CA2533812C - Substituted cycloalkylidene compounds - Google Patents

Substituted cycloalkylidene compounds Download PDF

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Publication number
CA2533812C
CA2533812C CA2533812A CA2533812A CA2533812C CA 2533812 C CA2533812 C CA 2533812C CA 2533812 A CA2533812 A CA 2533812A CA 2533812 A CA2533812 A CA 2533812A CA 2533812 C CA2533812 C CA 2533812C
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Canada
Prior art keywords
methyl
phenyl
hydroxyphenyl
mmol
tetramethylcyclohexylidene
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Expired - Fee Related
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CA2533812A
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English (en)
French (fr)
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CA2533812A1 (en
Inventor
Jonathan E. Britton
Jing Fang
Dennis Heyer
Aaron Bayne Miller
Frank Navas Iii
Terrence Lee Smalley, Jr.
William J. Zuercher
Subba Reddy Katamreddy
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SmithKline Beecham Corp
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SmithKline Beecham Corp
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    • C07—ORGANIC CHEMISTRY
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
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    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
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Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008545699A (ja) * 2005-05-25 2008-12-18 スミスクライン ビーチャム コーポレーション 選択的エストロゲン受容体モジュレーターとしてのシクロアルキリデン化合物
US20060281788A1 (en) 2005-06-10 2006-12-14 Baumann Christian A Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor
WO2007062190A2 (en) * 2005-11-22 2007-05-31 Smithkline Beecham Corporation Chemical compounds
KR101367645B1 (ko) 2006-04-20 2014-02-27 얀센 파마슈티카 엔.브이. Ｃ-ｆｍｓ 키나제의 저해제로서의 복소환식 화합물
EP2016070B1 (en) 2006-04-20 2016-01-13 Janssen Pharmaceutica N.V. Inhibitors of c-fms kinase
US8697716B2 (en) 2006-04-20 2014-04-15 Janssen Pharmaceutica Nv Method of inhibiting C-KIT kinase
WO2008030771A1 (en) * 2006-09-08 2008-03-13 Smithkline Beecham Corporation Cyclic alkylidene compounds as selective estrogen receptor modulators
JO3240B1 (ar) 2007-10-17 2018-03-08 Janssen Pharmaceutica Nv c-fms مثبطات كيناز
CN102786394B (zh) * 2012-07-30 2017-03-01 中国医学科学院医药生物技术研究所 取代双芳基亚甲基环烷基衍生物及其制备方法和应用
ES2607807T3 (es) 2012-08-07 2017-04-04 Janssen Pharmaceutica Nv Procedimiento para la preparación de los inibidores de las quinasas c-fms
AU2013299922B2 (en) 2012-08-07 2018-06-21 Janssen Pharmaceutica Nv Process for the preparation of heterocyclic ester derivatives
RU2525397C2 (ru) * 2012-09-10 2014-08-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет" 1-(4-этилфенил)-2-[3-(4-этилфенил)-2-(1н)-хиноксалинилиден]-1-этанон, обладающий анальгетической активностью
AP2015008858A0 (en) * 2013-05-28 2015-11-30 Astrazeneca Ab Chemical compounds
EP3044216B1 (en) 2013-08-20 2022-02-23 University of Washington through its Center for Commercialization Novel and specific inhibitors of cytochrome p450 26 retinoic acid hydroxylase
CN107849072B (zh) 2015-06-12 2020-12-15 西蒙弗雷泽大学 酰胺连接的ep4激动剂-二膦酸盐化合物及其用途
EP4135675A4 (en) * 2020-04-17 2024-04-10 Essa Pharma, Inc. SOLID FORMS OF AN N-TERMINAL DOMAIN ANDROGEN RECEPTOR INHIBITOR AND USES THEREOF
US20240383930A1 (en) * 2021-10-01 2024-11-21 University Of Fukui Method for producing vinylphosphonic acid monoester
EP4722209A1 (en) * 2023-05-26 2026-04-08 Beijing Shenogen Pharma Group Protac compound targeting estrogen receptor, preparation method therefor, and use thereof

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB971908A (en) * 1960-11-22 1964-10-07 Ferrosan Ab Dihydroxybenzhydrylidene cycloalkanes and derivatives thereof
US3760007A (en) 1970-06-11 1973-09-18 Schering Corp Bicyclic benzhydrylidene derivatives
US3936493A (en) 1973-04-17 1976-02-03 Ortho Pharmaceutical Corporation Diarylmethylenes
DE3777366D1 (de) 1986-12-27 1992-04-16 Takeda Chemical Industries Ltd 2,3-dihydro-cumaron-derivate, ihre herstellung und verwendung.
SU1680693A1 (ru) * 1987-03-25 1991-09-30 Институт Органического Синтеза Ан Латвсср Этил-3-(2,2-диметил-2-этилгидразиний)пропионат иодистый, про вл ющий антиаритмическую активность
DE3731913A1 (de) 1987-09-23 1989-04-06 Hoechst Ag Pharmazeutische praeparate enthaltend ein 7-diphenylmethylenbicycloheptan- oder 7-diphenylmethylenbicyclohepten-derivat, die verwendung dieser verbindungen als arzneimittel sowie neue 7-diphenylmethylenbicycloheptane und 7-diphenylmethylenbicloheptene und verfahren zu ihrer herstellung
JP2876060B2 (ja) 1989-04-03 1999-03-31 株式会社リコー 電子写真感光体
US5132190A (en) 1989-04-10 1992-07-21 Mitsui Toatsu Chemicals Incorporated Hydrozones and electrophotographic photoreceptors comprising them
JPH02285356A (ja) 1989-04-26 1990-11-22 Kao Corp 電子写真感光体
JPH0315853A (ja) 1989-06-14 1991-01-24 Kao Corp 電子写真感光体
JPH03158852A (ja) 1989-11-17 1991-07-08 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料の処理方法及び定着能を有した組成物
ATE122673T1 (de) 1990-10-10 1995-06-15 Schering Corp Pyridin- und pyridin-n-oxid-derivate von diarylmethyl- piperidinen oder piperazinen, deren zusammensetzungen und anwendung.
AU659157B2 (en) 1991-04-30 1995-05-11 Asahi Kasei Kogyo Kabushiki Kaisha Triphenylethylene derivative and pharmaceutical preparation containing the same
JPH0651546A (ja) 1991-07-19 1994-02-25 Ricoh Co Ltd 電子写真用感光体
US5962731A (en) 1992-04-22 1999-10-05 Ligand Pharmaceuticals Incorporated Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
WO1993024446A1 (en) * 1992-06-02 1993-12-09 The Australian National University Anthelmintic and/or nematocidal compounds
US5306752A (en) 1992-10-09 1994-04-26 Loctite Corporation Cyanoacrylate adhesives utilizing quinoid compound polymer stabilizer
WO1994015901A1 (en) 1993-01-11 1994-07-21 Ligand Pharmaceuticals Inc. Compounds having selectivity for retinoid x receptors
JPH06332206A (ja) 1993-05-26 1994-12-02 Konica Corp 電子写真感光体及び電子写真法
DE19526146A1 (de) 1995-07-07 1997-01-09 Schering Ag Triphenylethylene, Verfahren zu deren Herstellung, diese Triphenylethylene enthaltene pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
LV11727B (en) * 1995-08-21 1997-08-20 Kalvins Ivars Pharmaceutical composition
EP0935000A3 (en) 1995-09-08 1999-09-08 Karo Bio Ab Orphan receptor
FR2751964B1 (fr) 1996-08-01 1998-10-30 Union Pharma Scient Appl Nouveaux derives diarylmethylene carbocycliques, leurs procedes de preparation, et leurs utilisations en therapeutique
TW548271B (en) 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
EP1000925A4 (en) 1997-06-17 2001-08-08 Sumitomo Chemical Co TRIPHENYLMETHANE DERIVATIVES AND THEIR USE
CN1275911A (zh) * 1997-08-15 2000-12-06 杜克大学 一种预防或治疗雌激素依赖性疾病及失调的方法
TW593256B (en) 1999-11-16 2004-06-21 Hormos Medical Oy Ltd Triphenylalkene derivatives and their use as selective estrogen receptor modulators
US6787764B2 (en) * 2000-02-18 2004-09-07 Bruker Daltonics, Inc. Method and apparatus for automating a matrix-assisted laser desorption/ionization (MALDI) mass spectrometer
US6552036B2 (en) 2000-03-03 2003-04-22 Ortho-Mcneil Pharmaceutical, Inc. 3-(Diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives
JP2002008865A (ja) 2000-06-23 2002-01-11 Matsushita Electric Ind Co Ltd 有機電界発光素子
WO2002044141A2 (en) 2000-09-20 2002-06-06 Schering Corporation Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists
EP1417169A2 (en) 2001-08-11 2004-05-12 Bristol-Myers Squibb Pharma Company Selective estrogen receptor modulators
JP2008545699A (ja) * 2005-05-25 2008-12-18 スミスクライン ビーチャム コーポレーション 選択的エストロゲン受容体モジュレーターとしてのシクロアルキリデン化合物

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