CA2526205C - Dispositif microfluidique - Google Patents
Dispositif microfluidique Download PDFInfo
- Publication number
- CA2526205C CA2526205C CA 2526205 CA2526205A CA2526205C CA 2526205 C CA2526205 C CA 2526205C CA 2526205 CA2526205 CA 2526205 CA 2526205 A CA2526205 A CA 2526205A CA 2526205 C CA2526205 C CA 2526205C
- Authority
- CA
- Canada
- Prior art keywords
- microchannel
- pressure
- input
- enclosure
- flow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000012530 fluid Substances 0.000 claims abstract description 39
- 239000000047 product Substances 0.000 claims description 51
- 239000007788 liquid Substances 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 14
- 238000004891 communication Methods 0.000 claims description 13
- 238000006243 chemical reaction Methods 0.000 claims description 11
- 238000004458 analytical method Methods 0.000 claims description 6
- 238000001962 electrophoresis Methods 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 5
- 238000004587 chromatography analysis Methods 0.000 claims description 4
- 238000011209 electrochromatography Methods 0.000 claims description 3
- 238000005530 etching Methods 0.000 claims description 3
- 238000000465 moulding Methods 0.000 claims description 3
- 238000000746 purification Methods 0.000 claims description 3
- 230000006835 compression Effects 0.000 claims description 2
- 238000007906 compression Methods 0.000 claims description 2
- 238000003745 diagnosis Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 238000001125 extrusion Methods 0.000 claims description 2
- 238000013537 high throughput screening Methods 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 239000012263 liquid product Substances 0.000 claims description 2
- 238000001308 synthesis method Methods 0.000 claims 1
- 239000007789 gas Substances 0.000 description 25
- 238000000926 separation method Methods 0.000 description 11
- 230000001276 controlling effect Effects 0.000 description 7
- 241000894007 species Species 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 6
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 5
- 238000003786 synthesis reaction Methods 0.000 description 4
- 239000011324 bead Substances 0.000 description 3
- 229920002521 macromolecule Polymers 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 229910052697 platinum Inorganic materials 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- OSBLTNPMIGYQGY-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid;boric acid Chemical compound OB(O)O.OCC(N)(CO)CO.OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O OSBLTNPMIGYQGY-UHFFFAOYSA-N 0.000 description 2
- 239000008051 TBE buffer Substances 0.000 description 2
- 238000004082 amperometric method Methods 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005370 electroosmosis Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 238000004377 microelectronic Methods 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 2
- 230000002572 peristaltic effect Effects 0.000 description 2
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- BHELIUBJHYAEDK-OAIUPTLZSA-N Aspoxicillin Chemical compound C1([C@H](C(=O)N[C@@H]2C(N3[C@H](C(C)(C)S[C@@H]32)C(O)=O)=O)NC(=O)[C@H](N)CC(=O)NC)=CC=C(O)C=C1 BHELIUBJHYAEDK-OAIUPTLZSA-N 0.000 description 1
- 241000701959 Escherichia virus Lambda Species 0.000 description 1
- 102000002068 Glycopeptides Human genes 0.000 description 1
- 108010015899 Glycopeptides Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000006037 cell lysis Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000005868 electrolysis reaction Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000001976 enzyme digestion Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000005669 field effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000007210 heterogeneous catalysis Methods 0.000 description 1
- 238000007731 hot pressing Methods 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 230000002706 hydrostatic effect Effects 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 239000006249 magnetic particle Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000002090 nanochannel Substances 0.000 description 1
- QGZKDVFQNNGYKY-NJFSPNSNSA-N nitrogen-16 Chemical compound [16NH3] QGZKDVFQNNGYKY-NJFSPNSNSA-N 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 239000011146 organic particle Substances 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920001992 poloxamer 407 Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000010349 pulsation Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00162—Controlling or regulating processes controlling the pressure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00788—Three-dimensional assemblies, i.e. the reactor comprising a form other than a stack of plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00851—Additional features
- B01J2219/00853—Employing electrode arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00851—Additional features
- B01J2219/00858—Aspects relating to the size of the reactor
- B01J2219/00862—Dimensions of the reaction cavity itself
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00891—Feeding or evacuation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/0095—Control aspects
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/14—Means for pressure control
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
- B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/4673—Plural tanks or compartments with parallel flow
- Y10T137/4757—Battery or electrolytic cell replenishment
- Y10T137/4774—Barometric supply
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/4673—Plural tanks or compartments with parallel flow
- Y10T137/479—Flow dividing compartments
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/7287—Liquid level responsive or maintaining systems
- Y10T137/7303—Control of both inflow and outflow of tank
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/7722—Line condition change responsive valves
- Y10T137/7758—Pilot or servo controlled
- Y10T137/7759—Responsive to change in rate of fluid flow
- Y10T137/776—Control by pressures across flow line valve
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/7722—Line condition change responsive valves
- Y10T137/7781—With separate connected fluid reactor surface
- Y10T137/7784—Responsive to change in rate of fluid flow
- Y10T137/7792—Movable deflector or choke
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Organic Chemistry (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Micromachines (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR03/06119 | 2003-05-21 | ||
| FR0306119A FR2855076B1 (fr) | 2003-05-21 | 2003-05-21 | Dispositif microfluidique |
| PCT/FR2004/001236 WO2004103566A1 (fr) | 2003-05-21 | 2004-05-19 | Dispositif microfluidique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2526205A1 CA2526205A1 (fr) | 2004-12-02 |
| CA2526205C true CA2526205C (fr) | 2012-03-13 |
Family
ID=33396644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2526205 Expired - Lifetime CA2526205C (fr) | 2003-05-21 | 2004-05-19 | Dispositif microfluidique |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7972561B2 (zh) |
| EP (1) | EP1628769B1 (zh) |
| JP (1) | JP4639189B2 (zh) |
| CN (1) | CN1816393B (zh) |
| CA (1) | CA2526205C (zh) |
| FR (1) | FR2855076B1 (zh) |
| WO (1) | WO2004103566A1 (zh) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7061595B2 (en) * | 2000-08-02 | 2006-06-13 | Honeywell International Inc. | Miniaturized flow controller with closed loop regulation |
| GB0320337D0 (en) * | 2003-08-29 | 2003-10-01 | Syrris Ltd | A microfluidic system |
| CN102759466A (zh) | 2004-09-15 | 2012-10-31 | 英特基因有限公司 | 微流体装置 |
| US7727477B2 (en) * | 2004-12-10 | 2010-06-01 | Bio-Rad Laboratories, Inc. | Apparatus for priming microfluidics devices with feedback control |
| JP2006181474A (ja) * | 2004-12-27 | 2006-07-13 | Kao Corp | マイクロプロセス方法及び装置並びにマイクロ分析方法 |
| DE102005008224B3 (de) * | 2005-02-23 | 2006-06-14 | Directif Gmbh | Vorrichtung und Verfahren zur automatischen Betätigung einer mikrofluidischen Einrichtung |
| JP4657867B2 (ja) * | 2005-09-27 | 2011-03-23 | セイコーインスツル株式会社 | マイクロリアクター及びマイクロリアクターシステム |
| US7334457B2 (en) * | 2005-10-12 | 2008-02-26 | Viscotek Corporation | Multi-capillary viscometer system and method |
| EP1979079A4 (en) | 2006-02-03 | 2012-11-28 | Integenx Inc | MICROFLUIDIC DEVICES |
| US8557570B2 (en) * | 2006-11-06 | 2013-10-15 | Massachusetts Institute Of Technology | Pumping and flow control in systems including microfluidic systems |
| KR100833679B1 (ko) * | 2006-11-07 | 2008-05-29 | 포항공과대학교 산학협력단 | 극소량 액체의 혼합 장치 및 그 혼합 방법 |
| US7798164B2 (en) * | 2007-01-26 | 2010-09-21 | California Institute Of Technology | Plasmon assisted control of optofluidics |
| WO2008115626A2 (en) | 2007-02-05 | 2008-09-25 | Microchip Biotechnologies, Inc. | Microfluidic and nanofluidic devices, systems, and applications |
| JPWO2008096563A1 (ja) * | 2007-02-06 | 2010-05-20 | コニカミノルタエムジー株式会社 | マイクロチップ検査システム、マイクロチップ検査装置及びプログラム |
| WO2008123022A1 (ja) * | 2007-03-20 | 2008-10-16 | Fujifilm Corporation | 送液装置及び送液制御方法 |
| US20080257713A1 (en) * | 2007-04-17 | 2008-10-23 | Robert Woodhull Grant | Catalytic reactors with active boundary layer control |
| DE102007032951B4 (de) | 2007-07-14 | 2010-09-02 | Karlsruher Institut für Technologie | Vorrichtung und Verfahren zur Zuführung eines Flüssigkeitsstroms aus mindestens zwei Flüssigkeitsabschnitten in eine Messzelle |
| WO2009039466A1 (en) | 2007-09-20 | 2009-03-26 | Vanderbilt University | Free solution measurement of molecular interactions by backscattering interferometry |
| EP2077149A1 (en) * | 2007-12-21 | 2009-07-08 | Corning Incorporated | Microreactor assembly incorporating an interconnecting element and diverse fluidic microstructures |
| US20090253181A1 (en) | 2008-01-22 | 2009-10-08 | Microchip Biotechnologies, Inc. | Universal sample preparation system and use in an integrated analysis system |
| US20090325159A1 (en) * | 2008-06-30 | 2009-12-31 | Canon U.S. Life Sciences, Inc. | System and method to prevent cross-contamination in assays performed in a microfluidic channel |
| US8122901B2 (en) | 2008-06-30 | 2012-02-28 | Canon U.S. Life Sciences, Inc. | System and method for microfluidic flow control |
| WO2010077322A1 (en) | 2008-12-31 | 2010-07-08 | Microchip Biotechnologies, Inc. | Instrument with microfluidic chip |
| GB0902836D0 (en) | 2009-02-19 | 2009-04-08 | Iti Scotland Ltd | Flow control |
| JP2010214347A (ja) * | 2009-03-19 | 2010-09-30 | Tosoh Corp | 微小流路構造体を用いたマイクロ化学装置、その洗浄方法及び微粒子製造方法 |
| US8388908B2 (en) | 2009-06-02 | 2013-03-05 | Integenx Inc. | Fluidic devices with diaphragm valves |
| US8584703B2 (en) * | 2009-12-01 | 2013-11-19 | Integenx Inc. | Device with diaphragm valve |
| US8512538B2 (en) | 2010-05-28 | 2013-08-20 | Integenx Inc. | Capillary electrophoresis device |
| WO2011156713A1 (en) | 2010-06-11 | 2011-12-15 | Vanderbilt University | Multiplexed interferometric detection system and method |
| US8763642B2 (en) | 2010-08-20 | 2014-07-01 | Integenx Inc. | Microfluidic devices with mechanically-sealed diaphragm valves |
| WO2012024658A2 (en) | 2010-08-20 | 2012-02-23 | IntegenX, Inc. | Integrated analysis system |
| US9562853B2 (en) | 2011-02-22 | 2017-02-07 | Vanderbilt University | Nonaqueous backscattering interferometric methods |
| EP2570488A1 (en) | 2011-09-16 | 2013-03-20 | Centre National de la Recherche Scientifique (C.N.R.S) | Method for longitudinal macromolecule spreading and method for analyzing macromolecules |
| US10865440B2 (en) | 2011-10-21 | 2020-12-15 | IntegenX, Inc. | Sample preparation, processing and analysis systems |
| US20150136604A1 (en) | 2011-10-21 | 2015-05-21 | Integenx Inc. | Sample preparation, processing and analysis systems |
| EP3301677B1 (en) | 2011-12-21 | 2019-08-28 | Huawei Technologies Co., Ltd. | Very short pitch detection and coding |
| US9273949B2 (en) | 2012-05-11 | 2016-03-01 | Vanderbilt University | Backscattering interferometric methods |
| FR2994103B1 (fr) | 2012-08-03 | 2016-05-27 | Centre Nat Rech Scient | Procede de separation de molecules en solution |
| DE102012019819A1 (de) * | 2012-10-10 | 2014-04-10 | Claus Fütterer | Verfahren und eine Vorrichtung zur Steuerung des Drucks in einem Mikro- oder Mesofluidik-Kanal |
| EP2720103B1 (en) * | 2012-10-10 | 2020-06-17 | Fluigent SA | Flow-rate calibration and control in a microfluidic device |
| JP6001507B2 (ja) * | 2013-06-19 | 2016-10-05 | 日本電信電話株式会社 | 送液装置および送液方法 |
| US9732377B2 (en) * | 2013-10-11 | 2017-08-15 | Virginia Tech Intellectual Properties, Inc. | Microfluidic systems and methods for chromatin immunoprecipitation (ChIP) |
| US10076751B2 (en) | 2013-12-30 | 2018-09-18 | General Electric Company | Systems and methods for reagent storage |
| US9399216B2 (en) | 2013-12-30 | 2016-07-26 | General Electric Company | Fluid transport in microfluidic applications with sensors for detecting fluid presence and pressure |
| WO2015178381A1 (ja) * | 2014-05-21 | 2015-11-26 | コニカミノルタ株式会社 | 細胞展開用デバイスの前処理方法、細胞展開用デバイス、および細胞展開用デバイスの前処理システム |
| EP3247988A4 (en) | 2015-01-23 | 2018-12-19 | Vanderbilt University | A robust interferometer and methods of using same |
| US11940422B2 (en) | 2015-07-12 | 2024-03-26 | Pharmafluidics Nv | Microfluidic device |
| BE1023273B1 (nl) * | 2015-07-12 | 2017-01-19 | PharmaFluidics N.V. | Microfluïdische inrichting |
| EP3120928A1 (en) | 2015-07-24 | 2017-01-25 | Centre National De La Recherche Scientifique | Fluidic devices with at least one actionnable fiber |
| CN105170204B (zh) * | 2015-08-25 | 2017-01-18 | 辽宁中医药大学 | 一种液体无间断切换结构及具有该结构的微流控芯片 |
| JP6792845B2 (ja) * | 2016-01-05 | 2020-12-02 | 日本板硝子株式会社 | 反応処理装置および反応処理方法 |
| EP3408649B1 (en) | 2016-01-29 | 2023-06-14 | Vanderbilt University | Free-solution response function interferometry |
| CN108245931A (zh) * | 2016-12-29 | 2018-07-06 | 天津领世生物科技开发有限公司 | 机械式柱层析装置 |
| JP6931540B2 (ja) | 2017-02-27 | 2021-09-08 | シスメックス株式会社 | 検体処理チップを用いた送液方法、検体処理チップの送液装置 |
| FR3064621B1 (fr) | 2017-04-03 | 2022-02-18 | Fluigent | Dispositif microfluidique |
| CN106940333A (zh) * | 2017-04-17 | 2017-07-11 | 山西医科大学 | 离体细胞外神经电生理研究用灌流系统 |
| CN106990443A (zh) * | 2017-04-24 | 2017-07-28 | 北京交通大学 | 一种改变导电液体内部导电路径的磁性液体装置 |
| US11918961B2 (en) * | 2017-07-04 | 2024-03-05 | Universite Libre De Bruxelles | Droplet and/or bubble generator |
| US11648555B2 (en) * | 2017-10-21 | 2023-05-16 | The Royal Institution For The Advancement Of Learning/Mcgill University | Domino capillary microfluidic circuit |
| DE102018206463A1 (de) * | 2018-04-26 | 2019-10-31 | Robert Bosch Gmbh | Verfahren zum Verdünnen, Mischen und/oder Aliquotieren von zwei Flüssigkeiten in einem mikrofluidisches System |
| FR3092011B1 (fr) | 2019-01-25 | 2021-11-05 | Fluigent | Dispositif et procédé pour créer une émulsion |
| CN111019806B (zh) * | 2019-12-25 | 2023-08-11 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | 基因序列分选合成装置及分选合成方法 |
| CN111207988B (zh) * | 2020-02-18 | 2021-08-27 | 中南大学 | 一种基于微流体的矿浆监测装置 |
| WO2021237031A1 (en) * | 2020-05-22 | 2021-11-25 | Microfluidics International Corporation | High-pressure priming valve |
| CN112007705A (zh) * | 2020-09-07 | 2020-12-01 | 新羿制造科技（北京）有限公司 | 微液滴生成装置 |
| US20220147076A1 (en) * | 2020-11-07 | 2022-05-12 | Yehuda Yuval Nagar | Shabbat compressor |
| EP4019774A1 (en) | 2020-12-22 | 2022-06-29 | Fluigent | Apparatus for controlling pressure or flow in a fluidic system |
| CN113070108B (zh) * | 2021-03-01 | 2022-05-06 | 清华大学 | 图案化水凝胶微粒制备方法及微流控装置 |
| DE102021005140A1 (de) * | 2021-10-14 | 2023-04-20 | Evorion Biotechnologies Gmbh | Vorrichtung zur Steuerung der Strömung einer Flüssigkeit durch eine mikrofluidische Verbindungsvorrichtung |
| EP4170169A1 (en) | 2021-10-25 | 2023-04-26 | Fluigent | Apparatus for controlling positive and negative pressure or flow in a fluidic system |
| CN114252477B (zh) * | 2021-12-30 | 2023-12-15 | 中国科学院力学研究所 | 一种二氧化碳混合工质的循环微通道换热实验装置 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3590910A (en) * | 1970-01-02 | 1971-07-06 | Trane Co | Heating-cooling air-conditioning system control |
| US5195494A (en) * | 1992-02-27 | 1993-03-23 | Walbro Corporation | Fuel delivery system with outlet pressure regulation |
| US5578179A (en) * | 1995-07-12 | 1996-11-26 | The Perkin-Elmer Corporation | Method and silicate composition for conditioning silica surfaces |
| US5726404A (en) * | 1996-05-31 | 1998-03-10 | University Of Washington | Valveless liquid microswitch |
| EP0988529B1 (en) * | 1997-04-25 | 2013-06-12 | Caliper Life Sciences, Inc. | Microfluidic devices incorporating improved channel geometries |
| US6012902A (en) | 1997-09-25 | 2000-01-11 | Caliper Technologies Corp. | Micropump |
| CN1326549A (zh) | 1998-10-13 | 2001-12-12 | 微生物系统公司 | 基于无源流体动力学的流体管路元件 |
| KR100865105B1 (ko) | 1999-06-28 | 2008-10-24 | 캘리포니아 인스티튜트 오브 테크놀로지 | 마이크로 가공된 탄성중합체 밸브 및 펌프 시스템 |
| US6395232B1 (en) * | 1999-07-09 | 2002-05-28 | Orchid Biosciences, Inc. | Fluid delivery system for a microfluidic device using a pressure pulse |
| US6875619B2 (en) * | 1999-11-12 | 2005-04-05 | Motorola, Inc. | Microfluidic devices comprising biochannels |
| US7040144B2 (en) * | 2000-02-23 | 2006-05-09 | Caliper Life Sciences, Inc. | Microfluidic viscometer |
| AU2001259770A1 (en) | 2000-05-15 | 2001-11-26 | Biomicro Systems, Inc. | Air flow regulation in microfluidic circuits for pressure control and gaseous exchange |
| US6615856B2 (en) | 2000-08-04 | 2003-09-09 | Biomicro Systems, Inc. | Remote valving for microfluidic flow control |
| WO2002064253A2 (en) * | 2001-02-09 | 2002-08-22 | Microchem Solutions | Method and apparatus for sample injection in microfabricated devices |
-
2003
- 2003-05-21 FR FR0306119A patent/FR2855076B1/fr not_active Expired - Lifetime
-
2004
- 2004-05-19 CN CN2004800188528A patent/CN1816393B/zh not_active Expired - Lifetime
- 2004-05-19 EP EP04742779.4A patent/EP1628769B1/fr not_active Expired - Lifetime
- 2004-05-19 CA CA 2526205 patent/CA2526205C/fr not_active Expired - Lifetime
- 2004-05-19 JP JP2006530369A patent/JP4639189B2/ja not_active Expired - Lifetime
- 2004-05-19 WO PCT/FR2004/001236 patent/WO2004103566A1/fr active Application Filing
- 2004-05-19 US US10/557,308 patent/US7972561B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007511744A (ja) | 2007-05-10 |
| US20060275179A1 (en) | 2006-12-07 |
| EP1628769A1 (fr) | 2006-03-01 |
| CA2526205A1 (fr) | 2004-12-02 |
| US7972561B2 (en) | 2011-07-05 |
| JP4639189B2 (ja) | 2011-02-23 |
| EP1628769B1 (fr) | 2018-07-04 |
| WO2004103566A1 (fr) | 2004-12-02 |
| FR2855076B1 (fr) | 2006-09-08 |
| CN1816393B (zh) | 2011-05-18 |
| FR2855076A1 (fr) | 2004-11-26 |
| CN1816393A (zh) | 2006-08-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2526205C (fr) | Dispositif microfluidique | |
| US11607684B2 (en) | Microfluidic sample chip, assay system using such a chip, and PCR method for detecting DNA sequences | |
| Wang et al. | Two-dimensional protein separation with advanced sample and buffer isolation using microfluidic valves | |
| Novo et al. | Current advances and challenges in microfluidic free-flow electrophoresis—A critical review | |
| JPWO2006106643A1 (ja) | マイクロ総合分析システム、検査用チップ、及び検査方法 | |
| EP3548167A1 (en) | Methods for mixing fluids in microfluidic devices, and devices and systems therefor | |
| EP3085444B1 (fr) | Dispositif microfluidique de contrôle d'écoulement d'un fluide | |
| Hernández Vera et al. | Modular microfluidic systems cast from 3D-printed molds for imaging leukocyte adherence to differentially treated endothelial cultures | |
| US20110032513A1 (en) | Fluid flow device, assembly for determining at least one characteristic of a physico-chemical system therewith | |
| EP3712244B1 (fr) | Procédé d'enrichissement en gaz et simultanément de déplacement d'un fluide et système pour le contrôle de l'environnement cellulaire sur une plaque de culture cellulaire multipuits correspondant | |
| Lee et al. | Self-assembled particle membranes for in situ concentration and chemostat-like cultivation of microorganisms on a chip | |
| EP3877744B1 (fr) | Dispositif microfluidique de preparation d'echantillons offrant une grande repetabilite | |
| WO2018100421A1 (en) | Methods for mixing fluids in microfluidic devices, and devices and systems therefor | |
| FR2831081A1 (fr) | Dispositif d'injection parallelisee et synchronisee pour injections sequentielles de reactifs differents | |
| Liu et al. | Hermetic encapsulation of negative-pressure-driven PDMS microfluidic devices using paraffin wax and glass | |
| Team | PDMS: A review | |
| JP2005043075A (ja) | 流量制御装置及び流量制御システム | |
| US20220016627A1 (en) | Detection of components | |
| Gaillard et al. | Isolation of Extracellular Vesicles from Cell Culture and Blood Through Nano-Targeted DLD Microfluidic Device | |
| FR3074810A1 (fr) | Puce echantillon micro-fluidique, systeme d'analyse utilisant une telle puce et procede pcr pour la detection de sequences adn | |
| Mu et al. | Oil–water biphasic parallel flow for the precise patterning of metals and cells | |
| Bai et al. | A handheld, wide-range pressure pump for portable microfluidic applications | |
| FR3060418A1 (fr) | Puce micro fluidique, systeme utilisant une telle puce et procede pcr pour la detection de sequences adn | |
| Chen | Microfluidic devices for droplet sorting, on-line sensing, and microwinery |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |