CA2560522A1

CA2560522A1 - Use of compounds for the prevention of drug-induced cell toxicity

Use of compounds for the prevention of drug-induced cell toxicity Download PDF

Info

Publication number: CA2560522A1
Authority: CA; Canada
Prior art keywords: compound; alkyl; use according; receptor; compounds
Prior art date: 2003-03-26
Legal status : Abandoned

Application number

CA002560522A

Other languages

English (en)

French (fr)

Inventor

Anders Nykjaer

Current Assignee

ReceptIcon ApS

Original Assignee

Individual

Priority date

2003-03-26

Filing date

2004-03-25

Publication date

2004-10-07

2004-03-25 Application filed by Individual filed Critical Individual

2004-10-07 Publication of CA2560522A1 publication Critical patent/CA2560522A1/en

Status Abandoned legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 title claims abstract description 183
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230000002265 prevention Effects 0.000 title description 4
108010015372 Low Density Lipoprotein Receptor-Related Protein-2 Proteins 0.000 claims abstract description 53
238000011282 treatment Methods 0.000 claims abstract description 25
238000011321 prophylaxis Methods 0.000 claims abstract description 18
238000004519 manufacturing process Methods 0.000 claims abstract description 11
-1 cyano, amino Chemical group 0.000 claims description 61
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108020003175 receptors Proteins 0.000 claims description 43
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108010003082 intrinsic factor-cobalamin receptor Proteins 0.000 claims description 41
125000004429 atom Chemical group 0.000 claims description 29
125000000217 alkyl group Chemical group 0.000 claims description 26
229910052757 nitrogen Inorganic materials 0.000 claims description 24
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 22
150000003839 salts Chemical class 0.000 claims description 21
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IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 18
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