CA2557540A1 - A cancer combination therapy comprising an antitumor agent and an hdac inhibitor - Google Patents
A cancer combination therapy comprising an antitumor agent and an hdac inhibitor Download PDFInfo
- Publication number
- CA2557540A1 CA2557540A1 CA002557540A CA2557540A CA2557540A1 CA 2557540 A1 CA2557540 A1 CA 2557540A1 CA 002557540 A CA002557540 A CA 002557540A CA 2557540 A CA2557540 A CA 2557540A CA 2557540 A1 CA2557540 A1 CA 2557540A1
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- CA
- Canada
- Prior art keywords
- antitumor agent
- antitumor
- agent
- cancer
- histone deacetylase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 239000003085 diluting agent Substances 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
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- VMGAPWLDMVPYIA-HIDZBRGKSA-N n'-amino-n-iminomethanimidamide Chemical compound N\N=C\N=N VMGAPWLDMVPYIA-HIDZBRGKSA-N 0.000 description 1
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- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
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- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 1
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- 235000010234 sodium benzoate Nutrition 0.000 description 1
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004050520 | 2004-02-25 | ||
| JP2004-050520 | 2004-02-25 | ||
| US56607704P | 2004-04-29 | 2004-04-29 | |
| US60/566,077 | 2004-04-29 | ||
| PCT/JP2005/003689 WO2005079827A2 (en) | 2004-02-25 | 2005-02-25 | Antitumor agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2557540A1 true CA2557540A1 (en) | 2005-09-01 |
Family
ID=34889383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002557540A Abandoned CA2557540A1 (en) | 2004-02-25 | 2005-02-25 | A cancer combination therapy comprising an antitumor agent and an hdac inhibitor |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7951780B2 (https=) |
| EP (1) | EP1718322B1 (https=) |
| JP (1) | JP4930055B2 (https=) |
| AT (1) | ATE516041T1 (https=) |
| CA (1) | CA2557540A1 (https=) |
| CY (1) | CY1111926T1 (https=) |
| DK (1) | DK1718322T3 (https=) |
| PL (1) | PL1718322T3 (https=) |
| PT (1) | PT1718322E (https=) |
| SI (1) | SI1718322T1 (https=) |
| WO (1) | WO2005079827A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP4238728B2 (ja) * | 2001-08-21 | 2009-03-18 | アステラス製薬株式会社 | ヒストンデアセチラーゼ阻害剤の医薬用途ならびにその抗腫瘍効果の評価方法 |
| US8673888B2 (en) * | 2002-04-05 | 2014-03-18 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Depsipeptide for therapy of kidney cancer |
| EP1595952A4 (en) * | 2003-02-19 | 2008-05-21 | Astellas Pharma Inc | METHOD FOR EVALUATING THE ANTITUMOR EFFECT OF A HISTONE DEACETYLASE INHIBITOR |
| ES2425083T3 (es) * | 2003-09-25 | 2013-10-11 | Astellas Pharma Inc. | Agente antitumoral que comprende FK228 como inhibidor de histona desacetilasa y doxorrubicina como inhibidor de topoisomerasa II |
| US7951780B2 (en) | 2004-02-25 | 2011-05-31 | Astellas Pharma Inc. | Antitumor agent |
| CA2627129A1 (en) * | 2005-11-04 | 2007-05-18 | Merck & Co., Inc. | Methods of using saha and bortezomib for treating cancer |
| US20070129290A1 (en) * | 2005-11-18 | 2007-06-07 | Or Yat S | Metabolite derivatives of the HDAC inhibitor FK228 |
| EP2012801A4 (en) * | 2006-04-24 | 2009-08-05 | Gloucester Pharmaceuticals Inc | GEMCITABINE COMBINATION THERAPY |
| US8957027B2 (en) * | 2006-06-08 | 2015-02-17 | Celgene Corporation | Deacetylase inhibitor therapy |
| DK2596801T3 (en) * | 2006-10-06 | 2018-08-13 | Bavarian Nordic As | RECOMBINANT MODIFIED VACCINIA ANKARA VIRUS CODING A HER-2 ANTIGEN FOR USING CANCER TREATMENT |
| AU2007342028B2 (en) * | 2006-12-29 | 2013-06-13 | Celgene Corporation | Purifiction of romidepsin |
| CN101687010A (zh) * | 2006-12-29 | 2010-03-31 | 格洛斯特制药公司 | 制备Romidepsin |
| WO2010036404A2 (en) * | 2008-05-09 | 2010-04-01 | University Of Maryland, Baltimore | Novel retinamide retinoic acid metabolism blocking agents |
| EP2366398A1 (en) * | 2010-03-17 | 2011-09-21 | Deutsches Krebsforschungszentrum | Cancer therapy with a parvovirus combined with an HDAC inhibitor |
| JP6031437B2 (ja) * | 2010-06-07 | 2016-11-24 | アブラクシス バイオサイエンス， エルエルシー | 増殖性疾患を処置するための組み合わせ療法 |
| NZ605526A (en) | 2010-07-12 | 2015-04-24 | Celgene Corp | Romidepsin solid forms and uses thereof |
| US8859502B2 (en) | 2010-09-13 | 2014-10-14 | Celgene Corporation | Therapy for MLL-rearranged leukemia |
| AU2013202506B2 (en) | 2012-09-07 | 2015-06-18 | Celgene Corporation | Resistance biomarkers for hdac inhibitors |
| AU2013202507B9 (en) | 2012-11-14 | 2015-08-13 | Celgene Corporation | Inhibition of drug resistant cancer cells |
| NZ630311A (en) | 2013-12-27 | 2016-03-31 | Celgene Corp | Romidepsin formulations and uses thereof |
| CN106860872B (zh) * | 2017-01-18 | 2019-03-22 | 上海交通大学 | 用于逆转肿瘤对铂类抗癌药多药耐药性的两亲性药-药纳米颗粒药物及其制备方法与应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
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| GB8817743D0 (en) | 1988-07-26 | 1988-09-01 | Fujisawa Pharmaceutical Co | Fr901228 substance & preparation thereof |
| JPH0315810A (ja) * | 1989-06-13 | 1991-01-24 | Minolta Camera Co Ltd | カメラ |
| CA2308565A1 (en) * | 1997-11-05 | 1999-05-14 | Baylor College Of Medicine | Sequences for targeting metastatic cells |
| JP2003513912A (ja) * | 1999-11-10 | 2003-04-15 | ワーナー−ランバート・カンパニー | 組合せ化学療法 |
| CN1414971A (zh) * | 1999-12-08 | 2003-04-30 | 埃克斯西特治疗公司 | 用作免疫抑制剂的缩肽及其同类物 |
| ATE425177T1 (de) | 2000-07-17 | 2009-03-15 | Astellas Pharma Inc | Reduziertes fk228 und seine verwendung |
| WO2002020817A1 (en) | 2000-09-01 | 2002-03-14 | Fujisawa Pharmaceutical Co., Ltd. | A method of producing fr901228 |
| DK1355566T3 (da) * | 2000-12-18 | 2013-03-04 | Univ Texas | Lokal regional kemoterapi og radioterapi ved anvendelse af hydrogel in situ |
| US6905669B2 (en) * | 2001-04-24 | 2005-06-14 | Supergen, Inc. | Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase |
| US6620816B2 (en) * | 2001-04-26 | 2003-09-16 | Bristol-Myers Squibb Company | Method for treating tumors by the administration of tegafur, uracil, folinic acid, and cyclophosphamide |
| JP4238728B2 (ja) | 2001-08-21 | 2009-03-18 | アステラス製薬株式会社 | ヒストンデアセチラーゼ阻害剤の医薬用途ならびにその抗腫瘍効果の評価方法 |
| SK1102004A3 (sk) * | 2001-08-31 | 2005-05-05 | Bristol-Myers Squibb Company | Liečivo na liečenie proliferačných ochorení a farmaceutická kompozícia na liečenie rakoviny |
| EP1293205A1 (en) | 2001-09-18 | 2003-03-19 | G2M Cancer Drugs AG | Valproic acid and derivatives thereof for the combination therapy of human cancers, for the treatment of tumour metastasis and minimal residual disease |
| US8673888B2 (en) | 2002-04-05 | 2014-03-18 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Depsipeptide for therapy of kidney cancer |
| AU2003226408B2 (en) | 2002-04-15 | 2007-06-14 | Sloan-Kettering Institute For Cancer Research | Combination therapy for the treatment of cancer |
| PA8578001A1 (es) * | 2002-08-07 | 2004-05-07 | Warner Lambert Co | Combinaciones terapeuticas de inhibidores de quinasa de erb b y terapias antineoplasicas |
| WO2004064727A2 (en) | 2003-01-16 | 2004-08-05 | Georgetown University | Method of cancer treatment using hdac inhibitors |
| EP1595952A4 (en) | 2003-02-19 | 2008-05-21 | Astellas Pharma Inc | METHOD FOR EVALUATING THE ANTITUMOR EFFECT OF A HISTONE DEACETYLASE INHIBITOR |
| SI2238982T1 (sl) | 2003-06-27 | 2013-01-31 | Astellas Pharma Inc. | Terapevtsko sredstvo za mehkotkivni sarkom |
| CA2472842C (en) | 2003-07-22 | 2012-05-29 | Honda Motor Co., Ltd. | Working machine |
| ES2425083T3 (es) | 2003-09-25 | 2013-10-11 | Astellas Pharma Inc. | Agente antitumoral que comprende FK228 como inhibidor de histona desacetilasa y doxorrubicina como inhibidor de topoisomerasa II |
| US7951780B2 (en) | 2004-02-25 | 2011-05-31 | Astellas Pharma Inc. | Antitumor agent |
| US20050187148A1 (en) | 2004-02-25 | 2005-08-25 | Yoshinori Naoe | Antitumor agent |
-
2005
- 2005-02-24 US US11/064,292 patent/US7951780B2/en not_active Expired - Lifetime
- 2005-02-25 CA CA002557540A patent/CA2557540A1/en not_active Abandoned
- 2005-02-25 WO PCT/JP2005/003689 patent/WO2005079827A2/en not_active Ceased
- 2005-02-25 PT PT05719967T patent/PT1718322E/pt unknown
- 2005-02-25 DK DK05719967.1T patent/DK1718322T3/da active
- 2005-02-25 AT AT05719967T patent/ATE516041T1/de active
- 2005-02-25 PL PL05719967T patent/PL1718322T3/pl unknown
- 2005-02-25 JP JP2006526473A patent/JP4930055B2/ja not_active Expired - Lifetime
- 2005-02-25 EP EP05719967A patent/EP1718322B1/en not_active Expired - Lifetime
- 2005-02-25 SI SI200531350T patent/SI1718322T1/sl unknown
-
2011
- 2011-03-11 US US13/046,082 patent/US8822422B2/en active Active
- 2011-10-10 CY CY20111100965T patent/CY1111926T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US8822422B2 (en) | 2014-09-02 |
| DK1718322T3 (da) | 2011-08-29 |
| PT1718322E (pt) | 2011-09-05 |
| US7951780B2 (en) | 2011-05-31 |
| US20110160295A1 (en) | 2011-06-30 |
| WO2005079827A2 (en) | 2005-09-01 |
| JP4930055B2 (ja) | 2012-05-09 |
| EP1718322A2 (en) | 2006-11-08 |
| PL1718322T3 (pl) | 2011-12-30 |
| US20050187149A1 (en) | 2005-08-25 |
| ATE516041T1 (de) | 2011-07-15 |
| WO2005079827A3 (en) | 2005-12-08 |
| EP1718322B1 (en) | 2011-07-13 |
| JP2007524650A (ja) | 2007-08-30 |
| CY1111926T1 (el) | 2015-11-04 |
| SI1718322T1 (sl) | 2011-09-30 |
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