MXPA05010143A

MXPA05010143A - Uso de compuestos para la prevencion de toxicidad celular inducida por farmaco.

Uso de compuestos para la prevencion de toxicidad celular inducida por farmaco.

Info

Publication number: MXPA05010143A
Authority: MX; Mexico
Prior art keywords: compound; alkyl; receptor; compounds; use according
Prior art date: 2003-03-26

Application number

MXPA05010143A

Other languages

English (en)

Spanish (es)

Inventor

Anders Nykjaer

Original Assignee

Reception Aps

Priority date

2003-03-26

Filing date

2004-03-25

Publication date

2006-03-17

2004-03-25 Application filed by Reception Aps filed Critical Reception Aps

2006-03-17 Publication of MXPA05010143A publication Critical patent/MXPA05010143A/es

Links

150000001875 compounds Chemical class 0.000 title claims abstract description 182
239000003814 drug Substances 0.000 title claims abstract description 104
230000007541 cellular toxicity Effects 0.000 title claims abstract description 47
229940079593 drug Drugs 0.000 title claims description 23
230000002265 prevention Effects 0.000 title description 5
108010015372 Low Density Lipoprotein Receptor-Related Protein-2 Proteins 0.000 claims abstract description 52
238000011282 treatment Methods 0.000 claims abstract description 25
238000011321 prophylaxis Methods 0.000 claims abstract description 18
238000004519 manufacturing process Methods 0.000 claims abstract description 11
-1 cyano, amino Chemical group 0.000 claims description 65
229940124597 therapeutic agent Drugs 0.000 claims description 59
102000005962 receptors Human genes 0.000 claims description 44
108020003175 receptors Proteins 0.000 claims description 44
102100031096 Cubilin Human genes 0.000 claims description 35
108010003082 intrinsic factor-cobalamin receptor Proteins 0.000 claims description 35
125000000217 alkyl group Chemical group 0.000 claims description 34
125000004429 atom Chemical group 0.000 claims description 31
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 25
229910052757 nitrogen Inorganic materials 0.000 claims description 25
150000003839 salts Chemical class 0.000 claims description 21
229910052717 sulfur Inorganic materials 0.000 claims description 19
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 18
229910052736 halogen Inorganic materials 0.000 claims description 18
150000002367 halogens Chemical class 0.000 claims description 18
210000003734 kidney Anatomy 0.000 claims description 16
125000006850 spacer group Chemical group 0.000 claims description 16
229910052799 carbon Inorganic materials 0.000 claims description 15
239000000126 substance Substances 0.000 claims description 14
125000003118 aryl group Chemical group 0.000 claims description 13
125000000753 cycloalkyl group Chemical group 0.000 claims description 13
150000001412 amines Chemical class 0.000 claims description 12
125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 12
125000001072 heteroaryl group Chemical group 0.000 claims description 12
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 12
125000003545 alkoxy group Chemical group 0.000 claims description 10
VHRGRCVQAFMJIZ-UHFFFAOYSA-N cadaverine Chemical compound NCCCCCN VHRGRCVQAFMJIZ-UHFFFAOYSA-N 0.000 claims description 10
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 10
NAQMVNRVTILPCV-UHFFFAOYSA-N hexane-1,6-diamine Chemical compound NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 claims description 9
QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 claims description 8
XFNJVJPLKCPIBV-UHFFFAOYSA-N trimethylenediamine Chemical compound NCCCN XFNJVJPLKCPIBV-UHFFFAOYSA-N 0.000 claims description 8
VCDXYRUOTHQYNM-UHFFFAOYSA-N 1-(methylamino)-3-(4-methylpiperazin-1-yl)propan-2-ol Chemical compound CNCC(O)CN1CCN(C)CC1 VCDXYRUOTHQYNM-UHFFFAOYSA-N 0.000 claims description 7
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125000000623 heterocyclic group Chemical group 0.000 claims description 7
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PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims description 6
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125000000304 alkynyl group Chemical group 0.000 claims description 6
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238000009826 distribution Methods 0.000 claims description 6
125000000592 heterocycloalkyl group Chemical group 0.000 claims description 6
229910052739 hydrogen Inorganic materials 0.000 claims description 6
239000001257 hydrogen Substances 0.000 claims description 6
KIDHWZJUCRJVML-UHFFFAOYSA-N putrescine Chemical compound NCCCCN KIDHWZJUCRJVML-UHFFFAOYSA-N 0.000 claims description 6
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 6
PAOXFRSJRCGJLV-UHFFFAOYSA-N 2-[4-(2-aminoethyl)piperazin-1-yl]ethanamine Chemical compound NCCN1CCN(CCN)CC1 PAOXFRSJRCGJLV-UHFFFAOYSA-N 0.000 claims description 5
125000004432 carbon atom Chemical group C* 0.000 claims description 5
PWSKHLMYTZNYKO-UHFFFAOYSA-N heptane-1,7-diamine Chemical compound NCCCCCCCN PWSKHLMYTZNYKO-UHFFFAOYSA-N 0.000 claims description 5
SFQSZZGLAJRHHB-UHFFFAOYSA-N piperazin-2-one;hydrochloride Chemical compound Cl.O=C1CNCCN1 SFQSZZGLAJRHHB-UHFFFAOYSA-N 0.000 claims description 5
229940077476 2,5-piperazinedione Drugs 0.000 claims description 4
VAVOYRCCWLRTMS-UHFFFAOYSA-N 4-piperazin-1-ylaniline Chemical compound C1=CC(N)=CC=C1N1CCNCC1 VAVOYRCCWLRTMS-UHFFFAOYSA-N 0.000 claims description 4
125000005843 halogen group Chemical group 0.000 claims description 4
BXRNXXXXHLBUKK-UHFFFAOYSA-N piperazine-2,5-dione Chemical compound O=C1CNC(=O)CN1 BXRNXXXXHLBUKK-UHFFFAOYSA-N 0.000 claims description 4
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125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims description 2
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