CA2528510C - Conserved hbv and hcv sequences useful for gene silencing - Google Patents

Conserved hbv and hcv sequences useful for gene silencing Download PDF

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Publication number
CA2528510C
CA2528510C CA2528510A CA2528510A CA2528510C CA 2528510 C CA2528510 C CA 2528510C CA 2528510 A CA2528510 A CA 2528510A CA 2528510 A CA2528510 A CA 2528510A CA 2528510 C CA2528510 C CA 2528510C
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Prior art keywords
seq
promoter
sequence
sequences
rna
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Expired - Lifetime
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CA2528510A
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French (fr)
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CA2528510A1 (en
Inventor
Catherine J. Pachuk
C. Satishchandran
Vincent R. Zurawski, Jr.
Liat Mintz
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Alnylam Pharmaceuticals Inc
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Alnylam Pharmaceuticals Inc
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • C12N2310/111Antisense spanning the whole gene, or a large part of it
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/50Physical structure
    • C12N2310/53Physical structure partially self-complementary or closed
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/50Physical structure
    • C12N2310/53Physical structure partially self-complementary or closed
    • C12N2310/531Stem-loop; Hairpin

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  • Engineering & Computer Science (AREA)
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  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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CA2528510A 2003-06-12 2004-06-10 Conserved hbv and hcv sequences useful for gene silencing Expired - Lifetime CA2528510C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3040025A CA3040025C (en) 2003-06-12 2004-06-10 Conserved hbv and hcv sequences useful for gene silencing

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47807603P 2003-06-12 2003-06-12
US60/478,076 2003-06-12
PCT/US2004/019229 WO2005014806A2 (en) 2003-06-12 2004-06-10 Conserved hbv and hcv sequences useful for gene silencing

Related Child Applications (1)

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CA3040025A Division CA3040025C (en) 2003-06-12 2004-06-10 Conserved hbv and hcv sequences useful for gene silencing

Publications (2)

Publication Number Publication Date
CA2528510A1 CA2528510A1 (en) 2005-02-17
CA2528510C true CA2528510C (en) 2019-06-04

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CA2528510A Expired - Lifetime CA2528510C (en) 2003-06-12 2004-06-10 Conserved hbv and hcv sequences useful for gene silencing
CA3040025A Expired - Lifetime CA3040025C (en) 2003-06-12 2004-06-10 Conserved hbv and hcv sequences useful for gene silencing

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US (1) US8350021B2 (enExample)
EP (4) EP3470518A1 (enExample)
JP (2) JP4980716B2 (enExample)
CN (1) CN1836042A (enExample)
AU (1) AU2004263832B2 (enExample)
BR (1) BRPI0411219A (enExample)
CA (2) CA2528510C (enExample)
DK (1) DK2270162T3 (enExample)
HU (1) HUE042261T2 (enExample)
IL (1) IL172268A0 (enExample)
SG (1) SG173218A1 (enExample)
SI (1) SI2270162T1 (enExample)
WO (1) WO2005014806A2 (enExample)

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SG173218A1 (en) 2011-08-29
EP1631670B1 (en) 2012-08-08
JP2011224013A (ja) 2011-11-10
AU2004263832B2 (en) 2010-07-01
IL172268A0 (en) 2006-04-10
JP2007503474A (ja) 2007-02-22
EP2284268A3 (en) 2012-05-30
BRPI0411219A (pt) 2006-07-18
CA3040025C (en) 2023-01-10
EP2270162A2 (en) 2011-01-05
WO2005014806A3 (en) 2005-12-01
WO2005014806A2 (en) 2005-02-17
HUE042261T2 (hu) 2019-06-28
EP2270162B1 (en) 2018-10-03
US20080070854A1 (en) 2008-03-20
EP2270162A3 (en) 2012-05-30
EP2284268A2 (en) 2011-02-16
CN1836042A (zh) 2006-09-20
JP5593279B2 (ja) 2014-09-17
DK2270162T3 (en) 2019-01-21
AU2004263832A1 (en) 2005-02-17
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