue Augmentation with Injectable Fillers | |
| HK40017002B (en) | Silicone oil-in-water composition useful as an injectable filler and as a scaffold for collagen growth | |
| HK40017002A (en) | Silicone oil-in-water composition useful as an injectable filler and as a scaffold for collagen growth |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |