CA2528597C - Stabilized immunomodulatory oligonucleotides - Google Patents
Stabilized immunomodulatory oligonucleotides Download PDFInfo
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- CA2528597C CA2528597C CA2528597A CA2528597A CA2528597C CA 2528597 C CA2528597 C CA 2528597C CA 2528597 A CA2528597 A CA 2528597A CA 2528597 A CA2528597 A CA 2528597A CA 2528597 C CA2528597 C CA 2528597C
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Classifications
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/17—Immunomodulatory nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2310/3183—Diol linkers, e.g. glycols or propanediols
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/336—Modified G
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
- C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47760803P | 2003-06-11 | 2003-06-11 | |
| US60/477,608 | 2003-06-11 | ||
| US49903803P | 2003-08-29 | 2003-08-29 | |
| US60/499,038 | 2003-08-29 | ||
| US50427903P | 2003-09-18 | 2003-09-18 | |
| US60/504,279 | 2003-09-18 | ||
| PCT/US2004/018745 WO2005001055A2 (en) | 2003-06-11 | 2004-06-10 | Stabilized immunomodulatory oligonucleotides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2528597A1 CA2528597A1 (en) | 2005-01-06 |
| CA2528597C true CA2528597C (en) | 2014-08-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2528597A Expired - Lifetime CA2528597C (en) | 2003-06-11 | 2004-06-10 | Stabilized immunomodulatory oligonucleotides |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8008267B2 (ko) |
| EP (2) | EP2371834B1 (ko) |
| JP (2) | JP4874801B2 (ko) |
| KR (1) | KR101137572B1 (ko) |
| CN (1) | CN102604957B (ko) |
| AU (2) | AU2004252505B2 (ko) |
| CA (1) | CA2528597C (ko) |
| ES (1) | ES2569927T3 (ko) |
| MX (1) | MXPA05013658A (ko) |
| WO (1) | WO2005001055A2 (ko) |
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| JP4598389B2 (ja) * | 2001-06-21 | 2010-12-15 | ダイナバックス テクノロジーズ コーポレイション | キメラ免疫調節化合物とその使用方法 |
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- 2004-06-10 ES ES10011770.4T patent/ES2569927T3/es not_active Expired - Lifetime
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- 2004-06-10 MX MXPA05013658A patent/MXPA05013658A/es active IP Right Grant
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- 2004-06-10 KR KR1020057023889A patent/KR101137572B1/ko not_active IP Right Cessation
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- 2004-06-10 WO PCT/US2004/018745 patent/WO2005001055A2/en active Application Filing
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- 2011-05-31 JP JP2011122456A patent/JP2011200248A/ja active Pending
- 2011-08-16 US US13/210,903 patent/US8946175B1/en active Active
Also Published As
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| US8946175B1 (en) | 2015-02-03 |
| MXPA05013658A (es) | 2006-03-02 |
| AU2004252505B2 (en) | 2010-10-28 |
| US20050026861A1 (en) | 2005-02-03 |
| JP2007500018A (ja) | 2007-01-11 |
| CN102604957B (zh) | 2015-10-07 |
| EP2371834A1 (en) | 2011-10-05 |
| WO2005001055A2 (en) | 2005-01-06 |
| CN102604957A (zh) | 2012-07-25 |
| AU2011200272B2 (en) | 2011-12-22 |
| KR20060007444A (ko) | 2006-01-24 |
| EP1631576A2 (en) | 2006-03-08 |
| EP1631576A4 (en) | 2010-08-25 |
| CA2528597A1 (en) | 2005-01-06 |
| WO2005001055A3 (en) | 2005-10-13 |
| EP2371834B1 (en) | 2016-02-17 |
| US8008267B2 (en) | 2011-08-30 |
| AU2004252505A1 (en) | 2005-01-06 |
| AU2004252505A2 (en) | 2005-01-06 |
| AU2011200272A1 (en) | 2011-02-17 |
| ES2569927T3 (es) | 2016-05-13 |
| KR101137572B1 (ko) | 2012-05-30 |
| JP2011200248A (ja) | 2011-10-13 |
| JP4874801B2 (ja) | 2012-02-15 |
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